AndrologyPub Date : 2025-09-27DOI: 10.1111/andr.70123
Jesús Martínez-Hernández, Ferran Garriga, Adeel Ahmad, Lorena Padilla, Carolina Maside, Sergi Bonet, Isabel Barranco, Jordi Roca, Luis Miguel Pastor, Marc Yeste
{"title":"The Oxytocin Receptor in Spermatozoa May Originate From Both Spermatogenesis and Epididymal Maturation, and Regulates Capacitation.","authors":"Jesús Martínez-Hernández, Ferran Garriga, Adeel Ahmad, Lorena Padilla, Carolina Maside, Sergi Bonet, Isabel Barranco, Jordi Roca, Luis Miguel Pastor, Marc Yeste","doi":"10.1111/andr.70123","DOIUrl":"https://doi.org/10.1111/andr.70123","url":null,"abstract":"<p><strong>Background: </strong>The oxytocin receptor (OR) is a G-protein-coupled receptor recently identified in human spermatozoa, whose origin and role in sperm physiology remain unknown.</p><p><strong>Objectives: </strong>In this study, using the pig as a model, we examine the presence of the OR in ejaculated spermatozoa through immunofluorescence and immunoblotting, and investigate the receptor's origin in the male gamete via immunohistochemistry in testicular and epididymal tissues. Additionally, we assess the involvement of the OR in in vitro capacitation and the acrosome reaction by utilizing physiological concentrations of agonists (oxytocin and carbetocin) and an antagonist (L-371,257).</p><p><strong>Results: </strong>The results indicate that, in addition to the expected presence in ejaculated spermatozoa, the OR is expressed during spermatogenesis. Besides, this receptor is found in Leydig and Sertoli cells, as well as in the principal, basal, and apical cells of the epididymis. Furthermore, our data suggest that, during epididymal maturation, the OR could be incorporated in spermatozoa via extracellular vesicles within the apical blebs. The OR is involved in sperm capacitation, as the combination of the antagonist (L-371,257) and the agonist (carbetocin) increases intracellular calcium levels and membrane lipid disorders, which are known as capacitation markers.</p><p><strong>Conclusions: </strong>The presence of the OR in mammalian spermatozoa could originate from both spermatogenesis and epididymal maturation. Moreover, in the male gamete, this receptor regulates sperm capacitation by interacting with its ligand in the female reproductive tract.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AndrologyPub Date : 2025-09-25DOI: 10.1111/andr.70124
Qianghui Zhong, Chunlin Wang, Dake Zhu, Karl H Pang, Elena Colonnello, Andrea Sansone, Qingshan Chen, Emmanuele A Jannini, Yan Zhang
{"title":"The severity classification of lifelong premature ejaculation based on the premature ejaculation diagnostic tool.","authors":"Qianghui Zhong, Chunlin Wang, Dake Zhu, Karl H Pang, Elena Colonnello, Andrea Sansone, Qingshan Chen, Emmanuele A Jannini, Yan Zhang","doi":"10.1111/andr.70124","DOIUrl":"https://doi.org/10.1111/andr.70124","url":null,"abstract":"<p><strong>Background: </strong>Grading premature ejaculation (PE) may hold significant value. However, although previous studies have attempted to achieve a uniform severity scale for PE, this has not been widely accepted since design and methodological limitations.</p><p><strong>Objectives: </strong>In patients with lifelong PE (LPE), we re-evaluated the items suitable for severity grading and established the appropriate severity classification reference through reasonable statistical methods and logic.</p><p><strong>Materials and methods: </strong>Patient perceived intravaginal ejaculatory latency time (PIELT) and premature ejaculation diagnostic tool (PEDT) scores from 264 men (149 with LPE and 115 without PE) were used to analyze surrogate item suitable for classification. Classification and Regression Trees were used to determine the optimal score interval for different severity levels in patients with LPE.</p><p><strong>Results: </strong>For the LPE population with PIELT < 3.5 min, PIELT had no value in the classification of severity of LPE patients. PEDT items 1 and 4, showing high correlation (0.84 and 0.89, respectively) with PEDT total score, reflect the physical and mental effects of LPE patients in terms of ejaculatory control and interpersonal relationship. These items may serve as proxy for the severity scale of LPE patients. Hence, patients diagnosed with LPE can be classified into the following grades based on PEDT scores: mild (11-14), moderate (15-17), severe (18-20). Substantial agreement was shown between these predicted and \"true\" classes (weighted kappa 0.71).</p><p><strong>Discussion: </strong>Assessing LPE according to three dimensions is a widely accepted definition. While PIELT showed no statistically significant differences in the classification (p > 0.05), the two subjective dimensions of ejaculation control and negative psychological influence did predict the severity grading of LPE. Not only can grading the subjective feelings of patients with LPE help them to self-assess the extent of the disease, but also provide a valuable reference for further treatment.</p><p><strong>Conclusion: </strong>Within the PIELT of 3.5 min, the severity of LPE can be classified into severe, moderate, and mild categories based on the PEDT score.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AndrologyPub Date : 2025-09-19DOI: 10.1111/andr.70118
Alfonso Cepeda-Emiliani, María Otero-Alén, Juan Suárez-Quintanilla, Marina Gándara-Cortés, Tomás García-Caballero, Rosalía Gallego, Lucía García-Caballero
{"title":"The sensory penis: A comprehensive immunohistological and ontogenetic exploration of human penile innervation.","authors":"Alfonso Cepeda-Emiliani, María Otero-Alén, Juan Suárez-Quintanilla, Marina Gándara-Cortés, Tomás García-Caballero, Rosalía Gallego, Lucía García-Caballero","doi":"10.1111/andr.70118","DOIUrl":"https://doi.org/10.1111/andr.70118","url":null,"abstract":"<p><strong>Background: </strong>Penile sexual sensation relies on intricate neural structures that remain incompletely characterized. Immunohistological insights into their development and organization can enhance understanding of penile neuroanatomy and function, while optimizing surgical outcomes.</p><p><strong>Objectives: </strong>To elucidate the ontogeny, organization, and immunohistological features of human penile innervation in fetal and adult specimens, primarily focusing on the frenular delta, sensory corpuscles, and related structures to address gaps in anatomical knowledge and inform surgical practices.</p><p><strong>Materials and methods: </strong>Formalin-fixed, paraffin-embedded tissues from 30 fetal (8-24 weeks) and 14 adult cadaveric penile specimens were analyzed. Routine histological stains and immunohistochemical markers targeting neural structures were applied. Serial sections were examined for histology, neuroanatomical mapping, sensory corpuscle characterization, and neural density assessments.</p><p><strong>Results: </strong>Fetal penile neurodevelopment exhibited two phases: the pre-corpuscular stage (8-16 weeks), marked by axonal hyperinnervation and exuberant ventral intraepithelial nerve fibers, and the corpuscular stage (17-24 weeks), characterized by Pacinian corpuscle emergence and targeted neural pruning. Adult specimens showed region-specific neural distributions, with heightened densities in the frenular delta. Intracorporeally, sensory corpuscles exhibited a bimodal intraspongiosal distribution, with Pacinians in the bulb and glans. Molecular profiles of sensory corpuscles, including novel immunoreactivities, were comprehensively documented. The preputial dartos and vasculature displayed dense autonomic innervation. A superficial glans tunica albuginea was identified, with implications for neural organization.</p><p><strong>Discussion: </strong>These findings reveal previously unrecognized transitions during fetal penile neural development and into adulthood, providing a foundation for the neurodevelopmental biology of the human penis and documenting the frenular delta's unique innervation. The characterization of penile neural components and the glans tunica albuginea addresses longstanding anatomical and sexological questions. Our results inform current debates on penile circumcision and neurotomy.</p><p><strong>Conclusion: </strong>This study provides a comprehensive ontogenetic framework of penile innervation, emphasizing the frenular delta as a specialized center of sexual sensation.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AndrologyPub Date : 2025-09-19DOI: 10.1111/andr.70125
Bangbei Wan
{"title":"Comment on \"Comparative Efficacy of Varicocelectomy and Intrauterine Insemination in Varicocoele Patients With Mild Semen Abnormalities: An Observational Study\".","authors":"Bangbei Wan","doi":"10.1111/andr.70125","DOIUrl":"https://doi.org/10.1111/andr.70125","url":null,"abstract":"","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AndrologyPub Date : 2025-09-16DOI: 10.1111/andr.70122
Tuomisto A, Pinola P, Pesonen P, Franks S, Martikainen H, Tapanainen Js, Niinimäki M, Morin-Papunen L
{"title":"Low testosterone levels in men at age 31 associates with future risk of prediabetes and type 2 diabetes: A birth cohort study.","authors":"Tuomisto A, Pinola P, Pesonen P, Franks S, Martikainen H, Tapanainen Js, Niinimäki M, Morin-Papunen L","doi":"10.1111/andr.70122","DOIUrl":"https://doi.org/10.1111/andr.70122","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to investigate the association of a low serum testosterone concentration with the risk of abnormal glucose metabolism (i.e., prediabetes and type 2 diabetes) in men at a 15-year follow-up.</p><p><strong>Study population and methods: </strong>In a population birth cohort, men with low testosterone (testosterone < 12.1 nmol/L, n = 136) and normal testosterone concentration (testosterone ≥ 12.1 nmol/L, n = 2555) at age 31 were followed up until age 46. Blood samples were drawn at ages 31 and 46, and an oral glucose tolerance test (n = 1409) was performed at age 46.</p><p><strong>Results: </strong>Men with low testosterone had significantly greater body mass index and waist circumference than men with normal testosterone at ages 31 and 46 (p < 0.001 in all comparisons). In men with low testosterone, the association with abnormal glucose metabolism was mainly driven by adiposity (p = 0.4 after adjusting for waist circumference). However, the risk remained increased, independently of waist circumference, when comparing the lowest and highest quartiles of testosterone (odds ratio:1.8 [95% confidence interval 1.3-2.7]) or when using testosterone as a continuous variable (odds ratio: 0.97 [95% confidence interval 0.95-0.99]). Between ages 31 and 46, body mass index increased more in men with normal testosterone at age 31 and low testosterone at age 46 than in men with normal testosterone or low testosterone at both ages (p < 0.001). Higher sex hormone binding globulin levels were associated with a lower risk for abnormal glucose metabolism independently of waist circumference (p < 0.001).</p><p><strong>Conclusion: </strong>Low levels of testosterone and sex hormone binding globulin at age 31 associated with an increased risk of developing abnormal glucose metabolism after 15 years' follow-up. This association was partly independent of adiposity but was linked to waist circumference and weight gain.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Expression of miR-339-3p and OPRM1 in relation to sperm function in male infertility.","authors":"Ashraf Elsaid, Ahmed Fathy State, Adel Zalata, Randa El-Gamal, Moheiddin Alghobary","doi":"10.1111/andr.70121","DOIUrl":"https://doi.org/10.1111/andr.70121","url":null,"abstract":"<p><strong>Background: </strong>Infertility is the inability of a couple to conceive after 12 months of unprotected intercourse. The µ-opioid receptor involved in mediating opioid effects and may be associated with male fertility. µ-Opioid receptors were expressed in testicular tissues and spermatozoa, where they may influence spermatogenesis and sperm motility. miR-339-3p was thought to suppress OPRM1 mRNA expression in neuronal cells following opioid exposure through post-transcriptional modulation. However, its role in male infertility remains unexplored.</p><p><strong>Objectives: </strong>To investigate the relationship between miR-339-3p expression, OPRM1 mRNA expression, and µ-opioid receptor protein level in spermatozoa of infertile versus fertile men, and to assess their association with semen parameters, oxidative stress, and hormonal profile.</p><p><strong>Materials and methods: </strong>This case-controlled study was conducted on 45 infertile men and 45 healthy fertile men recruited from andrology outpatient clinic, Mansoura University Hospital. Semen analysis, acrosin activity, oxidative stress markers, and serum hormones levels were evaluated. Relative quantification of miR-339-3p and OPRM1 mRNA expression was quantified using qRT-PCR. µ-Opioid receptor protein levels were measured by enzyme-linked immunosorbent assay technique. Correlation and receiver-operating characteristic analyses were performed.</p><p><strong>Results: </strong>Infertile men exhibited significantly elevated levels of µ-opioid receptor protein (median: 6.41 ng/mL) compared to fertile controls (5.45 ng/mL, p < 0.001), alongside a marked upregulation of OPRM1 mRNA expression (relative quantification = 4.05 vs. 0.993, p < 0.001), representing approximately a 4.08-fold increase. In contrast, miR-339-3p expression was significantly reduced in the infertile group (relative quantification = 0.538 vs. 1.01, p < 0.001), indicating an approximate 0.53-fold change, or nearly 2-fold downregulation. A significant negative correlation was observed between miR-339-3p and OPRM1 mRNA levels (r<sub>s</sub> = -0.704, p < 0.001). Receiver-operating characteristic analysis indicated excellent diagnostic accuracy for OPRM1 mRNA (AUC = 0.916) and miR-339-3p (AUC = 0.914) in differentiating infertile from fertile men.</p><p><strong>Conclusions: </strong>Downregulation of miR-339-3p and overexpression of µ-opioid receptor are associated with impaired semen quality and oxidative imbalance in infertile men. These molecular markers may serve as potential diagnostic indicators in male infertility, pending further validation.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of neonatal hypothyroidism on testicular development and undifferentiated spermatogonia in prepubertal rats.","authors":"Daisuke Matsumoto, Kentaro Mizuno, Hidenori Nishio, Hideyuki Kamisawa, Takuya Sakata, Taiki Kato, Akihiro Nakane, Satoshi Kurokawa, Tetsuji Maruyama, Yutaro Hayashi, Takahiro Yasui","doi":"10.1111/andr.70116","DOIUrl":"https://doi.org/10.1111/andr.70116","url":null,"abstract":"<p><strong>Background: </strong>Thyroid hormones play a key role in testicular development, particularly in the regulation of Sertoli cell proliferation and differentiation. While congenital hypothyroidism is common and treatable, the effects of thyroid hormone insufficiency on early testicular development during the neonatal period remain unclear.</p><p><strong>Objectives: </strong>This study investigated the effects of transient and continuous hypothyroidism during the neonatal and prepubertal periods on testicular development, focusing on spermatogonial stem cell dynamics through histological and germ cell marker analyses.</p><p><strong>Materials and methods: </strong>We established two neonatal rat models using 6-n-propyl-2-thiouracil: a continuous hypothyroidism model and a transient neonatal hypothyroidism model. 6-n-Propyl-2-thiouracil was administered to lactating dams at concentrations of 0.001%, 0.01%, and 0.03%. Male offspring were evaluated on postnatal days 7, 10, and 20 for serum hormone levels, body and testicular growth, and immunohistochemical markers (GFRA1, DDX4, SOX9, and Ki-67).</p><p><strong>Results: </strong>The transient hypothyroidism model successfully induced transient hypothyroidism without systemic growth impairment. Serum thyroxine and thyroid-stimulating hormone levels were normalized by day 20. GFRA1-positive undifferentiated germ cells consistently increased in all 6-n-propyl-2-thiouracil groups on days 7 and 20. Co-expression with Ki-67 indicated cell proliferation. The formation of seminiferous tubule lumen was reduced in a dose-dependent manner.</p><p><strong>Discussion: </strong>Transient neonatal hypothyroidism increases the number of undifferentiated germ cells, potentially including spermatogonial stem cells. The transient hypothyroidism model minimizes systemic effects and allows the observation of testis-specific responses to thyroid disruption.</p><p><strong>Conclusion: </strong>This study demonstrated that even low-dose transient hypothyroidism during the neonatal period enhances the population of undifferentiated germ cells, potentially including spermatogonial stem cells. The transient hypothyroidism model offers a physiologically relevant and minimally invasive platform to explore how early thyroid hormone imbalances influence germ cell population establishment during a critical window of testicular development, potentially reflecting the clinical scenarios of treated congenital hypothyroidism.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AndrologyPub Date : 2025-09-12DOI: 10.1111/andr.70119
Wenxin Ma, Chang Liu, Jing Pu, Ziyu Liu, Na Hu, Li Yang, Dongmei Chen, Hongmei Li, HuiMing Ma
{"title":"Lycium barbarum polysaccharides enhance testicular spermatogenesis in d-galactose-induced aging rats via calcium signaling.","authors":"Wenxin Ma, Chang Liu, Jing Pu, Ziyu Liu, Na Hu, Li Yang, Dongmei Chen, Hongmei Li, HuiMing Ma","doi":"10.1111/andr.70119","DOIUrl":"https://doi.org/10.1111/andr.70119","url":null,"abstract":"<p><strong>Background: </strong>Lycium barbarum polysaccharide (LBP) has long been recognized as having a wide range of beneficial properties for improving proliferation. However, the protective effects and specific mechanisms of d-galactose-induced testicular dysfunction in reproductively senescent rats are not fully understood.</p><p><strong>Materials and methods: </strong>A d-galactose-induced senescence model in male rats and a d-galactose-induced TM3 cell model were used to investigate the effects of LBP. The protective effect on testicular spermatogenic function was assessed by histological analysis and SA-β-gal staining. In addition, key calcium signaling pathway alterations involved in LBP were assessed using a multi-omics approach and validated by tissue. Single-cell sequencing data were used to further analyze the cellular heterogeneity of calcium signaling.</p><p><strong>Results: </strong>LBP significantly improved testicular structure, increased the number of spermatogonia in the seminiferous tubules, and significantly attenuated oxidative stress and testicular apoptosis. In addition, LBP restored the expression of key steroidogenic enzymes, as well as elevated levels of testosterone, follicle-stimulating hormone (FSH), and estradiol (E2), and decreased levels of luteinizing hormone (LH). Mechanistically, LBP regulates key signaling pathways, including calcium homeostasis, Hippo and mTOR pathways, which play important roles in cell growth, apoptosis, and tissue regeneration. Single-cell sequencing data show that calcium signaling is more active in the elderly compared to the young, mainly in Leydig cells, Round Spermatids, and Smooth Muscle Cells. In TM3 cell experiments, the LBP reduced SA-β-gal activity, downregulated aging markers (p16, p21, p53), and restored steroid production function. In addition, LBP regulated the Ca<sup>2</sup>⁺/CaM/CaMKII signaling pathway, improved calcium homeostasis, and reduced apoptosis in rats and cells.</p><p><strong>Conclusion: </strong>LBP improves d-galactose-induced testicular spermatogenesis mainly by regulating calcium signaling and metabolic pathways and is closely related to elongating spermatids, round spermatids.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Real-world pharmacovigilance assessment of drug-induced male hypogonadism risks: An analysis of FDA adverse drug event data.","authors":"Yujia Xi, Yijun Jia, Zhanlong Zheng, Xinfang Cao, Zhinan Jing, Jingqi Wang","doi":"10.1111/andr.70120","DOIUrl":"https://doi.org/10.1111/andr.70120","url":null,"abstract":"<p><strong>Background: </strong>Drug-induced hypogonadism is an underrecognized but significant adverse effect of various medications, contributing to male sexual dysfunction and infertility. Despite its clinical significance, comprehensive studies systematically identifying high-risk drugs remain limited.</p><p><strong>Objectives: </strong>This study aimed to investigate the potential drugs associated with hypogonadism from FDA Adverse Event Reporting System.</p><p><strong>Materials and methods: </strong>This study analyzed adverse drug events reported from FDA Adverse Event Reporting System covering the period from the first quarter of 2004 to the third quarter of 2024. Cases related to hypogonadism were identified using standardized Medical Dictionary for Regulatory Activities preferred terms. Disproportionality analyses were conducted using the reporting odds ratio and the Bayesian confidence propagation neural network. Drugs were classified according to Anatomical Therapeutic Chemical classification system and clinical applications. This study utilized FDA Label to determine whether adverse drug events related to male hypogonadism are mentioned on their labels.</p><p><strong>Results: </strong>We identified 10 classes including 42 drugs that showed positive signals for both reporting odds ratio and Bayesian confidence propagation neural network: anesthetics and analgesics, psychiatric and neurological medications, antineoplastic agents, urological medications, hormonal agents, cardiovascular medications, gastrointestinal medications, bone metabolism modifiers, antiretroviral agents, and other drugs. According to the Bayesian confidence propagation neural network algorithm, 6 drugs were considered to have a high risk of causing hypogonadism, and 11 drugs had medium risk. In addition, 20 drugs did not mention adverse drug events related to male hypogonadism, of which 3 were identified as high risk using the Bayesian confidence propagation neural network algorithm.</p><p><strong>Conclusions: </strong>This research summarized a list of potential drugs associated with hypogonadism. A clear understanding of the risk and frequency of drug-induced hypogonadism can reduce the likelihood of patients developing the condition.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AndrologyPub Date : 2025-09-08DOI: 10.1111/andr.70105
{"title":"Joint Congress of the American Society of Andrology & International Congress of Andrology 2025","authors":"","doi":"10.1111/andr.70105","DOIUrl":"https://doi.org/10.1111/andr.70105","url":null,"abstract":"","PeriodicalId":7898,"journal":{"name":"Andrology","volume":"13 S1","pages":"1-148"},"PeriodicalIF":3.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145012017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}