Cancer drug delivery最新文献_第6页

Effect of vesicle size on the clearance, distribution, and tumor uptake of temperature-sensitive liposomes. 囊泡大小对温度敏感脂质体的清除、分布和肿瘤摄取的影响。

Cancer drug delivery Pub Date : 1986-01-01 DOI: 10.1089/cdd.1986.3.223

R L Magin, J M Hunter, M R Niesman, G A Bark

{"title":"Effect of vesicle size on the clearance, distribution, and tumor uptake of temperature-sensitive liposomes.","authors":"R L Magin, J M Hunter, M R Niesman, G A Bark","doi":"10.1089/cdd.1986.3.223","DOIUrl":"https://doi.org/10.1089/cdd.1986.3.223","url":null,"abstract":"The blood clearance, tissue distribution, and tumor uptake of temperature-sensitive liposomes containing the anticancer drug cytosine [3H]-1-beta-D-arabino-furanoside (Ara-C) or [3H]-methotrexate (MTX) were measured. Large unilamellar liposomes composed of a mixture of dipalmitoylphosphatidylcholine and dipalmitoylphosphatidylglycerol (4:1 by weight) were formed by reverse-phase evaporation and sequentially extruded through polycarbonate membranes with pore sizes of 0.4, 0.2, 0.1, 0.08, and 0.05 micron. The liposomes were injected intravenously via the tail vein into B6D2F1 mice containing solid tumors (M5076 ovarian carcinoma) implanted in both hind feet. Drug release, organ distribution, and tumor uptake were studied during and following local hyperthermia treatments (42 degrees C, 60 minutes). Local hyperthermia increased the relative amount of liposome encapsulated drug delivered to a heated solid tumor compared with the unheated control. The clearance studies showed that liposome blood clearance was inversely proportional to liposome size. However, tumor uptake was not significantly affected by reducing liposome size. In addition, for the range of liposome sizes studied, the majority of the liposome encapsulated drug was found in the liver, spleen, and kidney; not in the heated tumor.","PeriodicalId":77686,"journal":{"name":"Cancer drug delivery","volume":"3 4","pages":"223-37"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/cdd.1986.3.223","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14689714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Cytotoxicity of 2-chlorodeoxyadenosine in a human tumor colony-forming assay. 2-氯脱氧腺苷在人肿瘤集落形成试验中的细胞毒性。

Cancer drug delivery Pub Date : 1986-01-01 DOI: 10.1089/cdd.1986.3.115

J J Hutton, D D Von Hoff

引用次数: 11

Phase II study of hepatic arterial degradable starch microspheres and mitomycin. 肝动脉可降解淀粉微球和丝裂霉素的二期研究。

Cancer drug delivery Pub Date : 1986-01-01 DOI: 10.1089/cdd.1986.3.279

I S Wollner, S C Walker-Andrews, J E Smith, W D Ensminger

引用次数: 33

Drug sensitivity testing of carcinoma of the gallbladder and biliary tree in a human tumor cloning assay. 人肿瘤克隆试验中胆囊癌和胆道树的药物敏感性试验。

Cancer drug delivery Pub Date : 1986-01-01 DOI: 10.1089/cdd.1986.3.197

G J Harris, D D Von Hoff

引用次数: 2

Lack of dihydrofolate reductase in human tumor and leukemia cells in vivo. 人肿瘤和白血病细胞体内缺乏二氢叶酸还原酶。

Cancer drug delivery Pub Date : 1985-01-01 DOI: 10.1089/cdd.1985.2.133

B A Kamen, P A Nylen, V M Whitehead, H T Abelson, B J Dolnick, D W Peterson

引用次数: 36

Daily intraperitoneal administration of cytarabine in a patient with peritoneal mesothelioma. 腹膜间皮瘤患者每日腹腔内给予阿糖胞苷。

Cancer drug delivery Pub Date : 1985-01-01 DOI: 10.1089/cdd.1985.2.285

M Markman, S B Howell

引用次数: 5

The effect of iron dextran on ferritin content and 131I-antiferritin localization in experimental hepatomas. 右旋糖酐铁对实验性肝癌中铁蛋白含量及131i -抗铁蛋白定位的影响。

Cancer drug delivery Pub Date : 1985-01-01 DOI: 10.1089/cdd.1985.2.3

R A Rostock, K A Kopher, T W Bauer, J L Klein

{"title":"The effect of iron dextran on ferritin content and 131I-antiferritin localization in experimental hepatomas.","authors":"R A Rostock, K A Kopher, T W Bauer, J L Klein","doi":"10.1089/cdd.1985.2.3","DOIUrl":"https://doi.org/10.1089/cdd.1985.2.3","url":null,"abstract":"Polyclonal 131I rabbit antirat ferritin localizes in certain hepatoma models. The effect of intraperitoneal iron dextran on tumor and sera ferritin content and tumor and normal tissue localization with 131I antiferritin was studied. Separate groups of 10-12 animals were injected with escalating doses of 131I-antiferritin IgG, or nonspecific IgG, one week after injection with iron dextran or normal saline. The results demonstrate that tumor, serum, and normal tissue ferritin content was increased after iron dextran administration but tumor localization increased after administration of 131I-antiferritin in the H4II-E and 7800 models. The 3924A and 7777 models showed no tumor localization with or without iron dextran but did show an increase in normal tissue localization after iron dextran. Immunoperoxidase staining of tissues with antiferritin revealed increased staining in the liver and spleen and only a slight increase in the tumors after iron dextran was administered. The results demonstrate that tumor localization is a complex phenomenon that depends on normal tissue, sera, and tumor-antigen distribution.","PeriodicalId":77686,"journal":{"name":"Cancer drug delivery","volume":"2 1","pages":"3-9"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/cdd.1985.2.3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15016839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The intraoperative intraperitoneal administration of cisplatin: a case report. 术中腹腔给药顺铂1例。

Cancer drug delivery Pub Date : 1985-01-01 DOI: 10.1089/cdd.1985.2.87

M Markman, R Weiss, S B Howell, W E Lucas

引用次数: 4

Dosage predictions in high-dose methotrexate infusions. Part 2: Bayesian estimation of methotrexate clearance. 大剂量甲氨蝶呤输注的剂量预测。第2部分:甲氨蝶呤清除率的贝叶斯估计。

Cancer drug delivery Pub Date : 1985-01-01 DOI: 10.1089/cdd.1985.2.277

R Bruno, A Iliadis, R Favre, N Lena, A M Imbert, J P Cano

引用次数: 18

Immunotoxins containing ricin A or B chains with modified carbohydrate residues act synergistically in killing neoplastic B cells in vitro. 含有蓖麻毒素A链或B链的免疫毒素与修饰的碳水化合物残基在体外协同杀死肿瘤B细胞。

Cancer drug delivery Pub Date : 1985-01-01 DOI: 10.1089/cdd.1985.2.191

E S Vitetta, P E Thorpe

引用次数: 14