Annales de biologie clinique最新文献_第8页

Acromegaly: an endocrine pathology with serious consequences 肢端肥大症:一种后果严重的内分泌病理

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-06-30 DOI: 10.1684/abc.2022.1735

Afef Horchani, Ines Bayar, Bilel Ben Amor, Ilhem Hellara, Mabrouk Abdelali, Fadoua Neffati, Ines Khochtali, Mohamed Fadhel Najjar

引用次数: 0

Usual transaminase values: should they be reviewed and adjusted? 通常的转氨酶值:是否需要重新检查和调整?

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-06-30 DOI: 10.1684/abc.2022.1734

Alexandre Raynor, Anna Soavelomandroso, Tiphaine Robert-Mercier, Dominique Valla, Katell Peoc'h, Célia Raulet-Bussian

{"title":"Usual transaminase values: should they be reviewed and adjusted?","authors":"Alexandre Raynor, Anna Soavelomandroso, Tiphaine Robert-Mercier, Dominique Valla, Katell Peoc'h, Célia Raulet-Bussian","doi":"10.1684/abc.2022.1734","DOIUrl":"https://doi.org/10.1684/abc.2022.1734","url":null,"abstract":"Alanine (ALT) and aspartate aminotransferases (AST) are intracellular enzymes involved in the metabolism of amino acids. The measurements of their activities are two of the most ordered tests in clinical laboratories, used to screen, diagnose and follow diseases affecting the liver. Recent works highlighted that reference values for ALT and AST vary according to the analytical method and the individual’s characteristics, like with many other biomarkers. Reference values for ALT show clinically significant differences according to the analytical method (higher when supplementing samples with phosphate pyridoxal), gender (higher in males than in females), body mass index (positive correlation), and age (higher in infants and the elderly), but not according to ethnicity or employed analyzer. According to the analytical method and age, reported reference values for AST show clinically significant differences, similar to ALT. These observations prove clinical laboratories’ interest in updating their reference values according to sex, body mass index, age (especially when providing testing to pediatric or elderly populations), and the analytical method employed. If possible, a standardized method should be used, including sample supplementation with pyridoxal phosphate, to ensure the comparability of results between laboratories.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":"80 3","pages":"213-222"},"PeriodicalIF":0.5,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40478060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Monitoring of glycemic balance by glycated hemoglobin assay on D-10® (Biorad) and Minicap Flex Piercing® (Sebia) biochemical systems at the Rodolph-Mérieux Laboratory in Bamako 在巴马科rodolpher - m<s:1> rieux实验室，通过糖化血红蛋白检测D-10®(Biorad)和Minicap Flex穿刺®(Sebia)生化系统监测血糖平衡

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-06-30 DOI: 10.1684/abc.2022.1738

Aboubacar Dit Tietie Bissan, Casimir Kletigui Dembélé, Djibril Coulibaly, Yaya Goïta, Djambatolom Saidou Tolo, Boubacar Mohammed, Asmaou Soumaré, Madiné Tall, Lassana Gadi Timbiné, Bakary Cissé, Bourèma Kouriba

{"title":"Monitoring of glycemic balance by glycated hemoglobin assay on D-10® (Biorad) and Minicap Flex Piercing® (Sebia) biochemical systems at the Rodolph-Mérieux Laboratory in Bamako","authors":"Aboubacar Dit Tietie Bissan, Casimir Kletigui Dembélé, Djibril Coulibaly, Yaya Goïta, Djambatolom Saidou Tolo, Boubacar Mohammed, Asmaou Soumaré, Madiné Tall, Lassana Gadi Timbiné, Bakary Cissé, Bourèma Kouriba","doi":"10.1684/abc.2022.1738","DOIUrl":"https://doi.org/10.1684/abc.2022.1738","url":null,"abstract":"This study aims to determine the concordance of results between D-10® and Minicap Flex Piercing® and the impact of the presence of hemoglobin variants in the glycated hemoglobin assay. All the samples were assayed in parallel. The agreement between these methods was assessed using the Bland and Altman plot. We collected a total of 166 samples. In the entire study population and in patients with a hemoglobin variant, the Bland and Altman graph showed good agreement between the values (for respective biases of 0.21% and 0.29%) as well as a significant correlation (p < 0.001). Our results differ from those found by Kesso Barry et al. This difference can be explained by the high prevalence of patients with abnormal hemoglobins S and C (39.2 %) in our study population. Despite a good agreement between the methods, the results do not allow us to confirm a transferability between the two systems in diabetics and carriers of hemoglobin variants.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":"80 3","pages":"245-251"},"PeriodicalIF":0.5,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40488760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological markers and metabolic impact of chronic nitrous oxide consumption 慢性氧化亚氮消耗的生物学标记和代谢影响

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-06-30 DOI: 10.1684/abc.2022.1729

Guillaume Grzych, Sylvie Deheul, Jean-Baptiste Davion, Fanny Lemonnier, Dries Dobbelaere, Louise Carton, Isabelle Kim, Jean Claude Guichard, Marie Girot, Linda Humbert, Audrey Joly, Claire Douillard, Céline Tard

引用次数: 1

Triad of diabetic ketoacidosis-acute pancreatitis-hypertriglyceridaemia: interest of genetic exploration 糖尿病酮症酸中毒-急性胰腺炎-高甘油三酯血症三联症:基因探索的兴趣

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-06-30 DOI: 10.1684/abc.2022.1737

Hugo Alarcan, Antoine Guillon, François Maillot, Delphine Collin-Chavagnac, Andres Christian, Hélène Blasco, Eric Piver

{"title":"Triad of diabetic ketoacidosis-acute pancreatitis-hypertriglyceridaemia: interest of genetic exploration","authors":"Hugo Alarcan, Antoine Guillon, François Maillot, Delphine Collin-Chavagnac, Andres Christian, Hélène Blasco, Eric Piver","doi":"10.1684/abc.2022.1737","DOIUrl":"https://doi.org/10.1684/abc.2022.1737","url":null,"abstract":"A 16-year-old child with no medical history was admitted to the hospital emergency for abdominal pain associated with polyuria-polydipsia and weight loss (baseline BMI: 25,4 kg/m2). Diagnosis of severe ketoacidosis was quickly raised regarding major metabolic acidosis, high ketonemia and glycemia. Acute pancreatitis was then diagnosed according to a plasmatic lipase more than tenfold normal values associated with a severe hypertriglyceridemia superior to 100 mmol/L. The triad composed of diabetic ketoacidosis-acute pancreatitis-hypertriglyceridemia is rarely found in childhood and can have deleterious consequences. The etiology of this disease is still enigmatic, as one can be both, cause and consequence of the other. Genetic investigation of familial chylomicronemia legitimated to invalidate the dyslipidemia etiology of this event. On the other hand, the association of a genetic variant of lipoprotein lipase leading to a decrease in its activity, with the insulinopenia of type 1 diabetes most certainly triggered this episode of hypertriglyceridemia.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":"80 3","pages":"259-267"},"PeriodicalIF":0.5,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40488759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reports of Euromedlab 2021, in 2022 2022年Euromedlab 2021报告

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-06-30 DOI: 10.1684/abc.2022.1728

Bruno Baudin, Amandine Boeuf, Vincent Delatour, Aurore Desmons, Bernard Gouget, Damien Gruson, Katell Peoc'h, Vincent Sapin, Anne Vassault, Michel Vaubourdolle

引用次数: 0

Hemolysis interference on clinical chemistry tests analyzed on DxC 700 AU (Beckman Coulter®) and kaliemia rendering algorithm 采用DxC 700 AU (Beckman Coulter®)和血钾绘制算法分析溶血对临床化学试验的干扰

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-06-30 DOI: 10.1684/abc.2022.1726

Emeline Sanandedji, Julien André, Alexi Lienard, Caroline Hentgen, Alain Barrans

{"title":"Hemolysis interference on clinical chemistry tests analyzed on DxC 700 AU (Beckman Coulter®) and kaliemia rendering algorithm","authors":"Emeline Sanandedji, Julien André, Alexi Lienard, Caroline Hentgen, Alain Barrans","doi":"10.1684/abc.2022.1726","DOIUrl":"https://doi.org/10.1684/abc.2022.1726","url":null,"abstract":"The influence of hemolysis was evaluated for 26 clinical chemistry parameters on DxC 700AU (Beckman Coulter®). Ten sample pools were prepared and separated into six aliquots. These aliquots were overloaded with hemolysis in increasing amounts to reach levels equivalent to the maximum hemolysis thresholds H1 (+), H2 (++), H3 (+++) and H4 (++++). Each aliquot is compared to its reference aliquot (not hemolyzed) and a ratio is calculated for each parameter. We proposed that there was a significant difference if, for a given analyte and threshold, more than 20% of the ratios are above the total acceptable limit variability. A significant difference was found for TGP, TGO, cholesterol, creatine kinase (CPK), lactate deshydrogenase (LDH), phosphorus and potassium at H1 (+), chlorine, iron, γ-glutamyltransferase (GGT), and magnesium at H2 (++), amylase and alkaline phosphatase (PAL) at H3 (++++), and prealbumin at H4 (++++). No interference was found until H4 included for uric acid, calcium, creatinine, lipase, glucose, HDL-cholesterol, triglycerides, urea, sodium and immunoglobulins A, G and M. The overestimation of kalemia was calculated as a function of hemolysis, ranging from 0.28 mM +/–0.047 (upper H1 threshold) to 1.37 mM +/–0.126 (upper H4 threshold). Its estimation makes it possible to propose a result rendering algorithm of kalemia according to the hemolysis index. Evaluation of the automates hemolysis indexes is highly recommended for each laboratory. It can allow for some critical parameters the establishment of a decision tree facilitating the result rendering, after clinicobiological consultation.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":"80 3","pages":"225-232"},"PeriodicalIF":0.5,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40478054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Reports of the Juniors’ Euromedlab 大三学生的Euromedlab报告

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-06-30 DOI: 10.1684/abc.2022.1730

Fanny Lemonnier, Manon Deschildt, Aleksei Tikhonov, Guillaume Grzych

引用次数: 0

Clinicopathological and prognostic significance of DNA mismatch-repair protein expression in gastric adenocarcinoma 胃腺癌DNA错配修复蛋白表达的临床病理及预后意义

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-06-30 DOI: 10.1684/abc.2022.1733

Nabiha Missaoui, Nozha Mhamdi, Hanene Saad, Ahlem Bdioui, Nihed Abdessayed, Atef Ben Abdelkader, Thouraya Zahmoul, Hajer Hamchi, Sihem Hmissa, Moncef Mokni

{"title":"Clinicopathological and prognostic significance of DNA mismatch-repair protein expression in gastric adenocarcinoma","authors":"Nabiha Missaoui, Nozha Mhamdi, Hanene Saad, Ahlem Bdioui, Nihed Abdessayed, Atef Ben Abdelkader, Thouraya Zahmoul, Hajer Hamchi, Sihem Hmissa, Moncef Mokni","doi":"10.1684/abc.2022.1733","DOIUrl":"https://doi.org/10.1684/abc.2022.1733","url":null,"abstract":"Although the significance of DNA mismatch repair (MMR) protein expression in colorectal cancer is well-established, it remains contentious in extra-colorectal cancers and mainly in gastric adenocarcinoma. Data from Africa and Arab world remain limited. This study explored the MMR expression in gastric adenocarcinoma and evaluated its clinicopathological and prognostic signification among Tunisian patients. A retrospective study of 72 gastric adenocarcinomas was carried out. Clinicopathological particularities and patient outcomes were recorded. MMR expression was determined by immunohistochemistry on whole sections of archived material. Survival analysis was realized utilizing the Kaplan-Meier estimates and Log-Rank test. Expression of MMR proteins was observed in 84.7% of gastric adenocarcinoma samples. The 11 remaining samples (15.3%) exhibited an altered pattern of MMR protein. A significant association was identified between deficient MMR expression and advanced age (p = 0.03), intestinal type (p = 0.04) and lymph node metastases (p = 0.04). No other significant relationship was observed with the remaining selected tumor features. Patient survival was significantly associated with lymph node invasion (p = 0.002), distant metastases (p = 0.02) and tumor differentiation (p = 0.03), but not with MMR status (p = 0.83). MMR deficiency was related to advanced-age, intestinal type and nodal metastasis, but not to survival of Tunisian patients with gastric adenocarcinoma. Larger multicenter studies with additional molecular investigation are required to more explore these tumors.","PeriodicalId":7892,"journal":{"name":"Annales de biologie clinique","volume":"80 3","pages":"233-243"},"PeriodicalIF":0.5,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40478059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hairy lymphoproliferations: a case report and review of the literature 毛状淋巴细胞增生:1例报告及文献复习

IF 0.5 4区医学

Annales de biologie clinique Pub Date : 2022-06-30 DOI: 10.1684/abc.2022.1732

Mélissa Julien, Véronique Latger-Cannard, Sylvain Salignac, Christopher Aubert, Delphine Gérard, Julien Broseus, Jean-François Lesesve

引用次数: 0