Andrologia最新文献

{"title":"Complanatuside A Inhibits Seminal Vesicle Cell Apoptosis by Activating SerpinB1a in Type 2 Diabetic Mice","authors":"Dawei Ni,&nbsp;Kun Liu,&nbsp;Bin You,&nbsp;Ning Wu,&nbsp;Wei Wu,&nbsp;Yanbin Zhang,&nbsp;Baibing Yang,&nbsp;Yutian Dai","doi":"10.1155/2024/2994194","DOIUrl":"https://doi.org/10.1155/2024/2994194","url":null,"abstract":"<div>\u0000 <p>Type 2 diabetes mellitus (T2DM) can trigger cell apoptosis of seminal vesicles (SVs) and impair seminal secretory functions. Complanatuside A (CA) is known for its anti-inflammatory and antioxidant effects, as well as its ability to repair cellular damage. This study aimed to explore the potential molecular mechanisms through which CA mitigates cell apoptosis in the SVs of type 2 diabetic mice. A streptozotocin-induced type 2 diabetic mice model was utilized, and a 1-month intervention using CA (70 mg/kg) was administered. We monitored body weight, blood glucose levels, SV volume, and concentration of SV fluid. Hematoxylin and eosin staining was used to assess tissue damage. RNA sequencing was applied to identify differential gene expression, and the expression of target genes (ARG2, PBK, SerpinB1a, E2F2) was verified by qRT-PCR. Changes in the apoptosis level of SV tissues in mice were detected with TUNEL staining. Compared to the control group, mice with T2DM exhibited decreased SV volume and SV fluid content, which was improved with CA treatment. Elevated expression of SerpinB1a and reduced apoptosis were observed in the T2DM-CA group compared to T2DM mice. In summary, CA can inhibit cell apoptosis in the SVs, there by improving tissue damage in type 2 diabetic mice. SerpinB1a may be involved in this process. This study provides a new theoretical foundation for the treatment of seminal vesicle secretory dysfunction in type 2 diabetes mellitus.</p>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2024 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/2994194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141584034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upregulation of miR-486 Expression in the Corpus Cavernosum of Spontaneously Hypertensive Rats Improves Erectile Function","authors":"XiangJun Kong,&nbsp;Jing Liu,&nbsp;QinWen Liu,&nbsp;Ge Li,&nbsp;Yong Cheng,&nbsp;Rui Jiang","doi":"10.1155/2024/8843591","DOIUrl":"https://doi.org/10.1155/2024/8843591","url":null,"abstract":"<div>\u0000 <p>This study aims to investigate whether transfection of miR-486 in the corpus cavernosum of spontaneously hypertensive rats (SHR) can improve erectile function and its mechanism. SHR penile cavernous smooth muscle cells were divided into control group, mimic negative control transfection group, inhibitor negative control transfection group, miR-486 mimic transfection group, and miR-486 inhibitor transfection group. miR-486 mimic (50 nM), miR-486 inhibitor (100 nM), and corresponding negative control preparation were transfected into the corresponding groups of cells. The mRNA expressions of miR-486, TGF-<i>β</i>1, Collagen I, and Collagen III in each group were detected after transfection. Twelve 12-week-old healthy male SHR and 12 WKY rats were randomly divided into WKY control group, SHR control group, SHR + Agomir negative control (NC) group, and SHR + miR-486 Agomir group. In the SHR + miR-486 Agomir group, penile cavernosa was transfected with miR-486 agonist. Penile sponge internal pressure (ICPmax)/mean arterial pressure (MAP), the expression of miR-486, the ratio of smooth muscle to collagen (SM/C), and the expression of TGF-<i>β</i>1, Collagen I, and Collagen III in penile cavernosum tissues were determined. Compared with the control group, the expressions of TGF-<i>β</i>1, Collagen I, and Collagen Ⅲ in the miR-486 mimic transfection group of SHR rat corpus cavernosum smooth muscle cells were significantly decreased, while those in the miR-486 inhibitor transfection group were significantly increased (<i>P</i>  &lt; 0.05). The ratios of ICPmax/MAP and SM/C in the SHR group were significantly lower than those in the WKY group and in the SHR + miR-486 Agomir group were significantly higher than those in the SHR group and the SHR + Agomir NC group (<i>P</i>  &lt; 0.05). The expressions of TGF-<i>β</i>1, Collagen I, and Collagen Ⅲ in SHR group were significantly increased compared with those in WKY group, while those in SHR + miR-486 Agomir group were significantly lower than those in SHR group and SHR + Agomir NC group (<i>P</i>  &lt; 0.05). The upregulation of the expression of miR-486 in the corpus cavernosum of SHR rats can inhibit fibrosis of the corpus cavernosum and improve erectile function.</p>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2024 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/8843591","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141439571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can General Anesthesia Facilitate the Detection of Clinically Significant Prostate Cancer in Prostate Fusion Biopsy?","authors":"Emrah Yakut","doi":"10.1155/2024/6676603","DOIUrl":"https://doi.org/10.1155/2024/6676603","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. Although the use of anesthetics in prostate biopsy on pain has been well studied, its effect on the diagnosis of clinically significant prostate cancer (csCPa) is not well known. We aimed to investigate the contribution of performing the prostate fusion biopsy (PFB) procedure under general anesthesia (GA) to diagnosing csCPa. <i>Materials and Methods</i>. We retrospectively analyzed the data of 252 patients who underwent multiparametric magnetic resonance imaging (MpMRI)—guided PFB. Patients were divided into two groups: those under local anesthesia (LA) and GA. For LA and GA groups, csCPa capture rates in PFB were evaluated separately and in total for Prostate Imaging Reporting and Data System (PIRADS) 3, PIRADS 4, and PIRADS 5 lesions. It was investigated whether the PFB application under GA increases the chance of csCPa capture. Chi-square and <i>z</i>-ratio analysis was performed to determine the change in pathological diagnosis according to the anesthesia method. <i>Results</i>. A total of 411 lesions were detected by MpMRI in 252 men included in the study. LA was applied to 61.5% and GA to 38.5% of the patients. We found that the type of anesthesia affected the frequency of csCPa detection only for anterior lesions. Clinically insignificant prostate cancer (CIPC) was detected more frequently in the GA group than in the LA group. Considering PIRADS 3, PIRADS 4, and all lesion groups, benign pathology was statistically significantly more frequent in the LA group, while CIPC was statistically significantly more frequent in the GA group (<i>p</i>  = 0.000). <i>Conclusion</i>. Our study showed that performing PFB under GA may contribute to the diagnosis of csCPa in anterior region lesions. However, this effect could not be demonstrated when all lesions were examined. In fact, it causes more CIPCs to be caught. Considering that the CIPC approach is contradictory in the literature; multicenter, prospective studies with large participation are needed, taking into account patient and lesion characteristics.</p>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2024 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/6676603","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141315321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coridius chinensis Extract Promotes Leydig Cell Endocrine Function Rescuing Testosterone Deficiency and Sexual Behavior Insufficiency in Manganese-Exposed Rat","authors":"Nanjian Luo,&nbsp;Keyi Xiong,&nbsp;Yong Wang,&nbsp;Changhuo Cen,&nbsp;Qiongyou Liu,&nbsp;Fengyue Wang,&nbsp;Yu Hu,&nbsp;Xiaohui Hou","doi":"10.1155/2024/6629144","DOIUrl":"https://doi.org/10.1155/2024/6629144","url":null,"abstract":"<div>\u0000 <p><i>Coridius chinensis</i> is a traditional Chinese medicinal insect, whose extract (CcE) is widely used for male reproductive disorders. Manganese (Mn²⁺) as a heavy metal pollutant can cause toxicity to the reproductive system in mammals. Previous studies found that CcE can resist the apoptosis and oxidation by Mn²⁺ exposed to repair the damage of seminiferous epithelium in rat. However, the therapeutic effect of CcE in the testicular stroma remains unclear. Our study found that the slow mating behaviors of capture, riding, insertion, and ejaculation with Mn²⁺ exposure were improved by CcE treatment in male rat. The level of testosterone was significantly increased in CcE-treated groups. Meanwhile, the damage about less area and cell number in testicular stroma due to Mn²⁺ exposure was repaired after CcE treatment. Ultrastructure analysis of Leydig cells showed the larger mitochondria and more endoplasmic reticulum in Mn²⁺CcE groups became than that in Mn²⁺ group. Further experiments showed that mRNA and protein level of steroidogenic-related regulators (STAR, CYP11<i>α</i>1, and HSD3<i>β</i>1) were significantly decreased in Mn²⁺ group and strongly upregulated occurred at medium concentration of CcE given. Taken together, our results provide a new insight of CcE in promoting testosterone production of Leydig cells to protect male reproductive behavior from Mn²⁺ toxicity.</p>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2024 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/6629144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141298847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tocopherol Alleviates Oxidative Stress and Increases Androgen Receptors in Mice Testicular Tissues under Forced Swimming in Warm Water","authors":"Marjan Daeihamed,&nbsp;Navid Fallah Kochakam,&nbsp;Amirhossein Taghizadeh Valdi,&nbsp;Masoumeh Faghani,&nbsp;Ali Farzanegan,&nbsp;Fahimeh Mohammadghasemi","doi":"10.1155/2024/8190937","DOIUrl":"https://doi.org/10.1155/2024/8190937","url":null,"abstract":"<div>\u0000 <p>The purpose of this study was to investigate the effect of tocopherol supplementation and swimming in warm water on the spermatogenesis, expression of androgen receptors (ARs), and oxidative stress markers in mouse testis. Adult male mice were divided into seven groups: (A) control, (B) solvent, (C) vitamin E (VE), (D) swimming at 23°C water, (E) swimming at 23°C water and receiving VE, (F) swimming at 35°C water, and (G) swimming at 35°C water and receiving VE. Hormones were measured using ELISA. Spermatogenesis was examined through histopathology. The ARs were studied by immunohistochemistry. The testis oxidative stress markers were assessed using colorimetric assays. The distribution of VE in testis tissue was also evaluated using high-performance liquid chromatography (HPLC). Swimming of mice at 23°C was safe for sperm development. Swimming at 35°C resulted in lower testosterone, LH, sperm parameters, sperm differentiation, AR expression, SOD activity, and increased MDA in the testis, compared to control (<i>P</i>  &lt; 0.05). The abovementioned parameters were significantly altered by VE, in comparison to the animals that swam in warm water at 35°C (<i>P</i>  &lt; 0.05). The results of HPLC showed that tissue distribution of VE was significantly higher in group G, compared to group E (<i>P</i>  &lt; 0.05). Swimming in water at 23°C is conducive to sperm development, whereas swimming at 35°C impairs sperm production. In conclusion, VE counteracts the negative effects of swimming at 35°C water on sperm development by altering the hypothalamic–pituitary–gonadal axis, distribution of VE, AR expression, and lipid peroxidation in testicular tissue.</p>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2024 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/8190937","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141246149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Triglyceride–Glucose (TyG) Index and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) Index in Prediction of Male Hypogonadism","authors":"Berk Hazir,&nbsp;Andrea Salonia,&nbsp;Aleksander Giwercman,&nbsp;Angel Elenkov","doi":"10.1155/2024/1865552","DOIUrl":"https://doi.org/10.1155/2024/1865552","url":null,"abstract":"<div>\u0000 <p>Several studies have shown the association between decreased insulin sensitivity and the risk of male hypogonadism. Homeostatic model assessment of insulin resistance (HOMA-IR) is a well-established marker of decreased insulin sensitivity. The triglyceride–glucose index (TyG), calculated as ln (fasting triglyceride (mg/dL) ×  fasting glucose (mg/dL)/2), was recently suggested to be a cheaper and a reliable surrogate marker to detect insulin resistance (IR). Our aim was to compare the performance of those two indexes in the prediction of male hypogonadism. The data on 192 men from infertile couples (18–50 years; sperm concentration &lt;20 x 10⁶/mL) and 199 population-based matched controls collected during the years 2009–2012 (baseline) were evaluated retrospectively. Half of these subjects (72 subfertile men and 122 controls) were reinvestigated 5–10 years later (median year (range): 7 (5–10)). The patients receiving any hormonal therapy were excluded. Hypogonadism was defined as fasting, morning serum testosterone below 12 nmol/L. In receiver operating characteristic curve analysis, the optimal diagnostic cutoff values for baseline HOMA-IR and TyG to predict MetS at re-examination were 2.68 (Area Under Curve (AUC) = 0.886, <i>p</i> &lt; 0.001) and 8.60 (AUC = 0.816, <i>p</i>  &lt; 0.001), respectively. Moreover, in binary logistic regression analysis performed on the whole cohort using these thresholds for high values of HOMA-IR and high TyG, the odds-ratios (ORs) for hypogonadism were 6.48 (95% Confidence Interval (CI): 3.77–11.2; <i>p</i>  &lt; 0.001) and 3.58 (95% CI: 2.17–5.94; <i>p</i>  &lt; 0.001), respectively. Even though high HOMA-IR levels provided better risk estimates, high TyG was also highly related to the risk of hypogonadism. These markers can be utilized to identify men being at high risk of hypogonadism.</p>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2024 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/1865552","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141246046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Male Reproduction and Health after Recovery from COVID-19 Infection","authors":"Xiangyang Sun,&nbsp;Jian Li,&nbsp;Lianbing Sheng,&nbsp;Song Liu,&nbsp;Ganggang Wang,&nbsp;Zhida Shi","doi":"10.1155/2024/9026330","DOIUrl":"10.1155/2024/9026330","url":null,"abstract":"<div>\u0000 <p><i>Objective</i>. To study the reproductive hormones, semen quality, psychology, and sexual function of childbearing age men after recovery from Corona Virus Disease-2019 (COVID-19) infection. <i>Materials and Methods</i>. We recruited 387 men of childbearing age who recovered from COVID-19 infection and underwent prepregnancy health checks at the Reproductive Center of Shandong Maternal and Child Health Hospital from January to March 2023 as study subjects. Routine semen analysis and reproductive hormones were performed. The clinical symptoms, anxiety, depression, erectile function, and premature ejaculation questionnaire were investigated during the COVID-19 infection period. A control group of 226 men of childbearing age who were not infected with COVID-19 between August 2022 and October 2022 were selected based on questionnaire responses, reproductive hormones, and semen parameters. <i>Results</i>. The main clinical symptoms during COVID-19 infection of the 387 research subjects were fever (342/387, 88.37%), muscle pain (155/387, 40.05%), anosmia (124/387, 32.04%), cough (106/387, 27.39%), throat pain (53/387, 13.70%), nausea and vomiting (16/387, 4.13%), and testicular discomfort (5/387, 1.29%). The rates of anxiety and depression were 11.37% (44/387) and 32.82% (127/387), respectively; erectile dysfunction (ED) and premature ejaculation (PE) of the research subjects were accounted for 32.30% (125/387) and 6.98% (27/387). The IEF-5 score (<i>P</i> &lt; 0.001) decreased significantly compared to the control group, while the PHQ-9 score (<i>P</i> &lt; 0.001), the rate of increased ED (<i>P</i> &lt; 0.001), and the rate of depression increased (<i>P</i> &lt; 0.001). There were statistically significant differences in liquefaction time (<i>P</i> &lt; 0.05), the progressive sperm motility (<i>P</i> &lt; 0.05), total sperm motility (<i>P</i> &lt; 0.05), the rates of progressive sperm motility &lt;32% (<i>P</i> &lt; 0.05), and total sperm motility &lt;40% (<i>P</i> &lt; 0.05) between the 1 month, the 2 months after recovery from COVID-19 and controls. Circular cell counts (<i>P</i> &lt; 0.05) at 2 and 3 months were lower than in the controls. No changes in reproductive hormones before and after recovery from infection. <i>Conclusion</i>. COVID-19 infection exacerbates depression and ED. It has a sustained effect on sperm motility and liquefaction time in men. The effects of COVID-19 infection on semen persist for approximately 2 months, with recovery occurring in the third month. Reproductive hormone levels do not appear to be continuously affected after recovery from COVID-19.</p>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2024 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/9026330","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141103243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified Essed–Schroder Technique in Congenital Penile Curvature: Long-Term Outcomes and Quality of Life Evaluation","authors":"Fatih Akdemir,&nbsp;Önder Kayıgil","doi":"10.1155/2024/6563751","DOIUrl":"10.1155/2024/6563751","url":null,"abstract":"<div>\u0000 <p><i>Background</i>. In this study, long-term functional, cosmetic, and quality-of-life outcomes of patients with congenital penile curvature who were operated on using the modified Essed–Schröder procedure were evaluated. <i>Materials and Methods</i>. Between 2009 and 2022, 233 patients with congenital penile curvature were operated using a modification of the Essed–Schröder technique. The average age of the cases was found to be 23.7 ± 4.6 (18–37). The mean postoperative follow-up period was 76.1 ± 16.8 (18–153) months. At the end of the follow-up period, 203 of 233 patients were interviewed retrospectively, and standard questionnaires were filled out to evaluate the functional, cosmetic, and quality-of-life results of the procedure. <i>Results</i>. There was a curvature ventral in 103, left lateral in 40, right lateral in 30, dorsal in 17, dorsolateral in 8, and ventrolateral in 5 cases. The mean degree of curvature was found to be 51.7 ± 9.4 (30–80). Recurrent curvature was detected in 16 cases (7.14%), and discomfort due to suture palpation was detected in 17 cases (8.37%). No case reporting erectile dysfunction was detected. 90.6% of the patients reported that they were satisfied with the operation. As a result, the curvature was effectively corrected, and the sensation of postoperative suture palpation was minimized. It has been determined that it increases patient and partner satisfaction and improves the quality of life. <i>Conclusions</i>. The modified Essed–Schröder technique is a relatively simple technique and provides successful functional and cosmetic results. It also provides a significant improvement in quality of life.</p>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2024 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/6563751","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141127119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperlipidemia Is Not Related to Semen Quality, but to Serum Testosterone Levels","authors":"Jiajie Bi,&nbsp;Jing Ma,&nbsp;Chaoju Yang,&nbsp;Yuanjing Li,&nbsp;Xuan Liu,&nbsp;Yanqing Tie,&nbsp;Shusong Wang","doi":"10.1155/2024/6166698","DOIUrl":"10.1155/2024/6166698","url":null,"abstract":"<p><i>Background</i>. Currently, there are few studies on the effects of hyperlipidemia on semen parameters and serum hormones in men. In this study, we divided the study subjects into two groups of normal and hyperlipidemia according to the criteria, and observed the differences between semen parameters and serum reproductive hormones in hyperlipidaemic men and normal men, to explore the potential associations between the indicators. <i>Materials and Methods</i>. Eight hundred eighty five men attending infertility clinics in six hospitals from September 2016 to June 2017 were selected. Their lipid levels, semen parameters, and serum reproductive hormone levels were tested, and a total of 480 men with normal lipids and 405 men with hyperlipidemia were selected according to the criteria, and the relationship between semen quality, serum reproductive hormones, lipids and semen parameters, and serum hormones was statistically analyzed. <i>Results</i>. There was no significant difference in semen parameters between hyperlipidaemic men and normal men (<i>P</i>  &gt; 0.05), serum testosterone levels were significantly lower in hyperlipidaemic men (<i>P</i>  &lt; 0.05), and there was a negative correlation between triglycerides (TG) and testosterone in the blood (<i>P</i>  &lt; 0.05).<i>Conclusion</i>. Hyperlipidemia does not affect male semen parameters, and changes in testosterone in hyperlipidaemic men may be related to triglycerides.</p>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2024 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140987868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testis–Gut-Reproduction Axis: The Key to Reproductive Health","authors":"Hede Zou,&nbsp;Wenkang Chen,&nbsp;Baofeng Hu,&nbsp;Hanfei Liu,&nbsp;Jiayou Zhao","doi":"10.1155/2024/5020917","DOIUrl":"10.1155/2024/5020917","url":null,"abstract":"<p>Reproductive health is an important issue for humanity. In the context of the increasing incidence rate of male infertility, it is essential to find the factors that affect male reproductive health. Gastrointestinal health is closely related to reproductive health. Gastrointestinal hormones (GIH) and gut microbiota (GM), as important material foundations for gastrointestinal function, can promote or inhibit testicular reproductive function, including spermatogenesis, sperm maturation, androgen synthesis, and even broader male diseases such as sexual function, prostate cancer, etc. On the contrary, the functional health of the testes is also of great significance for the stability of gastrointestinal function. This review mainly discusses the important regulatory effects of GIH and GM on male reproductive function.</p>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2024 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140990251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}