Effect of insulin of the in vitro synthesis of sterol and fatty acid by aorta and liver from diabetic rats

Abstract

In the in vitro aorta intima-media preparation, glucose stimulates the synthesis of non-saponifiable lipids and fatty acids (FA), while addition of insulin has no effect. The synthesis of these lipids is depressed in aorta and liver from diabetic rats. Insulin treatment increases FA synthesis by aorta of diabetic rats only, but in liver of diabetic and normal animals insulin enhances the synthesis of FA and non-saponifiable lipids.