{"title":"Antioxidants and Male Infertility: Interpreting Meta-Analytical Evidence to the Skeptics and Discerning Clinicians","authors":"Selahittin Çayan, Rossella Cannarella, Mohamed Arafa, Ashok Agarwal","doi":"10.1155/and/4666847","DOIUrl":null,"url":null,"abstract":"<div>\n <p>Elevated levels of oxidative stress (OS) in semen are linked to sperm dysfunction, DNA damage, and reduced male fertility, leading to impaired sperm parameters. Antioxidants (AOXs) are widely available, relatively inexpensive, and more accessible compared to other medical and surgical treatments for male infertility. However, there is significant debate in the literature regarding their efficacy, and a clear consensus has yet to be reached. This review aims to evaluate the use of AOX in male infertility by analyzing the latest meta-analytical evidence and presenting case scenarios. Our review found evidence-based consensus demonstrating significant improvements in pregnancy rates and sperm parameters following AOX treatment. However, a careful clinical workup and additional randomized controlled trials (RCTs) are necessary to support AOX treatment in infertile men.</p>\n </div>","PeriodicalId":7817,"journal":{"name":"Andrologia","volume":"2025 1","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/and/4666847","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Andrologia","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/and/4666847","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ANDROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Elevated levels of oxidative stress (OS) in semen are linked to sperm dysfunction, DNA damage, and reduced male fertility, leading to impaired sperm parameters. Antioxidants (AOXs) are widely available, relatively inexpensive, and more accessible compared to other medical and surgical treatments for male infertility. However, there is significant debate in the literature regarding their efficacy, and a clear consensus has yet to be reached. This review aims to evaluate the use of AOX in male infertility by analyzing the latest meta-analytical evidence and presenting case scenarios. Our review found evidence-based consensus demonstrating significant improvements in pregnancy rates and sperm parameters following AOX treatment. However, a careful clinical workup and additional randomized controlled trials (RCTs) are necessary to support AOX treatment in infertile men.
期刊介绍：
Andrologia provides an international forum for original papers on the current clinical, morphological, biochemical, and experimental status of organic male infertility and sexual disorders in men. The articles inform on the whole process of advances in andrology (including the aging male), from fundamental research to therapeutic developments worldwide. First published in 1969 and the first international journal of andrology, it is a well established journal in this expanding area of reproductive medicine.
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