Renal physiology最新文献_第8页

Acute effects of various diuretics on lithium clearance. Studies in rats on medium and low sodium diet. 各种利尿剂对锂清除的急性影响。中、低钠饮食大鼠的研究。

Renal physiology Pub Date : 1986-01-01 DOI: 10.1159/000173070

K. Thomsen, P. Leyssac

引用次数: 42

In vitro phosphorylation of rat kidney proximal tubular brush border membranes. 大鼠肾近端管刷边界膜的体外磷酸化。

Renal physiology Pub Date : 1985-01-01 DOI: 10.1159/000173030

J Biber, V Scalera, H Murer

{"title":"In vitro phosphorylation of rat kidney proximal tubular brush border membranes.","authors":"J Biber, V Scalera, H Murer","doi":"10.1159/000173030","DOIUrl":"https://doi.org/10.1159/000173030","url":null,"abstract":"The phosphorylation of rat renal brush border membrane protein was analyzed after incubation of cortical slices with 32P-orthophosphate and compared with the phosphorylation by gamma-32P-ATP of isolated brush border vesicles. Phosphate incorporation into brush border membranes isolated from slices was linearly related to the incubation time as well as to the specific activity of orthophosphate present during slice incubation. Incorporation of phosphate into proteins reached an equilibrium after about 60 min, whereas incorporation of phosphate into lipids increased continuously. In brush border membranes isolated from slices incubated with orthophosphate (32P), the addition of cAMP or theophylline produced a dephosphorylation of a 47,000-dalton protein; no increased phosphorylation was observed. In brush border membranes, phosphorylated with gamma-32P-ATP, cAMP and dibutyryl cAMP (dB-cAMP) produced an increase in phosphorylation but no dephosphorylation. Sodium-dependent phosphate transport in brush border membranes was not altered by an incubation of slices with cAMP or dB-cAMP. These observations suggest that the phosphorylation machinery of isolated rat renal brush border membranes does not correspond with the mechanisms leading to phosphate incorporation into brush border membrane proteins in the intact cell.","PeriodicalId":77779,"journal":{"name":"Renal physiology","volume":"8 1","pages":"19-29"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000173030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14115857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The movement of solutes and water across the vertebrate distal nephron. 溶质和水穿过脊椎动物远端肾元的运动。

Renal physiology Pub Date : 1985-01-01 DOI: 10.1159/000173057

L C Stoner

引用次数: 19

Endocrine control of renal handling of solutes and water in vertebrates. 脊椎动物对溶质和水的肾脏处理的内分泌控制。

Renal physiology Pub Date : 1985-01-01 DOI: 10.1159/000173060

H Nishimura

{"title":"Endocrine control of renal handling of solutes and water in vertebrates.","authors":"H Nishimura","doi":"10.1159/000173060","DOIUrl":"https://doi.org/10.1159/000173060","url":null,"abstract":"Hormones influence renal function by both extrarenal and intrarenal mechanisms. Extrarenal mechanisms include the effects through systemic hemodynamic and neural pathways, whereas intrarenal mechanisms can be largely divided into the effects on intrarenal hemodynamics and those on tubular transport epithelia. Neurohypophysial hormones and the renin-angiotensin system appear to act primarily on systemic and preglomerular vasculature in primitive vertebrates, while direct tubular action appears to have evolved at a later stage of phylogeny. Although aldosterone is an essential hormone for fluid mineral balance in mammals, the action of mineralocorticoids on tubular Na transport has not been established in nonmammalian tetrapods. In bony fishes in hyperosmotic environments, cortisol accelerates active Na extrusion from the gill. In contrast, prolactin is important for maintaining low osmotic water permeability of the transport epithelia in fishes in hypoosmotic media. Thus, both function and site of hormone action appear to have changed during the evolution of vertebrates interacting with changing environments, and in response to the demands from other bodily functions. Furthermore, evolution of interactions, at the cellular level, between systemic and locally formed hormones such as prostaglandins, kinins, and perhaps angiotensin may have developed more elaborate controlling systems of renal handling of solutes and water.","PeriodicalId":77779,"journal":{"name":"Renal physiology","volume":"8 4-5","pages":"279-300"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000173060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15021226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

Verapamil effect on renal function of normotensive and hypertensive rats. 维拉帕米对正常和高血压大鼠肾功能的影响。

Renal physiology Pub Date : 1985-01-01 DOI: 10.1159/000173042

M MacLaughlin, M de Mello Aires, G Malnic

{"title":"Verapamil effect on renal function of normotensive and hypertensive rats.","authors":"M MacLaughlin, M de Mello Aires, G Malnic","doi":"10.1159/000173042","DOIUrl":"https://doi.org/10.1159/000173042","url":null,"abstract":"The effect of verapamil, a Ca++ antagonist drug, on renal function and proximal fluid reabsorption in normal and hypertensive (GII) rats was studied. During intravenous infusion of verapamil, mean arterial pressure (MAP) fell significantly in both groups, 23% more in hypertensive than in normotensive rats. Glomerular filtration rate (GFR) was significantly higher in hypertensive rats and also increased significantly in this group during verapamil infusion. Effective renal plasma flow (ERPF) was similar in both groups and did not change significantly during verapamil infusion. The increase in urine flow, Na+ and Ca++ excretion was higher in hypertensive than in normotensive rats during verapamil infusion. When 10(-5) M verapamil was added to the luminal perfusate of proximal tubules, fluid reabsorption was reduced to 64% in normotensive and to 42% in hypertensive rats. When added to capillary perfusate, fluid reabsorption was almost completely but reversibly inhibited (92% in normotensive and 83% in hypertensive rats). Our findings indicate a direct effect of verapamil on renal Na+ and possibly also on Ca++ reabsorption, suggesting involvement of the Na+-Ca++ countertransport system. The greater effect of verapamil on Na+ excretion in hypertensive rats was not due to increased action on proximal Na+ reabsorption.","PeriodicalId":77779,"journal":{"name":"Renal physiology","volume":"8 2","pages":"112-9"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000173042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15103906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Production and excretion of dopamine by the isolated perfused rat kidney. 离体灌注大鼠肾脏多巴胺的产生和排泄。

Renal physiology Pub Date : 1985-01-01 DOI: 10.1159/000173048

W R Adam, B A Adams

引用次数: 21

Permselectivity and proteinuria in 'minimal-lesion' nephrosis. “小病变”肾病的选择性与蛋白尿。

Renal physiology Pub Date : 1985-01-01 DOI: 10.1159/000173035

L. Wesson

引用次数: 0

An attempt to measure glomerular plasma flow by the cationic dyes alcian blue and ruthenium red. 用阳离子染料阿利新蓝和钌红测定肾小球血浆流量的尝试。

Renal physiology Pub Date : 1985-01-01 DOI: 10.1159/000173046

O J Lavik, K Aukland

引用次数: 0

Effect of free fatty acids on renal metabolism of very low density lipoprotein triglyceride. 游离脂肪酸对极低密度脂蛋白甘油三酯肾脏代谢的影响。

Renal physiology Pub Date : 1985-01-01 DOI: 10.1159/000173028

M E Trimble

引用次数: 4

Impaired sodium excretion in experimental glomerulonephritis: an explanation for the controversies in the literature. 实验性肾小球肾炎钠排泄障碍:对文献争议的解释。

Renal physiology Pub Date : 1985-01-01 DOI: 10.1159/000173066

A Chachati, J P Godon

{"title":"Impaired sodium excretion in experimental glomerulonephritis: an explanation for the controversies in the literature.","authors":"A Chachati, J P Godon","doi":"10.1159/000173066","DOIUrl":"https://doi.org/10.1159/000173066","url":null,"abstract":"Considerable discrepancies exist in the literature concerning Na excretion by the rat kidney in experimental antiglomerular basement membrane (GBM) glomerulonephritis (GN). Previous studies in our laboratories demonstrated a disturbance in Na excretion with an impaired absolute (UNa X V) and fractional (FENa) excretion of Na after saline loading. However, most of the other authors in the literature failed to observe similar findings. The present study was undertaken to elucidate some of these controversies: We showed that a difference in Na excretion between anesthetized GN and normal rats might not be detected after a volume expansion if the latter is small or slow (FENa in GN 2 +/- 0.1%, in normals 2 +/- 0.2%; not significant). Only a rapid and important volume expansion is sufficient to unmask such a difference between the two groups (FENa 3 +/- 0.3 and 6 +/- 1%, respectively, p less than 0.001), and detect an impaired Na excretion in GN animals. The same amount of NaCl was nevertheless administered during slow and rapid volume expansion. Similarly, in GN conscious rats only after a saline load or repeated water loads did we observe a significantly smaller UNa X V compared to normals while no difference was present between the two groups after a single water load. In the literature, all the authors, that failed to demonstrate a disturbance in Na excretion in anti-GBM GN, administered slow and small isotonic saline loads to their rats. The hypothesis we formulate to explain these controversies is that the nonobserved disturbance in sodium excretion in most of these studies is probably secondary to insufficient natriuretic stimuli.","PeriodicalId":77779,"journal":{"name":"Renal physiology","volume":"8 6","pages":"338-47"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000173066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15193918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6