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Journal of atherosclerosis research最新文献

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Ileal bypass in the treatment of the hyperlipidemias 回肠旁路术治疗高脂血症
Journal of atherosclerosis research Pub Date : 1969-07-08 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80075-X
Henry Buchwald
{"title":"Ileal bypass in the treatment of the hyperlipidemias","authors":"Henry Buchwald","doi":"10.1016/S0368-1319(69)80075-X","DOIUrl":"10.1016/S0368-1319(69)80075-X","url":null,"abstract":"","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 1","pages":"Pages 1-4"},"PeriodicalIF":0.0,"publicationDate":"1969-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80075-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16462691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
The effect of clofibrate on the serum triglyceride concentration in normal males fed high-sucrose diets 氯贝酸酯对饲喂高糖饲料的正常雄性血清甘油三酯浓度的影响
Journal of atherosclerosis research Pub Date : 1969-07-08 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80086-4
D. Zakim , R.H. Herman
{"title":"The effect of clofibrate on the serum triglyceride concentration in normal males fed high-sucrose diets","authors":"D. Zakim ,&nbsp;R.H. Herman","doi":"10.1016/S0368-1319(69)80086-4","DOIUrl":"10.1016/S0368-1319(69)80086-4","url":null,"abstract":"<div><p>The effect of Clofibrate administration on the serum triglyceride response to high caloric sucrose diets has been investigated in normal males. In each subject the sucrose diet increased the serum triglyceride concentration. Clofibrate treatment of normal individuals eating an <em>ad-libitum</em> diet did not decrease the serum triglyceride concentration. Clofibrate therapy did not block the hypertriglyceridemic response to the sucrose diet.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 1","pages":"Pages 91-95"},"PeriodicalIF":0.0,"publicationDate":"1969-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80086-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16462703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
The effect of physical exercise on cholesterol degradation in man 体育锻炼对人体胆固醇降解的影响
Journal of atherosclerosis research Pub Date : 1969-07-08 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80089-X
M.R. Malinow, A. Perley
{"title":"The effect of physical exercise on cholesterol degradation in man","authors":"M.R. Malinow,&nbsp;A. Perley","doi":"10.1016/S0368-1319(69)80089-X","DOIUrl":"10.1016/S0368-1319(69)80089-X","url":null,"abstract":"<div><p>[26-<sup>14</sup>C]Cholesterol was injected intravenously into 4 healthy male subjects. Muscular exercise greatly increased the respiratory excretion of <sup>14</sup>C0<sub>2</sub>.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 1","pages":"Pages 107-111"},"PeriodicalIF":0.0,"publicationDate":"1969-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80089-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16462687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Effect of insulin of the in vitro synthesis of sterol and fatty acid by aorta and liver from diabetic rats 胰岛素对糖尿病大鼠主动脉和肝脏体外合成甾醇和脂肪酸的影响
Journal of atherosclerosis research Pub Date : 1969-07-08 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80092-X
D.P. Chattopadhay, J.M. Martin
{"title":"Effect of insulin of the in vitro synthesis of sterol and fatty acid by aorta and liver from diabetic rats","authors":"D.P. Chattopadhay,&nbsp;J.M. Martin","doi":"10.1016/S0368-1319(69)80092-X","DOIUrl":"10.1016/S0368-1319(69)80092-X","url":null,"abstract":"<div><p>In the <em>in vitro</em> aorta intima-media preparation, glucose stimulates the synthesis of non-saponifiable lipids and fatty acids (FA), while addition of insulin has no effect. The synthesis of these lipids is depressed in aorta and liver from diabetic rats. Insulin treatment increases FA synthesis by aorta of diabetic rats only, but in liver of diabetic and normal animals insulin enhances the synthesis of FA and non-saponifiable lipids.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 1","pages":"Pages 131-134"},"PeriodicalIF":0.0,"publicationDate":"1969-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80092-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16462689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
The cholesterol-lowering effect of dextran-40 葡聚糖-40的降胆固醇作用
Journal of atherosclerosis research Pub Date : 1969-07-08 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80076-1
J. Ditzel, J. Dyerberg
{"title":"The cholesterol-lowering effect of dextran-40","authors":"J. Ditzel,&nbsp;J. Dyerberg","doi":"10.1016/S0368-1319(69)80076-1","DOIUrl":"10.1016/S0368-1319(69)80076-1","url":null,"abstract":"<div><p>During a double-blind investigation of the haemorrheological effects of low molecular weight dextran (mol.wt. 40,000) in 33 patients with acute myocardial infarction, a significant cholesterol-lowering effect of Dextran-40 was demonstrated.</p><p>The average serum cholesterol level decreased from 264 mg/100 ml to 166 mg/100 ml on the 7th day in the group of patients receiving a daily infusion of 500 ml of Dextran-40 for 5 days, whereas the serum cholesterol level only decreased from 289 mg/100 ml-240 mg/100 ml in the placebo group. The possible mechanism of the hypolipidaemic effect of dextran and other osmotic active compounds is discussed.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 1","pages":"Pages 5-10"},"PeriodicalIF":0.0,"publicationDate":"1969-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80076-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16002779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Phospholipid changes in the eye and aorta of cholesterol-fed rabbits 喂胆固醇家兔眼睛和主动脉磷脂的变化
Journal of atherosclerosis research Pub Date : 1969-07-08 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80091-8
H.G. Roscoe, B.A. Riccardi
{"title":"Phospholipid changes in the eye and aorta of cholesterol-fed rabbits","authors":"H.G. Roscoe,&nbsp;B.A. Riccardi","doi":"10.1016/S0368-1319(69)80091-8","DOIUrl":"10.1016/S0368-1319(69)80091-8","url":null,"abstract":"<div><p>The phospholipid changes which occur in the diseased cornea, iris and atherosclerotic intima from rabbits fed 1 % cholesterol for 2 or 3 months, were studied. A significant correlation between total cholesterol and total phospholipid was found in each of the three tissues at both time intervals studied. The composition of the tissue phospholipid, which accumulated as a result of cholesterol feeding, was compared to that of the plasma in animals fed 1% cholesterol for 3 months. The distribution of phospholipid in the diseased cornea was essentially the same as that found in the plasma, both being characterized by a high percentage of lecithin (77.5 and 67.4 %, respectively). On the other hand, the phospholipids obtained from the diseased iris and atherosclerotic intima contained a high percentage of sphingomyelin (35.0 and 37.7 %, respectively) and lower percentage of lecithin (34.0 and 40.1 %, respectively) than did the plasma (sphingomyelin = 15.8 % and lecithin = 67.4 %). The decrease in percent of tissue lecithin was not a result of increase in sphingomyelin since the concentration of the two phospholipids increased in both tissues. These data suggest that the mechanism of lipid accumulation in the atherosclerotic intima and the diseased iris may be similar and may not be the result of simple lipid infiltration from the plasma.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 1","pages":"Pages 123-130"},"PeriodicalIF":0.0,"publicationDate":"1969-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80091-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16462688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Aortic atherosclerosis of turkeys induced by feeding of cholesterol 喂胆固醇致火鸡主动脉粥样硬化
Journal of atherosclerosis research Pub Date : 1969-07-08 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80083-9
C.F. Simpson, R.H. Harms
{"title":"Aortic atherosclerosis of turkeys induced by feeding of cholesterol","authors":"C.F. Simpson,&nbsp;R.H. Harms","doi":"10.1016/S0368-1319(69)80083-9","DOIUrl":"10.1016/S0368-1319(69)80083-9","url":null,"abstract":"<div><p>Aortic atherosclerosis was induced by feeding turkeys 2% cholesterol from 6–14, 24, 30 and 32 weeks of age. Simple, intermediate and advanced stages of aortic atherosclerosis, resulting from feeding cholesterol for the 4 different time intervals, were studied by histologic and electron microscopic techniques. The simplest lesion was characterized by lipid vacuoles in the aortic endothelium, non-membrane bound lipid between cells in the plaque, widening of the extracellular spaces, and fraying of basement membranes of modified smooth muscle cells.</p><p>An intermediate lesion contained foam cells and necrotic modified smooth muscle cells widely separated by fibrillar material and pools of lipid which appeared to be in the process of crystallization.</p><p>The advanced atherosclerotic lesions contained foam cells. Many of these cells were necrotic, and some were binucleated. Cholesterol and mineral were present in foam cells as well as in the extracellular spaces. Fibrillar-flocculent material was also present in these spaces.</p><p>The origin of foam cells and fibrillar-flocculent material in the advanced atheroma is also discussed.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 1","pages":"Pages 63-75"},"PeriodicalIF":0.0,"publicationDate":"1969-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80083-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16462699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Preliminary evaluation of the hypolipidemic effects in man of a new phenolic ether (Su-13437, CIBA) 新型酚醚(Su-13437, CIBA)降血脂作用的初步评价
Journal of atherosclerosis research Pub Date : 1969-07-08 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80088-8
M.M. Best, C.H. Duncan
{"title":"Preliminary evaluation of the hypolipidemic effects in man of a new phenolic ether (Su-13437, CIBA)","authors":"M.M. Best,&nbsp;C.H. Duncan","doi":"10.1016/S0368-1319(69)80088-8","DOIUrl":"10.1016/S0368-1319(69)80088-8","url":null,"abstract":"<div><p>A new phenolic ether (Su-13437, CIBA) which has been reported to be hypolipidemic in the rat has been given to 8 volunteer subjects for an 8-week period. A reduction in serum triglyceride and to a lesser extent cholesterol and phospholipid occurred in 7 of the 8 subjects.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 1","pages":"Pages 103-106"},"PeriodicalIF":0.0,"publicationDate":"1969-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80088-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16462686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Magnesium levels in patients with coronary heart disease 冠心病患者体内的镁含量
Journal of atherosclerosis research Pub Date : 1969-07-08 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80085-2
D.J. Murnaghan , M.P. Ryan, N.J. Hickey, B.J. Maurer , D.J. Hingerty, R. Mulcahy
{"title":"Magnesium levels in patients with coronary heart disease","authors":"D.J. Murnaghan ,&nbsp;M.P. Ryan,&nbsp;N.J. Hickey,&nbsp;B.J. Maurer ,&nbsp;D.J. Hingerty,&nbsp;R. Mulcahy","doi":"10.1016/S0368-1319(69)80085-2","DOIUrl":"10.1016/S0368-1319(69)80085-2","url":null,"abstract":"<div><p>The serum magnesium levels of 214 patients with coronary heart disease were significantly higher (<em>P</em> &lt; 0.01) than in 54 control subjects. Correlations of serum magnesium with 10 CHD attributes or risk factors failed to show any significant association except for a negative association (<em>P</em> &lt; 0.05) with glucose tolerance. The literature on serum magnesium levels in patients with coronary heart disease is briefly reviewed.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 1","pages":"Pages 85-89"},"PeriodicalIF":0.0,"publicationDate":"1969-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80085-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16462700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Pig atherosclerosis 猪动脉粥样硬化
Journal of atherosclerosis research Pub Date : 1969-07-08 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80084-0
D. Harman (Professor of Biochemistry and Professor of Medicine)
{"title":"Pig atherosclerosis","authors":"D. Harman (Professor of Biochemistry and Professor of Medicine)","doi":"10.1016/S0368-1319(69)80084-0","DOIUrl":"10.1016/S0368-1319(69)80084-0","url":null,"abstract":"<div><p>The antihistamine, chlorpheniramine, has been shown previously to inhibit cholesterol-induced rabbit atherosclerosis. The effect of chlorpheniramine has now been evaluated on the spontaneous atherosclerosis of uncastrated male minipigs.</p><p>Three groups of pigs of 10 each were started at age 3 months on a nutritionally adequate diet containing 30 % by weight of lard to which was added either 0, 0.5 or 1.0 mg of chlorpheniramine/kg body weight. The animals were killed and autopsied at age 24 months. The aortas were stained with Sudan IV and graded on a basis of 0-4 + in the arch and abdominal areas. Atherosclerosis involvement was small in all groups; there were no significant differences although the 1.0-mg chlorpheniramine group had the least atherosclerosis.</p><p>Chlorpheniramine appeared to increase the serum cholesterol levels while analysis of the fatty acid composition of the total serum lipids showed an increase in the percentage of 18:2 and decreases in 16:0 and 18:1.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 1","pages":"Pages 77-84"},"PeriodicalIF":0.0,"publicationDate":"1969-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80084-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15494182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
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