Revista argentina de endocrinologia y metabolismo最新文献

{"title":"Estatus de vitamina D en mujeres adultas hipotiroideas controladas. Relación con el estado nutricional","authors":"María Elena Torresani","doi":"10.1016/j.raem.2016.11.001","DOIUrl":"10.1016/j.raem.2016.11.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Vitamin D deficiency is prevalent worldwide. It can affect people of different ages. This vitamin deficiency has been linked with diseases such as type 2 diabetes mellitus, insulin resistance, metabolic syndrome, obesity, cardiovascular disease, cancer, immune disorders, muscle disorders and falls, among others.</p></div><div><h3>Objective</h3><p>To determine the plasma concentrations of vitamin D in hypothyroid adult women and its relationship with nutritional status.</p></div><div><h3>Material and methods</h3><p>A retrospective cross-sectional study limited to 80 hypothyroid adult women, aged over 40 years, controlled with levothyroxine, and for whom weight, height, and 25-hydroxyvitamin D (25OHD) data were available. They attended a private clinic in Martínez (Buenos Aires Province, Argentina).</p><p>Dependent variable: Serum 25(OH)D concentration (ng/ml) stratified as sufficient (&gt; 30 ng/ml), mild deficiency (20 to 30 ng/ml), and severe deficiency (&lt;20 ng/ml).</p><p>Independent variable: nutritional status by BMI, classified as normal weight (18.5 to 24.9<!--> <!-->kg/m²) and overweight or obesity (≥ 25<!--> <!-->kg/m²).</p><p>Data were obtained from clinical records. Total serum 25(OH)D concentration was measured using radioimmunoassay (Diasorin^NR) in a fasting venous blood specimen by the laboratory of the medical centre. Weight and height were measured by a nutritionist using standardised methodology.</p><p>Statistical analysis was performed using SPSS 19.0 software, establishing measurements of central tendency. Mean differences were compared using the Student t-test or ANOVA, χ², and Pearson correlation, with significance level set at <em>P</em>&lt;.05.</p></div><div><h3>Results</h3><p>The mean age was 57.4 (SD: 5) years, with 57.5% being of normal weight and 42.5% overweight or obesity. The mean value of 25(OH)D was 26.9 (SD: 10.5) ng/ml. Sufficient vitamin status, was observed in 35%, a mild deficiency in 36.3%, and a severe deficiency in 28.7%. No significant differences were found between the mean 25(OH)D and thyrotropin (TSH) levels (<em>P</em>=.563). There was a significant inverse association between 25(OH)D and BMI (r<!--> <!-->=<!--> <!-->−0.577; <em>P</em>=.000) and age (r<!--> <!-->=<!--> <!-->−0.270; <em>P</em>=.015).</p></div><div><h3>Conclusions</h3><p>Most of the patient sample showed decreased plasma levels of 25(OH)D. Serum 25(OH)D was shown to decrease as body weight and age increased.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"53 4","pages":"Pages 128-134"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2016.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54996365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevención primaria de diabetes tipo 2 en Argentina: estudio piloto en la provincia de Buenos Aires","authors":"Juan José Gagliardino ,&nbsp;Graciela Etchegoyen ,&nbsp;Marcelo Bourgeois ,&nbsp;Gabriel Fantuzzi ,&nbsp;Silvia García ,&nbsp;Lorena González ,&nbsp;Jorge Federico Elgart ,&nbsp;Matías Ré ,&nbsp;Alberto Ricart ,&nbsp;Juan Pablo Ricart ,&nbsp;Eduardo Spinedi","doi":"10.1016/j.raem.2016.11.002","DOIUrl":"10.1016/j.raem.2016.11.002","url":null,"abstract":"<div><h3>Lifestyle interventions</h3><p>Prevent/delay the development of type 2 diabetes (T2DM) in people with impaired glucose tolerance or impaired fasting blood glucose (IGT and IFG, respectively), alone or combined.</p></div><div><h3>Objective</h3><p>To evaluate the effectiveness of adopting a healthy lifestyle on the clinical manifestation of T2DM in people at risk of its development.</p></div><div><h3>Methodology</h3><p>A prospective study will be conducted, using the FINDRISC questionnaire, on participants selected from three municipalities of the Province of Buenos Aires (La Plata, Berisso and Ensenada). An oral glucose tolerance test will be performed on those participants who exceed their risk score (≥ 13). The study will include all people with IGT/ IFG who wish to participate and sign an informed consent form. They will be randomly divided into two groups: a) self-administered intervention and b) Intensified Intervention (monthly group sessions on healthy meal plan and weekly sessions of physical activity). Both groups will be followed-up for two years. Questionnaires will be used to assess welfare (WHO-5), eating habits, and physical activity of each participant at baseline and every six months of follow-up. Individual anthropometric measurements and laboratory analysis will be performed in both groups at 0, 12 and 24 months. The cost-effectiveness of the strategies implemented will also be assessed.</p></div><div><h3>Results and conclusions</h3><p>The results of the study will allow to: a) demonstrate the feasibility and cost of such programs, b) identify genotypes of people at risk that would facilitate early implementation of effective prevention strategies; c) define whether these interventions would also improve other associated cardiovascular risk factors, d) Identify and quantify microangiopathy lesions (retinal micro-aneurysms) in a population with IGT/IFG, and e) identify barriers and interdisciplinary strategic alliances for effective implementation of such programs.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"53 4","pages":"Pages 135-141"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2016.11.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54996381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alteraciones endocrinometabólicas en pacientes ambulatorios con infección por virus de la inmunodeficiencia humana","authors":"Mónica Lucía Drnovsek,&nbsp;Gabriela Beatríz Estela Portunato,&nbsp;Patricia Rosa Isabel San Martín,&nbsp;Mónica Rosana Virga,&nbsp;Marcelo Losso,&nbsp;Javier Toibaro,&nbsp;Mónica Ruth Moss,&nbsp;Ana María Fuentes,&nbsp;Hilda Srabstein,&nbsp;Mónica Alejandra Ercolano","doi":"10.1016/j.raem.2016.09.002","DOIUrl":"10.1016/j.raem.2016.09.002","url":null,"abstract":"<div><p>The human immunodeficiency virus causes a chronic systemic disease. Treatment with highly active antiretroviral drugs has changed the evolution of the disease, and increasing the rate of survival. However, due to the disease and/or the antiretroviral drugs, there are other multiple chronic diseases that compromise the quality of life of the patients even more. The aim of this study is to present endocrine and metabolic changes in outpatients with human immunodeficiency virus, and present an update of the related literature.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"53 4","pages":"Pages 121-127"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2016.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54996320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Síndrome de ovario poliquístico: fenotipos y enfermedad cardiovascular","authors":"Juan Manuel Gamez ,&nbsp;Giselle Abruzzese ,&nbsp;Gloria Cerrone ,&nbsp;Gustavo Lioy ,&nbsp;Eduardo Mormandi ,&nbsp;Patricia Otero ,&nbsp;Susana Belli ,&nbsp;Oscar Levalle ,&nbsp;Mabel Graffigna ,&nbsp;Alicia Motta","doi":"10.1016/j.raem.2016.11.004","DOIUrl":"10.1016/j.raem.2016.11.004","url":null,"abstract":"<div><h3>Introduction</h3><p>Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age. It is associated with insulin resistance (IR) and high cardiovascular risk (CVR). According to the Rotterdam consensus, four PCOS phenotypes could be established: three with clinical and/or biochemical hyperandrogenism (HA), and one non-hyperandrogenic (NHA). It is necessary to identify which of these patients are at risk of metabolic disturbances and CVR. Two indexes: lipid accumulation product (LAP) and visceral adiposity index (VAI) have been suggested as reliable markers of IR and CVR in PCOS.</p></div><div><h3>Objective</h3><p>The present study aims to assess the reliability of LAP and VAI as IR markers in a young local population of PCOS patients. Their association with CVR parameters is also evaluated.</p></div><div><h3>Methodology</h3><p>LAP and VAI were calculated in 130 PCOS patients. The PCOS patients were divided in two groups as HA and NHA, taking into account the signs of hyperandrogenism (clinical or biochemical). An evaluation was also made of the metabolic and anthropometric characteristics of the population and their association with CVR and IR.</p></div><div><h3>Results</h3><p>Both LAP and VAI showed to be effective markers to asses CVR and IR in these PCOS women (cutoff values: LAP: 14.02 (sensitivity: 93.94% specificity: 93.22%) VAI: 2.17 (sensitivity: 87.88% specificity: 91.38%). There was a positive correlation of both markers with abdominal circumference and triglycerides (TG), and negative with HDL-cholesterol. The risk of IR and metabolic disturbances was similar in both phenotypes (NHA versus HA).</p></div><div><h3>Conclusion</h3><p>Our data show that both LAP and VAI are representative markers for assessing IR and associated CVR in PCOS patients. These results also suggest that the NHA phenotype in the population studied shows the same risk of metabolic disturbances and cardiovascular disease when compared to HA phenotypes.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"53 4","pages":"Pages 149-156"},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2016.11.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54996409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La hormona antimülleriana como marcador de función ovárica","authors":"Estefanía Capecce,&nbsp;Melina Pelanda,&nbsp;Mariana Dicugno,&nbsp;Eduardo González de Sampaio,&nbsp;Graciela Buongiorno,&nbsp;Nora Corazza,&nbsp;Matías Peñaloza,&nbsp;Ana María Sequera,&nbsp;Gabriela Ruibal","doi":"10.1016/j.raem.2016.06.003","DOIUrl":"10.1016/j.raem.2016.06.003","url":null,"abstract":"<div><p>For many years, the clinical significance of the anti-Müllerian hormone (AMH) was limited to its critical role in foetal sexual development. However, in the last 20 years it has also emerged as a marker of ovarian function.</p><p>AMH has specific functions as a regulator of follicular growth, playing its role as negative feedback signal. It may also play an important role in the regulation of the number of growing follicles (inhibiting the recruitment) as well as in their selection to be ovulated (inhibiting FSH).</p><p>AMH is synthesised as a pre-pro-hormone. In the cytoplasm each monomer is cleaved, generating one N-terminal fragment: 110 KDa (pro region) and another C-terminal fragment: 25 KDa, non-covalently bound by two disulphide bridges. The C-terminal domain is bioactive, binding to the receptor, but requires the N-terminal fragment to trigger a biological response. A mixture of pro-AMH complex and C-terminal/N-terminal complex can be found in the bloodstream, which can be measured by the assays available.</p><p>Several authors have shown that AMH is an early marker of the decrease and depletion of ovarian reserve. It shows a close correlation with follicular reserve and reproductive capacity more than FSH and oestradiol.</p><p>This review leaves no doubt about the usefulness of AMH in the fertile phase. It has proven to be an excellent tool in characterising poor responders in assisted reproduction procedures, as an early alert in young women of a low ovarian reserve in relation to their chronological age, as well as in expressing a number of follicles in high growth, as in polycystic ovary syndrome, to avoid ovarian hyperstimulation. The growing number of patients who have decided to delay motherhood and the role of AMH in ovarian physiology has led it to an integral part of the assessment of women with impaired fertility.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"53 3","pages":"Pages 106-113"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2016.06.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54996252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibidores de tirosina cinasa y disfunción tiroidea","authors":"Laila Y. Bielski,&nbsp;Ana M. Orlandi,&nbsp;Hugo R. Boquete","doi":"10.1016/j.raem.2016.07.001","DOIUrl":"10.1016/j.raem.2016.07.001","url":null,"abstract":"<div><p>Tyrosine kinase inhibitors are used for the treatment of different types of tumours, interfering in various cell proliferation pathways, and tumour angiogenesis. These oral agents have side effects, thyroid dysfunction outstanding among them. There are different mechanisms through which these agents lead to hypothyroidism, as well as thyrotoxicosis. There is still no consensus on the treatment and follow-up of the above mentioned effects.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"53 3","pages":"Pages 96-105"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2016.07.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54996281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fe de errores de «Evaluación diagnóstica y terapéutica del incidentaloma suprarrenal»","authors":"Reynaldo M. Gómez ,&nbsp;Raul Chervín ,&nbsp;Ester M. Pardes ,&nbsp;Susana Lupi ,&nbsp;María Elena Surraco ,&nbsp;Jorge Herrera ,&nbsp;León Schurman ,&nbsp;Claudio Gonzáles","doi":"10.1016/j.raem.2016.09.003","DOIUrl":"10.1016/j.raem.2016.09.003","url":null,"abstract":"","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"53 3","pages":"Page 119"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2016.09.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54996328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detección y caracterización de autoanticuerpos anti-ZnT8 en pacientes argentinos con diabetes mellitus tipo 1","authors":"Natalia Inés Faccinetti ,&nbsp;Bruno David Rovitto ,&nbsp;Luciano Lucas Guerra ,&nbsp;Adriana Victoria Sabljic ,&nbsp;Ruben Francisco Iacono ,&nbsp;Liliana Trifone ,&nbsp;Edgardo Poskus ,&nbsp;Aldana Trabucchi ,&nbsp;Silvina Noemí Valdez","doi":"10.1016/j.raem.2016.09.001","DOIUrl":"10.1016/j.raem.2016.09.001","url":null,"abstract":"<div><h3>Introduction and objectives</h3><p>The aim of this study involved the detection and immunochemical characterisation of ZnT8 autoantibodies (ZnT8A) in new-onset type 1 Argentinian diabetic patients.</p></div><div><h3>Material and methods</h3><p>One hundred sera from type 1 diabetic patients were tested for ZnT8A. The antigens employed were obtained using cDNA plasmids encoding the C-terminal domains of ZnT8 carrying 325Arg, 325Trp and 3 dimeric constructs (ZnT8-Arg-Trp325, ZnT8-Arg-Arg325 and ZnT8-Trp-Trp325). ZnT8A were assessed by radioligand binding assay (RBA). Other islet-autoantibodies were also tested by RBA.</p></div><div><h3>Results</h3><p>Among the 100 type 1 diabetic patients, the prevalence of ZnT8A was 65.0%, 8 recognized all recombinant forms of ZnT8. Most patients (56) were positive for the heterodimer (ZnT8-Arg-Trp325), being 25 of them also positive for the homodimer ZnT8-Arg-Arg325 and monomer ZnT8-Arg325. Single reactivity against ZnT8A was found in 9.0% of the group. Besides, the highest signal values were obtained with the heterodimeric variant (median 17.99 vs. 10.71, 6.32, 5.66 and 4.44 SD scores for ZnT8-Arg325, ZnT8-Trp325, ZnT8-Arg-Arg325 y ZnT8-Trp-Trp325, respectively; p &lt; 0.05, Mann-Whitney t test).</p></div><div><h3>Conclusion</h3><p>Immunochemical characterisation of ZnT8A present in type 1 Argentinian diabetic patients was accomplished, employing different variants of ZnT8. An increased detection of autoimmunity was found when ZnT8A was employed in combination with the other islet-autoantibodies. The presence of autoantibodies that recognized only constructions containing Arg reveals the existence of epitopes dependent of the amino acid present at residue 325. Furthermore, application of dimeric constructions revealed the existence of quaternary structure–defined epitopes which were recognized by type 1 diabetic patients. Finally, the highest combined sensitivity and specificity for routine screening of ZnT8A was accomplished with the heterodimeric construction.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"53 3","pages":"Pages 77-83"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2016.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54996309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relación entre estradiol plasmático, glucemia en ayunas y triglicéridos en varones con síndrome metabólico","authors":"Diego Damián Del Balzo,&nbsp;Diego Nicolás Messina,&nbsp;Carla Antonela Corte,&nbsp;Jessica Anabel Mussi Stoizik,&nbsp;José Daniel López Laur,&nbsp;Rafael Fernando Pérez Elizalde","doi":"10.1016/j.raem.2016.07.002","DOIUrl":"10.1016/j.raem.2016.07.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Oestradiol circulates in low concentrations (8-40<!--> <!-->pg/ml) in males, with its functions still not being entirely clear. In this context, there is a need to determine the effects it has on males. Apart from studying the potential role oestradiol has on male reproduction in recent years, efforts have been made to determine the relationship between oestradiol levels and metabolic syndrome components. Nevertheless, the existing bibliography does not clarify whether oestradiol plays a protective or detrimental role in this condition.</p></div><div><h3>Objectives</h3><p>The present work aimed to analyse the relationship between serum oestradiol levels and metabolic syndrome components in overweight men from Mendoza.</p></div><div><h3>Methodology</h3><p>The sample consisted of 40 overweight or obese males, aged 53-74, with metabolic syndrome, and living in the city of Mendoza. Based on a health routine check-up, they were evaluated by determining the levels of oestradiol, testosterone, fasting blood glucose, insulin, HOMA index, lipid profile, and uric acid. Nutritional status was assessed using anthropometric measurements: weight, height, circumferences, and skinfold thickness. Statistical analysis was carried out using Pearson or Spearman correlation according to the normality of variables and the Student <em>t</em> test for independent samples. A minimum level of significance of <em>P</em>&lt;.05 was used.</p></div><div><h3>Results</h3><p>Oestradiol levels negatively correlated with triglyceride values (r = -0.401; <em>P</em>=.013) and fasting blood glucose (r= -0.333; <em>P</em>=.041). Furthermore, those with normal triglycerides (triglyceride values &lt;150<!--> <!-->mg/dl) showed higher oestradiol levels compared to those with high triglycerides (<em>P</em>=.02).</p></div><div><h3>Conclusions</h3><p>Oestradiol levels show an inverse relationship as regards triglycerides and fasting blood glucose in men with metabolic syndrome.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"53 3","pages":"Pages 90-95"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2016.07.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54996300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dificultades técnicas en el dosaje de testosterona","authors":"María Andrea Dacunda,&nbsp;María Antonella D’Amico,&nbsp;María Silvia de la Vega,&nbsp;Lorena Elizabeth Gomez,&nbsp;Nicolás Eduardo Jaeggi,&nbsp;María del Rosario Navia,&nbsp;Carolina Beatriz Yulán,&nbsp;Andrea Kozak,&nbsp;Gabriela Ruibal","doi":"10.1016/j.raem.2016.06.002","DOIUrl":"10.1016/j.raem.2016.06.002","url":null,"abstract":"<div><h3>Objective</h3><p>Bibliographic analysis of the constraints and technical difficulties in the total testosterone (TT) assay.</p></div><div><h3>Methods</h3><p>Review of articles published in various databases from 2003 to 2014. (PubMed, Health Library, Cochrane). Evaluation and comparison of serum TT assays using the different methods available in our country, validated or not validated by LC-MS/MS.</p></div><div><h3>Results</h3><p>Development of a monograph in which technical problems are evaluated in current TT assays.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"53 3","pages":"Pages 114-118"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2016.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54996243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}