Annals of Internal Medicine最新文献

{"title":"Patients' Values and Preferences Regarding Pharmacologic Treatments for the Prevention of Episodic Migraine Headache: A Systematic Review for the American College of Physicians.","authors":"Bada Yang, Robin W M Vernooij, Demy L Idema, Linde Huis In 't Veld, Mike P T Kusters, Rene Spijker, Kim van der Braak, Pauline Heus, Kevin Jenniskens, Lotty Hooft, Johanna A A Damen","doi":"10.7326/ANNALS-24-00317","DOIUrl":"10.7326/ANNALS-24-00317","url":null,"abstract":"<p><strong>Background: </strong>Decision making regarding pharmacologic treatments for the prevention of episodic migraine may depend on the importance that patients place on outcomes and specific treatment preferences.</p><p><strong>Purpose: </strong>To assess patients' values and preferences regarding pharmacologic treatments for the prevention of episodic migraine.</p><p><strong>Data sources: </strong>MEDLINE and CINAHL from inception to April 2024.</p><p><strong>Study selection: </strong>Quantitative studies reporting on values and preferences regarding pharmacologic treatments for the prevention of migraine in adults were eligible.</p><p><strong>Data extraction: </strong>We extracted data on study design, participants, and findings and assessed risk of bias using a tool developed by the GRADE (Grading of Recommendations Assessment, Development and Evaluation) working group.</p><p><strong>Data synthesis: </strong>We included 6 studies (5 discrete choice experiments and 1 survey) comprising a total of 2307 participants and assessing the importance of a total of 32 attributes. Risk of bias was moderate in 3 and low in 3 studies; all but 1 were industry spon sored. Migraine severity, frequency, and duration were found to be the most important among several outcomes including acute medication need and side effects (low certainty). Other outcomes of importance were migraine attack on day 1 postdosing (moderate certainty) and duration of daily activity limitations (high certainty). Patients preferred oral tablets to injections and infusions (moderate certainty).</p><p><strong>Limitations: </strong>Importance of attributes relative to each other could not be assessed due to the scarcity of direct comparisons. Participant sampling was unclearly reported in most studies.</p><p><strong>Conclusion: </strong>Patients may have the strongest preference for oral treatments that reduce the severity, frequency, and duration of their migraine attacks, which reduce the duration of daily activity limitations and reduce risk of migraine on day 1. Side effects may be less important.</p><p><strong>Primary funding source: </strong>American College of Physicians. (PROSPERO: CRD42023414305).</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"381-388"},"PeriodicalIF":19.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the Health of Medicare Advantage and Traditional Medicare Beneficiaries: Risk Scores Versus Reality.","authors":"Amal N Trivedi, Richard Kronick","doi":"10.7326/ANNALS-25-00088","DOIUrl":"10.7326/ANNALS-25-00088","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"441-442"},"PeriodicalIF":19.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In acute MI and acute or chronic anemia, liberal vs. restrictive transfusion did not affect recurrent MI or death.","authors":"Julianah O Oguntala, Andrew T Yan","doi":"10.7326/ANNALS-25-00161-JC","DOIUrl":"10.7326/ANNALS-25-00161-JC","url":null,"abstract":"<p><strong>Clinical impact ratings: </strong>GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text] Hematology: [Formula: see text].</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"JC35"},"PeriodicalIF":19.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In patients with acute MI, spironolactone did not reduce cardiac events at 3 y.","authors":"Michelle D Kelsey, L Kristin Newby","doi":"10.7326/ANNALS-25-00335-JC","DOIUrl":"10.7326/ANNALS-25-00335-JC","url":null,"abstract":"<p><strong>Clinical impact ratings: </strong>Cardiology: [Formula: see text].</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"JC33"},"PeriodicalIF":19.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Strategy Using Color Doppler Ultrasound of Temporal Arteries in Patients With High Clinical Suspicion of Giant Cell Arteritis.","authors":"Wolfgang A Schmidt, Christian Dejaco","doi":"10.7326/ANNALS-24-02869","DOIUrl":"https://doi.org/10.7326/ANNALS-24-02869","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":"178 3","pages":"454"},"PeriodicalIF":19.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introducing Annals Guide to Journal Club: The Importance of Interpreting Clinical Research With Scientific Nuance.","authors":"Christina C Wee, Eliseo Guallar, Christine Laine","doi":"10.7326/ANNALS-25-00326","DOIUrl":"https://doi.org/10.7326/ANNALS-25-00326","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":"178 3","pages":"445-446"},"PeriodicalIF":19.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Man With the Rose Tattoo.","authors":"Lucie Joerg","doi":"10.7326/ANNALS-24-01866","DOIUrl":"https://doi.org/10.7326/ANNALS-24-01866","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":"178 3","pages":"449"},"PeriodicalIF":19.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Personal Is Political.","authors":"Katherine McKenzie","doi":"10.7326/ANNALS-24-02706","DOIUrl":"https://doi.org/10.7326/ANNALS-24-02706","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":"178 3","pages":"447-448"},"PeriodicalIF":19.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Effectiveness of Pharmacologic Treatments for the Prevention of Episodic Migraine Headache: A Systematic Review and Network Meta-analysis for the American College of Physicians.","authors":"Johanna A A Damen, Bada Yang, Demy L Idema, Robin W M Vernooij, Linde Huis In 't Veld, Mike Kusters, Rene Spijker, Kim van der Braak, Pauline Heus, Kevin Jenniskens, Lotty Hooft","doi":"10.7326/ANNALS-24-00315","DOIUrl":"10.7326/ANNALS-24-00315","url":null,"abstract":"<p><strong>Background: </strong>Various treatments for preventing episodic migraine are available.</p><p><strong>Purpose: </strong>To evaluate the comparative effectiveness and harms of pharmacologic prevention of episodic migraine, focusing on treatments already determined to be superior to placebo.</p><p><strong>Data sources: </strong>MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials from inception until April 2024.</p><p><strong>Study selection: </strong>Randomized trials evaluating selected efficacious pharmacologic treatments in adults with episodic migraine. Selection was done independently by 2 reviewers.</p><p><strong>Data extraction: </strong>Data were extracted by 1 reviewer and checked by a second. Risk of bias and certainty of the evidence were assessed using the Cochrane Risk of Bias tool and the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach, respectively.</p><p><strong>Data synthesis: </strong>Sixty-one studies (20 680 patients) evaluating 16 treatments were included. Nineteen studies had low risk of bias. All selected treatments were deemed efficacious against placebo on the basis of previous systematic reviews. In network meta-analyses, calcitonin gene-related peptide antagonist monoclonal antibodies (CGRP-mAbs) probably resulted in fewer discontinuations due to adverse events than topiramate (risk difference, -16.2% [95% CI, -18.4% to -12.8%]; moderate-certainty evidence), and CGRP-mAbs may result in less migraine-related disability and improved quality of life compared with gepants (mean differences, -4.12 [CI, -9.30 to 1.05] and 2.25 [CI, -0.85 to 5.34], respectively; low-certainty evidence). For other outcomes and comparisons, there was moderate- or low-certainty evidence of no clinically important differences, uncertain evidence, or no evidence.</p><p><strong>Limitations: </strong>Limited literature was available to determine the minimal important differences. The number of head-to-head comparisons of treatments was limited.</p><p><strong>Conclusion: </strong>No high-certainty evidence favored one pharmacologic treatment for prevention of episodic migraine over another. Evidence was mostly insufficient or of low certainty.</p><p><strong>Primary funding source: </strong>American College of Physicians. (PROSPERO: CRD42023414305).</p>","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"369-380"},"PeriodicalIF":19.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large Language Models for Screening Search Results in Systematic Reviews: Are We There Yet?","authors":"S Swaroop Vedula, Daniel Khashabi","doi":"10.7326/ANNALS-25-00012","DOIUrl":"10.7326/ANNALS-25-00012","url":null,"abstract":"","PeriodicalId":7932,"journal":{"name":"Annals of Internal Medicine","volume":" ","pages":"443-444"},"PeriodicalIF":19.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}