Annales de biologie clinique最新文献_第8页

Chylopericardium or contamination by injectable lipid emulsion? 乳糜心包或注射性脂质乳污染?

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-09-01 DOI: 10.1684/abc.2022.1753

Bertrand Lefrère, Randa Bittar, Antoine Levasseur, Cécile Lambe, Elie Abi-Nader, Margaux Pontailler, Régis Gaudin, Valérie Fesel-Fouquier, Mehdi Sakka, Dominique Bonnefont-Rousselot

{"title":"Chylopericardium or contamination by injectable lipid emulsion?","authors":"Bertrand Lefrère, Randa Bittar, Antoine Levasseur, Cécile Lambe, Elie Abi-Nader, Margaux Pontailler, Régis Gaudin, Valérie Fesel-Fouquier, Mehdi Sakka, Dominique Bonnefont-Rousselot","doi":"10.1684/abc.2022.1753","DOIUrl":"https://doi.org/10.1684/abc.2022.1753","url":null,"abstract":"Effusions can show some surprises. We document the case of a fourteen-month-old male patient with short-bowel syndrome, hospitalized in a cardiology unit, receiving a chronic parenteral nutrition by a Broviac® catheter. The patient presented several thrombosis following iterative catheter replacements. In parallel with superior vena cava plasty, a right intra-atrial Broviac® catheter was placed in the absence of other peripheral venous accesses. This device has a cutaneous exit site to allow for infusion of a hyperosmolar lipid emulsion. Seven days later, a milky liquid was secreted from pericardial/mediastinal redon. A gel lipoprotein electrophoresis of the fluid suggested a preliminary diagnosis of chylopericardium. However, biochemical testing of certain analytes evoked a parenteral nutrition-related pericardial effusion and a possible pseudochyloperitoneum caused by the shearing of a migrated Broviac® in pericardium. The patient, on a fat-free diet, was admitted to the ICU to drain the effusion and reposition the catheter, with success. In the light of new datas on the interference of parenteral lipid emulsions with the lipoproteins gel electrophoresis, we will try to determine whether the apparent presence of chylomicrons in the gel would be the sign of a lesion of the lymphatic system, or rather the result of a contamination by artificial chylomicron in the lipid emulsion, if not the sign of contaminated blood. In our article, we highlight several considerations in identifying and confirming cases of pericardial effusion, such as chylopericardium and parenteral nutrition-related one, as well as points concerning the use of lipid emulsions for pediatric patients with short-bowel syndrome.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40547126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Genetic of thoracic aorta aneurysm 胸主动脉动脉瘤的遗传

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-07-01 DOI: 10.1684/abc.2022.1742

Margaux Cadenet, Nadine Hanna, Pauline Arnaud

引用次数: 0

Review of nutritional components in Covid-19: what about micronutrients? 2019冠状病毒病营养成分综述:微量营养素情况如何?

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-07-01 DOI: 10.1684/abc.2022.1741

Muriel Bost, Emmanuel Richard, Isabelle Redonnet-Vernhet, François Parant, Lysiane Boulet, Thierry Dupré, Delphine Collin-Chavagnac, Samir Mesli, Marie-Christine Beauvieux

{"title":"Review of nutritional components in Covid-19: what about micronutrients?","authors":"Muriel Bost, Emmanuel Richard, Isabelle Redonnet-Vernhet, François Parant, Lysiane Boulet, Thierry Dupré, Delphine Collin-Chavagnac, Samir Mesli, Marie-Christine Beauvieux","doi":"10.1684/abc.2022.1741","DOIUrl":"https://doi.org/10.1684/abc.2022.1741","url":null,"abstract":"Nutritional status is an important protection factor against viral infections. Both undernutrition and malnutrition cause deficits in micronutrients, trace elements and vitamins necessary for various physiological functions and the appropriate functioning of the immune system. These deficiencies and infectious diseases often coexist, with complex interactions. An assessment of the micro-nutrient nutritional status of Covid-19 patients has not been at the center of priorities and recommendations, due to both the medical emergency and the absence of direct evidence and rapid effects of supplementation. Few recommendations have come from learned societies due to the lack of significant evidence of the effects of supplementation in positive patients and a need for robust studies. Essential trace elements and vitamins are necessary for the differentiation, activation and execution of many functions of immune cells, but their specific role has yet to be defined. This review article discusses in the context of Covid-19 the importance of micronutrients (selenium, copper, zinc, vitamins C, D, A and those of group B) in the host to tend towards an optimization of the immune response to infections. A nutritional balance remains the key word for achieving micronutrient homeostasis. Attention had to be paid to micronutrients in primary prevention, in the general population, in order to reduce the risk of impaired nutritional status in case of major health situations.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33464970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hematological hypereosinophilia 血液学嗜酸性粒细胞增多

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-07-01 DOI: 10.1684/abc.2022.1731

Ines Ghariani, Oumaima Mahmoud, Saloua Hamzaoui, Néjia Braham, Leila Bekir

{"title":"Hematological hypereosinophilia","authors":"Ines Ghariani, Oumaima Mahmoud, Saloua Hamzaoui, Néjia Braham, Leila Bekir","doi":"10.1684/abc.2022.1731","DOIUrl":"https://doi.org/10.1684/abc.2022.1731","url":null,"abstract":"Introduction: Hematological disorders are the third cause of hypereosinophilia, after allergic and parasitic disease. The objective of our study is to show the epidemiological, clinical, biological and therapeutic characteristics of hematological hypereosinophilia.Patients and methods: This is a retrospective study over a 4-year period (March 2017-March 2021) concerning 14 patients with hematological hypereosinophilia.Results: Fourteen patients were included (9 women and 5 men). The median age at diagnosis was 55 years. Hematological hypereosinophilia was mainly of clonal etiology. Clinical manifestations were either specific to hypereosinophilia, such as organ damage, or related to the etiology of hypereosinophilia, such as hepato-splenomegaly and lymphadenopathy. Moderate and severe forms were the most commonly reported. Several other quantitative and qualitative abnormalities of the blood picture were reported. Identification of the FIP1L1-PDGFRA fusion gene by molecular biology (RT-PCR) was positive in two patients. Imatinib was the main treatment for clonal forms.Conclusion: Hematological hypereosinophilia is a rare and complex pathology. Our study has confirmed this epidemiological, clinical, biological and therapeutic heterogeneity and has enabled us to realize the contribution of molecular biology in the diagnosis and the treatment of hypereosinophilia.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33465472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two-year clinico-biological feedback in Overseas France and French-speaking territories during Covid-19 pandemic 在2019冠状病毒病大流行期间，在法国海外和法语地区进行为期两年的临床生物学反馈

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-07-01 DOI: 10.1684/abc.2022.1740

Yann Barguil, Stéphane Busca, Pierre-Henri Moury, Morgan Lamorinière, Maxime Raz, Anaelle Chavant, Madeline Duhin, Laura Chiaradia, Emmanuel Couadou, Annie M Bérard, Vincent Sapin, Marie-Christine Beauvieux

{"title":"Two-year clinico-biological feedback in Overseas France and French-speaking territories during Covid-19 pandemic","authors":"Yann Barguil, Stéphane Busca, Pierre-Henri Moury, Morgan Lamorinière, Maxime Raz, Anaelle Chavant, Madeline Duhin, Laura Chiaradia, Emmanuel Couadou, Annie M Bérard, Vincent Sapin, Marie-Christine Beauvieux","doi":"10.1684/abc.2022.1740","DOIUrl":"https://doi.org/10.1684/abc.2022.1740","url":null,"abstract":"The French Society of Clinical Biology (SFBC) set up a working group “Biochemical markers of Covid-19” whose main objective is to review, analyse and monitor biological prescriptions according to the patient’s care path. This study covers all public and private sectors of medical biology in metropolitan France and overseas and extends to the French-speaking world. We present a summary of feedbacks after 2 years of the pandemic. At the early stage of Covid-19, with regard to the regions surveyed, a common symptomatology with local zoonosis (dengue fever, zika, malaria, leptospirosis, etc.) complicates the diagnosis of Covid-19. At a more advanced stage, it is a question of managing an influx of patients suffering from acute respiratory distress syndrome. In this case, the biology is then simpler and delocalized medical biology devices have proven their effectiveness. As a result, ICU clinicians can better manage the frequent comorbidities encountered in these regions: obesity, diabetes, chronic renal failure, cardiovascular diseases.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33465474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of pink urine associated with abdominal pain crisis 尿粉红色伴腹痛危象1例

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-07-01 DOI: 10.1684/abc.2022.1743

Emeline Gernez, Isabelle Kim, Claire Douillard, Dries Dobbelaere, Guillaume Grzych

引用次数: 1

Ferritin as a predictive biomarker of severity in Covid-19 铁蛋白作为Covid-19严重程度的预测性生物标志物

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-07-01 DOI: 10.1684/abc.2022.1725

Jérémy Perottet, Clémentine Gondolf, Frédérique Grandhomme, Christian Creveuil, Stéphane Allouche

{"title":"Ferritin as a predictive biomarker of severity in Covid-19","authors":"Jérémy Perottet, Clémentine Gondolf, Frédérique Grandhomme, Christian Creveuil, Stéphane Allouche","doi":"10.1684/abc.2022.1725","DOIUrl":"https://doi.org/10.1684/abc.2022.1725","url":null,"abstract":"Background: To prevent the crisis-level shortage of beds in hospitals and for a more efficient support, it’s necessary to early identify coronavirus disease-19 (Covid-19) patients at risk to develop a severe form of the disease.Objective: The goal of our study was to determine whether biological markers, including the serum ferritin, could predict the severity of the Covid-19.Methods: One hundred and seventy-one patients, who were admitted to Caen University Hospital, were included retrospectively with a positive diagnosis of Covid-19 by RT-PCR. A serum ferritin measurement was performed for all patients. They were further classified either into a non-severe or a severe group based on their hospitalization in intense care unit (ICU) for mechanical ventilation or death.Results: Univariate analysis revealed a significant association between increased serum ferritin and CRP levels, obesity, CT scan lesions, pathological respiratory rate, decreased PaO2/FiO2 ratio, the NEWS-2 score and the severe (n = 59) vs the non-severe (n = 112) outcome of Covid-19 patients. However, in a multivariate analysis, only CRP and obesity were associated with the severe form of Covid-19.Conclusion: While pathological level of serum ferritin at admission is associated with severe form of Covid-19, combination of increased CRP level and obesity would better predict the severity of the disease.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33465471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Urine toxicological screening method using an immunoenzymatic assay based on a biochip array technology: comparative study with immunochromatography and Liquid chromatography–mass spectrometry 基于生物芯片阵列技术的免疫酶分析尿液毒理学筛选方法:与免疫色谱法和液相色谱-质谱法的比较研究

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-07-01 DOI: 10.1684/abc.2022.1744

David Metsu, Malika Nouhaud, Souleiman El-Balkhi, Michel Lavit, Hélène Paillard, Pierre Berthomès, Chantal Martinez, Nathalie Gicquel-Bordelongue, Benjamin Blonstein, Julien Latier, Sabine Billoré, Claire Chassagne, Thomas Lanot, Frédéric Février

{"title":"Urine toxicological screening method using an immunoenzymatic assay based on a biochip array technology: comparative study with immunochromatography and Liquid chromatography–mass spectrometry","authors":"David Metsu, Malika Nouhaud, Souleiman El-Balkhi, Michel Lavit, Hélène Paillard, Pierre Berthomès, Chantal Martinez, Nathalie Gicquel-Bordelongue, Benjamin Blonstein, Julien Latier, Sabine Billoré, Claire Chassagne, Thomas Lanot, Frédéric Février","doi":"10.1684/abc.2022.1744","DOIUrl":"https://doi.org/10.1684/abc.2022.1744","url":null,"abstract":"Multiparametric toxicology research is mainly based on immunochromatography [IC] and chromatography methods. A new automated method using an immunoenzymatic (IE) assay based on a biochip array technology combines short turning around time and analytical performances close to chromatography in terms of positivity cut-off. The aim of our study was to compare IE versus IC and chromatography methods using urines samples from clinical cases. Seventy-two samples were analyzed by IC (amphetamines, opiates, benzodiazepines, THC, methadone, cocaine), IE and chromatography (previous classes plus opioids and cathinone). Immunochromatography results were read by at least 7 operators to assess reading subjectivity. Immunoenzymatic, IC, and chromatrography results were compared with each other. Chromatographic quantification was analyzed to understand discrepancies. Significant discrepancies (29-64%) were observed between IC and IE for most of the drug families investigated except for benzodiazepines, methadone and opiates. These discrepancies were not identified between IE and chromatography, except for some substances (28% to 67% discrepancies for buprenorphine, tramadol and oxycodone, 100% for cathinone). In contrast to IC, the performance of IE approached those of chromatography, except for some substances for which cross-reactions must be investigated. Reading discrepancies were frequent with IC (33% of samples) and made robust result output challenging. In conclusion, the Multistat® is an interesting method for first-line toxicological screening for laboratories without chromatography method.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33464971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiphospholipid antibodies: what is new in 2022 抗磷脂抗体:2022年的新动向

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-07-01 DOI: 10.1684/abc.2022.1745

Sophie Melicine, Nicolas Gendron, Luc Darnige, Laetitia Mauge

{"title":"Antiphospholipid antibodies: what is new in 2022","authors":"Sophie Melicine, Nicolas Gendron, Luc Darnige, Laetitia Mauge","doi":"10.1684/abc.2022.1745","DOIUrl":"https://doi.org/10.1684/abc.2022.1745","url":null,"abstract":"Antiphospholipid syndrome (APS) is a clinicobiological entity defined by the association of thrombotic events and/or obstetric complications and the presence of persistent antiphospholipid antibodies (aPLs) detected by coagulation tests (lupus anticoagulant, LAC) and/or immunological assays (anticardiolipin and anti-glycoprotein-beta-I antibodies). The increased use of direct oral anticoagulants (DOAC) for the treatment of venous thromboembolism (VTE) is now a challenge for hematology laboratories for the diagnosis of APS. DOAC interfere with LAC screening and confirmation tests resulting in a risk of false positive results. To avoid these interferences, several solutions are suggested. Some of them rely on the use of DOAC-reversal systems (activated charcoal tablet, filter system) others on the use of reagents insensitive to DOAC presence in the sample. Detection of anti-phosphatidylserine/prothrombin antibodies may be helpful because they are strongly associated to the presence of LAC and are increasingly recognized as a useful tool in the diagnosis and prognosis of APS. Finally, positivity of LA in the setting of a viral infection is frequent and not specific to APS. During the Covid-19 pandemic, many patients developed arterial and VTE that could suggest testing for aPLs. The association between LAC and a risk of VTE or in-hospital mortality in hospitalized Covid-19 patients was not demonstrated. Moreover, aPLs do not persist after Covid-19. Currently, testing for aPLs in Covid-19 patients is not recommended.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33464972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A word from the editor in chief 总编辑的一句话

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-07-01 DOI: 10.1684/abc.2022.1750

Laurence Pieroni

引用次数: 0