Andrology最新文献

{"title":"The Prognostic Role of Residual SYNTAX Score in the Recovery of Erectile Function Following Myocardial Infarction Treated with Percutaneous Coronary Intervention.","authors":"Timucin Sipal, Çağlar Alp, Ferhat Yakup Suçeken, Çağlar Sarioğlu, Muhammet Karadeniz, Erdal Yilmaz","doi":"10.1111/andr.70178","DOIUrl":"10.1111/andr.70178","url":null,"abstract":"<p><strong>Background: </strong>Erectile dysfunction (ED) and acute coronary events are closely linked, yet the trajectory of ED following percutaneous coronary intervention (PCI) remains incompletely understood. The residual SYNTAX score (RSS) quantifies incomplete revascularization and is an established prognostic tool in cardiology; however, its role in erectile function recovery after myocardial infarction (MI) is unclear.</p><p><strong>Objectives: </strong>To evaluate whether RSS predicts recovery of erectile function after MI treated with PCI.</p><p><strong>Materials and methods: </strong>In this prospective cohort study, 82 men aged 40-70 years who underwent PCI for MI were evaluated. ED was assessed using the International Index of Erectile Function-5 (IIEF-5) at baseline (after recovery from PCI, reflecting erectile functions before MI), and at 3 and 6 months. ED was defined as an IIEF-5 score ≤21. Patients were stratified according to RSS (<8 vs. ≥8). Anxiety (sexual-fear subscale) and depressive symptoms (BDI-II) were also assessed.</p><p><strong>Results: </strong>ED was present in 57.3% of patients at baseline, increased to 68.7% at 3 months, and decreased to 37.3% at 6 months. At 6 months, mean IIEF-5 scores improved significantly in men with RSS <8 (from 17.9 to 21.2; p < 0.001), but not in those with RSS ≥8 (from 17.2 to 16.3; p = 0.314). While severe ED remained largely unchanged over time, mild-to-moderate ED demonstrated the greatest improvement. Anxiety independently predicted ED at 3 months (OR 1.223, p = 0.049). At 6 months, RSS ≥8 independently predicted persistent ED (OR 3.22, p = 0.033), with moderate discriminatory accuracy (AUC 0.72).</p><p><strong>Conclusion: </strong>RSS ≥8 may identify men at increased risk for persistent ED after MI. The differential recovery patterns suggest that reversible functional impairment may predominate in milder forms of ED, whereas persistent severe ED may reflect more extensive systemic and penile vascular disease. Early recognition of anxiety and targeted sexual counseling may support erectile recovery following PCI.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":"2189-2198"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145997218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different Miscarriage Rate and Birthweights After In Vitro Fertilization versus Intracytoplasmic Sperm Injection Embryo Transfer in Couples With Male Hepatitis B Virus Infection: A Retrospective Study.","authors":"Meng Ma, Yong Fan, Minghua Liu, Haiyan Guo, Kaibo Lin, Qifeng Lyu","doi":"10.1111/andr.70216","DOIUrl":"10.1111/andr.70216","url":null,"abstract":"<p><strong>Background: </strong>The influence of paternal Hepatitis B virus infection on reproductive outcomes after in vitro fertilization or intracytoplasmic sperm injection is still debated. While differences in sperm-oocyte interaction duration and intensity between in vitro fertilization and intracytoplasmic sperm injection may lead to divergent viral exposure effects. Nevertheless, research specifically examining these differences remains limited.</p><p><strong>Objectives: </strong>To evaluate how various insemination techniques influence the effects of paternal Hepatitis B virus infection on reproductive outcomes in couples during in vitro fertilization/intracytoplasmic sperm injection treatments.</p><p><strong>Material and methods: </strong>This retrospective study analyzed 37,088 initial frozen-thawed embryo transfer cycles among women without Hepatitis B virus infection from February 2007 to August 2023. Patients were grouped into two categories based on paternal Hepatitis B virus surface antigen status: paternal Hepatitis B virus surface antigen positive (Hepatitis B virus surface antigen [+]) and negative (Hepatitis B virus surface antigen [-]) categories. Further stratified analyses were performed according to the insemination method. The primary endpoints were measures of pregnancy and neonatal results. An analysis using logistic regression was conducted to explore the independent link between paternal Hepatitis B virus infection and the specified outcomes.</p><p><strong>Results: </strong>In in vitro fertilization-derived embryos, paternal Hepatitis B virus infection was significantly associated with an elevated risk of miscarriage (adjusted odds ratio 1.55, 95% confidence interval 1.22-1.96), small for gestational age (adjusted odds ratio 1.70, 95% confidence interval 1.12-2.59), and very small for gestational age (adjusted odds ratio 3.07, 95% confidence interval 1.64-5.76) by comparison with controls. No such associations occurred with intracytoplasmic sperm injection-derived embryos.</p><p><strong>Discussion: </strong>Prior studies have shown inconsistent findings on the effects of paternal Hepatitis B virus infection on these outcomes. This study provides evidence that paternal infection with the Hepatitis B virus independently elevates the risks of miscarriage, small for gestational age, and very small for gestational age births following in in vitro fertilization, but not intracytoplasmic sperm injection. This discrepancy might be due to differences in the extent and duration of oocyte exposure to the Hepatitis B virus.</p><p><strong>Conclusions: </strong>Male Hepatitis B virus infection independently increases the risk of miscarriages and the birth of small for gestational age and very small for gestational age infants after in vitro fertilization embryo transfer, but not after intracytoplasmic sperm injection.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":"2309-2319"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Association of RXFP2 T222P Variant With Cryptorchidism: A Meta-Analytic Study.","authors":"Jacek Kabziński, Jerzy Niedzielski, Ireneusz Majsterek","doi":"10.1111/andr.70187","DOIUrl":"10.1111/andr.70187","url":null,"abstract":"<p><strong>Background: </strong>The RXFP2 receptor plays a key role in testicular descent, mediating the action of relaxin on gubernaculum development. The T222P polymorphism in the RXFP2 gene has previously been investigated in relation to cryptorchidism, but reported associations have been inconsistent across populations.</p><p><strong>Objectives: </strong>The aim of this meta-analysis was to assess the association of the T222P variant in the RXFP2 gene with the risk of cryptorchidism and to analyze effect-modifying factors, including population structure and allele frequencies in control groups.</p><p><strong>Materials and methods: </strong>A systematic literature review was conducted in PubMed, Embase, Web of Science, Scopus, and supplementary sources. Five studies with genotypic data for the T222P variant in case and control populations were selected. Allele and genotype frequencies were calculated, followed by cumulative OR values with 95% confidence intervals. Between-study heterogeneity was assessed using the I² statistic, and moderator analyses (Italy vs. other countries and P allele frequency in controls) as well as leave-one-out sensitivity analyses were performed. Study quality was assessed using the Newcastle-Ottawa Scale.</p><p><strong>Results: </strong>Carriers of the T222P variant showed a trend toward increased odds of cryptorchidism, with a more pronounced effect observed in Italian cohorts. Heterogeneity was moderate (I² ≈ 50%), and moderator analysis suggested that population differences and P allele frequency in controls may contribute to variability in effect estimates. Sensitivity analyses and alternative genotype models supported the consistency of the findings across analytical approaches.</p><p><strong>Discussion: </strong>The results support a potential association between the RXFP2 T222P variant and cryptorchidism risk, with population-specific effects likely reflecting underlying genetic background.</p><p><strong>Conclusion: </strong>The RXFP2 T222P variant may be associated with an increased risk of cryptorchidism, but current evidence remains hypothesis-generating. Further studies in larger, ethnically diverse samples, with full genotyping and functional analysis, are needed to confirm and elucidate the mechanisms underlying the observed effect.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":"2221-2230"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Sorting and Catch Media on Porcine Sperm Motility, Capacitation, and Viability.","authors":"Tyler Weide, Juan Steibel, Karl Kerns","doi":"10.1111/andr.70184","DOIUrl":"10.1111/andr.70184","url":null,"abstract":"<p><strong>Background: </strong>Fluorescence-activated cell sorting (FACS) has emerged as a powerful tool for selecting spermatozoa of a desired population of fluorescent biomarkers, offering potential applications in reproductive biology and agriculture. However, concerns remain regarding sorting-induced physiological alterations that could compromise spermatozoa and/or their ability to capacitate.</p><p><strong>Objectives: </strong>Our objective was to determine whether catch media composition influences sperm recovery rate and physiological responses post-sort, before and after in vitro capacitation (IVC).</p><p><strong>Materials and methods: </strong>Five million spermatozoa per treatment were sorted and assessed immediately (0 h) and after 4 h of in vitro capacitation (4 h) using computer-aided sperm analysis (CASA) and Image-Based Flow Cytometry (IBFC). Treatments included six FACS-sorted groups across three media types with BSA or PVA supplementation, and one unsorted control. Functional parameters, including motility, zinc efflux, oxidative stress, membrane remodeling, and mitochondrial activity, were quantitatively assessed.</p><p><strong>Results: </strong>We found that catch media without PVA or BSA had a near 10%-24% sperm recovery compared to 88%-92% with supplementation (p < 0.05). Immediately post-sort, spermatozoa exhibited minimal alterations relative to controls; however, after 4 h IVC, sorted groups demonstrated significant shifts in zinc efflux (p < 0.05), increased plasma membrane remodeling (p < 0.05), and reduced mitochondrial activity (p < 0.05). While LTX-based media preserved motility, differential responses in membrane integrity and zinc signature distribution were observed between treatments, suggesting that catch media can modulate capacitation outcomes. Notably, mitochondrial and membrane changes became more evident after capacitation incubation, indicating a delayed effect of sorting stress.</p><p><strong>Conclusion: </strong>These findings highlight the importance of optimizing catch media and incubation conditions to maintain post-sorting sperm functionality and inform the refinement of FACS protocols for agricultural and assisted reproductive technologies. By minimizing sorting-associated stress through media composition, sperm quality and fertilization potential may be better preserved.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":"2207-2220"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146058612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CRISPR/Cas9-mediated Genome-editing Reveals 10 Testis-enriched Genes and One Non-testis-enriched Gene are Dispensable for Male Fecundity in Mice.","authors":"Yumiao Qiu, Keisuke Shimada, Masahito Ikawa","doi":"10.1111/andr.70144","DOIUrl":"10.1111/andr.70144","url":null,"abstract":"<p><strong>Background: </strong>More than 1000 genes have been identified as predominantly expressed in the human testis. Advances in gene editing technologies have enabled the rapid and efficient generation of genetically engineered mice. This approach facilitates the screening of genes essential for spermatogenesis by analyzing knockout mouse models.</p><p><strong>Objectives: </strong>This study aimed to elucidate the essential genes in male reproductive function by generating knockout mouse models.</p><p><strong>Materials and methods: </strong>We selected 11 target genes that may have potential roles in the male reproductive system based on a public database. Knockout mouse lines of these target genes were generated using the CRISPR/Cas9 system to elucidate their functions in male reproduction. Also, we conducted natural mating tests to elucidate fecundity and analyzed the phenotype of the knockout males.</p><p><strong>Results: </strong>Natural mating tests revealed that all 11 gene-deficient mouse lines maintained normal male fertility. The phenotypic analysis, including testis appearance and weight, histology of testis and epididymis, and sperm motility and morphology, showed no apparent abnormalities.</p><p><strong>Discussion and conclusion: </strong>These results suggest that each gene is not essential for male reproductive function.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":"2150-2159"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12961275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Sperm Retrieval Yield and Freezing on ICSI Outcomes in Non-Obstructive Azoospermia: A Retrospective Study of 1394 Micro-TESE Cycles.","authors":"Li Lei, Ming Li, Qingqing Tao, Jin Huang, Qin Li, Ying Lian, Xiulian Ren, Kai Hong, Ping Liu, Jie Qiao, Rong Li","doi":"10.1111/andr.70180","DOIUrl":"10.1111/andr.70180","url":null,"abstract":"<p><strong>Background: </strong>Microdissection testicular sperm extraction is the preferred method for sperm retrieval in men with non-obstructive azoospermia. However, the effects of sperm retrieval quantity and freezing on intracytoplasmic sperm injection outcomes remain incompletely understood.</p><p><strong>Objectives: </strong>To evaluate the impact of sperm quantity and freezing status on fertilization and cumulative live birth rate following intracytoplasmic sperm injection using microdissection testicular sperm extraction spermatozoa in non-obstructive azoospermia patients.</p><p><strong>Materials and methods: </strong>We retrospectively analyzed 1394 microdissection testicular sperm extraction-intracytoplasmic sperm injection cycles performed between 2017 and 2022 at a single tertiary center. Sperm retrieval yield was stratified into three groups: sufficient sperm count (> 10 spermatozoa/100 fields), low sperm count (6-10/100), and extremely low sperm count (1-5/100). Fertilization rate (two pronuclei) and cumulative live birth rate were compared across sperm retrieval yield and freezing subgroups. Multivariable regression and interaction models assessed the independent and combined effects of sperm quantity and freezing status.</p><p><strong>Results: </strong>Fertilization and cumulative live birth rate declined significantly with reduced sperm counts (two pronuclei: 53.6%→32.2%; cumulative live birth rate: 49.8%→21.8%; p < 0.001). Frozen spermatozoa yielded comparable outcomes to fresh spermatozoa overall, but in the extremely low sperm count group, frozen spermatozoa were associated with a significantly lower cumulative live birth rate than fresh spermatozoa (12.3% vs. 29.3%; p = 0.015). Interaction analysis confirmed this adverse effect (OR = 0.39; 95% CI 0.16-0.95; p = 0.038). No significant freezing effect was observed in the other groups.</p><p><strong>Conclusion: </strong>Sperm retrieval quantity is an important predictor of intracytoplasmic sperm injection success in men with non-obstructive azoospermia. Freezing generally does not affect outcomes, but may significantly reduce live birth rates when sperm availability is extremely limited. Prioritizing the use of fresh spermatozoa in such cases may improve clinical outcomes.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":"e70180"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146016967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Pre-treatment Testosterone Levels on Severity of Adverse Effects in Men on Androgen Deprivation Therapy for Prostate Cancer.","authors":"Milena Braga, Thomas G Travison, Mary-Ellen Taplin, Daniel Habtemariam, Alyssa B Dufour, Marie McDonnell, Donald C Simonson, Alexander P Lin, Elizabeth Borwick, Leila Chammas, Hussein Kafel, Praful Ravi, Adam S Kibel, Paul L Nguyen, Thomas Storer, Shehzad Basaria","doi":"10.1111/andr.70194","DOIUrl":"10.1111/andr.70194","url":null,"abstract":"<p><strong>Background: </strong>Men undergoing androgen deprivation therapy (ADT) for prostate cancer experience various adverse effects. Those with higher pre-treatment testosterone levels often express concerns about experiencing increased severity of these side effects, but this association has not been studied previously.</p><p><strong>Objectives: </strong>The aim of this study was to assess the association of pre-treatment testosterone levels with changes in body composition, physical function, sexual function, and energy in men undergoing 24 weeks of ADT.</p><p><strong>Materials and methods: </strong>Thirty-nine men were assessed at baseline and after 24 weeks of ADT. Body composition was assessed using dual-energy x-ray absorptiometry. Energy and vitality were evaluated using the Hypogonadism Energy Diary, and sexual function was assessed using the Sexual Arousal, Interest, and Drive scale. Physical function was assessed using the PF-10 subscale of the Short Form-36 Health Survey. Total and free testosterone levels were measured using liquid chromatography-tandem mass spectrometry and equilibrium dialysis, respectively. The association between pre-treatment testosterone levels and variables of interest was tested using linear regression analysis.</p><p><strong>Results and discussion: </strong>At 24 weeks, the mean serum total testosterone level declined from 471 ± 157 to 7.7 ± 4.5 ng/dL, total fat mass increased by 3.7 kg (p < 0.0001), and total lean mass decreased by 2.2 kg (p < 0.0001). Participants experienced a decline in physical function, overall energy, and sexual desire. Pre-treatment testosterone levels were not associated with the magnitude of worsening in any of these outcomes.</p><p><strong>Conclusion: </strong>Severity of adverse effects of ADT is not influenced by pre-treatment testosterone levels. This finding allows clinicians and patients to make informed decisions regarding treatment.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":"2244-2251"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146257206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seminal Plasma Exosomal miRNA Profiling Reveals hsa-miR-7-5p as a Key Regulator of Sperm Motility in Asthenozoospermia.","authors":"Zhi-Jian Zhu, Meng-Li Cui, Wen-Jing Yuan, Jia-Ning Zhang, Shuo Zhang, Xi-Qiao Yao, Ruo-Qing Li, Jin-Feng Li, En-Zhong Li","doi":"10.1111/andr.70159","DOIUrl":"10.1111/andr.70159","url":null,"abstract":"<p><strong>Background: </strong>Asthenozoospermia is a significant contributing factor to male infertility. Accumulating evidence indicates that impaired sperm motility is closely linked to dysregulated microRNA expression during spermatogenesis. Seminal plasma exosomes are enriched with diverse microRNAs, which play pivotal roles in modulating sperm motility, the acrosome reaction, capacitation, and fertilization.</p><p><strong>Objective: </strong>To investigate the association between exosomal microRNA profiles and sperm motility by comparing microRNA expression patterns in seminal plasma exosomes from asthenozoospermic patients and healthy controls, thereby elucidating the molecular mechanisms underlying exosomal microRNA-mediated regulation of sperm motility.</p><p><strong>Materials and methods: </strong>Seminal plasma exosomes were isolated from 21 asthenozoospermic patients and 21 age-matched healthy donors via ultracentrifugation, followed by characterization via transmission electron microscopy, nanoparticle tracking analysis, and Western blotting. Exosomal microRNA profiles were analyzed via unique molecular identifier-based small RNA sequencing to identify motility-associated microRNAs.</p><p><strong>Results: </strong>Comparative analysis revealed 13 significantly upregulated microRNAs in the exosomes of asthenozoospermic patients, among which hsa-miR-7-5p exhibited the greatest abundance. Functional enrichment analysis revealed that the target genes of hsa-miR-7-5p were associated primarily with cellular metabolism, macromolecule metabolic processes, and nitrogen compound metabolism, as well as several crucial signaling pathways, including mTOR signaling, endocrine resistance, and gonadotropin-releasing hormone secretion. A dual-luciferase reporter assay verified that hsa-miR-7-5p directly targets rapidly accelerated fibrosarcoma 1, a pivotal component of the gonadotropin-releasing hormone signaling pathway.</p><p><strong>Discussion and conclusion: </strong>hsa-miR-7-5p may regulate sperm motility through the rapidly accelerated fibrosarcoma 1 -mediated gonadotropin-releasing hormone secretion and MAPK signaling networks. Our findings highlight the potential role of exosomal microRNAs in male infertility. Future prospective studies are warranted to elucidate the molecular mechanisms underlying the regulation of sperm motility.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":"2166-2179"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145817488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SIEDY Diagnostic Accuracy in Assessing Erectile Dysfunction in Young Men Living With HIV.","authors":"Giorgio Tiecco, Federico Cesanelli, Cosimo Colangelo, Marco Di Gregorio, Andrea Delbarba, Paolo Facondo, Matteo Riva, Carlo Cappelli, Emanuele Focà, Francesco Castelli, Eugenia Quiros-Roldan","doi":"10.1111/andr.70215","DOIUrl":"10.1111/andr.70215","url":null,"abstract":"<p><strong>Background: </strong>Erectile dysfunction (ED) is a multidimensional condition commonly affecting men living with HIV. The structured interview of erectile dysfunction (SIEDY) is the only validated tool assessing organic, relational, and psychological factors contributing to ED, while dynamic penile color Doppler ultrasound (dPCDU) is a reliable method for evaluating vascular causes of ED.</p><p><strong>Objectives: </strong>This monocentric cross-sectional study aims to assess the reliability of the SIEDY questionnaire in determining the underlying causes of ED in young men living with HIV.</p><p><strong>Materials and methods: </strong>Young men (<50 years) living with HIV, on antiretroviral therapy for at least the last 12 months, and reporting symptoms of ED were enrolled. The degree of sexual dysfunction was assessed with the International Index of Erectile Function-5 (IIEF-5), while SIEDY was used to explore the pathogenetic components of ED. dPCDU was performed to assess vascular damage in the penile district. Univariate binomial logistic regression models were used to evaluate the association between ultrasound parameters and SIEDY results.</p><p><strong>Results: </strong>A total of 50 young men living with HIV were enrolled, of whom 40 (80%) had at least one altered SIEDY scale, most frequently Scale 3 (70%). Forty-five (90%) participants presented with at least one abnormal ultrasound parameter, with intima-media thickness being the most common (76%). No correlation was found between ultrasound parameters and the SIEDY Scale 1, while logistic regression identified IMT as the only variable significantly associated with SIEDY Scales 2 (relational) and 3 (psychological).</p><p><strong>Discussion and conclusions: </strong>SIEDY may have limited reliability in detecting vascular causes of ED in this population, particularly underestimating organic causes. The lack of correlation with objective vascular findings highlights the importance of including tools like dPCDU for vascular assessment in routine clinical evaluations of the ED.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":"2290-2296"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147388764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Clinical Practices for Premature Ejaculation: A National Survey of Chinese Physicians.","authors":"Jun Zhu, Gang Ma, Tianbiao Zhang, Xianming Tan, Changwei Yuan, Yuan Tang, Wanshou Cui, Weidong Song, Yiming Yuan, Yifeng Yuan, Zhichao Zhang, Hui Jiang, Jing Peng","doi":"10.1111/andr.70224","DOIUrl":"10.1111/andr.70224","url":null,"abstract":"<p><strong>Background: </strong>Premature ejaculation is a prevalent male sexual dysfunction, yet real-world clinical practices in China remain poorly characterized.</p><p><strong>Objectives: </strong>To evaluate current premature ejaculation management practices among Chinese physicians.</p><p><strong>Materials and methods: </strong>A nationwide cross-sectional survey of 1000 physicians was conducted using a structured, self-administered questionnaire exploring diagnostic practices, treatment modalities, and perceived therapeutic effectiveness. Associations between physician characteristics and treatment choices were analyzed using chi-square tests.</p><p><strong>Results: </strong>Diagnostic reliance on clinical history (67.4%) exceeded that on standardized tools (32.6%). Around 46.5% of physicians reported treating intravaginal ejaculation latency time < 1 min without distress, while 32.6% reported treating intravaginal ejaculation latency time > 10 min with distress. Oral dapoxetine (59.7%) and psychotherapy (92.1%) were preferred first-line therapies, followed by long-acting selective serotonin reuptake inhibitors (13.7%). Prescriptions for long-acting selective serotonin reuptake inhibitors were primarily driven by guideline adherence (25.95%), anxiety/depression comorbidity (17.56%), dapoxetine inefficacy (6.11%), and clinician experience (6.11%). Combination therapy was common (52.1%), whereas surgical interventions remained rare (14.7%) but more prevalent among andrologists than among non-andrologists (p < 0.001). Compared with non-andrologists, andrologists demonstrated greater use of behavioral therapy (p = 0.001) and topical agents (p = 0.006) than non-andrologists. Drug selection (54.5%) and psychological factors (16.6%) were identified as key efficacy determinants.</p><p><strong>Discussion and conclusion: </strong>Chinese physicians commonly use combined pharmacological and psychological approaches for premature ejaculation treatment, but significant challenges persist, including inappropriate treatment of non-premature ejaculation cases, unwarranted surgical interventions, and insufficient utilization of evidence-based selective serotonin reuptake inhibitors, highlighting the need for standardized diagnostic criteria and enhanced physician education on guideline-recommended therapies.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":"2320-2328"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}