Annals of Internal Medicine最新文献

{"title":"<i>Super Mario</i> Soldiers.","authors":"Jue Wang","doi":"10.7326/ANNALS-26-02552","DOIUrl":"https://doi.org/10.7326/ANNALS-26-02552","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":"179 10","pages":"1506-1507"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149222966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality Indicators for Diabetes in Adults.","authors":"Karen Campos, Peter Basch, Rebecca A Andrews, Scott T MacDonald, Amir Qaseem","doi":"10.7326/ANNALS-26-02187","DOIUrl":"https://doi.org/10.7326/ANNALS-26-02187","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":"179 10","pages":"1524"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cost-Effectiveness of Semaglutide and Tirzepatide for Patients With Knee Osteoarthritis and Obesity.","authors":"Karen C Smith, Elena Losina","doi":"10.7326/ANNALS-26-02925","DOIUrl":"https://doi.org/10.7326/ANNALS-26-02925","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":"179 10","pages":"1523-1524"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Provision of Onsite Prenatal Care Services at U.S. Federally Qualified Health Centers.","authors":"Megan B Cole, Samantha Auty, Ginger Zi Jin, Cara Safon, Sarah H Gordon","doi":"10.7326/ANNALS-26-00381","DOIUrl":"10.7326/ANNALS-26-00381","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"1519-1522"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13367413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periconception Parental Red Blood Cell Folate, Vitamin B₁₂, and Birth Defects in Offspring : A Prospective Cohort Study.","authors":"Hongyan Chen, Xiaotian Chen, Yi Zhang, Mengru Li, Qinyu Yao, Dingmei Wang, Quming Zhao, Yuanzhou Peng, Yalan Dou, Wennan He, Yuanchen He, Youping Tian, Xiaojing Ma, Xiaojing Hu, Xiaoling Ge, Wei Sheng, Fang Liu, Duolao Wang, Weili Yan, Guoying Huang","doi":"10.7326/ANNALS-25-05243","DOIUrl":"10.7326/ANNALS-25-05243","url":null,"abstract":"<p><strong>Background: </strong>Maternal folic acid prevents neural tube defects, but associations of parental folate and vitamin B₁₂ with birth defects remain unclear.</p><p><strong>Objective: </strong>To quantify associations of parental vitamin B₁₂ and red blood cell (RBC) folate with offspring birth defects.</p><p><strong>Design: </strong>Prospective cohort study.</p><p><strong>Setting: </strong>Shanghai Preconception Cohort, China.</p><p><strong>Participants: </strong>3032 couples (73 birth defect cases) with biomarkers sampled within 4 months before conception, and 17 765 women (327 birth defect cases) sampled at 4 months' gestation or earlier.</p><p><strong>Measurements: </strong>Standardized predicted prevalences of birth defects ascertained among live births, stillbirths, and abortions due to fetal abnormalities were estimated using weighted logistic regression.</p><p><strong>Results: </strong>Higher preconception parental levels of vitamin B₁₂ were associated with lower predicted prevalences of birth defects in dose-response analyses. For preconception maternal vitamin B₁₂ from the lowest (<148 pmol/L) to highest (≥590 pmol/L) categories, predicted prevalence decreased from 49.6 to 16.2 cases per 1000 pregnancies; paternal vitamin B₁₂ showed a similar but attenuated pattern (55.5 to 24.0 cases per 1000 pregnancies). Preconception parental RBC folate showed imprecise patterns of lower predicted prevalence. For postconception maternal RBC folate, predicted prevalence was lower at levels of 906 to 1131 nmol/L than at levels below 453 nmol/L (16.5 vs. 25.7 cases per 1000 pregnancies), with little further reduction at higher levels. For postconception maternal vitamin B₁₂, predicted prevalence changed little across lower categories but was lower at higher levels (11.8 vs. 20.4 cases per 1000 pregnancies at ≥590 vs. 148 to 294 pmol/L, respectively).</p><p><strong>Limitation: </strong>Residual confounding.</p><p><strong>Conclusion: </strong>Periconception parental vitamin B₁₂ and postconception maternal RBC folate were associated with lower predicted prevalences of birth defects.</p><p><strong>Primary funding source: </strong>National Key Research and Development Program of China, National Natural Science Foundation of China, and Chinese Academy of Medical Sciences.</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"1386-1397"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In recently relapsed polymyalgia rheumatica during GC tapering, secukinumab increased sustained remission rates at 1 y.","authors":"David S Pisetsky","doi":"10.7326/ANNALS-26-03576-JC","DOIUrl":"10.7326/ANNALS-26-03576-JC","url":null,"abstract":"<p><strong>Clinical impact ratings: </strong>GIM/FP/GP: [Formula: see text] Rheumatology: [Formula: see text].</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"JC113"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delirium.","authors":"Blair P Golden, Eduard E Vasilevskis","doi":"10.7326/ANNALS-26-03322","DOIUrl":"10.7326/ANNALS-26-03322","url":null,"abstract":"<p><p>Delirium is a common, acute confusional state that is associated with adverse patient, caregiver, and health system outcomes. All patients are at risk for delirium, although those with advanced age or acute infection and those taking sedatives and anticholinergics are at greater risk. The pathophysiology of delirium is complex and includes neuronal injury, inflammation, metabolic imbalance, and blood-brain barrier disruption. It is important to note that delirium is preventable; recognizing people at risk and identifying and addressing predisposing and precipitating factors is paramount. No single intervention or medication has been shown to be effective in treating delirium; therefore, standard-of-care treatments rely on multifaceted strategies to address contributing factors.</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"ITC145-ITC160"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Changes in Heart Stress and the Risk for Cardiovascular Disease and Mortality in Older Adults : An Observational Study.","authors":"Anping Cai, Antoni Bayes-Genis, Rory Wolfe, Andrew M Tonkin, Chao Zhu, James L Januzzi, Jiazhen Zheng, Mark R Nelson, Johannes T Neumann, Robyn L Woods, Cammie Tran, Ambarish Pandey, Lin Yee Chen, Yingqing Feng, Yingling Zhou, Bryan P Yan, Junguo Zhang, Lin Liu, John J McNeil, Lawrence J Beilin, Peng Qiu, Joanne Ryan, Zhen Zhou","doi":"10.7326/ANNALS-26-00245","DOIUrl":"10.7326/ANNALS-26-00245","url":null,"abstract":"<p><strong>Background: </strong>Age-specific elevation in N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations, previously termed \"heart stress (HS),\" has been associated with adverse cardiovascular disease (CVD) outcomes. Yet, HS status, as defined by longitudinal changes in NT-proBNP concentrations, may improve risk assessment for CVD and mortality in older adults.</p><p><strong>Objective: </strong>To evaluate HS status on the basis of 3-year changes in NT-proBNP concentrations with risk for total CVD and all-cause mortality in community-dwelling older adults free of prior CVD.</p><p><strong>Design: </strong>Observational study.</p><p><strong>Setting: </strong>The ASPREE (ASPirin in Reducing Events in the Elderly) trial and subsequent observational extension (ASPREE-XT).</p><p><strong>Participants: </strong>8454 participants (mean age, 78.0 years at year 3; 52.9% women) without prior CVD who had NT-proBNP measured at trial enrollment and year 3.</p><p><strong>Measurements: </strong>Heart stress status, based on changes in NT-proBNP concentrations from enrollment to year 3, was examined in 4 categories: persistently HS-free, HS remission, incident HS, or sustained HS. The 2 coprimary outcomes were total CVD (nonfatal myocardial infarction, fatal or nonfatal stroke, coronary heart disease death, or heart failure hospitalization) and all-cause mortality.</p><p><strong>Results: </strong>Over a median follow-up of 8.0 years, 818 CVD events and 1584 deaths occurred. At year 8, compared with the persistently HS-free category, the adjusted absolute risks (ARs) for total CVD were increased by 7.4% (95% CI, 4.8% to 10.0%) for incident HS and 6.7% (CI, 4.3% to 9.0%) for sustained HS; adjusted ARs were also increased for all-cause mortality by 6.1% (CI, 3.7% to 8.5%) for incident HS and 7.5% (CI, 5.2% to 9.8%) for sustained HS. The HS remission category had similar adjusted ARs to those of the persistently HS-free group.</p><p><strong>Limitation: </strong>Observational design and predominantly White participants.</p><p><strong>Conclusion: </strong>Heart stress status based on longitudinal changes in NT-proBNP concentration may improve risk stratification of CVD and mortality.</p><p><strong>Primary funding source: </strong>None.</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"1375-1385"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The First Translator.","authors":"Dana Hazem","doi":"10.7326/ANNALS-25-05463","DOIUrl":"https://doi.org/10.7326/ANNALS-25-05463","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":"179 10","pages":"1513"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cost-Effectiveness of Semaglutide and Tirzepatide for Patients With Knee Osteoarthritis and Obesity.","authors":"Liangsheng Wei, Yi Zhang, Qiaoning Yue, Xiguang Zhang","doi":"10.7326/ANNALS-26-02922","DOIUrl":"https://doi.org/10.7326/ANNALS-26-02922","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":"179 10","pages":"1522-1523"},"PeriodicalIF":17.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}