Anesthesiology Research and Practice最新文献

{"title":"Assessment of Maternal Satisfaction and Associated Factors among Parturients Who Underwent Cesarean Delivery under Spinal Anesthesia at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2019.","authors":"Samuel Debas Bayable,&nbsp;Seid Adem Ahmed,&nbsp;Girmay Fitiwi Lema,&nbsp;Debas Yaregal Melesse","doi":"10.1155/2020/8697651","DOIUrl":"https://doi.org/10.1155/2020/8697651","url":null,"abstract":"Background Spinal anesthesia is the most common anesthetic technique for cesarean delivery. Patient satisfaction is a subjective and complicated concept, involving physical, emotional, psychological, social, and cultural factors. Regular evaluation of maternal satisfaction related to anesthesia service is an important parameter to the required changes and expansion of high-quality care services. We aimed to assess maternal satisfaction and associated factors among parturients who underwent cesarean delivery under spinal anesthesia. Methods Institutional-based cross-sectional study was conducted from February to May 2019. A total of 383 parturients were enrolled to assess maternal satisfaction using a 5-point Likert scale. Both bivariable and multivariable logistic regression analyses were done. Variables of p value ≤0.2 in the bivariable analysis were a candidate for multivariable logistic regression. A p value <0.05 was considered as significantly associated with maternal satisfaction at 95% CI. Results This study revealed that 315 (82.3%) of the parturients were satisfied. Single spinal prick attempts (AOR = 2.08, 95% CI = 1.05–4.11), successful spinal block (AOR = 7.17, 95% CI = 3.33–15.43), less incidence of postdural puncture headache (AOR = 2.36, 95% CI = 1.33–4.20), and prophylactic antiemetic use (AOR = 0.35, 95% CI = 0.19–0.66) were positively associated with maternal satisfaction. Conclusions The overall maternal satisfaction receiving spinal anesthesia was considerably low. Single spinal prink attempts, successful spinal block, and less incidence of postural puncture headache can increase maternal satisfaction. Therefore, effective perioperative management, skillful techniques, and using the small-gauge Quincke spinal needle (25–27 gauge) may increase the maternal satisfaction and quality of spinal anesthesia management.","PeriodicalId":7834,"journal":{"name":"Anesthesiology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8697651","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38526694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Controlled Trial: Comparison of 4% Articaine versus 0.5% Bupivacaine for Ambulatory Orthopedic Surgery under Supraclavicular Block.","authors":"Simon H Armanious, Gamal A Abdelhameed","doi":"10.1155/2020/2194873","DOIUrl":"10.1155/2020/2194873","url":null,"abstract":"<p><strong>Background: </strong>Articaine has been used in many dental and ophthalmic outpatient procedures. In the era of ultrasound-guided regional techniques, we searched for short and potent local anesthetic for patients undergoing ambulatory upper limb procedures. However, studies about articaine efficacy in brachial plexus block are limited. In this study, we compared its safety and efficacy against bupivacaine as a commonly used anesthetic agent for ultrasound-guided supraclavicular brachial plexus block.</p><p><strong>Methods: </strong>This randomized prospective study was performed at Ain Shams University Hospital from January to March 2020. A total of 117 patients aged 20 to 60 years, with the American Society of Anesthesiologists physical status I and II, were enrolled in the study. Patients were randomly allocated into two groups: in group A, patients received 30 ml articaine 2%, and in group B, patients received 30 ml of bupivacaine 0.5%. We measured motor and sensory block duration as a primary outcome. Other secondary outcomes such as onset of block, duration of analgesia, patient satisfaction, and time to home discharge readiness were also measured.</p><p><strong>Results: </strong>We analyzed data collected from 97 patients. The motor block duration was significantly shorter in group A (165.73 ± 20.33 min) than in group B (220.27 ± 37.73 min). The onset of motor block was faster in group A (8.73 ± 4.33 min), and the postoperative VAS score was lower in group B. Patients in group A achieved an earlier home discharge of 289.67 ± 2.73 min.</p><p><strong>Conclusion: </strong>Earlier resolution of articaine block makes it more favorable than bupivacaine for ambulatory surgery. This trial is registered with (NCT04189198).</p>","PeriodicalId":7834,"journal":{"name":"Anesthesiology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38464952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Undesirable Postoperative Anesthesia Outcomes at Two National Referral Hospitals: A Cross-Sectional Study in Eritrea.","authors":"Yonatan Mehari Andemeskel,&nbsp;Traudl Elsholz,&nbsp;Ghidey Gebreyohannes,&nbsp;Eyasu H Tesfamariam","doi":"10.1155/2020/9792170","DOIUrl":"https://doi.org/10.1155/2020/9792170","url":null,"abstract":"<p><strong>Background: </strong>Postoperative undesirable anesthesia outcomes are common among patients undergoing surgery. They may affect body systems and lead into more serious postoperative problems. This research is conducted in the Eritrean National Referral Hospitals with the aim of assessing the prevalence of undesirable anesthesia outcomes during the postoperative period.</p><p><strong>Method: </strong>A cross-sectional study design was applied on 470 patients who underwent different types of surgeries within a three-month period. Patients were interviewed 24 hours after operation (POD 1) using the Leiden Perioperative care Patient Satisfaction questionnaire (LPPSq). This study reports one component of a large study conducted. The dimension \"Discomfort and needs\" of the LPPSq was considered, and the measurements of that dimension are presented in this report. Items of the dimension were standardized and measured using a five-point Likert scale from \"Not at all\" to \"Extremely.\" Multivariable logistic regression was used to look for the association of the outcomes with the types of surgery and types of anesthesia using SPSS (Version 22).</p><p><strong>Results: </strong>The prevalence were computed in two manners, prevalence of those with 'at least a little bit' outcomes, which was computed to see the total occurrence of these outcomes, and prevalence of those having 'more than moderate' outcomes to see the severe experience of these outcomes. Prevalence of the predominant undesirable outcome, postoperative pain, for 'at least a little bit' and 'more than moderate' were 82.6% and 43.6%, respectively. The rest of the postoperative undesirable outcomes were less frequently reported.</p><p><strong>Conclusion: </strong>Postoperative pain was found to be the most prevalent undesirable outcome. Enhancement of proper assessment and management of postoperative pain through the development and implementation of specific pain management modalities is needed.</p>","PeriodicalId":7834,"journal":{"name":"Anesthesiology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/9792170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38452508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An In Vitro Pilot Study Comparing the Novel HemoClear Gravity-Driven Microfiltration Cell Salvage System with the Conventional Centrifugal XTRA™ Autotransfusion Device.","authors":"Anneloes Hoetink, Sabine F Scherphof, Frederik J Mooi, Paul Westers, Jack van Dijk, Sjef J van de Leur, Arno P Nierich","doi":"10.1155/2020/9584186","DOIUrl":"10.1155/2020/9584186","url":null,"abstract":"<p><strong>Background: </strong>In 2013, the World Health Organization reported a shortage of 17 million red blood cell units, a number that remains growing. Acts to relieve this shortage have primarily focused on allogeneic blood collection. Nevertheless, autologous transfusion can partially alleviate the current pressure and dependence on blood banking systems. To achieve this, current gold standard autotransfusion devices should be complemented with widely available, cost-efficient, and time-efficient devices. The novel HemoClear cell salvage device (HemoClear BV, Zwolle, Netherlands), a gravity-driven microfilter, potentially is widely employable. We evaluated its performance in the cardiac postoperative setting compared to the centrifugal XTRA™ autotransfusion device.</p><p><strong>Methods: </strong>In a split-unit study (<i>n</i> = 18), shed blood collected 18 hours after cardiothoracic surgery was divided into two equal volumes. One-half was processed by the XTRA™ device and the other with the HemoClear blood separation system. In this paired set-up, equal washing volumes were used for both methods. Washing effectivity and cellular recovery were determined by measuring of complete blood count, free hemoglobin, complement C3, complement C4, and D-dimer in both concentrate as filtrate. Also, processing times and volumes were evaluated.</p><p><strong>Results: </strong>The HemoClear and XTRA™ devices showed equal effectiveness in concentrating erythrocytes and leucocytes. Both methods reduced complement C3, complement C4, and D-dimer by ≥90%. The centrifugal device reduced solutes more significantly by up to 99%. Free hemoglobin load was reduced to 12.9% and 15.5% by the XTRA™ and HemoClear, respectively.</p><p><strong>Conclusion: </strong>The HemoClear device effectively produced washed concentrated red blood cells comparably to the conventional centrifugal XTRA™ autotransfusion device. Although the centrifugal XTRA™ device achieved a significantly higher reduction in contaminants, the HemoClear device achieved acceptable blood quality and seems promising in settings where gold standard cell savers are unaffordable or unpractical.</p>","PeriodicalId":7834,"journal":{"name":"Anesthesiology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2020-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38408985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Propofol versus Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Ear, Nose, and Throat Surgery in Tikur Anbessa Specialized Hospital and Yekatit 12th Hospital, Addis Ababa, Ethiopia.","authors":"Abere Tilahun Bantie, Wosenyeleh Admasu, Sintayehu Mulugeta, Abera Regassa Bacha, Desalegn Getnet Demsie","doi":"10.1155/2020/4258137","DOIUrl":"10.1155/2020/4258137","url":null,"abstract":"<p><strong>Background: </strong>Postoperative nausea and vomiting (PONV) remain as common and unpleasant and highly distressful experience following ear, nose, and throat surgery. During ENT surgery, the incidence of PONV could be significantly reduced in patients who receive dexamethasone and propofol as prophylaxis. However, the comparative effectiveness of the two drugs has not been assessed. The aim of this study was to compare the effectiveness of propofol and dexamethasone for prevention of PONV in ear, nose, and throat surgery.</p><p><strong>Methods: </strong>This study was conducted in 80 patients, with ASA I and II, aged 18-65 years, and scheduled for ENT surgery between December 20, 2017, and March 20, 2018. Patients were randomly assigned to Group A and Group B. Immediately after the procedure, Group A patients received single dose of intravenous (IV) dexamethasone (10 mg/kg) and Group B patients were given propofol (0.5 mg/kg, IV), and equal follow-up was employed. The incidence of PONV was noted at 6th, 12th, and 24th hour of drug administration. Independent <i>t</i>-test and Mann-Whitney test were used for comparison of symmetric numerical and asymmetric data between groups, respectively. Categorical data were analyzed with the chi-square test, and <i>p</i> value of < 0.05 was considered as level of significance.</p><p><strong>Results: </strong>The incidences of PONV throughout the 24-hour postoperative period were 35% in the propofol group and 25% in the dexamethasone group. Statistical significance was found in incidence of PONV (0% versus 22.5%) and use of antiemetic (0% versus 5%) between dexamethasone and propofol groups, respectively, at 12-24 hours. Over 24 hours, 5% in dexamethasone group and 12.5% in propofol group developed moderate PONV, while none of the participants felt severe PONV.</p><p><strong>Conclusions: </strong>Dexamethasone was more effective than propofol to prevent PONV with lower requirements of rescue antiemetics.</p>","PeriodicalId":7834,"journal":{"name":"Anesthesiology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7492878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38408983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Leg Elevation to Prevent Spinal Anesthesia-Induced Hypotension during Cesarean Delivery in the Resource-Limited Area: Open Randomized Controlled Trial.","authors":"Sofia Assen,&nbsp;Bedru Jemal,&nbsp;Adane Tesfaye","doi":"10.1155/2020/5014916","DOIUrl":"https://doi.org/10.1155/2020/5014916","url":null,"abstract":"<p><strong>Background: </strong>Postspinal hypotension is the most common complication after spinal anesthesia for cesarean section (CS). Hypotension mainly occurs due to the reductions of vascular tone leading to decreased systemic vascular resistance and decreased venous return. The aim of this study was to assess the effectiveness of leg elevation (LE) as a method of prevention of postspinal hypotension in patients who undergo cesarean section under spinal anesthesia.</p><p><strong>Methods: </strong>This is a single-center parallel-randomized controlled trial study, and 52 full-term parturients scheduled for elective cesarean section who meets inclusion criteria were included in the study. The randomization sequence was created by a researcher not participating in patient management using a computer random generator. The participant was randomly assigned to the leg elevation group (<i>n</i> = 26) or to the control group (<i>n</i> = 26) of usual perioperative care.</p><p><strong>Results: </strong>The proportions of patients who develop hypotension are lower (8 (33.3%)) in the leg elevation group than the control group (15 (62.5%)) with an <i>X</i> ² (1, <i>N</i> = 48) = 4.09, <i>P</i>=0.043. The relative risk of developing postspinal hypotension in the leg elevation group compared to the control group was 0.47 (95% CI, 0.28-1.00). The proportion of severe hypotension was significantly decreased in the leg elevation group at a <i>P</i> value of 0.02.</p><p><strong>Conclusion: </strong>Performing leg elevation immediately after spinal anesthesia reduced the incidence of hypotension. The trial is registered with PACTR201908713181850.</p>","PeriodicalId":7834,"journal":{"name":"Anesthesiology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/5014916","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38363715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between Abdominal Circumference and Incidence of Hypotension during Cesarean Section under Spinal Anesthesia.","authors":"Pattaraleeya Thomard,&nbsp;Sunthiti Morakul,&nbsp;Nichawan Wirachpisit,&nbsp;Wichai Ittichaikulthol,&nbsp;Chawika Pisitsak","doi":"10.1155/2020/6547927","DOIUrl":"https://doi.org/10.1155/2020/6547927","url":null,"abstract":"<p><strong>Background: </strong>Enlarged uterus can compress the inferior vena cava and cause hypotension when lying supine. Previous studies have shown a positive association between the abdominal circumference and size of the uterus. Therefore, the aim of this study was to evaluate the relationship between abdominal circumference and incidence of hypotension during cesarean section under spinal anesthesia.</p><p><strong>Methods: </strong>The study cohort comprised women undergoing cesarean section under spinal anesthesia. Patients were divided into two groups according to the median abdominal circumference (<101 cm and ≥101 cm). Hypotension was defined as a systolic blood pressure of <90 mmHg or mean arterial pressure of <65 mmHg. The primary outcome of this study was the relationship between the incidence of hypotension and the abdominal circumference after spinal anesthesia in term pregnant women.</p><p><strong>Results: </strong>The study cohort comprised 100 women. The incidence of hypotension did not differ between the groups (71.42% in the smaller vs. 78.43% in the larger abdominal circumference group, <i>p</i>=0.419). However, the decrease in mean arterial pressure and its percentage decrease from baseline were greater in the larger than in the smaller abdominal circumference group (change in mean arterial pressure: 28.33 mmHg (18.66-33.67) in the smaller vs. 36.67 mmHg (23.34-43.34) in the larger abdominal circumference group, <i>p</i>=0.004; percentage decrease: 31.41% (22.74-39.22) in the smaller vs. 38.47% (28.00-44.81) in the larger abdominal circumference group, <i>p</i>=0.022).</p><p><strong>Conclusions: </strong>Large abdominal circumference in pregnancy is associated with greater decreases in mean arterial pressure from baseline. However, the incidence of hypotension defined by standard criteria did not differ between larger and smaller abdominal circumference groups.</p>","PeriodicalId":7834,"journal":{"name":"Anesthesiology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/6547927","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38363716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence, Outcomes, and Factors Associated with Intra-Abdominal Hypertension and Primary Abdominal Compartment Syndrome in Abdominopelvic Injury Patients.","authors":"Amonpon Kanlerd,&nbsp;Krissada Nakornchai,&nbsp;Karikarn Auksornchart,&nbsp;Warapan Watkwaw","doi":"10.1155/2020/1982078","DOIUrl":"https://doi.org/10.1155/2020/1982078","url":null,"abstract":"<p><strong>Background: </strong>The primary aim was to identify the incidence of intra-abdominal hypertension (IAH) and primary abdominal compartment syndrome (1^oACS) of abdominopelvic injury patients at Thammasat University Hospital (TUH), Thailand, and the secondary objective was to evaluate those factors that contributed to developing these conditions.</p><p><strong>Methods: </strong>The retrospective cohort of 38 abdominopelvic injury cases was admitted to the intensive care unit at Thammasat University Hospital, from January 1^st to December 31^st, 2018. The bladder pressure was recorded every 4 hours until the urethral catheter was removed. Data of age, gender, weight, height, body mass index, injury mechanisms, initial vital signs, imaging, laboratory data, blood component requirements, abdominal organs involved, treatments including surgery and intervention radiology, abbreviated injury scale (AIS) and injury severity score (ISS), length of ICU stays, and results of treatment were all analyzed.</p><p><strong>Results: </strong>The patients were mostly young (mean age 31.5 years), male (68.4%), and suffering from blunt trauma (89.5%). The mean maximum bladder pressure was 8.3 ± 5.2 mmHg. Six patients (15.8%) developed IAH, and one patient (2.6%) was diagnosed with 1^oACS. Two patients expired. The multivariate analysis showed the patient who had initial Cr ≥ 1.5 g/dL, lower extremity including pelvis AIS ≥3, and ISS >15 was significantly associated with the developing of IAH.</p><p><strong>Conclusions: </strong>The incidence of IAH and 1^oACS was 15.8% and 2.6%. Predicted factors to find developing IAH were initial Cr ≥ 1.5 g/dL, lower extremity AIS ≥3, and ISS >15. We should consider awareness of IAH and 1^oACS in abdominopelvic injury patients.</p>","PeriodicalId":7834,"journal":{"name":"Anesthesiology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/1982078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38338537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose Comparison of Dexmedetomidine Sedation following Spinal Anesthesia: Parturient versus Nonpregnant Women-A Randomized Trial.","authors":"Ming Xiong,&nbsp;Biyun Chen,&nbsp;Zurong Hu,&nbsp;Somdatta Gupta,&nbsp;Zhitao Li,&nbsp;Jiping Liu,&nbsp;Jing He,&nbsp;Shivani Patel,&nbsp;Jean Daniel Eloy,&nbsp;Bo Xu","doi":"10.1155/2020/1059807","DOIUrl":"https://doi.org/10.1155/2020/1059807","url":null,"abstract":"<p><strong>Background: </strong>This study was designed to investigate and compare the effective doses of dexmedetomidine for sedation in parturient patients who underwent Cesarean section (CS) and nonpregnant women who underwent elective gynecologic surgery.</p><p><strong>Methods: </strong>The study comprised 60 females aged between 25 and 35. They were divided into two groups. The parturient group received a bolus dose of dexmedetomidine over 15 min after the delivery of the fetus and placenta. In the nonpregnant women group, a bolus of dexmedetomidine was administered intravenously upon the completion of spinal anesthesia. The subsequent dose required by patients in each group was then determined through a modified two-stage Dixon up-and-down sequential method. Probit analysis was used to calculate the ED50 and the ED95 of dexmedetomidine for adequate sedation.</p><p><strong>Results: </strong>The ED50 of dexmedetomidine for adequate sedation in parturient patients was 1.58 <i>μ</i>g/kg (1.51-1.66 <i>μ</i>g/kg); in nonpregnant women, it was 0.96 <i>μ</i>g/kg (0.91-1.01 <i>μ</i>g/kg) (95% CI). The ED95 of dexmedetomidine in parturients was 1.80 <i>μ</i>g/kg (1.70-2.16) <i>μ</i>g/kg and that of nonpregnant women was 1.10 <i>μ</i>g/kg (1.04-1.30 <i>μ</i>g/kg) (95% CI). The ED50 in parturients was significantly higher than that in nonpregnant women (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The ED50 of dexmedetomidine for target sedation in parturients who received spinal anesthesia for CS is greater than 1.5 times that in nonpregnant women who received spinal anesthesia for lower abdominal gynecologic surgery. This study postulates that the dose of dexmedetomidine required to achieve optimal sedation following spinal anesthesia is much higher in parturients than in nonpregnant women undergoing gynecologic surgeries. This trial is registered with NCT02111421.</p>","PeriodicalId":7834,"journal":{"name":"Anesthesiology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/1059807","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38268968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Laryngeal Mask Airway Insertion on Intraocular Pressure Response: Systematic Review and Meta-Analysis.","authors":"Mohammed Suleiman Obsa,&nbsp;Zewde Zema Kanche,&nbsp;Robera Olana Fite,&nbsp;Tilahun Saol Tura,&nbsp;Bulcha Guye Adema,&nbsp;Aseb Arba Kinfe,&nbsp;Melkamu Worku Kercho,&nbsp;Kebreab Paulos Chanko,&nbsp;Getahun Molla Shanka,&nbsp;Atkuregn Alemayehu Lencha,&nbsp;Gedion Asnake Azeze,&nbsp;Lolemo Kelbiso Hanfore,&nbsp;Nefsu Awoke Adulo,&nbsp;Blen Kassahun Dessu,&nbsp;Getahun Dendir Wolde,&nbsp;Shimelash Bitew Workie","doi":"10.1155/2020/7858434","DOIUrl":"https://doi.org/10.1155/2020/7858434","url":null,"abstract":"<p><strong>Background: </strong>Use of laryngeal mask airway as an alternative to the endotracheal tube has attracted the attention of several workers with regard to intraocular pressure changes. However, the previous studies have reported different results while comparing intraocular pressure, following insertion of laryngeal mask airway or the endotracheal tube. Therefore, this systematic review and meta-analysis was aimed to generate the best possible evidence on the intraocular pressure response to endotracheal tube intubation and laryngeal mask airway insertion.</p><p><strong>Methods: </strong>Electronic databases like PubMed, CINAHL, EMBASE, Google Scholar, Cochrane library databases, and Mednar were used. All original peer-reviewed papers which reported the mean and standard deviation of IOP before and after airway instrumentation in both groups were included. Two reviewers independently extracted the data using a standardized data extraction format for eligibility and appraised their quality. Data were analyzed using the STATA version 14 software. The pooled standard mean difference was estimated with the random-effect model. Heterogeneity between studies was assessed by the <i>I</i> ² statistics test. A subgroup analysis was done to assess the source of variation between the studies.</p><p><strong>Result: </strong>A total of 47 research papers were reviewed, of which, six studies were finally included in this systematic review and meta-analysis. The overall pooled standard mean difference of intraocular pressure was 1.30 (95% CI, 0.70, 1.90), showing that LMA insertion is better than ETT intubation to maintain stable intraocular pressure. A random-effect model was employed to estimate the pooled standard mean differences due to severe heterogeneity (<i>I</i> ² 79.45,  <i>p</i> ≤ 0.001).</p><p><strong>Conclusion: </strong>The available information suggests that the LMA provides lesser intraocular pressure response in comparison with the conventional tracheal tube.</p>","PeriodicalId":7834,"journal":{"name":"Anesthesiology Research and Practice","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/7858434","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38186121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}