Andrology最新文献

{"title":"Mapping the immune cells of the testis: Key insights into sexual maturation.","authors":"Xiaoyu Wu, Chenzhao Feng, Zunpan Fan, Yongfeng Wang, Huiping Zhang, Kai Zhao","doi":"10.1111/andr.70077","DOIUrl":"https://doi.org/10.1111/andr.70077","url":null,"abstract":"<p><strong>Background: </strong>The testicular immune microenvironment sustains homeostasis and immune privilege. However, the presence and functional significance of B cells within this specialized niche remain poorly characterized. Furthermore, the intricate crosstalk between resident immune populations and testicular stromal cells that may orchestrate the immunological and endocrine microenvironment during sexual maturation warrants systematic investigation.</p><p><strong>Objective: </strong>To systematically delineate the immune cell atlas and developmental trajectory of testicular leukocytes before and after sexual maturation.</p><p><strong>Materials and methods: </strong>An integrated analysis of leukocytes in post-sexual maturity (8-week-old) and pre-sexual maturity (2-week-old) mouse testes using single-cell RNA sequencing (scRNA-seq) and mass cytometry (CyTOF), was performed. Magnetic-activated cell sorting (MACS) isolated immune subsets, followed by bioinformatics interrogation of cellular heterogeneity and ligand-receptor network analysis to map intercellular communication pathways.</p><p><strong>Results: </strong>Through scRNA-seq clustering analysis, we resolved 18 distinct leukocyte populations (11 lymphoid and seven myeloid lineages), which were further validated and expanded to 17 phenotypically discrete subsets (eight lymphoid and nine myeloid) via high-dimensional CyTOF profiling. Notably, we identified a rare but functionally significant B lymphocyte population within the testicular compartment. The myeloid compartment exhibited pronounced developmental plasticity, marked by progressive Il1b⁺Macrophages diminution and regulatory T cell expansion during maturation. Cell communication network analysis revealed intensified ligand-receptor cross-talk between androgen-producing Leydig cells and CD8⁺ T lymphocytes in post-pubertal testes, providing mechanistic insights into age-dependent immune privilege establishment.</p><p><strong>Discussion and conclusions: </strong>Multi-omics integration reveals dynamic immune remodeling during testicular maturation. These findings underscore the potential involvement of B cells in local immune surveillance while identifying maturation-associated signaling axes between stromal and immune cells. This comprehensive mapping of testicular leukocyte dynamics significantly advances our understanding of reproductive immunology and lays foundation for investigating immune-mediated testicular pathologies.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of iron in normal and impaired testicular function.","authors":"Aileen Harrer, Esther G Meyron-Holtz, Andreas Meinhardt","doi":"10.1111/andr.70068","DOIUrl":"https://doi.org/10.1111/andr.70068","url":null,"abstract":"<p><p>Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin-mediated systemic iron control and the iron-responsive element/iron regulatory protein (IRE/IRP) system at the cellular level. Germ cells require iron for cell divisions and development, while Leydig and Sertoli cells depend on iron for the biosynthesis of testosterone and the maintenance of sperm development, with iron-dependent enzymes playing essential roles in lipid metabolism, DNA synthesis, and mitochondrial function. Iron imbalances, including iron overload and deficiency, significantly impact testicular health. Excess iron accumulation induces oxidative stress, lipid peroxidation, and ferroptosis, contributing to testicular dysfunction. Hereditary hemochromatosis and beta-thalassemia major are associated with disrupted iron metabolism, leading to altered hormonal profiles and impaired spermatogenesis. Conversely, iron deficiency, often linked to dietary insufficiency or inflammatory conditions, can impair testosterone production and sperm quality. Bacterial and viral infections of the testis, such as those caused by Escherichia coli, Zika virus, and HIV, also alter iron metabolism, influencing immune responses and exacerbating testicular inflammation. Additionally, chronic conditions such as obesity and diabetes may disrupt iron regulation and contribute to reproductive dysfunction. Emerging evidence suggests a strong link between ferroptosis and testicular damage, with iron-dependent lipid peroxidation playing a key role in cell death pathways. This review highlights the complexity of iron regulation in the testis, the negative effects of disruptions of iron metabolism on male fertility and reproductive health as well as the gaps in knowledge that currently prevent therapeutic approaches to mitigate infertility associated with iron dysregulation.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the intersection of sleep disorders and erectile dysfunction: Outcomes from two EPISONO editions.","authors":"Monica Levy Andersen, Allan Saj Porcacchia, Guilherme Luiz Fernandes, Tathiana A Alvarenga, Sergio Tufik","doi":"10.1111/andr.70067","DOIUrl":"https://doi.org/10.1111/andr.70067","url":null,"abstract":"<p><strong>Background: </strong>There is growing interest in the relationship between sleep disorders and erectile dysfunction. We present the results from a 2015 follow-up study in relation to the 2007 edition of Epidemiologic Sleep Study (EPISONO), a population-based sleep study conducted in São Paulo, Brazil, and from the 4th edition of EPISONO (2018), with respect to the incidence and prevalence of erectile dysfunction, and the associated risk factors. We hypothesized that the presence of erectile dysfunction would be associated with total testosterone levels and obstructive sleep apnea in both longitudinal and cross-sectional analyses.</p><p><strong>Method: </strong>The participants underwent polysomnography, and testosterone assays were performed. They also completed a range of health questionnaires. The sample comprised men aged 20‒80 years. In the longitudinal analysis, incidence the (N = 256) and prevalence (N = 300) of erectile dysfunction were calculated, and a generalized estimating equation model was constructed. For the analysis of the data from 2018, prevalence (N = 314), binomial logistic regression, and mediation-moderation models were calculated.</p><p><strong>Results: </strong>An overall incidence of 10.55% of erectile dysfunction was found in the follow-up, which was higher in men older than 50 years. In the longitudinal model, older age (odds ratio = 1.09), more depression symptoms (odds ratio = 1.05), and low total testosterone concentration (odds ratio = 2.69) were significant predictors of erectile dysfunction. Psychological well-being (World Health Organization Quality of Life) was a predictor of lowered odds of having erectile dysfunction (odds ratio = 0.87). In EPISONO 2018, a 20.06% general prevalence of erectile dysfunction was identified, and this prevalence was higher in age groups over 50 years. The odds of having erectile dysfunction were increased by age (odds ratio = 1.07), and the psychological domain of World Health Organization Quality of Life was associated with lowered odds of having erectile dysfunction (odds ratio = 0.65). Mediation models revealed a statistically significant mediation of apnea‒hypopnea index between the effect of age on total testosterone. The model that included age as the independent variable, apnea‒hypopnea index as a mediator and erectile dysfunction as the outcome resulted in significant effects of age but not apnea‒hypopnea index.</p><p><strong>Conclusions: </strong>This study highlights the importance of aging, psychological quality of life, testosterone concentration, and depressive symptoms in the context of erectile dysfunction. An association between obstructive sleep apnea and erectile dysfunction was observed, but it was not independent of age. The longitudinal results emphasize that, besides aging, these are modifiable factors that can be the subject of interventions to mitigate the development of erectile dysfunction over time.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryptorchidism: Novel genetic insights into CCDC149 mutations.","authors":"Shengrong Du, Shan Xu, Lei Yang, Yan Ye, Yuhan Wu, Ziyun Xiao, Xiuqing Dong, Wenliang Yao, Hua Li","doi":"10.1111/andr.70072","DOIUrl":"https://doi.org/10.1111/andr.70072","url":null,"abstract":"<p><strong>Background: </strong>Cryptorchidism, characterized by the failure of one or both testes to descend into the scrotum, is a common congenital condition that can lead to infertility and increased risk of testicular cancer. CCDC149, a coiled-coil domain-containing protein, has been implicated in various developmental processes, but its role in the male reproductive system remains unexplored.</p><p><strong>Objective: </strong>This study aims to investigate the role of CCDC149 mutations in the development of bilateral cryptorchidism and to elucidate the underlying molecular mechanisms.</p><p><strong>Materials and methods: </strong>We conducted a whole-exome sequencing of an 8-year-old boy diagnosed with bilateral cryptorchidism, revealing a mutation in the CCDC149 gene. To further explore the functional implications of this mutation, we utilized CRISPR/Cas9 technology to generate Ccdc149 knockout mice. The phenotypic characteristics of these mice were assessed, focusing on testicular descent and sperm morphology. Additionally, single-cell RNA sequencing was performed to analyze the expression of genes associated with CCDC149, including anti-Müllerian hormone (AMH) and muscle-related factors.</p><p><strong>Results: </strong>The Ccdc149 knockout mice exhibited significant phenotypic traits consistent with cryptorchidism, including undescended testes and oligoasthenoteratozoospermia. Single-cell RNA sequencing analysis revealed altered expression patterns of AMH and several muscle-related genes, suggesting a potential regulatory interaction between CCDC149, AMH, and muscle development factors in the context of testicular descent.</p><p><strong>Discussion: </strong>Our findings provide novel genetic insights into the role of CCDC149 mutations in cryptorchidism. The observed phenotypic characteristics in the knockout mice, along with the gene expression analysis, indicate that CCDC149 may be crucial for normal testicular descent through its interaction with AMH and muscle-related factors. These results highlight the importance of further research into the molecular mechanisms underlying cryptorchidism, which could lead to improved diagnostic and therapeutic strategies for affected individuals.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of varicocelectomy and intrauterine insemination in varicocoele patients with mild semen abnormalities: An observational study.","authors":"Yanlin Ma, Weiming Deng, Tingting Wu, Qi Li, Yuanjie Li, Wenjie Mai, Lizheng Yan, Changwei Liang, Lingxiao Zhang","doi":"10.1111/andr.70070","DOIUrl":"https://doi.org/10.1111/andr.70070","url":null,"abstract":"<p><strong>Background: </strong>Varicocoele is a common cause of male infertility, affecting spermatogenesis through increased testicular temperature, venous stasis, and oxidative stress. Microsurgical subinguinal varicocelectomy improves semen quality, whereas intrauterine insemination is widely used for mild male factor infertility. The comparative efficacy of these treatments in varicocoele patients with mild semen abnormalities remains unclear.</p><p><strong>Objectives: </strong>To evaluate the efficacy of microsurgical subinguinal varicocelectomy and intrauterine insemination in improving clinical pregnancy and live birth rates in varicocoele patients with mild semen abnormalities and assess post-operative improvements in semen parameters following microsurgical subinguinal varicocelectomy.</p><p><strong>Materials and methods: </strong>A retrospective cohort study involving 650 microsurgical subinguinal varicocelectomy patients from five medical centers and 700 intrauterine insemination patients from one center was conducted. Inclusion criteria included varicocoele diagnosed via ultrasonography, mild semen abnormalities (total motile sperm count ≥5 million), and at least one abnormal semen parameter. Primary outcomes were clinical pregnancy and live birth rates. Secondary outcomes included sperm concentration, motility, and total motile sperm count changes post-microsurgical subinguinal varicocelectomy. Statistical analyses included chi-square tests and logistic regression.</p><p><strong>Results: </strong>Microsurgical subinguinal varicocelectomy patients demonstrated significant improvements in sperm concentration (35.2-43.3 × 10⁶/mL), motility (26%-38%), and total motile sperm count (18.8-34.9 × 10⁶, p < 0.001). Clinical pregnancy and live birth rates were higher in the microsurgical subinguinal varicocelectomy group (35.23% and 31.08%) compared to the intrauterine insemination group (29.57% and 24.00%, p < 0.05). Multivariate analysis revealed that microsurgical subinguinal varicocelectomy significantly increased pregnancy (OR = 1.43, 95% CI: 1.12-1.83, p < 0.05) and live birth rates (OR = 1.56, 95% CI: 1.21-2.02, p < 0.05).</p><p><strong>Discussion and conclusion: </strong>Microsurgical subinguinal varicocelectomy significantly enhances semen quality and achieves superior clinical pregnancy and live birth rates compared to intrauterine insemination for varicocoele patients with mild semen abnormalities. These findings suggest that microsurgical subinguinal varicocelectomy is a more effective treatment option, highlighting the importance of individualized treatment strategies and supporting the preferential use of surgical intervention in this specific patient population.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of varicocoelectomy on male semen parameters: A long-term analysis of sperm quality and outcomes.","authors":"Max D Sandler, Julio Yanes, Rohan Dureja, Vishal Ila, Aaron A Gurayah, Adam D Williams, David Miller","doi":"10.1111/andr.70075","DOIUrl":"https://doi.org/10.1111/andr.70075","url":null,"abstract":"<p><strong>Background: </strong>Varicocoeles are common in 40% of men presenting with infertility. Semen parameters including sperm motility, low sperm count and sperm morphology are altered by the presence of varicocoeles. Though varicocoelectomy has been associated with improvements in these parameters, studies on long-term outcomes are limited.</p><p><strong>Objectives: </strong>Analyze pre-operative samples with those collected at multiple post-operative timepoints to assess if sperm parameters continue to improve in the period following varicocoelectomy.  MATERIALS AND METHODS: Adult men who underwent varicocoelectomy under a single surgeon from 2017 to 2023 with at ≥1 post-operative semen analysis (SA) were included. Motile sperm count, progressive motility, round cells, semen volume, sperm concentration, sperm morphology, total motility and viability was collected from each patient's SA. Wilcoxon signed-rank tests were used to compare medians of sperm parameters from pre-operative baseline to 6, 12, 18 and 24 months follow up.</p><p><strong>Results: </strong>At 6 months, number of motile sperm increased from 4 to 8 million/mL (p < 0.0001), progressive motility increased from 34% to 42% (p < 0.0001), total motility rose from 37% to 45% (p <0.0001), concentration increased from 6.9 mil/mL to 9 mil/mL (p <0.0001), and morphology increased from 1% to 2% (p = .0026). Viability increased from 60% to 62% (p = .0002). At 6-12 months, number of motile sperm (7 mil/mL, p < 0.0001), progressive motility (38.5%, p = 0.0005), sperm concentration (8 mil/mL, p < 0.0001), and total motility (41.5%, p < 0.0001) remained statistically significant compared to baseline. At 12-18 months, significant increases in progressive motility (35%, p = 0.0272) and total motility (37%, p = 0.0022) persisted.</p><p><strong>Conclusions: </strong>Our retrospective study demonstrates significant short-term improvements across multiple parameters at 6-months after varicocoelectomy. While we note individual improvement in sperm parameters during longer follow-up period, there was variability based on the time frame. Our findings underscore the impact of varicocoelectomies may have on enhancing short-term male fertility. Future, prospective research is needed to validate these findings.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability of suprapubic pedicled phalloplasty to address genital gender-affirming surgery in transgender men: A single-center cohort analysis.","authors":"Anfosso Mattia, Cirigliano Lorenzo, Preto Mirko, Gontero Paolo, Falcone Marco","doi":"10.1111/andr.70074","DOIUrl":"https://doi.org/10.1111/andr.70074","url":null,"abstract":"<p><strong>Background: </strong>Over the years, numerous techniques have been used to address genital gender-affirming surgery (GGAS) in transgender men. Among the proposed surgical options to address TPC in transgender men, suprapubic pedicled phalloplasty (SPP) has rarely been considered in the current scientific literature.</p><p><strong>Objectives: </strong>The aim of the study is to report the surgical outcomes of the first step of suprapubic pedicled phalloplasty (SPP)-with or without urethral lengthening (UL)-evaluating possible risk factors affecting the incidence of complications.</p><p><strong>Methods: </strong>The study was conducted as a retrospective, single-center analysis at a regional tertiary referral center. Between April 2006 and August 2024, 40 transgender men underwent GGAS at our center. GGAS was conducted as a multistage procedure, consisting of (1) SPP (2) eventual radial artery-based forearm free-flap urethroplasty, (3) glans sculpting, join-up, vaginectomy and scrotoplasty, and (4) penile prosthesis implantation. Surgery time, intra- and postoperative complications, and hospital stay were selected as variables for surgical outcomes.</p><p><strong>Results: </strong>The median operative time was 130 min (111-158 min). Partial necrosis of the phallus was detected in 4 cases (10.5%) it was easily managed through a minor outpatient procedure. The median length loss after debridement was 1.3 cm (0.5-2 cm), without significant impact on the final length. A total loss of the neophallus occurred in a single case (2.5%) and required a staged salvage TPC. In the present series, only 14 patients (35%) opted for urethral reconstruction: 8 (20%) required a perineostomy, 4 (10%) underwent radial artery urethroplasty (RAU), while the remaining 5% required an additional metoidioplasty with urethral lengthening, ensuring that the clitoris was not incorporated into the neophallus during penile construction. Univariate and multivariate analyses failed to highlight any possible risk factors influencing the incidence of postoperative complications. The lack of a comparison group or randomization, the limited follow-up, and the absence of patient-reported outcome analysis are the main limitations of our study.</p><p><strong>Conclusion: </strong>Our evidence suggests that SPP is a reliable and technically accessible option for GGAS in transgender men, particularly when microsurgery is contraindicated. The technique offers the advantage of accommodating the patient's needs for urethral lengthening, simplifying the surgical process, and reducing operative times. While vascular complications may occur relatively frequently, they are mostly minor and can be managed with simple outpatient procedures.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of androgen deprivation therapy on sexual health in patients who underwent brachytherapy for prostate cancer.","authors":"Kenta Onishi, Yasushi Nakai, Fumisato Maesaka, Mitsuru Tomizawa, Takuto Shimizu, Shunta Hori, Yosuke Morizawa, Daisuke Gotoh, Makito Miyake, Kaori Yamaki, Isao Asakawa, Fumiaki Isohashi, Kiyohide Fujimoto, Nobumichi Tanaka","doi":"10.1111/andr.70066","DOIUrl":"https://doi.org/10.1111/andr.70066","url":null,"abstract":"<p><strong>Background: </strong>Androgen deprivation therapy (ADT) is used in the management of prostate cancer. Post-therapy recovery from the induced hypogonadal state is protracted and correlates with diminished quality of life (QOL).</p><p><strong>Objective: </strong>This study assessed the impact of short-term ADT on sexual health following brachytherapy.</p><p><strong>Materials and methods: </strong>The study included patients administered brachytherapy with or without short-term neoadjuvant ADT (≤6 months) at our institution from 2010 to 2018. Serum total testosterone levels, chronological changes in erectile function, and health-related QOL were evaluated.</p><p><strong>Results: </strong>Of 139 participants, 41 received neoadjuvant ADT (median, 4 months). Sexual health inventory for men (SHIM) scores and sexual function domain of the expanded prostate cancer index composite (EPIC) scores deteriorated significantly up to 36 months post-treatment in patients receiving brachytherapy with neoadjuvant ADT compared to those without. A significant decline was observed in the sexual bother domain of the EPIC scores of patients without neoadjuvant ADT up to 6 months post-treatment relative to those with neoadjuvant ADT. Total testosterone levels in the brachytherapy with neoadjuvant ADT group gradually recovered post-treatment and were similar to those in the brachytherapy without neoadjuvant ADT group after 12-month treatment. Neoadjuvant ADT and a lower pre-treatment SHIM score were risk factors for severe erectile dysfunction 12 months after treatment.</p><p><strong>Discussion: </strong>Restoring sexual health extends beyond the normalization of testosterone levels following cessation of ADT. ADT significantly influences erectile dysfunction after brachytherapy. Our research identified a time lag between the restoration of testosterone levels and the improvement of erectile function and sexual QOL. We hypothesized that individuals undergoing ADT had diminished sexual distress, attributable to fewer opportunities for sexual engagement than their untreated counterparts.</p><p><strong>Conclusion: </strong>Persistent sexual dysfunction occurs despite the normalization of testosterone levels post-ADT. Understanding sexual QOL changes following brachytherapy with ADT will help guide treatment recommendations and patient decision-making.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paternal ischemic heart disease and chance of successful pregnancy outcomes.","authors":"Anne-Sofie Sønnichsen-Dreehsen, Caroline Theilgaard Thorarinsson, Bente Mertz Nørgård, Jens Fedder, Mette Wod","doi":"10.1111/andr.70065","DOIUrl":"https://doi.org/10.1111/andr.70065","url":null,"abstract":"<p><strong>Background: </strong>Only approximately 30% of conceptions result in live births. Historically, research has predominantly focused on maternal factors impacting pregnancy success, despite the cause remaining unidentified in most cases. The influence of paternal factors on a couple's likelihood of achieving a successful pregnancy is still not well understood and warrants further investigation.</p><p><strong>Objectives: </strong>This study aims to examine the chance of biochemical pregnancy, clinical pregnancy, and a live-born child in couples where the male partner has ischemic heart disease.</p><p><strong>Materials and methods: </strong>This nationwide cohort study based on Danish health registries included couples undergoing in vitro fertilization with or without intracytoplasmic sperm injection from 2006 to 2019. The cohort was divided into two groups: exposed and unexposed. The exposed cohort included embryo transfers in couples where the male partner had ischemic heart disease, while the unexposed group included those where the male partner did not have this condition.</p><p><strong>Results: </strong>A total of 101,875 couples with a known male partner were included. Among these, 653 couples were included in the exposed cohort and 101,222 were included in the unexposed cohort. The adjusted odd ratios (ORs) for a biochemical pregnancy, clinical pregnancy, and live-born child were 0.99 (95% confidence interval [CI]: 0.79; 1.23), 0.79 (95% CI: 0.51, 1.23), and 0.94 (95% CI: 0.62, 1.44), respectively.</p><p><strong>Conclusions: </strong>These findings indicate that paternal ischemic heart disease prior to oocyte retrieval is not associated with a statistically significant decrease in the chances of biochemical pregnancy, clinical pregnancy, or live birth.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-intensity shockwave therapy for erectile dysfunction due to diabetes mellitus or coronary artery disease: An individual participant data meta-analysis from a single center.","authors":"Nikolaos Pyrgidis, Dimitrios Kalyvianakis, Ioannis Mykoniatis, Dimitrios Hatzichristou","doi":"10.1111/andr.70069","DOIUrl":"https://doi.org/10.1111/andr.70069","url":null,"abstract":"<p><strong>Background: </strong>Low-intensity shockwave therapy (LiST) is a first-line treatment for vasculogenic erectile dysfunction (ED). However, its efficacy in challenging cases, such as ED solely due to type 2 diabetes mellitus (DM) or coronary artery disease (CAD), has not been adequately assessed. Materials and Methods This study presents an individual participant data meta-analysis of five double-blind randomized controlled trials involving 208 patients treated in a single academic center using a standardized LiST protocol (ARIES 2 generator, 5000 impulses/session). Results For outcomes, including International Index of Erectile Function-Erectile Function Domain scores, sexual encounter profile question 3 responses, resistance index, and minimal clinically important differences, LiST was equally effective in patients with ED due to DM or CAD compared to other causes. Subgroup analyses showed equivalent efficacy for 6 versus 12 LiST sessions. No adverse events were reported. Conclusions These findings confirm LiST's safety and effectiveness across different causes of vasculogenic ED, supporting its broader application in clinical practice.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}