睾丸-肠道-生殖轴：生殖健康的关键

IF 2.1 4区医学 Q3 ANDROLOGY

Andrologia Pub Date : 2024-05-10 DOI:10.1155/2024/5020917

Hede Zou, Wenkang Chen, Baofeng Hu, Hanfei Liu, Jiayou Zhao

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引用次数: 0

摘要

生殖健康是人类面临的一个重要问题。在男性不育症发病率不断上升的背景下，找到影响男性生殖健康的因素至关重要。胃肠道健康与生殖健康密切相关。胃肠激素（GIH）和肠道微生物群（GM）作为胃肠功能的重要物质基础，可促进或抑制睾丸生殖功能，包括精子发生、精子成熟、雄激素合成，甚至性功能、前列腺癌等更广泛的男性疾病。相反，睾丸的功能健康对胃肠功能的稳定也具有重要意义。本综述主要讨论 GIH 和 GM 对男性生殖功能的重要调节作用。

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Testis–Gut-Reproduction Axis: The Key to Reproductive Health

Reproductive health is an important issue for humanity. In the context of the increasing incidence rate of male infertility, it is essential to find the factors that affect male reproductive health. Gastrointestinal health is closely related to reproductive health. Gastrointestinal hormones (GIH) and gut microbiota (GM), as important material foundations for gastrointestinal function, can promote or inhibit testicular reproductive function, including spermatogenesis, sperm maturation, androgen synthesis, and even broader male diseases such as sexual function, prostate cancer, etc. On the contrary, the functional health of the testes is also of great significance for the stability of gastrointestinal function. This review mainly discusses the important regulatory effects of GIH and GM on male reproductive function.

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来源期刊

Andrologia 医学-男科学

CiteScore

5.60

自引率

8.30%

发文量

292

审稿时长

6 months

期刊介绍： Andrologia provides an international forum for original papers on the current clinical, morphological, biochemical, and experimental status of organic male infertility and sexual disorders in men. The articles inform on the whole process of advances in andrology (including the aging male), from fundamental research to therapeutic developments worldwide. First published in 1969 and the first international journal of andrology, it is a well established journal in this expanding area of reproductive medicine.