L-carnitine Ameliorates Disturbed Testicular Parameters and Sex Hormone Level in Movento-Exposed Mice: Mitigation of Oxidative Stress and Inflammation

IF 2 4区 医学 Q3 ANDROLOGY
Andrologia Pub Date : 2025-07-23 DOI:10.1155/and/5555588
Ali Shamsara, Golnaz Shafiei, Mohammad Amin Rajizadeh, Tahereh Haghpanah, Faezeh Akhgarandouz, Iman Zangiabadi
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Abstract

Background: Spirotetramat (Movento) is one of the most widely used pesticides in agriculture. Prolonged exposure to Movento may adversely affect male fertility by inducing oxidative stress and inflammation. Conversely, L-carnitine (LC), a potent antioxidative and anti-inflammatory compound, has been shown to mitigate cellular damage. This study evaluates the protective effect of LC against Movento-induced testicular injury in male mice.

Methods: Thirty-two male mice (9–10 weeks old and weighing 25–35 g) were divided into four groups: Control (Con), received saline (Movento vehicle) via gavage for 35 days. Movento (M), received Movento (1000 mg/kg) every 48 h for 35 days via gavage. LC + Movento (LC + M), treated with LC (200 mg/kg) after Movento administration (same as M group). LC-only (LC), received LC (200 mg/kg) for 35 days via gavage. After treatment, mice were euthanized, and testicular histology, sperm parameters, inflammatory cytokines, and sex hormone levels were assessed.

Results: Movento exposure significantly increased sperm abnormalities, reduced sex hormone levels, and disrupted seminiferous tubule morphology compared to controls. However, LC consumption could partially improve the diminished sex hormone levels, sperm quality, and testicular structure, likely due to its antioxidative and anti-inflammatory properties.

Conclusion: LC ameliorates Movento-induced testicular damage by attenuating oxidative stress and inflammation.

Abstract Image

左旋肉碱改善运动暴露小鼠睾丸参数紊乱和性激素水平:减轻氧化应激和炎症
背景:螺虫是农业上应用最广泛的农药之一。长期暴露于Movento可能通过诱导氧化应激和炎症对男性生育能力产生不利影响。相反,左旋肉碱(LC),一种有效的抗氧化和抗炎化合物,已被证明可以减轻细胞损伤。本研究评价了LC对雄性小鼠睾丸损伤的保护作用。方法:32只雄性小鼠(9-10周龄,体重25-35 g)分为4组:对照组(Con),灌胃生理盐水(Movento vehicle) 35 d。Movento (M),每48 h给予Movento (1000 mg/kg),连续灌胃35天。LC + Movento (LC + M), Movento给药后加LC (200 mg/kg)处理(与M组相同)。LC-only (LC),给予200 mg/kg的LC,灌胃35天。治疗后,对小鼠实施安乐死,并评估睾丸组织学、精子参数、炎症细胞因子和性激素水平。结果:与对照组相比,Movento暴露显著增加了精子异常,降低了性激素水平,并破坏了精管形态。然而,LC的摄入可以部分改善性激素水平、精子质量和睾丸结构,这可能是由于它的抗氧化和抗炎特性。结论:LC可通过减轻氧化应激和炎症来改善运动诱导的睾丸损伤。
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来源期刊
Andrologia
Andrologia 医学-男科学
CiteScore
5.60
自引率
8.30%
发文量
292
审稿时长
6 months
期刊介绍: Andrologia provides an international forum for original papers on the current clinical, morphological, biochemical, and experimental status of organic male infertility and sexual disorders in men. The articles inform on the whole process of advances in andrology (including the aging male), from fundamental research to therapeutic developments worldwide. First published in 1969 and the first international journal of andrology, it is a well established journal in this expanding area of reproductive medicine.
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