Revista argentina de endocrinologia y metabolismo最新文献

{"title":"Impacto del compromiso ganglionar en el pronóstico y la evolución del carcinoma papilar de tiroides","authors":"Mariela Margarita Mac Dermott,&nbsp;Alicia Gauna,&nbsp;Judith E.W. de Yampey","doi":"10.1016/j.raem.2016.11.006","DOIUrl":"10.1016/j.raem.2016.11.006","url":null,"abstract":"<div><p>Cervical lymph node metastases are usually present in a high number of cases with papillary thyroid carcinoma. However, many studies have shown that not all lymph node metastases have the same impact on the outcome of this disease. Argentina, Chile, and Brazil have recently changed their differentiated thyroid carcinoma (DTC) guidelines and recommend a different ranking of risk and therapeutic approach according to the number, size, and extension of lymph node metastasis. An analysis of lymph node metastases is presented in this article, which includes their characteristics and impact on DTC. As this analysis was made before the latest publication of the new American Thyroid Association guidelines, some aspects of these guidelines have also been included.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"54 2","pages":"Pages 51-63"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2016.11.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49599094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Niveles de tirotrofina y anticuerpos antitiroperoxidasa en el primer trimestre de gestación asociados a complicaciones del embarazo en la mujer eutiroidea","authors":"Claudia M. Melillo ,&nbsp;Paola C. Prener ,&nbsp;María Olga Suescun","doi":"10.1016/j.raem.2017.01.005","DOIUrl":"10.1016/j.raem.2017.01.005","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;p&gt;Pregnancy is a physiological state presenting with endocrine and immunological changes. The thyroid gland modifies its output in order to provide enough hormones to the mother and foetus. Thyroid autoimmunity and thyroid dysfunction are prevalent in women of childbearing age and may affect the course of gestation and having maternal and foetal clinical consequences. The purpose of the present study was to establish the relationship between euthyroid pregnant women with thyrotropin (TSH) at two levels of the reference range (&lt; 1.2 and between 1.2 and 2.5 mIU/L), and positive or negative anti-thyroid peroxidase autoantibodies (TPO Ab) with the frequency of pregnancy complications and the development of thyroid dysfunction.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;A retrospective study of euthyroid women in their first trimester of pregnancy was performed. TSH, free thyroxine (FT4), total thyroxine (T4), and TPOAb values were analysed. A total of 580 women had positive TPOAb (EP group), and 533 women had negative TPOAb (EN group). The EP and EN groups were subdivided according to TSH levels into EP1: positive TPOAb and TSH&lt;!--&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;1.2, and EP2: positive TPOAb and TSH between 1.2 and 2.5 mIU/L. Maternal and foetal complications, such as miscarriage, intrauterine death, preterm delivery, and thyroid dysfunction during pregnancy and postpartum were taken into account.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;TSH values were higher in EP group vs EN group (&lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mover&gt;&lt;mtext&gt;X&lt;/mtext&gt;&lt;mo&gt;¯&lt;/mo&gt;&lt;/mover&gt;&lt;mo&gt;±&lt;/mo&gt;&lt;mtext&gt;SD&lt;/mtext&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;; 1.57&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;0.82 vs 1.16&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;0.54 mIU/L, &lt;em&gt;P&lt;/em&gt;=.01). FT4 and T4 values were similar in both groups. Out of the pregnant women in the EP group, 63% were included in EP1, and 37% in EP2. In the EN group, 80% of women were included in EN1 and 20% in EN2. A significant (&lt;em&gt;P&lt;/em&gt;=.001) increase in pregnancy complications in EP group (22%) vs EN (10%) was observed. In the EP group, TSH levels were: 1.65&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;0.67 vs 0.99± 0.77 (&lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mover&gt;&lt;mtext&gt;X&lt;/mtext&gt;&lt;mo&gt;¯&lt;/mo&gt;&lt;/mover&gt;&lt;mo&gt;±&lt;/mo&gt;&lt;mtext&gt;SD&lt;/mtext&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;) mIU/L (&lt;em&gt;P&lt;/em&gt;=.014) respectively, in women with and without miscarriage. TSH levels were 1.63&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;0.70 vs 1.15&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;0.53 (&lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mover&gt;&lt;mtext&gt;X&lt;/mtext&gt;&lt;mo&gt;¯&lt;/mo&gt;&lt;/mover&gt;&lt;mo&gt;±&lt;/mo&gt;&lt;mtext&gt;SD&lt;/mtext&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;) mIU/L (&lt;em&gt;P&lt;/em&gt;=.012), respectively, in women with and without preterm delivery. In the EN group TSH levels were: 1.45&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;0.61 vs 0.85± 0.66 (&lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mover&gt;&lt;mtext&gt;X&lt;/mtext&gt;&lt;mo&gt;¯&lt;/mo&gt;&lt;/mover&gt;&lt;mo&gt;±&lt;/mo&gt;&lt;mtext&gt;SD&lt;/mtext&gt;&lt;/mrow&gt;&lt;/math&gt;&lt;/span&gt;) mIU/L (&lt;em&gt;P&lt;/em&gt;=.001), respectively, in women with and without miscarriage. TSH levels were 1.59&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;0.71 vs 0.83&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;0.64 (&lt;span&gt;&lt;math&gt;&lt;mrow&gt;&lt;mover&gt;&lt;mtext&gt;X&lt;/mtext&gt;&lt;mo&gt;¯&lt;/mo&gt;&lt;/mover&gt;&lt;mo&gt;±&lt;/mo&gt;&lt;mtext&gt;SD&lt;/mtext&gt;&lt;/","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"54 1","pages":"Pages 1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2017.01.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54996592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnóstico de esteatosis hepática por métodos clínicos, bioquímicos y por imágenes","authors":"Mabel Graffigna,&nbsp;Natalia Catoira,&nbsp;Jimena Soutelo,&nbsp;Andreína Azpelicueta,&nbsp;Gabriela Berg,&nbsp;Cecilia Perel,&nbsp;Marta Elena Migliano,&nbsp;Marcela Aranguren,&nbsp;Carla Musso,&nbsp;Javier Farias","doi":"10.1016/j.raem.2016.12.001","DOIUrl":"10.1016/j.raem.2016.12.001","url":null,"abstract":"<div><p>Non-alcoholic fatty liver disease (NAFLD) includes a spectrum of liver diseases ranging from steatosis to steatohepatitis, fibrosis and cirrhosis. Its prevalence increases with age and with obesity, and is strongly associated with the presence of metabolic syndrome and increased cardiovascular and malignant diseases. It is caused by an accumulation of triglycerides in liver hepatocytes and muscles, and related to insulin resistance. Its presence is associated with the increase of alanine aminotransferase (alt), although it may not be elevated in advanced disease. There are 5 indexes used for the diagnosis of hepatic steatosis: SteatoTest, fatty liver index, NAFLD liver fat score, lipid accumulation product and hepatic steatosis index, whereas for esteatohepatitis the NASH test, NASH diagnostics, as well as the non-alcoholic steatohepatitis (NASH) score and HAIR (hypertension, ALT, and insulin resistance). In stages of fibrosis AST-ALT index increases as well as ferritin in blood and the NAFLD fibrosis score, which has a high specificity for diagnosis. Abdominal ultrasound is widely available, but its diagnostic sensitivity is lower when there are mild degrees of hepatic fatty infiltration. Computed tomography has a specificity of 100% when fat content is greater than 30%, but the radiation emitted prevents frequent use. Magnetic resonance spectroscopy is the method of choice for the detection and quantification of liver fat content. Liver biopsy is an invasive method that enables appropriate prognostic classification of the disease, but has some complications, and should only be performed in selected individuals: high risk of steatohepatitis or fibrosis risk of laboratory or clinical or other co-existing liver disease. Early identification of NAFLD allows early measures to be implemented in order to reduce morbidity and mortality associated with this condition.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"54 1","pages":"Pages 37-46"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2016.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54996429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes insípida central como manifestación inicial de histiocitosis de células de Langerhans en paciente adulto","authors":"Nerea Egaña Zunzunegui,&nbsp;Izaskun Olaizola Iregui,&nbsp;M. Luisa Antuñano López,&nbsp;Ana M. Chacón Oreja,&nbsp;Ismene Bilbao Garay","doi":"10.1016/j.raem.2017.01.004","DOIUrl":"10.1016/j.raem.2017.01.004","url":null,"abstract":"<div><p>Langerhans cell histiocytosis is considered a paediatric disease, although it may be diagnosed in adults. The histiocyte infiltration in adults is most frequently in bones, lungs and skin, and shows a particular predilection for hypothalamus-pituitary axis. A case is presented of a 51 year-old man who initially only presented with central insipidus diabetes, and over time developed systemic disease with skin, lungs, bones, pituitary, and central nervous system involvement. Chemotherapy and radiotherapy were effective, and there is currently no progression of the disease.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"54 1","pages":"Pages 47-49"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2017.01.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54996500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guía práctica para el manejo de efectos adversos por inhibidores multicinasas (sorafenib y vandetanib) en pacientes con cáncer de tiroides avanzado","authors":"Fabián Pitoia,&nbsp;Angelica Schmidt,&nbsp;Fernanda Bueno,&nbsp;Yamile Mocarbel,&nbsp;Fernando Jerkovich,&nbsp;Erika Abelleira","doi":"10.1016/j.raem.2017.01.002","DOIUrl":"10.1016/j.raem.2017.01.002","url":null,"abstract":"<div><p>The advent of multikinase inhibitors therapy has led to a radical change in the treatment of patients with advanced thyroid carcinoma. The ANMAT (the Argentinian regulatory health agency) has currently approved sorafenib for patients with radioiodine resistant differentiated thyroid carcinoma, and vandetanib for patients with medullary thyroid carcinoma (progressive and/or symptomatic disease). It has been demonstrated by phase <span>iii</span> clinical trials that these drugs improve progression free survival in this group of patients. Although they have a precise indication, an interdisciplinary team in close contact with a committed patient, are required for their effective management.</p><p>The adverse events of these drugs are common, but many of them may ameliorate over time, and most of them are manageable, even without the need for dose reduction or drug withdrawal. Knowledge of the correct management of the adverse events is a fundamental tool for the medical team and for the patient to prevent or minimise them, to avoid serious complications and to obtain better patient compliance. The primary objective of this article is to provide a guideline for the diagnosis and treatment of the adverse events produced by the multikinase inhibitors, and to present the initiative of the <em>Hospital de Clinicas</em> in order to implement these guidelines.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"54 1","pages":"Pages 8-20"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2017.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54996480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacto del empleo de umbrales específicos de referencia en el diagnóstico de las alteraciones funcionales tiroideas en la mujer gestante","authors":"David Ruiz Ochoa ,&nbsp;María Piedra León ,&nbsp;Bernardo Alio Lavín Gómez ,&nbsp;Carmela Baamonde Calzada ,&nbsp;María Teresa García Unzueta ,&nbsp;Rocío de Castro Fernández ,&nbsp;José Antonio Amado Señarís","doi":"10.1016/j.raem.2016.12.003","DOIUrl":"10.1016/j.raem.2016.12.003","url":null,"abstract":"<div><h3>Objective</h3><p>To determine trimester- and assay-specific reference intervals for thyroid hormones during pregnancy, and the impact of using non-specific intervals on the diagnosis of functional disorders in the first trimester.</p></div><div><h3>Methods</h3><p>A total of 759 healthy pregnant women older than 18 years with uncomplicated single intrauterine gestations and attending Primary Care Centres were consecutively recruited from January 2014 to September 2014. After excluding women who did not complete the follow-up during pregnancy, and those with functional thyroid disorders or with thyroid-specific autoantibodies, a total of 411 pregnant women were selected as the reference population. TSH, FT4, and FT3 were measured in each trimester using electrochemiluminescence immunoassay, and urinary iodine concentration was measured in the first and in the third trimester using high performance liquid chromatography.</p></div><div><h3>Results</h3><p>The TSH reference intervals expressed as median and 2.5-97.5 percentiles were: 1.53<!--> <!-->μIU/ml (0.26-3.95), 1.90<!--> <!-->μIU/ml (0.78-3.85) and 1.89<!--> <!-->μIU/ml (0.71-3.61) in first, second and third trimesters, respectively. The median urinary iodine concentration (UIC) was 171.31<!--> <!-->μg/l (90.7-274.9) in the first trimester and 190.37<!--> <!-->μg/l (96.44-360.38) in the third. Interpretation of thyroid function tests using non-local-pregnant reference intervals would result in misclassification of the thyroid function in a significant percentage of pregnant women (19.8% with the proposed international specific reference intervals, and 8.52% with the non-specific reference intervals of our assay).</p></div><div><h3>Conclusions</h3><p>The use of non-local reference intervals for the diagnosis of thyroid disorders during pregnancy could lead to a large number of misclassified results, contributing to sub-optimal patient care.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"54 1","pages":"Pages 21-28"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2016.12.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54996469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fe de errores de «Estatus de vitamina D en mujeres adultas hipotiroideas controladas. Relación con el estado nutricional»","authors":"María Elena Torresani,&nbsp;Cintia Biasatti,&nbsp;Lucía María Cáceres,&nbsp;Vanina Paola Minniti,&nbsp;María Mercedes Vattuone","doi":"10.1016/j.raem.2017.01.003","DOIUrl":"10.1016/j.raem.2017.01.003","url":null,"abstract":"","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"54 1","pages":"Page 50"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2017.01.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54996491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polimorfismos del receptor D2","authors":"María Eugenia Céspedes","doi":"10.1016/j.raem.2016.12.002","DOIUrl":"10.1016/j.raem.2016.12.002","url":null,"abstract":"<div><p>Prolactinomas are well differentiated tumours that originate in the pituitary lactotrope cells, a cell line that physiologically secretes prolactin (PRL). At pituitary level, dopamine is involved in the regulation of PRL secretion by lactotropes, and this inhibitory effect is mediated by activation of prolactin type 2 receptor (DRD2).</p><p>Of the several DRD2 polymorphisms, the first and most studied is TaqI A1. It has been demonstrated that this allele is associated with a reduced dopaminergic brain activity, and a reduction in its binding capacity of approximately 30% also being observed. This allele was associated with a lower density of DRD2 in the striatum, especially in the putamen and ventral caudate. The amount of DRD2 in A1 allele carriers was 30 - 40% lower than in non-carriers (this is, TaqI A2 Homozygotes).</p><p>There is evidence in the literature, that supports the possible involvement of DRD2 polymorphisms in the regulation of hormonal secretion.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"54 1","pages":"Pages 29-36"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2016.12.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54996448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frecuencia de hipoacusia y características audiométricas en pacientes con diabetes de un hospital de la ciudad de Chiclayo, Perú, 2015","authors":"Pedro M. Fanzo-González ,&nbsp;David R. Cornetero-Mendoza ,&nbsp;Ricardo A. Ponce-Linares ,&nbsp;Erick R. Peña-Sánchez","doi":"10.1016/j.raem.2016.09.004","DOIUrl":"10.1016/j.raem.2016.09.004","url":null,"abstract":"<div><h3>Introduction</h3><p>Diabetes is a metabolic disorder that affects more than 347 million people worldwide, and approximately 1.1 million in Peru. Its complications have been studied, but there is little about its effect on hearing. Although there are some hypotheses to try to explain this, the relationship between diabetes mellitus and hearing loss is still controversial.</p></div><div><h3>Objectives</h3><p>To determine the frequency of hearing loss and the audiometric characteristics of diabetic patients in a Level <span>II</span> Hospital of Chiclayo City during 2015.</p></div><div><h3>Materials and methods</h3><p>A descriptive cross-sectional study in which audiometry was performed on 185 patients with diabetes treated in the Endocrinology Department. The patients included where between 18 and 70 years, diagnosed with diabetes mellitus type 1 and 2, and lived in Chiclayo city. Simple random probability sampling was used. Those patients with sudden deafness, acute or chronic otitis media, a history or presence of tympanic perforation detected during ear examination, using hearing aid materials, on cytotoxic drugs, family history of hearing loss, and occupational exposure to noise, were excluded. Data were recorded in a conventional audiometry table in which other variables of interest (age, gender, and duration of the disease) were added. Measures of central tendency and dispersion were described.</p></div><div><h3>Results</h3><p>Almost half (49%) of diabetic patients had hearing loss, mainly slight (35%), bilateral (41%), sensorineural (45%), and with a tendency towards higher-pitched tones (42%). Most patients with hearing loss had more than 10 years of disease.</p></div><div><h3>Conclusions</h3><p>The frequency of hearing loss in patients with diabetes is high in our environment. It is usually a minor, sensorineural and bilateral type, independent of duration of disease. These data show that greater emphasis should be placed on the systematic review of changes in hearing levels in patients with diabetes.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"53 4","pages":"Pages 157-162"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2016.09.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54996348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efectividad del conteo de hidratos de carbono para el control metabólico de niños con diabetes mellitus tipo 1: revisión sistemática","authors":"Mario Delgado-Noguera,&nbsp;Juanita Mena Gallego,&nbsp;Javier D. Maya","doi":"10.1016/j.raem.2016.11.003","DOIUrl":"10.1016/j.raem.2016.11.003","url":null,"abstract":"<div><p>Carbohydrate counting as a therapeutic intervention in patients with Diabetes Mellitus type 1 (DM1) plays an important role in obtaining an optimal postprandial glucose level, which is demonstrated with the correct levels of glycosylated haemoglobin (HbA1c). However, recommendations for children with DM1 are based on narrative reviews of the available evidence. Our objective was to evaluate the effectiveness of carbohydrate counting on metabolic control of children with DM1. This study was a systematic review. The search was conducted in PubMed, Google Scholar, and controlled trials of the Cochrane collaboration (CENTRAL), published from January 2000 to September 2015. Five eligible trials out of 261 potentially relevant studies were identified, which include two trials. The quality of the studies was generally poor. The two studies included agreed on the positive impact of carbohydrate counting in reducing HbA1c levels as a measure of metabolic control. In general, the other parameters measured showed conflicting results with no significant differences, except for the high density lipoprotein in one study, higher in the intervention group. Although carbohydrate counting is a promising technique for metabolic control in children with type 1 diabetes, the evidence found in this review is not enough to recommend it.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"53 4","pages":"Pages 142-148"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2016.11.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54996397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}