Acute Effects of Ketamine Infusion on Postoperative Mood Scores in Patients Undergoing Dilation and Curettage: A Randomized Double-Blind Controlled Study.

IF 1.6 Q2 ANESTHESIOLOGY
Anesthesiology Research and Practice Pub Date : 2021-03-23 eCollection Date: 2021-01-01 DOI:10.1155/2021/6674658
Raham Hasan Mostafa, Ahmed Mohamed Khamis, Ashraf Nabil Saleh, Yehia Mamdouh Hassan Mekki, Mohamed Mohamed Kamal, Ismail Mohammed Ibrahim, Mohamed Abdulmohsen Abdulnaiem Ismaiel
{"title":"Acute Effects of Ketamine Infusion on Postoperative Mood Scores in Patients Undergoing Dilation and Curettage: A Randomized Double-Blind Controlled Study.","authors":"Raham Hasan Mostafa,&nbsp;Ahmed Mohamed Khamis,&nbsp;Ashraf Nabil Saleh,&nbsp;Yehia Mamdouh Hassan Mekki,&nbsp;Mohamed Mohamed Kamal,&nbsp;Ismail Mohammed Ibrahim,&nbsp;Mohamed Abdulmohsen Abdulnaiem Ismaiel","doi":"10.1155/2021/6674658","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Emotional and psychological effects following abortion are more common than physical side effects and can range from mild regret to more serious complications such as depression. In the last decade, it has been suggested that low dose of ketamine is a fast-acting antidepressant.</p><p><strong>Purpose: </strong>The aim of this study was to investigate the impact of intraoperative ketamine infusion on postoperative mood score in patients undergoing Dilation and Curettage (D&C) under spinal anesthesia. We hypothesized that a single low-dose administration of ketamine infusion during D&C surgery can improve mood scores in the immediate postoperative period.</p><p><strong>Methods: </strong>A prospective, randomized, double-blind, parallel-group, placebo-controlled trial. The study included a total of 60 patients, ≥18 years, physical status ASA II, with up to 12-week gestation undergoing elective D&C surgery. Patients were divided randomly into a ketamine group (group K) and a control group (group C). In group K, 0.4 mg/kg ketamine was given as a continuous infusion over 20 min intraoperatively. <i>Main Outcome Measure</i>. Profile of Mood States (POMS) was recorded preoperatively and 2 hours postoperatively.</p><p><strong>Results: </strong>There were no differences in preoperative POMS between the two groups. Mean postoperative POMS of group K was lower than that of group C indicating mood improvement. Ketamine group patients showed higher sedation score and increased, although self-limiting, psychedelic phenomena than the control group.</p><p><strong>Conclusion: </strong>Observed data here support an acute effect of ketamine on mood but any further claim will be speculative. Further future studies exploring postoperative mood scores after 24 hours post-infusion are needed. This trial is registered with PACTR201907779292947.</p>","PeriodicalId":7834,"journal":{"name":"Anesthesiology Research and Practice","volume":"2021 ","pages":"6674658"},"PeriodicalIF":1.6000,"publicationDate":"2021-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009713/pdf/","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anesthesiology Research and Practice","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2021/6674658","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}
引用次数: 6

Abstract

Background: Emotional and psychological effects following abortion are more common than physical side effects and can range from mild regret to more serious complications such as depression. In the last decade, it has been suggested that low dose of ketamine is a fast-acting antidepressant.

Purpose: The aim of this study was to investigate the impact of intraoperative ketamine infusion on postoperative mood score in patients undergoing Dilation and Curettage (D&C) under spinal anesthesia. We hypothesized that a single low-dose administration of ketamine infusion during D&C surgery can improve mood scores in the immediate postoperative period.

Methods: A prospective, randomized, double-blind, parallel-group, placebo-controlled trial. The study included a total of 60 patients, ≥18 years, physical status ASA II, with up to 12-week gestation undergoing elective D&C surgery. Patients were divided randomly into a ketamine group (group K) and a control group (group C). In group K, 0.4 mg/kg ketamine was given as a continuous infusion over 20 min intraoperatively. Main Outcome Measure. Profile of Mood States (POMS) was recorded preoperatively and 2 hours postoperatively.

Results: There were no differences in preoperative POMS between the two groups. Mean postoperative POMS of group K was lower than that of group C indicating mood improvement. Ketamine group patients showed higher sedation score and increased, although self-limiting, psychedelic phenomena than the control group.

Conclusion: Observed data here support an acute effect of ketamine on mood but any further claim will be speculative. Further future studies exploring postoperative mood scores after 24 hours post-infusion are needed. This trial is registered with PACTR201907779292947.

Abstract Image

Abstract Image

Abstract Image

氯胺酮输注对刮刮术患者术后情绪评分的急性影响:一项随机双盲对照研究。
背景:流产后的情绪和心理影响比生理副作用更常见,从轻微的后悔到更严重的并发症,如抑郁。在过去的十年里,有人认为低剂量的氯胺酮是一种速效抗抑郁药。目的:本研究旨在探讨术中氯胺酮输注对脊髓麻醉下行扩张刮刮术(D&C)患者术后情绪评分的影响。我们假设在D&C手术中单次低剂量氯胺酮输注可以改善术后即时的情绪评分。方法:前瞻性、随机、双盲、平行组、安慰剂对照试验。本研究共纳入60例患者,年龄≥18岁,身体状态ASA II,妊娠12周,择期行D&C手术。将患者随机分为氯胺酮组(K组)和对照组(C组)。K组术中给予氯胺酮0.4 mg/kg连续输注20 min以上。主要结果测量。术前和术后2小时分别记录心境状态(POMS)。结果:两组术前POMS无明显差异。K组术后平均POMS低于C组,提示情绪改善。氯胺酮组患者镇静评分高于对照组,迷幻现象虽有自限性,但有所增加。结论:这里观察到的数据支持氯胺酮对情绪的急性影响,但任何进一步的说法都将是推测性的。需要进一步研究输注后24小时的术后情绪评分。该试验注册号为PACTR201907779292947。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
3.10
自引率
0.00%
发文量
29
审稿时长
18 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信