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Carcinogenesis; a comprehensive survey最新文献

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Pathology of human and experimental skin tumors. 人类及实验性皮肤肿瘤病理。
Carcinogenesis; a comprehensive survey Pub Date : 1989-01-01
A J Klein-Szanto
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引用次数: 0
The transformation of human epidermal keratinocytes by carcinogens and viruses in vitro. 致癌物和病毒对人表皮角质形成细胞的体外转化。
Carcinogenesis; a comprehensive survey Pub Date : 1989-01-01
E K Parkinson
{"title":"The transformation of human epidermal keratinocytes by carcinogens and viruses in vitro.","authors":"E K Parkinson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"11 ","pages":"349-68"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13787580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Keratin expression in mouse epidermal tumors. 角蛋白在小鼠表皮肿瘤中的表达。
Carcinogenesis; a comprehensive survey Pub Date : 1989-01-01
D R Roop, T Mehrel, T M Krieg, H Nakazawa, C K Cheng, S H Yuspa
{"title":"Keratin expression in mouse epidermal tumors.","authors":"D R Roop, T Mehrel, T M Krieg, H Nakazawa, C K Cheng, S H Yuspa","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"11 ","pages":"257-71"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13612207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The action of oncogenes and growth factors in tumour initiation and promotion. 癌基因和生长因子在肿瘤发生和促进中的作用。
Carcinogenesis; a comprehensive survey Pub Date : 1989-01-01
R Akhurst, B Bailleul, K Brown, M Ramsden, F Fee, A Balmain
{"title":"The action of oncogenes and growth factors in tumour initiation and promotion.","authors":"R Akhurst, B Bailleul, K Brown, M Ramsden, F Fee, A Balmain","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"11 ","pages":"243-55"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13638279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chromosome alterations in human malignant melanoma. 人类恶性黑色素瘤的染色体改变。
Carcinogenesis; a comprehensive survey Pub Date : 1989-01-01
J M Trent, S P Leong, F L Meyskens
{"title":"Chromosome alterations in human malignant melanoma.","authors":"J M Trent,&nbsp;S P Leong,&nbsp;F L Meyskens","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This review has provided an update on current progress in identifying recurring sites of chromosome change in human malignant melanoma. Despite methodologic difficulties, a recurring and decidedly nonrandom pattern of chromosome change is beginning to emerge for this neoplasia. It appears most reasonable to suggest that as an increasing number of cases of melanoma are cytogenetically examined, the stratification of patients into defined subgroups based upon specific chromosome abnormalities will be possible. At present, the clinical utility of chromosome analysis in malignant melanoma is indeterminate. However, the pinpointing of regions of the genome which are characteristically altered in this tumor may be of significant benefit in targeting future molecular (and hopefully mechanistic) investigations. Continued study of the basic genetics of malignant melanoma would appear a particularly fruitful avenue to continue and it assuredly will add to our understanding of the causation, progression, and ultimately the control of this disorder.</p>","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"11 ","pages":"165-86"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13787575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultraviolet radiation-induced skin cancer. 紫外线辐射诱发皮肤癌。
Carcinogenesis; a comprehensive survey Pub Date : 1989-01-01
R J Fry, R D Ley
{"title":"Ultraviolet radiation-induced skin cancer.","authors":"R J Fry,&nbsp;R D Ley","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"11 ","pages":"321-37"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13787579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human melanoma xenografts. 人类黑色素瘤异种移植。
Carcinogenesis; a comprehensive survey Pub Date : 1989-01-01
A Pawlowski, P J Lea
{"title":"Human melanoma xenografts.","authors":"A Pawlowski,&nbsp;P J Lea","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"11 ","pages":"103-32"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13787649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunology of murine skin cancers. 小鼠皮肤癌的免疫学研究。
Carcinogenesis; a comprehensive survey Pub Date : 1989-01-01
M L Kripke
{"title":"Immunology of murine skin cancers.","authors":"M L Kripke","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"11 ","pages":"273-91"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13787577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor progression in melanoma: the biology of epidermal melanocytes in vitro. 黑色素瘤的肿瘤进展:表皮黑色素细胞的体外生物学。
Carcinogenesis; a comprehensive survey Pub Date : 1989-01-01
M L Mancianti, M Herlyn
{"title":"Tumor progression in melanoma: the biology of epidermal melanocytes in vitro.","authors":"M L Mancianti,&nbsp;M Herlyn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The propagation of pigmented cells derived from normal skin, common and precursor nevi, and primary and metastatic melanoma in tissue culture has allowed the study of tumor progression under experimental conditions. In accordance with Clark's hypothesis, which is based on histopathological observations, cells isolated from different stages of tumor progression show a stepwise development of a malignant phenotype as defined by different biological parameters: life span in culture, anchorage-independent growth, increased growth autonomy from exogenous growth factors, expression of melanoma-associated antigens, progressively severe chromosomal abnormalities, and tumorigenicity in nude mice. Qualitative and quantitative differences exist between normal melanocytes and nevus cells on the one hand, and between VGP primary and metastatic melanoma cells on the other. Little information, however, is available on cells from dysplastic nevi and RGP primary melanoma cells. Preliminary results suggest that the biologic, immunologic and genetic characterization of these cells from the intermediate stages of tumor development will significantly increase our understanding of the pathogenesis of melanoma.</p>","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"11 ","pages":"369-86"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13787581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic background and development of skin tumors. 皮肤肿瘤的遗传背景和发展。
Carcinogenesis; a comprehensive survey Pub Date : 1989-01-01
M Naito, J DiGiovanni
{"title":"Genetic background and development of skin tumors.","authors":"M Naito,&nbsp;J DiGiovanni","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Inbred mouse strains that differing widely in their susceptibility to multistage skin carcinogenesis provide useful models for studying the genetic factors involved and advancing our understanding of the biochemical and molecular events associated with this process. The process of skin tumor initiation appears to be somewhat similar in various strains of mice, and most data in the literature suggest that differences in response to skin tumor promoters are a major determinant in controlling susceptibility to multistage skin carcinogenesis. A model system has been developed for examining the genetics of susceptibility to skin tumor promotion. The susceptibility to phorbol ester skin tumor promotion in crosses between DBA/2 and C57BL/6 mice is inherited as an incomplete dominant trait, and neither X-chromosome nor cytoplasmic genetic determinants appear to play a major role in determining susceptibility in these two inbred strains. In addition, two or more genetic loci contribute to the higher sensitivity of DBA/2 mice than C57BL/6 mice to TPA-induced skin tumor promotion. Further studies to characterize these genes will contribute greatly to our understanding of the mechanisms of phorbol ester skin tumor promotion. In addition, much work should now be directed at understanding the cellular, biochemical, and molecular mechanisms for differential responsiveness not only to phorbol esters but also to other classes of tumor promoters.</p>","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"11 ","pages":"187-212"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13638277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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