The European Physical Journal E最新文献

Conformational properties of strictly two-dimensional equilibrium polymers. 严格二维平衡聚合物的构象性质。

IF 1.8 4区物理与天体物理

The European Physical Journal E Pub Date : 2025-07-23 DOI: 10.1140/epje/s10189-025-00505-3

J P Wittmer, A Cavallo, A Johner

{"title":"Conformational properties of strictly two-dimensional equilibrium polymers.","authors":"J P Wittmer, A Cavallo, A Johner","doi":"10.1140/epje/s10189-025-00505-3","DOIUrl":"https://doi.org/10.1140/epje/s10189-025-00505-3","url":null,"abstract":"Two-dimensional monodisperse linear polymer chains are known to adopt for sufficiently large chain lengths N and surface fractions <math><mi>ϕ</mi></math> compact configurations with fractal perimeters. We show here by means of Monte Carlo simulations of reversibly connected hard disks (without branching, ring formation and chain intersection) that polydisperse self-assembled equilibrium polymers with a finite scission energy E are characterized by the same universal exponents as their monodisperse peers. Consistently with a Flory-Huggins mean-field approximation, the polydispersity is characterized by a Schulz-Zimm distribution with a susceptibility exponent <math><mrow><mi>γ</mi> <mo>=</mo> <mn>19</mn> <mo>/</mo> <mn>16</mn></mrow> </math> for all not dilute systems and the average chain length <math> <mrow><mfenced><mi>N</mi></mfenced> <mo>∝</mo> <mo>exp</mo> <mrow><mo>(</mo> <mi>δ</mi> <mi>E</mi> <mo>)</mo></mrow> <msup><mi>ϕ</mi> <mi>α</mi></msup> </mrow> </math> thus increases with an exponent <math><mrow><mi>δ</mi> <mo>=</mo> <mn>16</mn> <mo>/</mo> <mn>35</mn></mrow> </math> . Moreover, it is shown that <math><mrow><mi>α</mi> <mo>=</mo> <mn>3</mn> <mo>/</mo> <mn>5</mn></mrow> </math> for semidilute solutions and <math><mrow><mi>α</mi> <mo>≈</mo> <mn>1</mn></mrow> </math> for larger densities. The intermolecular form factor F(q) reveals for sufficiently large <math><mfenced><mi>N</mi></mfenced> </math> a generalized Porod scattering with <math><mrow><mi>F</mi> <mrow><mo>(</mo> <mi>q</mi> <mo>)</mo></mrow> <mo>∝</mo> <mn>1</mn> <mo>/</mo> <msup><mi>q</mi> <mrow><mn>11</mn> <mo>/</mo> <mn>4</mn></mrow> </msup> </mrow> </math> for intermediate wavenumbers q consistently with a fractal perimeter dimension <math> <mrow><msub><mi>d</mi> <mi>s</mi></msub> <mo>=</mo> <mn>5</mn> <mo>/</mo> <mn>4</mn></mrow> </math> .","PeriodicalId":790,"journal":{"name":"The European Physical Journal E","volume":"48 6-7","pages":"41"},"PeriodicalIF":1.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of photothermal therapy using PANI-Fe₂O₃-Cys nanocomposites on breast cancer cells with antibacterial activity and cytotoxicity study. PANI-Fe₂O₃-Cys纳米复合材料光热治疗对乳腺癌细胞的抗菌活性及细胞毒性研究。

IF 1.8 4区物理与天体物理

The European Physical Journal E Pub Date : 2025-07-23 DOI: 10.1140/epje/s10189-025-00507-1

Huda Abdul Redha Abdullah, Mohanad Q Fahem, Zahraa T Turki, Mohammed H Jawad

{"title":"Effect of photothermal therapy using PANI-Fe₂O₃-Cys nanocomposites on breast cancer cells with antibacterial activity and cytotoxicity study.","authors":"Huda Abdul Redha Abdullah, Mohanad Q Fahem, Zahraa T Turki, Mohammed H Jawad","doi":"10.1140/epje/s10189-025-00507-1","DOIUrl":"10.1140/epje/s10189-025-00507-1","url":null,"abstract":"This study discusses the effect of photothermal therapy using PANI-conductive polymer composites with iron oxide and the amino acid cysteine (Cys) on breast cancer cells. The study focused on the biological and toxicological effects associated with the treatment process and its impact on these cancer cells. The materials were prepared using a very simple chemical oxidation method to produce polymer nanoparticles to which iron and cysteine molecules are attached. These composites were used as therapeutic agents in photothermal therapy, which relies primarily on the process of converting light into heat energy to kill cancer cells. The results showed that photothermal therapy using PANI-Fe2O3-Cys composites with near-infrared (NIR) light was significantly more effective in inhibiting breast cancer cells (MDA-MB-231) than using the composites without a laser. Significant changes in the morphology of the cancer cells were observed after treatment, demonstrating the treatment's effectiveness in destroying cancer cells. On the other hand, there was a slight and negligible effect on healthy cells, demonstrating the successful formulation and targeting of the treatment for cancerous tumors. Antibacterial evaluations also demonstrated effective activity against Staphylococcus aureus and Klebsiella bacteria. This study supports the use of composite nanomaterials in photothermal therapy as a targeted treatment for breast cancer, as well as enhancing the effectiveness of this treatment with lasers. It also explains how these materials could be used in future medical applications, particularly in cancer treatment, using methods that are considered less invasive and safer.","PeriodicalId":790,"journal":{"name":"The European Physical Journal E","volume":"48 6-7","pages":"40"},"PeriodicalIF":1.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Density-dependent cell migration in the absence of social interactions: a case study of Acanthamoeba castellanii. 在没有社会互动的情况下，密度依赖的细胞迁移：以棘阿米巴为例。

IF 1.8 4区物理与天体物理

The European Physical Journal E Pub Date : 2025-07-23 DOI: 10.1140/epje/s10189-025-00502-6

Nasser Ghazi, Mete Demircigil, Olivier Cochet-Escartin, Amandine Chauviat, Sabine Favre-Bonté, Christophe Anjard, Jean-Paul Rieu

{"title":"Density-dependent cell migration in the absence of social interactions: a case study of Acanthamoeba castellanii.","authors":"Nasser Ghazi, Mete Demircigil, Olivier Cochet-Escartin, Amandine Chauviat, Sabine Favre-Bonté, Christophe Anjard, Jean-Paul Rieu","doi":"10.1140/epje/s10189-025-00502-6","DOIUrl":"https://doi.org/10.1140/epje/s10189-025-00502-6","url":null,"abstract":"Cell migration is often influenced by intercellular or social interactions, ranging from long-range diffusive cues to direct contacts that can trigger biochemical signaling within the cell and affect the cell protruding activity or direction of turns. Here we study the density-dependent migration of the amoeba Acanthamoeba castellanii (Ac), a unicellular eukaryote that moves without social interactions. Using experiments and mean free path theory, we characterize how collisions affect motility parameters in crowded environments. We identify the collision rate as a key parameter linking cell density to the collision-induced reorientation rate, and we show its consistency across multiple independent approaches. Our findings reveal that the intrinsic migration speed remains constant, while persistence time and effective diffusion are entirely governed by collisions. At high densities, cells exhibit nearly ballistic trajectories between collisions, a behavior rarely reported in eukaryotes. These results establish Ac as a minimal model for motility in the absence of biochemical signaling, with implications for testing behaviors in complex crowded environments and pre-jamming dynamics.","PeriodicalId":790,"journal":{"name":"The European Physical Journal E","volume":"48 6-7","pages":"42"},"PeriodicalIF":1.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On degree-dependent topological study of line graph of some antiviral COVID-19 drugs. 一些抗病毒COVID-19药物线形图的度相关拓扑研究

IF 1.8 4区物理与天体物理

The European Physical Journal E Pub Date : 2025-07-14 DOI: 10.1140/epje/s10189-025-00503-5

Shibsankar Das, Arti Kumari, Jayjit Barman

{"title":"On degree-dependent topological study of line graph of some antiviral COVID-19 drugs.","authors":"Shibsankar Das, Arti Kumari, Jayjit Barman","doi":"10.1140/epje/s10189-025-00503-5","DOIUrl":"https://doi.org/10.1140/epje/s10189-025-00503-5","url":null,"abstract":" A topological index is a numerical value that correlates with a chemical structure. A degree-based topological index of drug molecular structures is beneficial for researchers investigating in the fields of medicals and pharmaceuticals because it is significant for testing the physicochemical properties of drugs. Graph theory has proven to be quite useful in this field of study. Graph analysis reveals insights into chemical structures. In physical chemistry, a line graph has multiple applications. This article focuses on the topological characterization of a line graph for antiviral COVID-19 drugs, namely Nirmatrelvir, Molnupiravir, Thalidomide, Theaflavin, Remdesivir, Ritonavir, Chloroquine, Hydroxychloroquine, Arbidol and Lopinavir. The computation of degree-based topological indices is carried out using their M-polynomials. Numerical values of topological indices of line graphs and geometric representations of the polynomials are shown graphically. A comparative study between the obtained values of the line graph and the values of an actual graph is presented through numerical and graphical representation. Furthermore, we conduct a QSPR analysis between the degree-based topological indices of the line graph of certain COVID-19 drugs and their physicochemical properties using curvilinear regression models. A comparison is made between the squared correlation coefficients derived from our curvilinear regression models and those obtained from earlier research. These findings may aid the applicability of newly developed drugs of similar kind, in predicting their physicochemical properties and in improving the associated QSPR studies and hence pave a way to improve treatments against the COVID-19 disease.","PeriodicalId":790,"journal":{"name":"The European Physical Journal E","volume":"48 6-7","pages":"39"},"PeriodicalIF":1.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Label-free metabolic imaging and energy costs in Chlamydomonas. 衣藻的无标签代谢成像和能量消耗。

IF 1.8 4区物理与天体物理

The European Physical Journal E Pub Date : 2025-07-11 DOI: 10.1140/epje/s10189-025-00499-y

Martine Boccara, Katia Wostrikoff, Benjamin Bailleuil, Claude Boccara

{"title":"Label-free metabolic imaging and energy costs in Chlamydomonas.","authors":"Martine Boccara, Katia Wostrikoff, Benjamin Bailleuil, Claude Boccara","doi":"10.1140/epje/s10189-025-00499-y","DOIUrl":"10.1140/epje/s10189-025-00499-y","url":null,"abstract":"We developed a label-free optical microscopy method to study movements of different frequencies and amplitudes within a cell. We use optical transmission tomography (OTT) that operates in transmission, and we record the changes of signal values of all the pixels of movies taken for a few seconds (dynamic signal). This signal is a metabolic signal in algae as it decreased in the presence of photosystem II inhibitors or when samples were illuminated at wavelengths where the photoreceptors are poorly operative. We used as model organism Chlamydomonas for which mutants are available. We used a mutant deleted of the chloroplastic gene encoding the large subunit of the Rubisco, ΔrbcL. This mutant is unable to fix atmospheric CO2 and is devoid of pyrenoid. We compared the dynamic signal between wild-type strain and ΔrbcL mutant of Chlamydomonas grown in dark condition and found it to be 5 to 10 times higher. This mutant overproduced starch, and we tempted to associate the metabolic signal to the cost in ATPeq consumption for building starch. The method is easy to implement and could be very valuable for studies of phytoplankton in situ or virus-infected cells.","PeriodicalId":790,"journal":{"name":"The European Physical Journal E","volume":"48 6-7","pages":"38"},"PeriodicalIF":1.8,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stochastic dynamics in determining fertilization outcomes in plants: effect of gamete number and pollen tube travel path length. 决定植物受精结果的随机动力学：配子数量和花粉管传播路径长度的影响。

IF 1.8 4区物理与天体物理

The European Physical Journal E Pub Date : 2025-07-08 DOI: 10.1140/epje/s10189-025-00501-7

Aneesa Manzoor, Mahima, Pushkin Kachroo, R Uma Shaanker, Ajeet K Sharma

引用次数: 0

A python-based novel vertex-edge-weighted modeling framework for enhanced QSPR analysis of cardiovascular and diabetes drug molecules. 一种基于python的顶点边缘加权模型框架，用于心血管和糖尿病药物分子的增强QSPR分析。

IF 1.8 4区物理与天体物理

The European Physical Journal E Pub Date : 2025-07-08 DOI: 10.1140/epje/s10189-025-00500-8

Sezer Sorgun, Asad Ullah

{"title":"A python-based novel vertex-edge-weighted modeling framework for enhanced QSPR analysis of cardiovascular and diabetes drug molecules.","authors":"Sezer Sorgun, Asad Ullah","doi":"10.1140/epje/s10189-025-00500-8","DOIUrl":"https://doi.org/10.1140/epje/s10189-025-00500-8","url":null,"abstract":"This study advances the quantitative structure-property relationship analysis by leveraging novel vertex-edge-weighted (VEW) molecular graphs to investigate 19 drug molecules commonly used to treat cardiovascular diseases and diabetes. The graphs are constructed by assigning weights to vertices and edges based on atomic properties, enabling a detailed and chemically meaningful representation of molecular structures. Python-based programs were developed to compute degree-based topological indices, which were then analyzed through robust linear regression models to uncover correlations with key physicochemical properties. The results reveal strong and consistent relationships between the computed indices and the physicochemical properties, validating the predictive capability of the proposed approach. Notably, the VEW model demonstrates significant improvements in accuracy and correlation strength over traditional unweighted molecular graph models, underscoring its enhanced ability to capture intricate molecular interactions. This work provides novel insights into the utility of degree-based topological indices in drug design, particularly for cardiovascular and diabetic treatments. By bridging theoretical modeling with practical pharmaceutical applications, it lays a solid foundation for optimizing molecular properties, improving drug efficacy, and accelerating the drug development pipeline. These findings reaffirm the growing significance of computational strategies in advancing precision medicine and pharmaceutical innovation.","PeriodicalId":790,"journal":{"name":"The European Physical Journal E","volume":"48 6-7","pages":"36"},"PeriodicalIF":1.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144582785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Droplet-on-demand using a positive pressure pulse. 使用正压脉冲按需滴注。

IF 1.8 4区物理与天体物理

The European Physical Journal E Pub Date : 2025-07-02 DOI: 10.1140/epje/s10189-025-00493-4

Mathieu Oléron, Grégoire Clement, Samuel Hidalgo-Caballero, Masoodah Gunny, Finn Box, Matthieu Labousse, Joshua D McGraw

{"title":"Droplet-on-demand using a positive pressure pulse.","authors":"Mathieu Oléron, Grégoire Clement, Samuel Hidalgo-Caballero, Masoodah Gunny, Finn Box, Matthieu Labousse, Joshua D McGraw","doi":"10.1140/epje/s10189-025-00493-4","DOIUrl":"10.1140/epje/s10189-025-00493-4","url":null,"abstract":"Droplet generation under steady conditions is a common microfluidic method for producing biphasic systems. However, this process works only over a limited range of imposed pressure: beyond a critical value, a stable liquid jet can instead form. Furthermore, for a given geometry, the pressure conditions set both the generation rate of droplets and their volume. Here, we report on-demand droplet production using a positive pressure pulse to the dispersed-phase inlet of a flow-focusing geometry. This strategy enables confined droplet generation within and beyond the pressure range observed under steady conditions, and decouples volume and production rate. In particular, elongated plugs not possible under steady conditions may be formed when the maximal pressure during the pulse reaches the jet regime. The measured volume of droplets-on-demand as well as the onset of droplet generation are both captured with a simple model that considers hydraulic resistances. This work provides a strategy and design rules for processes that require individual droplets or elongated plugs in a simple microfluidic chip design.","PeriodicalId":790,"journal":{"name":"The European Physical Journal E","volume":"48 6-7","pages":"35"},"PeriodicalIF":1.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osmotic pressure induces unexpected relaxation of contractile 3D microtissue. 渗透压诱导收缩的三维显微组织意想不到的松弛。

IF 1.8 4区物理与天体物理

The European Physical Journal E Pub Date : 2025-06-24 DOI: 10.1140/epje/s10189-025-00497-0

Giovanni Cappello, Fanny Wodrascka, Genesis Marquez-Vivas, Amr Eid Radwan, Parvathy Anoop, Pietro Mascheroni, Jonathan Fouchard, Ben Fabry, Davide Ambrosi, Pierre Recho, Simon de Beco, Martial Balland, Thomas Boudou

{"title":"Osmotic pressure induces unexpected relaxation of contractile 3D microtissue.","authors":"Giovanni Cappello, Fanny Wodrascka, Genesis Marquez-Vivas, Amr Eid Radwan, Parvathy Anoop, Pietro Mascheroni, Jonathan Fouchard, Ben Fabry, Davide Ambrosi, Pierre Recho, Simon de Beco, Martial Balland, Thomas Boudou","doi":"10.1140/epje/s10189-025-00497-0","DOIUrl":"10.1140/epje/s10189-025-00497-0","url":null,"abstract":"Cell contraction and proliferation, matrix secretion and external mechanical forces induce compression during embryogenesis and tumor growth, which in turn regulate cell proliferation, metabolism or differentiation. How compression affects tissue contractility, a hallmark of tissue function, is however unknown. Here we apply osmotic compression to microtissues of either mouse colon adenocarcinoma CT26 cells, mouse NIH 3T3 fibroblasts, or human primary colon cancer-associated fibroblasts. Microtissues are anchored to flexible pillars that serve as force transducers. We observe that low-amplitude osmotic compression induces a rapid relaxation of tissue contractility, primed by the deformation of the extracellular matrix. Furthermore, we show that this compression-induced relaxation is independent of the cell type, proportional to the initial tissue contractility, and depends on RhoA-mediated myosin activity. Together, our results demonstrate that compressive stress can relax active tissue force, and points to a potential role of this feedback mechanism during morphogenetic events such as onco- or embryogenesis.","PeriodicalId":790,"journal":{"name":"The European Physical Journal E","volume":"48 6-7","pages":"34"},"PeriodicalIF":1.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Size distribution of decaying foam bubbles. 衰变泡沫气泡的尺寸分布。

IF 1.8 4区物理与天体物理

The European Physical Journal E Pub Date : 2025-06-21 DOI: 10.1140/epje/s10189-025-00498-z

Ildoo Kim

引用次数: 0