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Carcinogenesis; a comprehensive survey最新文献

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The role of chemicals and radiation in the etiology of cancer. 化学物质和辐射在癌症病因学中的作用。
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
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引用次数: 0
Enhancement of lung tumor formation in mice. 促进小鼠肺肿瘤形成。
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
H P Witschi
{"title":"Enhancement of lung tumor formation in mice.","authors":"H P Witschi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There is now a great deal of data available that show that BHT enhances the development of lung tumors in mice. In many ways BHT behaves like a promoting agent. Interestingly, it also has tumor enhancing or promoting properties in other organs than mouse lung, such as rat liver, rat bladder, possibly rat GI tract, and in in vitro systems. The development of lung tumors by BHT may be influenced by comparatively low exposure regimens; the minimum dose found so far to be effective is 6 intraperitoneal injections of 50 mg/kg of BHT of feeding a diet containing 500 ppm of BHT for 2 weeks. While these findings seem to require that the continued use of BHT as a food additive needs to be reevaluated, it should be mentioned that other considerations have led to the conclusion that the use of BHT probably has a large margin of safety. This makes it important to establish the mechanism of action of BHT which at this time remains unknown.</p>","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"8 ","pages":"147-58"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15101075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-hit versus multi-hit concept of hepatocarcinogenesis. 肝癌发生的单点与多点概念。
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
C Peraino, S D Vesselinovitch
{"title":"Single-hit versus multi-hit concept of hepatocarcinogenesis.","authors":"C Peraino,&nbsp;S D Vesselinovitch","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"10 ","pages":"81-92"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15022632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancement and promotion in respiratory cancer. 增强和促进呼吸系统癌症。
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
J Higginson
{"title":"Enhancement and promotion in respiratory cancer.","authors":"J Higginson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"8 ","pages":"437-42"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15100380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neoplastic transformation of human diploid fibroblasts (KMST-6) by treatment with Co-60 gamma rays. 钴-60 γ射线治疗人二倍体成纤维细胞(KMST-6)的肿瘤转化。
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
M Namba
{"title":"Neoplastic transformation of human diploid fibroblasts (KMST-6) by treatment with Co-60 gamma rays.","authors":"M Namba","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"9 ","pages":"217-31"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15165502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence that the first step leading to carcinogen-induced malignant transformation is a high frequency, common event. 有证据表明，第一步导致致癌物质诱导的恶性转化是一种频率高、常见的事件。
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
A R Kennedy
{"title":"Evidence that the first step leading to carcinogen-induced malignant transformation is a high frequency, common event.","authors":"A R Kennedy","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"9 ","pages":"355-64"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15165508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genes and membrane signals involved in neoplastic transformation. 参与肿瘤转化的基因和膜信号。
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
N H Colburn
{"title":"Genes and membrane signals involved in neoplastic transformation.","authors":"N H Colburn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Figure 2 summarizes our current understanding of the signal transduction events that appear to be involved in promotion of transformation in JB6 cells. Among the earliest promotion-relevant events (at least for phorbol esters) appear to be C-kinase activation and superoxide anion elevation. Whether such events regulate expression of pro genes needs to be elucidated. Finally, Fig. 3 presents a model for the role of pro genes and transforming genes in inducing and maintaining neoplastic transformation in mouse JB6 cells. Our current hypothesis is that TPA interacts with its receptor (C-kinase) to trigger one or more promotion-relevant second messages, which then activate expression of pro gene(s). The product of a pro gene is postulated to then activate expression of a transforming gene so that its expression becomes constitutive in the neoplastic cell. In the P- cells the \"defect\" could be at the level of a missing second messenger signal to activate pro genes or a structural change in pro genes such that they are not expressed or they lack activity even though expressed. Recent evidence to be presented elsewhere indicates that pro genes are not limited to mouse cells but are found in certain human tumor and nontumor cells. If human pro homologues turn out to show biological activity for specifying sensitivity to neoplastic transformation, this finding will add a new dimension to testing the somatic mutation hypothesis of carcinogenesis.</p>","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"10 ","pages":"235-48"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15176464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stabilization of Z-DNA conformation by chemical carcinogens. 化学致癌物对Z-DNA构象的稳定性。
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
D Grunberger, R M Santella, L H Hanau, B F Erlanger
{"title":"Stabilization of Z-DNA conformation by chemical carcinogens.","authors":"D Grunberger,&nbsp;R M Santella,&nbsp;L H Hanau,&nbsp;B F Erlanger","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"10 ","pages":"465-80"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14132266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genes and signal transduction in tumor promotion: conclusions from studies with promoter resistant variants of JB-6 mouse epidermal cells. 肿瘤促进的基因和信号转导:来自JB-6小鼠表皮细胞启动子抗性变异的研究结论。
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
T D Gindhart, Y Nakamura, L A Stevens, G A Hegameyer, M W West, B M Smith, N H Colburn
{"title":"Genes and signal transduction in tumor promotion: conclusions from studies with promoter resistant variants of JB-6 mouse epidermal cells.","authors":"T D Gindhart,&nbsp;Y Nakamura,&nbsp;L A Stevens,&nbsp;G A Hegameyer,&nbsp;M W West,&nbsp;B M Smith,&nbsp;N H Colburn","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"8 ","pages":"341-67"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14288646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction between nontransforming retroviruses and chemicals in cells in vitro: association with progression to neoplastic phenotypes. 体外细胞中非转化逆转录病毒和化学物质之间的相互作用:与肿瘤表型进展的关联
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
W A Suk
{"title":"Interaction between nontransforming retroviruses and chemicals in cells in vitro: association with progression to neoplastic phenotypes.","authors":"W A Suk","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"9 ","pages":"423-36"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13561732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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