Animal genetics最新文献_第7页

Gestational Feed Restriction Induces Differential Expression of Novel Long Non-Coding RNAs in Offspring Skeletal Muscle 妊娠期饲料限制诱导子代骨骼肌中新型长链非编码rna的差异表达。

IF 2.2 3区生物学

Animal genetics Pub Date : 2026-06-29 DOI: 10.1002/age.70160

Maria M. M. Muniz, Thaís C. Costa, Lívia S. Rodrigues, Luiza V. Kladt, Luiz Jardel M. Motta, Mariana M. Lopes, Nicola V. L. Serão, Mateus P. Gionbelli, Marcio Duarte

{"title":"Gestational Feed Restriction Induces Differential Expression of Novel Long Non-Coding RNAs in Offspring Skeletal Muscle","authors":"Maria M. M. Muniz, Thaís C. Costa, Lívia S. Rodrigues, Luiza V. Kladt, Luiz Jardel M. Motta, Mariana M. Lopes, Nicola V. L. Serão, Mateus P. Gionbelli, Marcio Duarte","doi":"10.1002/age.70160","DOIUrl":"10.1002/age.70160","url":null,"abstract":"This study aimed to investigate how maternal feed restriction at different gestational stages alters the expression of novel long non-coding RNAs (lncRNAs) in the skeletal muscle of goat offspring. LncRNAs are emerging as important regulators of biological processes, including myogenesis, yet their role in fetal programming remains largely unexplored. Using RNA sequencing (RNA-Seq), we analyzed lncRNA expression in the Longissimus thoracis muscle of kids born to goats submitted to two feeding diets: early gestation restriction (50% of maintenance from Day 8–84 of gestation, then 100% until parturition; RM, n = 6) and late gestation restriction (100% from Day 8–84, then 50% until parturition; MR, n = 8). RNA-Seq data underwent quality control, alignment, transcript assembly, and differential expression analysis using Cufflinks and FEELnc pipelines. Three differentially expressed (DE; FDR ≤ 0.05) lncRNAs were identified and classified based on genomic position and predicted regulatory potential. The upregulated lncRNA_10996.1 in the RM group was linked to acyl-CoA dehydrogenase family member 10 and GTP-binding nuclear protein Ran-like genes. The downregulated lncRNAs, lncRNA_1180.1 and lncRNA_7992.1, were associated with ZNF546, PSMC4, SNORA65, ZNF79, LRSAM1, and RPL12 genes. Overall, these results suggest that maternal nutrition restriction is associated with alterations in lncRNA expression profile and may influence muscle development through potential regulatory interactions with protein-coding genes. These findings identified candidate lncRNAs and provide exploratory insights into the molecular mechanisms potentially involved in fetal programming in livestock.","PeriodicalId":7905,"journal":{"name":"Animal genetics","volume":"57 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/age.70160","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A NECAP1 Nonsense Variant is Associated With Leukoencephalomyelopathy With Oligodendroglial Dysplasia in a Belgian Malinois With Spinocerebellar Ataxia NECAP1无义变异与比利时玛利诺犬脊髓小脑共济失调伴少突胶质发育不良伴白质脑脊髓病相关。

IF 2.2 3区生物学

Animal genetics Pub Date : 2026-06-28 DOI: 10.1002/age.70156

Kimberley Stee, Mario Van Poucke, Jaume Alomar Huguet, Martí Pumarola Batlle, Kaatje Kromhout, Han Versnaeyen, Anke Van Ongeval, Raoul Dumoulin, Sofie F.M. Bhatti, Luc Peelman, Ine Cornelis

{"title":"A NECAP1 Nonsense Variant is Associated With Leukoencephalomyelopathy With Oligodendroglial Dysplasia in a Belgian Malinois With Spinocerebellar Ataxia","authors":"Kimberley Stee, Mario Van Poucke, Jaume Alomar Huguet, Martí Pumarola Batlle, Kaatje Kromhout, Han Versnaeyen, Anke Van Ongeval, Raoul Dumoulin, Sofie F.M. Bhatti, Luc Peelman, Ine Cornelis","doi":"10.1002/age.70156","DOIUrl":"10.1002/age.70156","url":null,"abstract":"<div>\u0000 \u0000 A 7-month-old Belgian Malinois puppy was presented for progressively worsening ataxia and episodes of aggression. General physical examination was unremarkable, and neurological examination revealed ambulatory tetraparesis, spinocerebellar ataxia, thoracic limb pseudo-hypermetria, exaggerated head movements, bilateral vestibular signs and a bilateral divergent strabismus. A magnetic resonance imaging (MRI) of the brain and cervical spinal cord revealed a generalized cerebral atrophy. The dog woke up from anesthesia in a severe episode of disorientation and aggression, wherefore he was euthanized. Histopathology of the brain revealed diffuse and widespread oligodendroglial dysplasia with myelinated fibers disorganization. A disease-associated nonsense variant in NECAP1 (NC_049248.1:g.8636271G>A on chromosome 27), introducing a stop codon at codon 48 (XM_038576681.1:c.142C>T (p.Arg48*)) and truncating the only isoform by 83%, was identified by whole genome sequencing (WGS). The variant segregated in the affected family with a recessive mode of inheritance, but was not present in 158 undiagnosed Belgian Malinois from the Belgian population. The exact same variant, as well as another NECAP1 variant (c.301 + 1G>A), have been associated with early onset epileptic encephalopathy (EOEE) in humans, a disease that is characterized by intractable epileptic seizures and profound global developmental delay in young children. In conclusion, a previously unreported leukoencephalomyelopathy with oligodendroglial dysplasia causes spinocerebellar ataxia and abnormal behavior in Belgian Malinois.\u0000 </div>","PeriodicalId":7905,"journal":{"name":"Animal genetics","volume":"57 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enrichment Analysis of Differentially Expressed Genes During Feather Regeneration in Landes Geese (Anser anser) 朗德鹅羽毛再生过程中差异表达基因富集分析

IF 2.2 3区生物学

Animal genetics Pub Date : 2026-06-25 DOI: 10.1002/age.70148

Haodong Liu, Yunzhou Yang, Shaojia Zhai, Huiying Wang, Daqian He

{"title":"Enrichment Analysis of Differentially Expressed Genes During Feather Regeneration in Landes Geese (Anser anser)","authors":"Haodong Liu, Yunzhou Yang, Shaojia Zhai, Huiying Wang, Daqian He","doi":"10.1002/age.70148","DOIUrl":"https://doi.org/10.1002/age.70148","url":null,"abstract":"<div>\u0000 \u0000 Feathers are valuable by-products of the poultry industry, and their growth and development markedly have significant impact on economic returns. This study used Landes geese as a model to analyze the expression of core genes involved in feather regeneration and inflammation through comparative transcriptomic analyzes between plucked and unplucked skin tissues. In Landes geese aged 180 days (LD180), 624 differentially expressed genes (DEGs) were identified at 5 days post-plucking (481 upregulated and 143 downregulated), whereas 1851 DEGs were identified at 14 days (1350 upregulated and 501 downregulated). In Landes geese aged 90 days (LD90), 694 DEGs were detected at five days post-plucking (513 upregulated and 181 downregulated), with 1154 DEGs identified at 14 days (887 upregulated and 267 downregulated). These DEGs were significantly enriched in GO terms, KEGG pathways, and protein–protein interaction networks associated with inflammatory responses (e.g., leukocyte-mediated immunity), and feather regeneration (e.g., epidermis development). Notably, signatures of both innate and adaptive immunity were detected at the early post-plucking stage. Compared with younger geese, the LD180 group showed faster inflammatory resolution than the LD90 group, as demonstrated by a more pronounced decrease in proinflammatory gene expression levels in LD180. Comparative analysis revealed that mechanical damage (such as feather plucking) induces immediate inflammatory and anti-inflammatory responses. In conclusion, the mechanical damage caused by feather plucking triggers a renewed cycle of feather growth, which requires overcoming the harm inflicted by the subsequent inflammatory responses. The ability to recover from inflammatory damage varies significantly with age.\u0000 </div>","PeriodicalId":7905,"journal":{"name":"Animal genetics","volume":"57 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148324518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Haemophilia A in a Female German Shepherd With Homozygosity for the FVIII p.C567Y Variant in Exon 11 of the F8 Gene F8基因外显子11中FVIII p.C567Y变异纯合的德国牧羊犬A型血友病

IF 2.2 3区生物学

Animal genetics Pub Date : 2026-06-24 DOI: 10.1002/age.70154

Bertram Brenig, Sabrina Pach

{"title":"Haemophilia A in a Female German Shepherd With Homozygosity for the FVIII p.C567Y Variant in Exon 11 of the F8 Gene","authors":"Bertram Brenig, Sabrina Pach","doi":"10.1002/age.70154","DOIUrl":"https://doi.org/10.1002/age.70154","url":null,"abstract":"Haemophilia A is an extremely rare disorder in females, as the causative F8 gene is located on the X chromosome. Female carriers, also known as ‘conductors,’ are typically heterozygous and therefore do not show clinical signs of the disease. However, in mild forms of haemophilia A, affected males may survive and mate. In such cases, mating a haemophilic male with a carrier female can result in female offspring who are homozygous for a pathogenic variant and consequently develop haemophilia A. In the present case, a female dog with a mild form of haemophilia A is described. Although it had a markedly increased bleeding tendency, bleeding episodes have so far not been fatal. There were no prior indications of haemophilia A inheritance in either parent. To identify a causative variant in the F8 gene, whole-genome sequencing was performed on the affected dog. A homozygous missense variant was identified in exon 11 of the F8 gene, resulting in an amino acid substitution within the A2 domain of factor VIII—a region critical for the stability and function of the coagulation factor. The same variant has previously been described in an unrelated German Shepherd. Notably, many examined variants along the entire X chromosome of the dog were homozygous. The rediscovery of this variant, more than 10 years after its initial description, underscores the importance of comprehensive genetic diagnostics, especially in rare diseases with atypical inheritance patterns.","PeriodicalId":7905,"journal":{"name":"Animal genetics","volume":"57 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/age.70154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-Omics Analysis Reveals Impacts of SCARB1, TYR, and TYRP1 Knockouts on Pigmentation and Metabolic Pathways in Oujiang Color Common Carp 多组学分析揭示SCARB1、TYR和TYRP1基因敲除对瓯江色鲤色素沉着和代谢途径的影响

IF 2.2 3区生物学

Animal genetics Pub Date : 2026-06-24 DOI: 10.1002/age.70140

Nusrat Hasan Kanika, Zhaoyang Guo, Roland Nathan Mandal, Muhammad Sajid Hanif, Xiaoxiao Bao, Xiaowen Chen, Jun Wang, Chenghui Wang

{"title":"Multi-Omics Analysis Reveals Impacts of SCARB1, TYR, and TYRP1 Knockouts on Pigmentation and Metabolic Pathways in Oujiang Color Common Carp","authors":"Nusrat Hasan Kanika, Zhaoyang Guo, Roland Nathan Mandal, Muhammad Sajid Hanif, Xiaoxiao Bao, Xiaowen Chen, Jun Wang, Chenghui Wang","doi":"10.1002/age.70140","DOIUrl":"https://doi.org/10.1002/age.70140","url":null,"abstract":"<div>\u0000 \u0000 Gene knockout (KO) techniques are important for understanding gene function and their impact on organismal traits. This study investigates the effects of targeted KO of SCARB1, TYR, and TYRP1 genes in Oujiang Color common carp, focusing on pigmentation changes, metabolic dysregulation, and host-microbiome interactions. Our multi-omics approach revealed that SCARB1 KO led to complete loss of red pigmentation, while TYR and TYRP1 KOs resulted in hypopigmentation and altered pigmentation patterns. Transcriptomic analysis identified seven key genes (PLA2G4, C3, F2, ERN1, UGP2, purA, and GRIN2A), linked to major pathways: glycerophospholipid metabolism, biosynthesis of cofactors, autophagy, and neuroactive ligand-receptor interaction. Notably, we observed significant upregulation of phosphatidylethanolamine (PE) and disruptions in glycolysis and tyrosine metabolism. Histological analysis showed reductions in epithelial and goblet cells, and microbiome profiling indicated shifts in microbial diversity, including significant changes in Firmicutes, Bacteroidetes, and genera such as Pseudomonas, Rhodobacter, Bacillus, and ZOR0006. These findings uncover pigmentation genes as pivotal players in regulating pigmentation, cellular stress, metabolism, and the microbiota. This study improves our understanding of pigmentation regulation in common carp and provides potential molecular targets for color trait improvement in aquaculture species.\u0000 </div>","PeriodicalId":7905,"journal":{"name":"Animal genetics","volume":"57 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Cross-Species Single-Cell Transcriptomic Atlas of Subcutaneous Adipose Tissue Reveals Conserved and Divergent Cellular Programs 皮下脂肪组织的跨物种单细胞转录组图谱揭示了保守和分化的细胞程序

IF 2.2 3区生物学

Animal genetics Pub Date : 2026-06-23 DOI: 10.1002/age.70152

Xinran Niu, Liwei Zhai, Lulu Wang, Jiahao Wang, Zhuoye Zheng, Jinyan Yang, Xini Wang, Jianfeng Liu, Kai Xing, Chuduan Wang

{"title":"A Cross-Species Single-Cell Transcriptomic Atlas of Subcutaneous Adipose Tissue Reveals Conserved and Divergent Cellular Programs","authors":"Xinran Niu, Liwei Zhai, Lulu Wang, Jiahao Wang, Zhuoye Zheng, Jinyan Yang, Xini Wang, Jianfeng Liu, Kai Xing, Chuduan Wang","doi":"10.1002/age.70152","DOIUrl":"https://doi.org/10.1002/age.70152","url":null,"abstract":"<div>\u0000 \u0000 Adipose tissue is not only the primary site of energy storage but also an essential metabolic organ for maintaining energy homeostasis to regulate adipogenesis, metabolism, and chronic inflammation in mammals. However, the cross-species conservation and divergence of its cellular composition and transcriptional features remain unclear. To address this, we analyzed single-cell RNA sequencing datasets from cattle, pigs, and humans. Conserved cell types, including adipocytes, adipose stem and progenitor cells (ASPCs), macrophages, endothelial cells, and T cells, were identified across all three species. In contrast, pigs uniquely contained mesenchymal cells (COL1A1, COL1A2) and B cells (CD37), cattle possessed distinct preadipocyte populations (COL3A1, PNPLA2, GPAM), and humans exhibited abundant dendritic (HLA-DRA, HLA-DRB1) and mast cells (KIT). Focusing on adipocytes, we identified 537, 160, and 73 species-specific DEGs in cattle, pigs, and humans, respectively. Gene Ontology enrichment analysis of adipocyte-specific DEGs revealed that genes enriched in cattle were primarily involved in cytoskeletal organization and triglyceride biosynthesis (LPIN1, DGAT2), those enriched in pigs in oxidative phosphorylation and thermogenesis (LIPE, CIDEA), and those enriched in humans in lipid transport and immune signaling (ADIPOQ, LPL). Overall, this study establishes a cross-species single-cell atlas of subcutaneous adipose tissue, providing insights into conserved architectures and species-specific adaptations, and serving as a valuable resource for comparative biology and livestock research.\u0000 </div>","PeriodicalId":7905,"journal":{"name":"Animal genetics","volume":"57 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic Insights Into Genetic Diversity and Population Structure of Pastoral ‘Belahi’ Cattle of North Himalayan (Shivalik) Foothills 北喜马拉雅（Shivalik）山麓牧民“Belahi”牛遗传多样性和种群结构的基因组学见解

IF 2.2 3区生物学

Animal genetics Pub Date : 2026-06-23 DOI: 10.1002/age.70157

Ashish Yadav, Kashif Dawood Khan, Shambhuraditya Chavan, Rinki Paul, V. N. Sahana, Rajesh Kumar Gahlyan, Rani Alex, Vikas Vohra, G. R. Gowane

{"title":"Genomic Insights Into Genetic Diversity and Population Structure of Pastoral ‘Belahi’ Cattle of North Himalayan (Shivalik) Foothills","authors":"Ashish Yadav, Kashif Dawood Khan, Shambhuraditya Chavan, Rinki Paul, V. N. Sahana, Rajesh Kumar Gahlyan, Rani Alex, Vikas Vohra, G. R. Gowane","doi":"10.1002/age.70157","DOIUrl":"https://doi.org/10.1002/age.70157","url":null,"abstract":"<div>\u0000 \u0000 Pastoral cattle breeding sustains nomadic communities by conserving local and non-commercial but valuable genetic resources. The aim of this study was to understand the genetic structure and diversity of newly registered pastoral Belahi cattle using genome-wide SNP data (Illumina BovineSNP50 v3.0 Array). After quality control, nearly 47% of SNPs were removed due to low minor allele frequency (< 0.05), yet the retained markers indicated well-distributed genetic variation across the genome, demonstrating substantial genetic diversity. Observed and expected heterozygosity were relatively high and nearly equal, suggesting adequate genetic variation and genomic inbreeding estimates indicated low inbreeding in Belahi cattle, although FROH analysis of longer runs of homozygosity revealed signs of recent inbreeding. The recent effective population size suggested a moderate risk of losing genetic diversity, which warrants attention for conservation management. The pattern of linkage disequilibrium decay showed relatively strong genetic linkage over short genomic distances, gradually decreasing over longer distances, indicating moderate recombination. Genetic diversity in Belahi cattle has been preserved, likely due to weaker artificial selection and higher historical effective population sizes. This study revealed that Belahi cattle had no evidence of recent admixture with taurine breeds. The breed exhibits a distinct genetic identity, clustering closely with other indigenous zebu breeds yet standing apart as a unique population. The findings suggest that historical management under low selection intensity and maintenance of sizable effective population size have helped preserve genetic variation in Belahi cattle.\u0000 </div>","PeriodicalId":7905,"journal":{"name":"Animal genetics","volume":"57 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Integrated Transcriptomic and Metabolomic Analysis Reveals Gut Microbiota-Mediated Regulation of Muscle Fiber Composition and Metabolism in Germ-Free Pigs". 更正“综合转录组学和代谢组学分析揭示肠道微生物介导的肌肉纤维组成和代谢调节在无菌猪”。

IF 2.2 3区生物学

Animal genetics Pub Date : 2026-06-01 DOI: 10.1002/age.70150

引用次数: 0

Neurobehavioural Genes Associated With Growth in Dusky Kob (Argyrosomus japonicus). 与日本野田鼠生长有关的神经行为基因。

IF 2.2 3区生物学

Animal genetics Pub Date : 2026-06-01 DOI: 10.1002/age.70130

J E Sampson, C Rhode

{"title":"Neurobehavioural Genes Associated With Growth in Dusky Kob (Argyrosomus japonicus).","authors":"J E Sampson, C Rhode","doi":"10.1002/age.70130","DOIUrl":"10.1002/age.70130","url":null,"abstract":"Growth is a complex trait, influenced by numerous genes and environmental factors that transect various physiological pathways. This study sought to characterise the relationship between neurobehavioural development genes and growth in dusky kob juveniles. Five candidate neurobehavioural genes were identified from the literature and assessed for gene sequence variants. Thirteen SNPs in two genes, Brain-derived neurotrophic factor (bdnf) and Early growth response 1 (egr1), were identified. Case-control association analyses were conducted applying two methods of correcting for family structure: (1) categorical, based on family identity; and (2) quantitative, based on co-ordinate analysis eigenvalues. The eigenvalue-corrected association analysis outperformed the categorical analysis in both model adherence and estimates of effect sizes. Six significantly associated SNPs were identified, three in each gene. Linkage disequilibrium was significant within both genes, with the formation of haplotype -GA- in egr1 associated with increased growth and haplotype -CG- in bdnf associated with decreased growth. A non-synonymous mutation (Serine > Proline) was identified in bdnf, and protein modelling suggests significant disruption of protein structure in small individuals that likely explains the functional mechanism of action. This study has identified novel SNPs and haplotypes in neurobehavioural development genes, which highlight the impact of neurological and behavioural pathways on growth in dusky kob.","PeriodicalId":7905,"journal":{"name":"Animal genetics","volume":"57 3","pages":"e70130"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting Myostatin for Sustainable Meat Production: Insights From Multiple Species. 针对肌肉生长抑制素的可持续肉类生产：来自多物种的见解。

IF 2.2 3区生物学

Animal genetics Pub Date : 2026-06-01 DOI: 10.1002/age.70149

Chiara Santomassimo, Francesco Perini, Daniele Colombi, Stefano Bettini, Maria Federica Trombetta, Marina Pasquini, Simone Ceccobelli, Ishaku L Haruna, Ketan Patel, Emiliano Lasagna

{"title":"Targeting Myostatin for Sustainable Meat Production: Insights From Multiple Species.","authors":"Chiara Santomassimo, Francesco Perini, Daniele Colombi, Stefano Bettini, Maria Federica Trombetta, Marina Pasquini, Simone Ceccobelli, Ishaku L Haruna, Ketan Patel, Emiliano Lasagna","doi":"10.1002/age.70149","DOIUrl":"10.1002/age.70149","url":null,"abstract":"Myostatin gene (MSTN), a TGF-β superfamily member, negatively regulates skeletal muscle growth, positioning it as a prime genetic target for enhancing livestock meat production. This review synthesizes evidence from 1979 to 2025 on MSTN mutations across cattle, pigs, poultry, sheep, goats, and rabbits, emphasising impacts on yield, quality, reproduction, and feed efficiency. Loss-of-function variants drive 20%-30% muscle mass increases in double-muscled phenotypes, boosting lean yield, carcass conformation, and dressing percentages while reducing fat (decreased by 50%). These changes improve growth rates and feed conversion ratios, and overall sustainability by lowering resource inputs and emissions, aligning with demands for low-fat and high-quality protein. Reproduction exhibits species-specific challenges, such as reduced fertility or dystocia, which are often manageable in heterozygotes through targeted breeding, while meat quality benefits from tender, lean profiles. From natural alleles to CRISPR/Cas9 knockouts in goats/pigs, MSTN manipulation enhances productivity without major welfare trade-offs. Multi-species insights underscore the value of heterozygous strategies for balanced gains by integrating genomic selection and editing tools to meet rising global meat needs efficiently, resiliently, and ethically.","PeriodicalId":7905,"journal":{"name":"Animal genetics","volume":"57 3","pages":"e70149"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13265248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148248932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0