{"title":"用阳离子染料阿利新蓝和钌红测定肾小球血浆流量的尝试。","authors":"O J Lavik, K Aukland","doi":"10.1159/000173046","DOIUrl":null,"url":null,"abstract":"<p><p>Autoradiography showed that 3H-labelled alcian blue injected into the rat renal artery was concentrated in the glomeruli. To test if the uptake could be used as a measure of local glomerular plasma flow, the one-pass extraction was measured in 19 rats. The average extraction was 31.9% (SD 8.0%). Impurities and heterogeneity of the tracer as well as reversible binding to erythrocytes may have contributed to the low estimated extraction. The average extraction of 103Ru-ruthenium red was 26.3%. We conclude that neither of these dyes are suitable for measurement of glomerular plasma flow.</p>","PeriodicalId":77779,"journal":{"name":"Renal physiology","volume":"8 3","pages":"136-9"},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000173046","citationCount":"0","resultStr":"{\"title\":\"An attempt to measure glomerular plasma flow by the cationic dyes alcian blue and ruthenium red.\",\"authors\":\"O J Lavik, K Aukland\",\"doi\":\"10.1159/000173046\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Autoradiography showed that 3H-labelled alcian blue injected into the rat renal artery was concentrated in the glomeruli. To test if the uptake could be used as a measure of local glomerular plasma flow, the one-pass extraction was measured in 19 rats. The average extraction was 31.9% (SD 8.0%). Impurities and heterogeneity of the tracer as well as reversible binding to erythrocytes may have contributed to the low estimated extraction. The average extraction of 103Ru-ruthenium red was 26.3%. We conclude that neither of these dyes are suitable for measurement of glomerular plasma flow.</p>\",\"PeriodicalId\":77779,\"journal\":{\"name\":\"Renal physiology\",\"volume\":\"8 3\",\"pages\":\"136-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1985-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1159/000173046\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Renal physiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1159/000173046\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Renal physiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000173046","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
An attempt to measure glomerular plasma flow by the cationic dyes alcian blue and ruthenium red.
Autoradiography showed that 3H-labelled alcian blue injected into the rat renal artery was concentrated in the glomeruli. To test if the uptake could be used as a measure of local glomerular plasma flow, the one-pass extraction was measured in 19 rats. The average extraction was 31.9% (SD 8.0%). Impurities and heterogeneity of the tracer as well as reversible binding to erythrocytes may have contributed to the low estimated extraction. The average extraction of 103Ru-ruthenium red was 26.3%. We conclude that neither of these dyes are suitable for measurement of glomerular plasma flow.
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