Revista argentina de endocrinologia y metabolismo最新文献

{"title":"Correlation Between Inflammatory Parameters and Thyroid Axis in Patients With COVID-19","authors":"V. Ilera, L. Delfino, Anabela Zunino, P. Glikman, M. Drnovsek, A. Reyes, Alicia Dios, J. Toibaro, Valeria Pachioli, Nayla Lannes, A. Guida, A. Gauna","doi":"10.21203/RS.3.RS-563531/V1","DOIUrl":"https://doi.org/10.21203/RS.3.RS-563531/V1","url":null,"abstract":"\u0000 Purpose: Inflammation plays a critical role in the progression of COVID-19. Nonthyroidal illness syndrome (NTIS) has been increasingly recognized in affected patients. We aim to evaluate the correlation of thyroid hormones with markers of inflammation and association with disease outcome in hospitalized patients with COVID-19, and in two profiles of NTIS (low T3-normal/low FT4 vs low T3-high FT4). Methods: prospective study of 55 patients (50.9% men, median age 56 years) admitted to a non-intensive care unit for COVID-19. Infection was mild in 22%, moderate in 27.1% and severe in 50.8%; 7.41% died. T4, T3, FT4, FT3 and their ratios (T3/T4, FT3/FT4) were correlated with albumin, ferritin, fibrinogen, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP], lactate dehydrogenase [LDH] and D-dimer. Results: Albumin correlated positively with T3 and hormones ratios, but negatively with FT4. T3, FT3, T3/T4 and FT3/FT4 ratios correlated inversely with ferritin, fibrinogen, ESR, CRP, LDH and D-dimer. FT4 showed direct correlation with fibrinogen and ESR. T3/T4 ratio was lower in severe compared to mild/moderate disease [7.5 (4.5-15.5) vs 9.2 (5.8-18.1); p=0.04], and lower in patients who died than in those discharged [5 (4.53-5.6) vs 8.1 (4.7-18.1); p=0.03]. A lowT3/high FT4 profile was associated with lower albumin, higher ferritin, and severity. Conclusion: In this cohort, thyroid hormones correlated with inflammation and outcome. T3 and T3/T4 ratio correlated inversely with inflammatory markers; a low T3/T4 ratio was associated with severity and poor prognosis. Patients with low T3 but high FT4 had higher ferritin, lower albumin, and more severe disease at presentation.","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"58 1","pages":"328-329"},"PeriodicalIF":0.0,"publicationDate":"2021-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48514715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Función gonadal en niños y adolescentes nacidos con restricción del crecimiento intrauterino","authors":"Alicia Martínez ,&nbsp;Titania Pasqualini ,&nbsp;Viviana Bengolea ,&nbsp;Miriam Azaretzky ,&nbsp;Florencia Kuspiel ,&nbsp;Elisa Vaiani ,&nbsp;Susana Campeni ,&nbsp;Viviana Pipman ,&nbsp;Martha Suárez","doi":"10.1016/j.raem.2017.09.001","DOIUrl":"10.1016/j.raem.2017.09.001","url":null,"abstract":"<div><p>Low birth weight due to intrauterine growth restriction (IUGR) is associated with an increased risk of obesity, hypertension, cardiovascular disease, insulin resistance, and type<!--> <!-->2 diabetes during postnatal life. Exposure to an unfavourable intrauterine environment in critical phases of development may have a deleterious effect on the forming gonad.</p><p>The objective was to carry out a bibliographic review and update on the possible association between IUGR and alterations of gonadal function in children and adolescents of both sexes. To facilitate the update, this was divided into stages: 1, prenatal; 2, postnatal and pre-pubertal; 3, puberal, and 4, adult.</p><p>Most children born preterm or with low birth weight make a normal transition from childhood to adulthood with respect to reproductive health. However, cryptorchidism, hypospadias, testicular cancer and lower fertility could be observed in boys, and early puberty and menarche, hyperandrogenism and polycystic ovarian syndrome in girls. However, the data are controversial, and further studies are needed to clarify the relationship between IUGR and pituitary gonadal function.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"54 4","pages":"Pages 196-203"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2017.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42332746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Riesgo aumentado de lesiones colónicas preneoplásicas en acromegalia: estudio multicéntrico caso control. Resultados preliminares","authors":"María Florencia Battistone ,&nbsp;Mónica Loto ,&nbsp;Débora Katz ,&nbsp;Mónica Agüero ,&nbsp;Analía Alfieri ,&nbsp;María Carolina Ballarino ,&nbsp;Laura Boero ,&nbsp;Karina Danilowicz ,&nbsp;Soledad Sosa ,&nbsp;Sabrina Diez ,&nbsp;Marina Donoso ,&nbsp;Patricia Fainstein Day ,&nbsp;Alejandra Furioso ,&nbsp;Mariela Glerean ,&nbsp;Susana Mallea Gil ,&nbsp;Marcela Martinez ,&nbsp;Karina Miragaya ,&nbsp;Amelia Rogozinski ,&nbsp;María Isabel Sabaté ,&nbsp;Marisa Servidio ,&nbsp;Mirtha Guitelman","doi":"10.1016/j.raem.2017.07.006","DOIUrl":"10.1016/j.raem.2017.07.006","url":null,"abstract":"<div><h3>Background</h3><p>The risk of developing cancerous lesions in the colon of acromegaly patients and their direct relationship with elevated growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels is not well established, and is still controversial in the international literature. The objective of this study was to evaluate the risk of developing advanced neoplastic lesions (ALN: greater than 1<!--> <!-->cm adenomas, villous component greater than 75% and/or high grade dysplasia) in patients with acromegaly compared to a control group.</p></div><div><h3>Materials and methods</h3><p>A multicentre, retrospective case-control study was conducted initially on 137 patients with acromegaly (cases) who underwent videocolonoscopy (VCC), although only 69 met inclusion criteria. Sixty-two controls were obtained, and for each case two “controls” were randomly selected and matched by age and gender. Risk was expressed as odds ratio (OR) and its corresponding 95% confidence interval (CI). <em>P</em> values<!--> <!-->&lt;<!--> <!-->.05 were considered statistical significantly.</p></div><div><h3>Results</h3><p>Of the 69 acromegaly patients with a completed VCC and adequate data for their analysis, 28 had a positive VCC with findings of polyps (40%), and 41 VCC negative with no lesions (60%). Within the group with positive VCC, 14 were ALN (20%) and one a colorectal cancer. In the case-control analysis, 31 cases were to be analysed against the control group (n<!--> <!-->=<!--> <!-->62). The presence of colonic polyps, adenomas, and ALN in patients with acromegaly was 19/31 (61.9%), 14/31 (45.16%), and 10/31 (32.25%), respectively, and in the control group, it was 18/62 (29.03%), 11/62 (17.74%), and 4/62 (6.45%), respectively. The risk of adenomas and ALN was higher in the acromegaly group compared to the control group: adenomas OR: 2.54 (95% CI 1.22-5.25) <em>P</em>=.005, ALN OR: 7.3 (2.4-25) <em>P</em>=.00.</p></div><div><h3>Conclusion</h3><p>This preliminary case control study showed an increased risk of pre-cancerous colprectal lesions in patients with acromegaly, supporting the VCC screening at diagnosis.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"54 4","pages":"Pages 169-175"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2017.07.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42931767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal cutoff for visceral adiposity index in a Venezuelan population: Results from the Maracaibo City Metabolic Syndrome Prevalence Study","authors":"Valmore J. Bermúdez ,&nbsp;Juan Salazar ,&nbsp;Roberto Añez ,&nbsp;José Ramón Rivas-Ríos ,&nbsp;Mervin Chávez-Castillo ,&nbsp;Wheeler Torres ,&nbsp;Victoria Núñez ,&nbsp;José Mejías ,&nbsp;Sandra Wilches-Durán ,&nbsp;Marcos Cerda ,&nbsp;Modesto Graterol ,&nbsp;Rosemily Graterol ,&nbsp;Juan Hernández ,&nbsp;Carlos Garicano ,&nbsp;Joselyn Rojas","doi":"10.1016/j.raem.2017.07.004","DOIUrl":"10.1016/j.raem.2017.07.004","url":null,"abstract":"<div><h3>Aim</h3><p>Visceral obesity is one of the most intensely researched cardiometabolic risk factors in recent years; nonetheless, its accurate assessment remains a challenge in regions were socioeconomic conditions hinder the widespread use of diagnostic methods for this purpose, such as imaging tests. In this setting, Visceral Adiposity Index (VAI) may be a useful tool. Thus, the objective of this study was to determine the VAI cutoff in adult population from Maracaibo City, Venezuela.</p></div><div><h3>Methods</h3><p>This is a descriptive, cross-sectional study with multi-staged sampling; 2026 subjects of both genders aged ≥18 years were selected from this database and had their VAI calculated. In order to determine VAI cutoffs, subsamples of metabolically healthy and sick individuals were determined, with 599 and 286 subjects, respectively. Gender-specific and general ROC curves were plotted in order to identify the most suitable cutoff according to sensitivity and specificity.</p></div><div><h3>Results</h3><p>Median VAI in the selected sample was 1.67 (0.97–2.78). The optimal cutoff was determined to be 1.91, with 70.3% sensitivity, 70.3% specificity [AUC<!--> <!-->=<!--> <!-->0.777 (0.745–0.808)]. No differences were found between genders. Analysis by age revealed VAI to have greater predictive power among subjects aged<!--> <!-->&lt;<!--> <!-->30 years (cutoff: 1.53), 78.6% sensitivity, 72.8% specificity [AUC<!--> <!-->=<!--> <!-->0.797 (0.709–0.884)].</p></div><div><h3>Conclusion</h3><p>We suggest a VAI cutoff of 1.9 for define dysfunctional adiposity in our population, with age being an important factor in the epidemiologic behavior of this variable, particularly in younger individuals.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"54 4","pages":"Pages 176-183"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2017.07.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43380646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencia de la actividad física y el consumo calórico sobre la adiposidad visceral en adultos de la ciudad de Cuenca, Ecuador","authors":"Rina Ortiz ,&nbsp;Maritza Torres ,&nbsp;Wilson Siguencia ,&nbsp;Nube Sigüenza-Cobos ,&nbsp;Juan Salazar ,&nbsp;Roberto Añez ,&nbsp;Joselyn Rojas ,&nbsp;Valmore Bermúdez","doi":"10.1016/j.raem.2017.07.007","DOIUrl":"10.1016/j.raem.2017.07.007","url":null,"abstract":"<div><h3>Introduction</h3><p>The visceral adiposity index (VAI) is a simple and cost effective method for the determination of visceral adiposity. The objective of this study is to evaluate the relationship between VAI and different cardiovascular risk factors, sociodemographic variables, and psychobiological habits in the adult population of the city of Cuenca, Ecuador.</p></div><div><h3>Materials and methods</h3><p>A descriptive cross-sectional study was performed on 318 adult individuals selected by multistage random sampling, who underwent a clinical, anthropometric and laboratory evaluation. VAI was determined using the proposed formula that used abdominal circumference, body mass index, triglycerides, and HDL-Cholesterol. A multiple logistic regression model was used to determine the main factors associated with the highest values of visceral adiposity.</p></div><div><h3>Results</h3><p>The mean VAI was 2.57 (1.66-3.94) in the 318 individuals studied, with higher values for females. In the multiple logistic regression model, significant risk factors for moderate-high VAI were: age (&gt;60 years: OR<!--> <!-->=<!--> <!-->3.87, 95% CI: 1.15-12.96, <em>P</em>=.03), calorie intake, impaired fasting glucose, and leisure time physical activity.</p></div><div><h3>Conclusion</h3><p>VAI is a useful method to define those subjects with visceral adiposity in our region. Age, daily calorie intake, and impaired fasting glucose are the main factors associated with higher index values, while leisure time physical activity was a protective factor for classifying subjects in the more advanced stages.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"54 4","pages":"Pages 160-168"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2017.07.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42888442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La tormentosa relación entre las grasas y el desarrollo de la diabetes mellitus tipo 2: actualizado. Parte 2","authors":"José Esteban Costa Gil ,&nbsp;Eduardo Spinedi","doi":"10.1016/j.raem.2017.06.002","DOIUrl":"https://doi.org/10.1016/j.raem.2017.06.002","url":null,"abstract":"<div><p>In this part of the review, the functional relationship between lipid and carbohydrate metabolisms and their interdependence is described, from the glucose-fatty acid cycle and the portal hypothesis of insulin resistance to the new knowledge on brown and beige adipocytes, with emphasis on the normal functioning of an endocrine pattern in which its dysfunction is a key factor in the pathophysiology of T2DM and obesity. Ectopic fat deposition in lean tissues due to the inability of the adipose tissue to continuously collect lipids and the endocrine activity of adipocytes is discussed. The production of molecules (adipokines) influencing some of the mechanisms involved in the development of insulin resistance (leptin, adiponectin, TNF-α, resistin, etc.) and beta cell dysfunction is also revisited. The decrease in the oxidative capacity in the mitochondrial respiratory chain and the rebirth of the concept of <em>de novo</em> lipogenesis are described, both effects favouring intracellular lipid accumulation. In lean tissues there are small intracellular lipid reserves that help to maintain the regulation of essential functions; however, when a lipid overload occurs the phenomenon could lead to severe cell dysfunction (lipotoxicity), and death (lipo-apoptosis). The stormy relationship between lipids and the Langerhans’ islets goes beyond the functional effort imposed by peripheral insulin-resistance on the β cells, either by the direct effect of lipids or by their derivatives on overall pancreatic islet function. Within a scenario of no insulin deficit, diabetes does not develop.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"54 4","pages":"Pages 184-195"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2017.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136920955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Síndrome metabólico, hipotiroidismo y riesgo cardiovascular en licenciadas y auxiliares de enfermería, Hospital Escuela Universitario octubre-noviembre 2016","authors":"Deysi Julissa Díaz-Valle,&nbsp;Katherine Rivas-Sevilla,&nbsp;Valeria Yanez-Salguero,&nbsp;Herman Leonel Zavala,&nbsp;Tirzo Israel Godoy","doi":"10.1016/j.raem.2017.09.002","DOIUrl":"10.1016/j.raem.2017.09.002","url":null,"abstract":"<div><h3>Background and objective</h3><p>Thyroid dysfunction in the population has significant consequences for numerous health problems, including cardiovascular diseases and metabolic syndrome. The objective of this study was to analyse the relationship between cardiovascular risk, hypothyroidism, and metabolic syndrome in nurses of the <em>Hospital Escuela Universitario</em> from October to November 2016.</p></div><div><h3>Patients and methods</h3><p>A descriptive, cross-sectional study was conducted on a stratified sample consisting of 150 auxiliary nurses and 50 registered nurses, all females. The interview technique was used in the data collection process, using a questionnaire consisting of 20 closed questions. The results were tabulated using the statistical software EPI-INFO version 7.2.0.1 and Microsoft Office Excel 2013. Univariate and bivariate analyses were performed.</p></div><div><h3>Results</h3><p>The study showed that 94 (47%) had neither non-metabolic syndrome nor sub-clinical hypothyroidism. The metabolic syndrome criteria was fulfilled by 82 (41%), 12 (6%) were only diagnosed with subclinical hypothyroidism, and 12 (6%) had both pathologies. The two main criteria for metabolic syndrome fulfilled by the study group were: 159 (79.5%) with central obesity and 151 (75.5%) with an HDL-cholesterol<!--> <!-->&lt;<!--> <!-->50<!--> <!-->mg/dL. The most important metabolic syndrome criteria found in this study group was triglycerides<!--> <!-->≥<!--> <!-->150<!--> <!-->mg/dL, with a score of 16. As regards cardiovascular risk, 194 (97%) nurses had a low risk.</p></div><div><h3>Conclusions</h3><p>Most of the study group had an altered body mass index and some associated dyslipidaemia. The prevalence of sub-clinical hypothyroidism in the nursing staff was similar to that found in other studies, and the prevalence of metabolic syndrome was higher than the reported worldwide (20-25%) and nationally (23%).</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"54 4","pages":"Pages e1-e8"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2017.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44971591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Síndrome de interrupción del tallo pituitario. Relaciones clínicas, bioquímicas y neurorradiológicas","authors":"Laura Cecilia Castro ,&nbsp;Silvia Edith Martín ,&nbsp;Sebastián Bulacio ,&nbsp;Daniela Dichko ,&nbsp;Liliana Silvano ,&nbsp;Gabriela Sobrero ,&nbsp;Cecilia Aguirre ,&nbsp;Liliana Franchioni de Muñoz ,&nbsp;Mirta Beatriz Miras","doi":"10.1016/j.raem.2017.08.001","DOIUrl":"10.1016/j.raem.2017.08.001","url":null,"abstract":"&lt;div&gt;&lt;p&gt;Pituitary stalk interruption syndrome (PSIS) is characterised by the combination of an interrupted or thin pituitary stalk, absent or ectopic posterior pituitary, and anterior pituitary hypoplasia. It is manifested as isolated (IGHD) or combined pituitary hormone deficiencies (CPHD) of variable degrees and timing of onset, with a wide spectrum of clinical phenotypes. PSIS may be an isolated morphological abnormality or be part of a syndrome. A retrospective evaluation is presented of clinical signs and symptoms present at early life stages, as well as an analysis of their relationship with hormone laboratory tests and diagnostic imaging in children with congenital hypopituitarism (CHP), and PSIS. This study was performed in a single centre on a sample of 42 children out of a total of 80 CHP patients, with a chronological age range between 5 days and 9.5 years from a database analysed over a period of 26 years. The study included 26/42 (62%) with CPHD and 16/42 (38%) with IGHD. The analysis of perinatal variables showed a natural delivery in 52% (11/21) of CPHD vs 13% (2/15) of IGHD. Four patients, two with CPHD and two IGHD had breech and transverse presentation respectively. All of them were resolved by caesarean section. The perinatal histories showed hypoglycaemia (61% CPHD vs 19% IGHD, &lt;em&gt;P&lt;/em&gt;=.0105), jaundice (38% CPHDvs25% IGHD), micropenis (75%CPHD), hypoglycaemic seizures (75% CPHD), and cholestasis (19% CPHD). The mean CA of consulting for CPHD patients was 2.1 years, 30% in neonatal period and 70% before 2 years. The mean chronical age (CA) was 3.6 years in IGHD patients, with 44% of them less than 2 years. MRI showed that 81% of CPHD patients had absence of pituitary stalk vs 19% with thin pituitary stalk (&lt;em&gt;P&lt;/em&gt;=.0001); Patients with IGHD presented 56% absence of pituitary stalk vs 44% with thin pituitary stalk (&lt;em&gt;P&lt;/em&gt;=.5067). All (100%) of the patients diagnosed in the neonatal stage had absent pituitary stalk. The characterisation of GH deficient patients by presence and type of hypothalamic-pituitary imaging abnormality provides valuable information as a predictor of phenotypic severity, treatment response, and the potential to develop additional hormonal deficiencies. We conclude that demonstrating PSIS in children with HPC provides valuable information as a predictor of phenotypic severity, presence of MPHD, and response to treatment. The low frequency of potentially dysfunctional positional obstetric history, as part of the pathophysiological mechanisms responsible for PSIS, would indicate the need to analyse the importance of possible genetic and epigenetic factors involved. Early diagnosis of HPC should be suspected in the presence of clinical signs and symptoms, such as hypoglycaemia, cholestasis, micropenis, and associated facial midline defects. MRI should be part of complementary studies in patients with this diagnostic suspicion, especially at an early age. Late recognition of this entity may increase m","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"54 4","pages":"Pages 151-159"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2017.08.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48697718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electronic survey of management of hyperprolactinemia in Brazil: Endocrinologists versus gynecologists","authors":"Vania dos Santos Nunes ,&nbsp;Henrique Claudio Vicentini ,&nbsp;Carlos Roberto Padovani ,&nbsp;Celia Regina Nogueira ,&nbsp;Lucio Vilar","doi":"10.1016/j.raem.2017.07.001","DOIUrl":"10.1016/j.raem.2017.07.001","url":null,"abstract":"<div><p>Hyperprolactinemia is a frequent condition in clinical practice, responsible for 20–25% of secondary amenorrhea cases. We performed an electronic survey among members of the Brazilian Society of Metabolism and Endocrinology (SBEM) and the Brazilian Federation of Association of Gynecology and Obstetrics (FEBRASGO) to assess diagnostic and therapeutic preferences for management of hyperprolactinemia. Electronic addresses of SBEM and FEBRASGO members were obtained from the directories of these societies, and these members were invited, through electronic messages (e-mail), to answer an online questionnaire that included 10 questions about the treatment of micro and macroprolactinomas, maximum dose of dopamine agonist, how to exclude primary hypothyroidism and macroprolactinemia, hyperprolactinemia and pregnancy. We received responses to the questionnaire by e-mail from 521 SBEM members and 233 FEBRASGO members. The results of this survey demonstrate that there are many area of agreement between SBEM and FEBRASGO members and most of their responses follow the latest Endocrine Society Guideline. Relative to a survey performed several years ago, our findings show that SBEM members have incorporated some of latest recommendations in this field. The principal issues of concern for both groups are duration of dopamine agonist treatment for patients with microprolactinoma and dopamine agonist withdrawal during pregnancy.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"54 3","pages":"Pages 124-129"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2017.07.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47609669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hipotiroidismo subclínico en pacientes con enfermedad renal crónica que concurren a centros de salud pública de la ciudad de Posadas, Misiones","authors":"Cristina Beatriz Aguirre ,&nbsp;María Susana Castillo Rascón ,&nbsp;Mariel Adriana Haseitel","doi":"10.1016/j.raem.2017.07.002","DOIUrl":"10.1016/j.raem.2017.07.002","url":null,"abstract":"<div><p>The objectives of the present study were: <em>1)</em> to determine the frequency of Subclinical Hypothyroidism (SCH) in patients with Chronic Renal Disease (CKD), and <em>2)</em> to evaluate the changes in renal function in patients with CKD and SCH after treatment with levothyroxine. A total of 182 patients were studied, 99 with CKD and 83 without CKD (control group), with ages between 20 and 70 years old, of both sexes, attending health centres and hospital clinics in Posadas, Misiones, Argentina. The frequency of SCH was 28.3% in the CKD group, and 14.5% in the control group (<em>P</em>=.025). Patients with CKD and SCH were referred to medical endocrinology, where after three months of treatment with levothyroxine, renal function was evaluated, after which a decrease in serum creatinine levels and an increase in the glomerular filtration rate were observed in all patients. Based on these findings, the study of thyroid function should be recommended for all patients with CKD of unknown cause, considering SCH among the possible causes of impaired renal function.</p></div>","PeriodicalId":78598,"journal":{"name":"Revista argentina de endocrinologia y metabolismo","volume":"54 3","pages":"Pages 130-135"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.raem.2017.07.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44973140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}