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Carcinogenesis; a comprehensive survey最新文献

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Transforming genes of human malignancies. 人类恶性肿瘤的转化基因。
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
S A Aaronson, S R Tronick
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引用次数: 0
Mammalian cell mutation and polycyclic hydrocarbon carcinogenesis. 哺乳动物细胞突变与多环烃致癌作用。
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
P Brookes, H W King, M R Osborne
{"title":"Mammalian cell mutation and polycyclic hydrocarbon carcinogenesis.","authors":"P Brookes, H W King, M R Osborne","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"10 ","pages":"433-47"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15022629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-event model of carcinogenesis: a mathematical model for cancer causation and prevention. 多事件致癌模型:癌症起因与预防的数学模型。
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
K C Chu
{"title":"Multi-event model of carcinogenesis: a mathematical model for cancer causation and prevention.","authors":"K C Chu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"8 ","pages":"411-21"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15100376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution and cancer. 进化和癌症。
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
M Calvin
{"title":"Evolution and cancer.","authors":"M Calvin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"10 ","pages":"51-63"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15176362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of malignant transformation of human diploid cells. 人二倍体细胞恶性转化的机制。
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
J B Little
{"title":"Mechanisms of malignant transformation of human diploid cells.","authors":"J B Little","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"10 ","pages":"337-53"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15176466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro studies of human lung carcinogenesis. 人肺癌发生的体外研究。
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
C C Harris, J F Lechner, G H Yoakum, P Amstad, B E Korba, E Gabrielson, R Grafstrom, A Shamsuddin, B F Trump
{"title":"In vitro studies of human lung carcinogenesis.","authors":"C C Harris,&nbsp;J F Lechner,&nbsp;G H Yoakum,&nbsp;P Amstad,&nbsp;B E Korba,&nbsp;E Gabrielson,&nbsp;R Grafstrom,&nbsp;A Shamsuddin,&nbsp;B F Trump","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Advances in the methodology to culture normal human lung cells have provided opportunities to investigate fundamental problems in biomedical research, including the mechanism(s) of carcinogenesis. Using the strategy schematically shown in Figure 1, we have initiated studies of the effects of carcinogens on the normal progenitor cells of the human cancers caused by these carcinogens. Extended lifespans and aneuploidy were found after exposure of mesothelial cells to asbestos and bronchial epithelial cells to nickel sulfate. These abnormal cells may be considered to be preneoplastic and at an intermediate position in the multistage process of carcinogenesis. Human bronchial epithelial cells can also be employed to investigate the role of specific oncogenes in carcinogenesis and tumor progression. Using the protoplast fusion method for high frequency gene transfection, vHa-ras oncogene initiates a cascade of events in the normal human bronchial cells leading to their apparent immortality, aneuploidy, and tumorigenicity in athymic nude mice. These results suggest that oncogenes may play an important role in human carcinogenesis.</p>","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"9 ","pages":"257-69"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13561730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical and biochemical dosimetry of exposure to genotoxic chemicals. 暴露于遗传毒性化学品的化学和生化剂量学。
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
G N Wogan
{"title":"Chemical and biochemical dosimetry of exposure to genotoxic chemicals.","authors":"G N Wogan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"10 ","pages":"167-76"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15019454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological basis for assessing carcinogenic risks of low-level radiation. 低水平辐射致癌风险评估的生物学基础。
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
A C Upton
{"title":"Biological basis for assessing carcinogenic risks of low-level radiation.","authors":"A C Upton","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ionizing radiation is carcinogenic to many, if not most, tissues. Its carcinogenicity varies, however, depending on the tissue exposed, conditions of exposure, genetic background, sex, age of the exposed individual, and other factors. The neoplasms induced by radiation also vary in their types and in their times of onset, depending on the age and sex of the exposed individual. The long induction period for radiation carcinogenesis and the enhancing or inhibiting effects of other agents acting after irradiation imply that the induction of cancer is a multistage process, in keeping with experiments on radiation-induced cell transformation in vitro. The molecular nature of the steps involved in radiation carcinogenesis remains to be fully elucidated, but it is being rapidly explored through advances in somatic cell genetics and molecular biology. The resulting insights will significantly extend epidemiological data in future attempts to estimate the carcinogenic risks of low-level radiation.</p>","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"10 ","pages":"381-401"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15022627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transformation of human cells with cloned and genomic DNAs: towards an understanding of human skin cancers. 克隆和基因组dna的人类细胞转化:对人类皮肤癌的理解。
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
B M Sutherland
{"title":"Transformation of human cells with cloned and genomic DNAs: towards an understanding of human skin cancers.","authors":"B M Sutherland","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"9 ","pages":"249-56"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15165503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biological mechanisms of stem cell carcinogenesis: a concept for multiple phases in the initiation of carcinogenesis and the role of differentiation control defects. 干细胞癌变的生物学机制:癌变起始的多阶段概念及分化控制缺陷的作用。
Carcinogenesis; a comprehensive survey Pub Date : 1985-01-01
R E Scott, J J Wille, M R Pittelkow, R L Sparks
{"title":"Biological mechanisms of stem cell carcinogenesis: a concept for multiple phases in the initiation of carcinogenesis and the role of differentiation control defects.","authors":"R E Scott,&nbsp;J J Wille,&nbsp;M R Pittelkow,&nbsp;R L Sparks","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77688,"journal":{"name":"Carcinogenesis; a comprehensive survey","volume":"9 ","pages":"67-80"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15017453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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