Journal of atherosclerosis research最新文献_第5页

Effects of exogenous and endogenous norepinephrine on the oxygen availability of intact muscular arteries 外源性和内源性去甲肾上腺素对完整肌肉动脉供氧性的影响

Journal of atherosclerosis research Pub Date : 1969-07-08 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80077-3

A.J. Moss, S.L. Minken, P. Samuelson, C. Angell

{"title":"Effects of exogenous and endogenous norepinephrine on the oxygen availability of intact muscular arteries","authors":"A.J. Moss, S.L. Minken, P. Samuelson, C. Angell","doi":"10.1016/S0368-1319(69)80077-3","DOIUrl":"10.1016/S0368-1319(69)80077-3","url":null,"abstract":"<div><p>A Polarographic technique was used to evaluate changes in arterial wall oxygen availability during systemically administered and endogenously released norepinephrine. A 125-<em>μ</em>, diameter bare-tipped platinum electrode was advanced into the media of exposed femoral arteries in 23 anesthetized dogs. Tissue oxygen availability was recorded in terms of current flow through the Polarographic electrode system. Intravenously administered norepinephrine produced a vasopressor response and was associated with significant reductions in the oxygen current in intact and autografted vessels. Similar reductions in intramural oxygen availability were produced by ipsilateral lumbar sympathetic ganglia stimulation. The norepinephrine-induced changes in oxygen availability were produced even when the blood pressure in the femoral artery was held constant by pump perfusion. Furthermore, intramural oxygen availability could not be reduced by passive increases in luminal pressure. These findings indicate that norepinephrine reduced intramural oxygen availability by a direct metabolic effect on the smooth muscle of the vessel wall.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 1","pages":"Pages 11-18"},"PeriodicalIF":0.0,"publicationDate":"1969-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80077-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16462694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

The influence of myristic acid of dietary fats on serum cholesterol 饲粮脂肪中肉豆蔻酸对血清胆固醇的影响

Journal of atherosclerosis research Pub Date : 1969-07-08 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80081-5

S. Mukherjee, R. Dutta, C. Bandyopadhyay

引用次数: 6

Oxidative phosphorylation in mitochondrial fractions isolated from rat aortae 从大鼠主动脉分离的线粒体片段氧化磷酸化

Journal of atherosclerosis research Pub Date : 1969-07-08 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80087-6

N. Simard-Duquesne

引用次数: 9

The distribution of lipids in malignant hypertensive fibrinoid necrosis 恶性高血压纤维蛋白样坏死的脂质分布

Journal of atherosclerosis research Pub Date : 1969-07-08 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80082-7

B. Veress, H. Jellinek, A. Kóczé, Ilona Venesz

引用次数: 0

Atheromata in an inbred strain of mice 一种近交系小鼠的动脉粥样硬化

Journal of atherosclerosis research Pub Date : 1969-07-08 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80090-6

J.S. Thompson

引用次数: 41

Platelet size and function in ischaemic heart disease 缺血性心脏病的血小板大小和功能

Journal of atherosclerosis research Pub Date : 1969-07-08 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80080-3

J.B. Enticknap, P.G. Gooding, T.S. Lansley, P.R.D. Avis

{"title":"Platelet size and function in ischaemic heart disease","authors":"J.B. Enticknap, P.G. Gooding, T.S. Lansley, P.R.D. Avis","doi":"10.1016/S0368-1319(69)80080-3","DOIUrl":"10.1016/S0368-1319(69)80080-3","url":null,"abstract":"<div><p>Platelet size and function have been studied in 192 subjects in equally-sized and carefully-matched groups of controls and patients with either acute or chronic ischaemic heart disease. The data were analysed by computer to determine significant correlations.</p><p>The platelets of subjects who have recently suffered acute myocardial necrosis are larger than those of control subjects and they respond less well and more slowly to ADP. They do not differ in numbers nor in behaviour at glass surfaces. The platelets of subjects with chronic ischaemic heart disease have properties intermediate between those of the acutely ill subjects and controls. As the healing of myocardial necrosis proceeds, these platelet abnormalities progressively reduce. The changes are insufficiently large to be of value in individual clinical diagnosis.</p><p>Adhesive platelets are smaller than non-adhesive platelets, but this difference is much more marked in control than in diseased subjects. We have not shown any differences between platelets that aggregate with ADP and those which do not.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"10 1","pages":"Pages 41-49"},"PeriodicalIF":0.0,"publicationDate":"1969-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80080-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16462693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Exacerbation of spontaneously occurring arteriosclerosis in breeder rats following chronic treatment with cortisone 可的松慢性治疗后大鼠自发性动脉硬化的恶化

Journal of atherosclerosis research Pub Date : 1969-05-06 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80021-9

B.C. Wexler

引用次数: 10

The pediatric aspects of atherosclerosis 动脉粥样硬化的儿科方面

Journal of atherosclerosis research Pub Date : 1969-05-06 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80020-7

J.P. Strong, H.C. McGill Jr.

{"title":"The pediatric aspects of atherosclerosis","authors":"J.P. Strong, H.C. McGill Jr.","doi":"10.1016/S0368-1319(69)80020-7","DOIUrl":"10.1016/S0368-1319(69)80020-7","url":null,"abstract":"<div><p>Atherosclerosis begins in childhood with the appearance of aortic fatty streaks. Aortic fatty streaks of some degree are present in practically all individuals from every human population that has been studied. The average amount of aortic intimai surface involved with fatty streaks does not differ much among human populations.</p><p>Coronary fatty streaks begin to form in adolescence. Most persons 20-29 years of age have coronary fatty streaks of some degree, even if they are from low socioeconomic strata.</p><p>While fatty streaking is clinically harmless and potentially reversible, the progression of fatty streaks to more advanced lesions is a critical stage of atherosclerosis. This conversion takes place at earlier ages in populations with high morbidity and mortality from coronary heart disease.</p><p>The development of fibrous plaques begins in the twenties. Therefore, even though control programs which attempt to reduce coronary heart disease by preventing atherosclerosis may meet some success when applied to middle-aged persons, these programs should be directed toward individuals in the twenties and thirties for maximum benefits. Dietary habits that retard atherosclerosis should be established in childhood.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"9 3","pages":"Pages 251-265"},"PeriodicalIF":0.0,"publicationDate":"1969-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80020-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16429065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 154

Arteriosclerosis and hypoxia 动脉硬化与缺氧

Journal of atherosclerosis research Pub Date : 1969-05-06 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80023-2

C. Garbarsch, M.E. Matthiessen, P. Helin, I. Lorenzen

{"title":"Arteriosclerosis and hypoxia","authors":"C. Garbarsch, M.E. Matthiessen, P. Helin, I. Lorenzen","doi":"10.1016/S0368-1319(69)80023-2","DOIUrl":"https://doi.org/10.1016/S0368-1319(69)80023-2","url":null,"abstract":"<div><p>Male albino rabbits were exposed to short daily periods of systemic hypoxia for 2 weeks. Thirteen out of 16 rabbits showed gross arteriosclerotic changes, while no gross changes were found in 14 controls. The microscopic changes were primarily located to the media and consisted of calcified necrotic foci surrounded by amorphous, metachromatic intercellular substance. Metachromatic intercellular substance was also found in the form of “lakes” between the elastic membranes. A similar increase in the metachromatical intercellular substance was seen in the intima. The meta-chromasia indicated accumulation of acid mucopolysaccharides, which in the present study appeared to be primarily chondroitin-4-sulphate and/or chondroitin-6-sulphate and some dermatan sulphate and/or heparitin sulphate. A distinct calcification of the endothelial lining was observed. The changes probably reflect a damage of the aortic wall following systemic hypoxia and secondary non-specific processes of repair in the vascular connective tissue. The alterations have features in common with human arteriosclerosis.</p></div>","PeriodicalId":78351,"journal":{"name":"Journal of atherosclerosis research","volume":"9 3","pages":"Pages 283-294"},"PeriodicalIF":0.0,"publicationDate":"1969-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0368-1319(69)80023-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72280017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 56

The effect of dipyridamole on increased levels of platelet adhesiveness 双嘧达莫对血小板粘附水平升高的影响

Journal of atherosclerosis research Pub Date : 1969-05-06 Epub Date: 2008-09-15 DOI: 10.1016/S0368-1319(69)80027-X

E.E. Mayne, J.M. Bridges, J.A. Weaver

引用次数: 7