Andrologia最新文献

{"title":"Mechanism of Shenqi Qiangjing Granules in Treating Cyclophosphamide-Induced Oligozoospermia Based on Network Pharmacology and Experimental Validation","authors":"Bing-Yu Xia,&nbsp;Xin Li,&nbsp;Jia-Yi Gao,&nbsp;Zheng Zhang,&nbsp;Qing-Tong Lan,&nbsp;Jun-Yu Tao,&nbsp;Ai-Cun Tang","doi":"10.1155/and/7034264","DOIUrl":"10.1155/and/7034264","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Research indicates that cyclophosphamide (CY), a cancer treatment, can cause oligozoospermia in men. Traditional Chinese medicine, particularly Shenqi Qiangjing (SQ) granules, may help improve this issue, but the exact way it works against CY–induced oligozoospermia is not completely clear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to verify that SQ can improve oligozoospermia caused by CY and explore its potential mechanism.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This research uses network pharmacology to identify common genes linked to SQ and oligozoospermia, as well as testicular macrophage polarization (TMP). Using databases such as TCMSP and GeneCard, relevant genes were identified, and a protein interaction network was created with STRING and Cytoscape. GO and KEGG analyses was used to identify pathways related to SQ. To induce oligozoospermia, male mice were given a 60 mg/kg dose of CY for 5 days. The plants were then treated with two doses of SQ (200 and 800 mg/kg) for 21 days to assess its protective effects on reproductive organs. Measurements included testicular and epididymal indices, sperm quality, hormone levels, oxidative stress markers, inflammatory cytokines, tissue changes, and proteins related to the nuclear factor κB (NF-κB) pathway.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Researchers identified 883 genes linked to SQ, with 16 key genes that help improve oligozoospermia by affecting TMP. Analysis suggests that SQ may promote oligozoospermia by regulating TMP through NF-κB. Studies have shown that SQ improves sperm quality, reduces oxidative damage, balances sex hormones, shifts macrophages from the M1 phenotype to the M2 phenotype, and decreases NF-κB protein levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SQ alleviates oligozoospermia by reversing M1 macrophage polarization via NF-κB, supporting its potential in treating male infertility and aligning with national fertility strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/and/7034264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147568102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Effects of Tetrahydrocannabinol and Cannabidiol on Sperm Quality and Reproductive Hormones in Male Rats: A Comparative Experimental Study","authors":"Adil Kbirou,&nbsp;Othmane Adli,&nbsp;Youness Kadil,&nbsp;Amine Moataz,&nbsp;Houda Filali,&nbsp;Rachid Aboutaieb","doi":"10.1155/and/4514624","DOIUrl":"https://doi.org/10.1155/and/4514624","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Cannabis is the most widely used drug in Morocco, particularly among young individuals, with potential repercussions on their reproductive health. Through its interaction with the endocannabinoid system, cannabis may interfere with spermatogenesis and hormonal regulation. The aim of this study was to investigate the effects of cannabis consumption on sperm quality parameters and reproductive hormones in male rats.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Twenty-one rats were divided into three groups receiving intraperitoneal injections of cannabidiol (CBD), tetrahydrocannabinol (THC), and saline at a dose of 5 mg for a period of 36 days. Sperm parameters were analyzed, including motility, concentration, morphology, and vitality. FSH, LH, and testosterone hormones were assayed, and histological analysis of the testes was performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>THC exposure significantly reduced the sperm motility (22.5% vs. 43.5%, <i>p</i> = 0.0014) and vitality (40% vs. 70%, <i>p</i> = 0.006) and altered hormonal profiles, increasing FSH and LH while decreasing testosterone (<i>p</i> &lt; 0.05). However, testicular weight, sperm morphology, and concentration were not significantly affected by THC. In contrast, the CBD-treated group did not differ significantly from the control group for any of the assessed parameters (<i>p</i> &gt; 0.05). Histological analysis did not find any testicular lesions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study highlights the deleterious effects of THC on sperm quality and the balance of reproductive hormones in rats. CBD, on the other hand, appears to have no major impact at equivalent doses, which suggests that young people should be made aware of the importance of preserving fertility.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/and/4514624","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147320792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Relationship Between Antihypertensive Drugs and Erectile Dysfunction Revealed Using a Mendelian Randomization Study","authors":"Zihao Zou,&nbsp;Xiaofeng Lv,&nbsp;Shanshan Liu,&nbsp;Xinmin Deng,&nbsp;Rui Lai,&nbsp;Ying Li","doi":"10.1155/and/5556680","DOIUrl":"https://doi.org/10.1155/and/5556680","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Erectile dysfunction (ED) is the leading cause of sexual dysfunction in hundreds of millions of men worldwide, with serious negative consequences for the quality of life of both men and their partners. Whereas antihypertensive drugs may play a role in the progression of ED, evidence of causality is limited. We aimed to investigate the causal effect of antihypertensive drugs on ED risk using Mendelian randomization (MR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Pooled data based on genome-wide association studies (GWASs) were included in relation to five antihypertensive drugs including: renin–angiotensin, calcium channel blockers, beta-blockers, diuretics, and overall antihypertensive medication use. We performed MR analyses to estimate the causal effect of antihypertensive medications on ED risk. We also performed some sensitivity analyses to assess the validity of the MR hypothesis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Genetically predicted drug use of drugs acting on the renin–angiotensin system (RAS), calcium channel blockers, β-blockers, and antihypertensive medications were all found to be significantly and positively associated with ED (agents acting on the RAS: odds ratio [OR] = 1.136; 95% CI = 1.049–1.230; <i>p</i> = 0.002; beta blocking agents: OR = 1.120; 95% CI = 1.001–1.252; <i>p</i> = 0.048; calcium channel blockers: OR = 1.103; 95% CI = 1.017–1.196; <i>p</i> = 0.018; blood pressure medication: OR = 1.867; 95% CI = 1.175–2.965; <i>p</i> = 0.008). In contrast, there was a lack of association between diuretic use and ED (diuretics: OR = 1.083; 95% CI = 0.994–1.180; <i>p</i> = 0.067). Sensitivity analyses showed more robust results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study supports the idea that medication use of drugs acting on the RAS, calcium channel blockers, β-blockers, and antihypertensive medications may have a negative effect on ED, whereas diuretic use had no effect on ED.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/and/5556680","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Date Palm (Phoenix dactylifera L) Pollen Therapeutic Potential on Citalopram-Induced Testicular Damage: In Vitro and In Vivo Toxicity","authors":"Maryam Hassanpoor,&nbsp;Mohammad Nabiuni,&nbsp;Elaheh Amini,&nbsp;Ensieh Salehghamari","doi":"10.1155/and/2302087","DOIUrl":"https://doi.org/10.1155/and/2302087","url":null,"abstract":"<p>Citalopram (CT) has indeed been demonstrated to induce sexual dysfunction, although its capacity to be harmful to the male reproductive system has not been fully explored. The current investigation analyzed the mechanism underlying the protective impact of date palm pollen (DPP) on CT-induced Sertoli cell (TM4 cells) apoptosis and clarified the harmful effects of CT on the mouse males’ reproductive system. Using flow cytometry, the apoptotic rate in each group was determined. The impact of DPP on the expression of <i>Bcl-2</i>, <i>Nrf2</i>, and <i>SOD1</i> molecular targets was identified. Also, male NMRI mice were orally treated simultaneously with CT and DPP for 30 days, and the testes underwent histological analysis. Our findings demonstrated that adding different doses of DPP to Sertoli cells raised the mRNA expression levels of <i>Nrf2</i>, <i>SOD1</i>, and <i>Bcl-2</i> to varying degrees (<i>p</i> &lt; 0.01). Our findings also demonstrated that DPP decreased the rate of TM4 cell death brought on by CT (<i>p</i> &lt; 0.01). In addition, many abnormalities were observed in testicular tissue in mice treated with CT. Our results showed that DPP can reduce the harmful effects of CT on testicular tissue and restore spermatogenesis. These results lend credence to the idea that CT can result in testicular injury and infertility. In contrast, treatment with DPP can lessen the negative effects of CT, most likely through the regeneration of testicular tissue and antioxidant systems.</p>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/and/2302087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146680404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Trends and Research Focus in Erectile Dysfunction Treatment: A 1993–2023 Bibliometric Analysis","authors":"Kefan Li,&nbsp;Wenpeng Song,&nbsp;Zhuo Zhou,&nbsp;Xiaohui Tan,&nbsp;Mancheng Xia,&nbsp;Pengchao Gao,&nbsp;Fangzhou Zhao,&nbsp;Honggang Ying,&nbsp;Weidong Song,&nbsp;Zhongcheng Xin,&nbsp;Yiming Yuan,&nbsp;Woong Jin Bae,&nbsp;Ruili Guan","doi":"10.1155/and/8826372","DOIUrl":"https://doi.org/10.1155/and/8826372","url":null,"abstract":"<p>Erectile dysfunction (ED) is a common sexual disorder worldwide significantly affects men’s quality of life. However, there remains a lack of comprehensive bibliometric analysis of ED treatment. This study aims to utilize bibliometric methods to assess the research progress in ED treatment and identify the research hot spots and emerging trends in this field. The publications associated with the treatment of ED from 1993 to 2023 were obtained from the Web of Science Core Collection (WOSCC) database. Articles and review articles published in English from 1993 to 2023 were selected and screened manually. The bibliometric software, CiteSpace, was used to conduct cooperative network analysis, keyword analysis, and reference co-citation analysis. A total of 5627 publications including 4696 articles and 931 review articles from 861 journals were extracted for analysis. The publication counts and citations reached its peak of 337 in 2023 and 10,556 in 2021, respectively. The United States accounted for the largest number of publications (32.2%), as well as the highest betweenness centrality (BC) among countries/regions (0.18). The most productive institution was the University of California System (<i>N</i> = 264). Furthermore, the Journal of Sexual Medicine published the most papers related to ED (<i>N</i> = 750). ED treatments were summarized by analyzing the keywords and co-cited references, including oral phosphodiesterase type 5 inhibitors (PDE5Is), testosterone supplements, intracavernosal injection, intraurethral suppository, wave therapy, and stem cell treatment. This study showed an overview of the treatment of ED from a fresh perspective. Wave therapy, stem cell treatment were emerging trends in future research in this field. An analysis of the intellectual bases, research hot spots, and emerging trends in the field will help to shape research strategies and treatment approaches in the future, offering potential benefits for patients with ED.</p>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/and/8826372","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146680348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Combination of Laparoscopic and Microscopic Vasovasostomy for the Treatment of Iatrogenic Upper Vas Deferens Obstruction","authors":"Yanzhong Liu,&nbsp;Chao Li,&nbsp;Longqiang Shu,&nbsp;Gang Guo,&nbsp;Chunyang Wang","doi":"10.1155/and/1727785","DOIUrl":"https://doi.org/10.1155/and/1727785","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>This study aims to evaluate the feasibility and surgical outcomes of laparoscopic and microscopic vasovasostomy for the treatment of iatrogenic upper vas deferens obstruction in the cases of five patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A retrospective analysis was conducted on the clinical data of five patients with iatrogenic inguinal vas deferens obstruction. All five patients are male, with an average age of 27.20 ± 1.79 (25–30). All five patients had a history of bilateral indirect inguinal hernia repair during childhood. Open surgical exploration of the original inguinal hernia incision showed the lack of continuity of the vas deferens in all the patients and the existence of obstruction sites in the inner ring opening of the inguinal canal. Laparoscopic surgery was performed to stretch the vas deferens from the outer ring opening of the inguinal canal to the outside of the abdomen. A standard vasovasostomy was then performed microscopically. The reconnected vas deferens was repositioned into the abdomen, with satisfactory placement confirmed via laparoscopic observation. The patency of the vas deferens was confirmed with a methylene blue test, and the posterior abdominal peritoneum was closed. Postoperative follow-ups were conducted to monitor changes in sperm quality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All surgeries on the five patients were successful, among which the vas deferens of three patients were completely ruptured, and those of the other two were partially ruptured with only connections with the epididymis of the vas deferens. The average operation time was 292.0 ± 17.89 (270–320) min. The average follow-up period was 11.0 ± 3.08 (range 7–15) months. Among the 5 patients, the sperm quality of 4 patients manifested improvement after the operation, while that of the other patient’s condition remained unchanged.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The combination of laparoscopic and microscopic vasovasostomy is a safe, reliable, and effective surgical technique for treating patients with iatrogenic inguinal vas deferens obstruction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/and/1727785","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146091292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seminal Extracellular Vesicles LGALS3BP as a Potential Biomarker of Varicocele-Associated Infertility in TMT-Based Quantitative Proteomic Analysis","authors":"Cheng Yang,&nbsp;Jian-xiong Li,&nbsp;Xian-yuan Lv,&nbsp;Ran-ran Zhou,&nbsp;Jun-hao Zhou,&nbsp;Cun-dong Liu,&nbsp;Shan-chao Zhao","doi":"10.1155/and/9374173","DOIUrl":"https://doi.org/10.1155/and/9374173","url":null,"abstract":"<p>The proteomic analysis of seminal plasma (SP) is a powerful tool for screening and identifying potential novel biomarkers of male infertility. However, the proteomic composition of seminal extracellular (SE) vesicles in varicocele (VC) is still poorly characterized. The main objective of the present study was to compare the proteome of SEs between infertile men with VC and fertile men without VC and to reveal differentially expressed SEs proteins (DESEPs) that can serve as potential novel biomarkers of VC-associated infertility. SEs were isolated and purified from SP, and SEs proteins were extracted and labeled with TMT and analyzed by high-resolution LC-MS/MS. A total of 1457 proteins were quantitatively identified in these SEs samples. Of these proteins, 175 DESEPs (76 upregulated and 99 downregulated) were identified. Bioinformatics analysis indicated that the molecular functions and biological processes of these DESEPs were involved in metabolism, cell growth and/or maintenance, energy pathways, transport, and cell activation. Among these DESEPs of interest, PGK2 and LGALS3BP were validated by Western blotting. The expression level of the SEs LGALS3BP was also determined by ELISA. A significant positive association was observed between the concentration of SEs LGALS3BP and clinical characteristics. Moreover, receiver operating characteristic (ROC) curve analysis showed that SEs LGALS3BP had better predictive efficacy than seminal LGALS3BP as a potential diagnostic biomarker of VC-associated infertility. Differences in the SEs protein profiles indicate that DESEPs may serve as potential biomarkers for VC-associated infertility.</p>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/and/9374173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146016443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Tadalafil on Testicular Histology and Sperm Parameters in An Experimental Varicocele Model","authors":"Melih Yetemen,&nbsp;Mehmet Çağatay Çiçek,&nbsp;Kadir Ömür Günseren,&nbsp;Mehmed Berk Toker,&nbsp;Onur Onguncan,&nbsp;Berna Aytaç Vuruşkan,&nbsp;Levent Turan,&nbsp;Hakan Kılıçarslan","doi":"10.1155/and/3436853","DOIUrl":"https://doi.org/10.1155/and/3436853","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Varicocele is a common cause of male infertility, often associated with oxidative stress and impaired testicular blood flow. This study aimed to evaluate whether orally administered tadalafil, through its cGMP-mediated vasodilatory and antioxidant effects, can protect against histological damage and altered sperm parameters in a rat model of experimental left varicocele.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Twenty-four male rats were assigned to three groups: control-sham (Group 1), left varicocele (Group 2), and left varicocele with daily oral tadalafil administration (Group 3; 1 mg/kg/day by oral gavage). After 75 days, left testicular tissues were harvested for histopathological and apoptotic analysis, and sperm samples were collected from left epididymal tissues. Histopathological evaluation was conducted using the modified Johnsen score, and apoptosis was assessed by the apoptotic index. Sperm count, motility, acrosomal defects, and morphological defects were also analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In our study, Group 2 (varicocele) showed significantly lower modified Johnsen scores (<i>p</i> = 0.005) and sperm motility (<i>p</i> = 0.042), and a higher apoptotic index (<i>p</i>  &lt; 0.001) compared to Group 1 (control-sham). Compared to Group 2, tadalafil treatment in Group 3 significantly improved sperm motility (<i>p</i>  &lt; 0.001) and reduced the apoptotic index (<i>p</i> = 0.004), while the increase in Johnsen score was not statistically significant (<i>p</i> = 0.140). The thickness of the tunica media layer was significantly higher in Groups 2 (<i>p</i> = 0.008) and 3 (<i>p</i> = 0.004) compared to Group 1, while no difference was observed between Groups 2 and 3.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Tadalafil demonstrates potential efficacy in preserving testicular tissue and maintaining sperm parameters against damage induced by varicocele. These findings support further investigation into the role of phosphodiesterase type 5 (PDE5) inhibitors as adjunctive agents in male reproductive health.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/and/3436853","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146007716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual Outcomes and Symptom Relief Following HoLEP Versus BipoLEP: A Prospective Cohort Study","authors":"Abdulmecit Yavuz,&nbsp;Onder Cinar","doi":"10.1155/and/5270047","DOIUrl":"https://doi.org/10.1155/and/5270047","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To prospectively compare the effects of Holmium Laser Enucleation of the Prostate (HoLEP) and Bipolar Transurethral Enucleation of the Prostate (BipoLEP) on erectile function and lower urinary tract symptom (LUTS) outcomes in men undergoing surgery for benign prostatic hyperplasia (BPH).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this two-center prospective observational study, sexually active men with BPH and significant LUTS refractory to medical therapy underwent either HoLEP or BipoLEP performed by high-volume surgeons. Preoperative assessment included International Prostate Symptom Score (IPSS), maximum urinary flow rate (Qmax), prostate-specific antigen (PSA), prostate volume, body mass index (BMI), and International Index of Erectile Function-5 (IIEF-5). Erectile function was evaluated at 3, 6, and 9 months postoperatively, while LUTS outcomes were assessed at 3 months. Prostate cancer was excluded in all participants prior to surgery. Between-group and within-group analyses were performed using appropriate statistical tests.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 140 patients were included (HoLEP: <i>n</i> = 74; BipoLEP: <i>n</i> = 66). Both procedures significantly improved IPSS and Qmax, with no postoperative differences between groups. HoLEP demonstrated stable erectile function across follow-up, with minimal deviation from baseline IIEF-5 scores. In contrast, BipoLEP produced a significant transient decline in erectile function at 3 months, followed by gradual recovery at 6 and 9 months, ultimately returning to preoperative levels. This early postoperative decline is likely associated with greater thermal dispersion inherent to bipolar electrosurgical energy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>HoLEP and BipoLEP yield comparable LUTS improvement and long-term preservation of erectile function. However, BipoLEP is associated with a temporary early decline in IIEF-5 scores, whereas HoLEP offers more stable sexual outcomes throughout follow-up. These findings highlight important functional nuances that may guide individualized procedure selection in the surgical management of BPH.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/and/5270047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145964025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of Male Infertility Among Men Aged 20–49 Years in Asia From 1990 to 2021 and Prediction to 2040: A Global Burden of Disease Study","authors":"Tianying Yang,&nbsp;Jing Lin,&nbsp;Xinyue Yang,&nbsp;Chunbo Li,&nbsp;Aijie Xin","doi":"10.1155/and/3606588","DOIUrl":"https://doi.org/10.1155/and/3606588","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study aims to investigate the epidemiological data and trends of male infertility aged 20–49 years in Asia from 1990 to 2021.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data for this study was obtained from the Global Burden of Disease (GBD) 2021 public database. Trends in prevalence, years lived with disability (YLDs), age-standardized prevalence rate (ASPR), and age-standardized YLD rate (ASYR), along with their correlation with the sociodemographic index (SDI), were analyzed. A join-point regression model was developed to assess trends across different time segments. In addition, an autoregressive integrated moving average (ARIMA) model was employed for predictions extending to 2040.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From 1990 to 2021, the burden of male infertility among individuals aged 20–49 years increased both globally and across all Asian regions. In East Asia, the burden was the highest in 1990 and had an initial rapid escalation through the early 1990s, then declined steadily since 1995. South and Southeast Asia experienced significantly accelerating upward trends, with South Asia saw the steepest increases. High-income Asia Pacific and Central Asia sustained relatively low disease burdens and stable trends throughout the study period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The disease burden in East Asia, South Asia, and Southeast Asia remains significant, with a notable upward trend observed in South Asia and Southeast Asia. Targeted interventions and policies are needed based on the epidemiological characteristics and changing trends of different Asian regions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2026 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/and/3606588","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145963865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}