Journal of atherosclerosis research最新文献

{"title":"Differential resorption rates of subcutaneous implants of [3H]cholesterol, various [3H]cholesterol esters and [3H]cholesterol-[1-14C]linolenate","authors":"Y.H. Abdulla ,&nbsp;C.W.M. Adams,&nbsp;R.S. Morgan","doi":"10.1016/S0368-1319(69)80069-4","DOIUrl":"10.1016/S0368-1319(69)80069-4","url":null,"abstract":"<div><p>Free [³H] cholesterol, various [³H] cholesterol esters and [³H]cholesterol-[¹⁴C]linolenate were implanted subcutaneously in rats. Three weeks after implantation [³H] cholesterol linolenate and arachidonate were resorbed to a significantly greater extent than free [³H]cholesterol, [³H] cholesterol linolenate and the more saturated labelled sterol esters. [³H]Cholesterol was more rapidly mobilized than the saturated and monounsaturated [³H] cholesterol esters. The resorption of esterified cholesterol did not appear to depend on rapid hydrolysis of the fatty acid moiety and slow removal of the sterol nucleus, for ³H and ¹⁴C labels disappeared at nearly equal rates from implants of [³H]cholesterol-[l-¹⁴C]linolenate. Addition of antioxidants to the polyunsaturated ester implants did not significantly accelerate resorption, even though it did reduce chromolipid formation. We infer that esterification of cholesterol with linolenic or arachidonic acids would accelerate its removal from the normal or atherosclerotic arterial wall.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"9 1","pages":"Pages 81-85"},"PeriodicalIF":0.0,"publicationDate":"1969-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80069-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16854354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Der einfluss wiechen und harten trinkwassers auf die ausbildung arteriosklerotischer frühveränderungen und die plasmalipoide beim hausschwein","authors":"H. Püschner ,&nbsp;E. Dahme ,&nbsp;N. Zöllner ,&nbsp;G. Wolfram ,&nbsp;J. Kalich","doi":"10.1016/S0368-1319(69)80062-1","DOIUrl":"10.1016/S0368-1319(69)80062-1","url":null,"abstract":"<div><p>Two groups of pigs were kept under identical environmental conditions except for drinking water. One group was supplied with distilled (ion-exchanged) water, the other with normal drinking water. The arteriosclerotic lesions were studied using histologic and planimetric methods. Serum lipids were measured. The results of these determinations confirm the opinion of other investigators that the mineral content of the drinking water does not influence the formation of early arteriosclerotic lesions in swine.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"9 1","pages":"Pages 17-23"},"PeriodicalIF":0.0,"publicationDate":"1969-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80062-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16861446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary arteries in immature monkeys","authors":"Z. Vlodaver,&nbsp;J. Medalie ,&nbsp;H.N. Neufeld","doi":"10.1016/S0368-1319(68)80006-7","DOIUrl":"10.1016/S0368-1319(68)80006-7","url":null,"abstract":"<div><p>A histological study of the structural changes in the coronary arteries of 53 unselected immature monkeys is presented.</p><p>Two species of Old World monkey—23 rhesus and 30 vervet monkeys were studied.</p><p>The development of intimai changes in these animals is similar to the degenerative and proliferative changes seen in human coronary arteries during early life.</p><p>The musculo-elastic layer found in man does not develop in young monkeys.</p><p>The intimai changes encountered in the immature captive monkeys in this study were apparently not related to the fat content of the diet, which was low in both groups, or to the level of serum cholesterol and phospholipids, which were within normal limits.</p><p>The possible relation between stress and physical activity and the development of intimai changes in the captive monkeys is stressed and the need for further studies to evaluate this problem is emphasized.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"8 6","pages":"Pages 923-933"},"PeriodicalIF":0.0,"publicationDate":"1968-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(68)80006-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16063229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relation of levels of dietary fat to atrial thrombosis in RF mice","authors":"Ben R. Clower (Fellow of the Mississippi Heart Association)","doi":"10.1016/S0368-1319(68)80002-X","DOIUrl":"10.1016/S0368-1319(68)80002-X","url":null,"abstract":"<div><p>Massive atrial thrombosis developed in <em>R_F</em> mice when fed a lipotropic-deficient diet containing either 40 %, 28 % or 6 % levels of lard as the fat. The protein content was 8 % casein. Carbohydrate (sucrose) levels of 45.5 %, 57.5 % and 79.5 % were used to balance the range in amount of fat. Within the 40 % fat group, 65 % of the mice developed atrial thrombosis as compared to a 36 % and 30 % incidence in the 28 % and 6 % fat level groups. The highest incidence of atrial lesions occurred during 10–12 weeks in the 6 % fat group, and during 18–22 weeks in mice fed the 28 % and 40 % fat levels. After feeding the diets for as long as 20 weeks the incidence of atrial thrombosis decreased rapidly in the 6 % and 28 % fat level groups. In contrast the incidence did not decline in the 40 % group until after 40 weeks.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"8 6","pages":"Pages 885-890"},"PeriodicalIF":0.0,"publicationDate":"1968-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(68)80002-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16783441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L’infiltration lipidique des protheses valvulaires de starr","authors":"R. Noiret ,&nbsp;P. Penther,&nbsp;J. Bensaid,&nbsp;J.-L. Beaumont,&nbsp;J. Lenegre","doi":"10.1016/S0368-1319(68)80012-2","DOIUrl":"10.1016/S0368-1319(68)80012-2","url":null,"abstract":"<div><p>Afin de contribuer à une étude des facteurs sanguins et hémodynamiques de l’athérosclérose, on a entrepris d’analyser les lipides présents dans les billes en matière plastique provenant de 4 valves de Starr ayant fonctionné pendant 34,28,4 et 2.5 mois. Deux d’entre elles proviennent de l’orifice aortique,une autre était insérée en position mitrale et la quatrième dans l’orifice tricuspide. Ces deux dernières proviennent du měme patient. Les lipides des valves ont ététudiés par Chromatographie en couche mince de silica-gel après extraction par le mélange de <span>Folch</span><em>et al.</em> Les 4 valves avaient un aspect jaunâatre, très différent de celui des valves neuves. L’une d’elle était rétractée. Dans toutes les prothèses, on a trouvé tous les lipides du plasma normal: esters du cholestérol, triglycérides, acides gras, cholestérol, phospholipides et de plus, on y a découvert la présence de monoglycérides et de diglycérides. En outre, les valves tricuspide et mitrale renferment une substance que l’on retrouve également dans le plasma laiteux. La prothèse tricuspide est de loin la plus riche en lipides, notamment en esters du cholestérol et en cholestérol, mais ces divers résultas devront ětre confirmés par une étude statistique.</p><p>Ces résultats permettent de dire que les lipides présents dans toute l’épaisseur des valves proviennent de la pénétration profonde des lipoprotéines du sang dans le matériel apparemment inerte de la prothèse. En outre, le rôle probable de l’état du sang circulant et de la pression sanguine dans l’apparition des altérations des valves de Starr rappelle à bien des égards, ce qu’on sait des conditions circulatoires qui provoquent l’athérosclérose. A ce titre, l’étude du devenir des billes en matière plastique placées dans les orifices cardiaques fournit un modèle de recherche particulièrement intéressant pour l’étude de cette maladie.</p></div><div><p>In an effort to contribute to the study of serum factors and haemodynamics in atherosclerosis, we analysed lipids present in the plastic balls of four starr valves which had been in position for 34, 28, 4 and 2.5 months, respectively. Two balls originated from an aortic valve prosthesis; the third came from a mitral and the fourth from a tricuspid valve prosthesis. The last two came from the same patient. The lipids were studied by thin-layer (silica-gel) chromatography after extraction with the aid of the mixture of <span>Folch</span><em>et al.</em> The four valves showed a yellowish appearance quite different from that of new valves. One was retracted. In all prostheses we found all the normal plasma lipids—cholesterol esters, triglycerides, fatty acids, cholesterol and phospholipids—and in addition we discovered monoglycerides and diglycerides. The tricuspid and mitral prostheses contained a substance which is also found in the milky plasma. The tricuspid prosthesis had by far the largest content of lipids, particularly cholesterol ester and cholesterol. T","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"8 6","pages":"Pages 975-980"},"PeriodicalIF":0.0,"publicationDate":"1968-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(68)80012-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16783449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term heparin infusion and plasma lipoprotein lipase activity","authors":"J.R. Muir","doi":"10.1016/S0368-1319(68)80014-6","DOIUrl":"10.1016/S0368-1319(68)80014-6","url":null,"abstract":"<div><p>The effect of a prolonged intravenous infusion of heparin on plasma lipolytic activity has been studied in 5 patients following recent myocardial infarction. The level of lipoprotein lipase in the plasma fell over the first 3-7 days, and then rose to a level higher than that present on the first day of the heparin infusion. This secondary peak was followed by a further fall in plasma activity.</p><p>The fluctuations in plasma lipoprotein lipase activity may have been due to changes in the sensitivity of the patients to heparin. Whether this was the result of acute myocardial infarction is not clear, as no control studies have been performed. The initial low levels of plasma enzyme may have been due to suppression of enzyme synthesis by high levels of plasma catecholamines and free fatty acids following the infarction.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"8 6","pages":"Pages 983-987"},"PeriodicalIF":0.0,"publicationDate":"1968-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(68)80014-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16783455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enzymatic studies of chondroitin sulphates in human arterial tissue","authors":"K. Murata,&nbsp;T. Harada,&nbsp;K. Okubo","doi":"10.1016/S0368-1319(68)80009-2","DOIUrl":"10.1016/S0368-1319(68)80009-2","url":null,"abstract":"<div><p></p><ul><li><span>(1)</span><span><p>Isomeric chondroitin sulphates of human arterial tissues were analysed by enzymatic methods with chondroitinases and sulphatases.</p></span></li><li><span>(2)</span><span><p>The enzymatic methods furnished a linear relation between the amount of arterial tissue sample and the yield of chondroitin sulphate isomers.</p></span></li><li><span>(3)</span><span><p>The present data showed that chondroitin sulphate C is a major component in arterial tissue, followed by chondroitin sulphate B as a lesser component. Evidence is presented for the presence of chondroitin sulphate A in approximately equal amount to chondroitin sulphate B. This finding was supported by chromatographic separation of the degraded products of chondroitin sulphate isomers with chondroitinases.</p></span></li></ul></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"8 6","pages":"Pages 951-958"},"PeriodicalIF":0.0,"publicationDate":"1968-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(68)80009-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16783448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The quantitation of aortic and coronary atherosclerotic lesions","authors":"F. Kuthan","doi":"10.1016/S0368-1319(68)80013-4","DOIUrl":"10.1016/S0368-1319(68)80013-4","url":null,"abstract":"","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"8 6","pages":"Pages 981-982"},"PeriodicalIF":0.0,"publicationDate":"1968-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(68)80013-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16783450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ethyl-p-chlorophenoxyisobutyrate, clofibrate, on the plasma and red blood cell free fatty acids of the rat","authors":"R.J. Cenedella,&nbsp;J.J. Jarrell,&nbsp;L.H. Saxe","doi":"10.1016/S0368-1319(68)80004-3","DOIUrl":"10.1016/S0368-1319(68)80004-3","url":null,"abstract":"<div><p>By using modifications of the Dole free fatty acid (FFA) extraction procedure, the present study demonstrated that ethyl-<em>p</em>-chlorophenoxyisobutyrate (Clofibrate or Atromid-S) given orally and intraperitoneally to rats at doses of 50, 100 and 800 mg/kg/day for 9–30 days produced 40–80 % decreases in the levels of plasma and red blood cell FFA. Near maximum FFA-lowering effects were obtained with the lower doses. These observations support the concept that some of the clofibrate-induced reductions in the circulating levels of cholesterol, phospholipids, and triglycerides are due to a reduction in FFA availability. Besides decreasing the circulating levels of FFA, Clofibrate treatment resulted in certain alterations in the relative composition of the plasma FFA. In particular, there was an increase in the relative content of plasma oleic acid, from 12 % of the total plasma in untreated rats to about 22 % in treated animals (100 mg/kg/day, i.p., for 24 days), and a decrease in the linoleic acid content, from about 9 % in untreated to 3 % in treated animals.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"8 6","pages":"Pages 903-911"},"PeriodicalIF":0.0,"publicationDate":"1968-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(68)80004-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16783445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A relatively non-toxic thrombogenic diet for rats","authors":"R.B. Wilson,&nbsp;W.S. Hartroft","doi":"10.1016/S0368-1319(68)80008-0","DOIUrl":"10.1016/S0368-1319(68)80008-0","url":null,"abstract":"<div><p>Rats were fed either a basal high-fat diet containing, among other ingredients, 5 % cholesterol and 0.3 % propylthiouracil or one of four modifications of the diet containing lesser amounts of these two ingredients. It was found that the amounts of dietary cholesterol and propylthiouracil could be reduced to at least 1 % and 0.02 %, respectively, without decreasing the incidence of cardiac thrombi and infarcts, but the high mortality seen during the first month when animals were given the basal diet, was abolished.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"8 6","pages":"Pages 945-950"},"PeriodicalIF":0.0,"publicationDate":"1968-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(68)80008-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16783452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}