Cancer drug delivery最新文献

In vitro chemosensitivity testing using the multicellular tumor spheroid model. 多细胞肿瘤球体模型体外化疗敏感性试验。

Cancer drug delivery Pub Date : 1987-01-01 DOI: 10.1089/cdd.1987.4.63

D J Kerr, T E Wheldon, A M Kerr, S B Kaye

引用次数: 23

Schedule-dependent toxicity of tumor necrosis factor in rodents. 啮齿动物肿瘤坏死因子的时间表依赖性毒性。

Cancer drug delivery Pub Date : 1987-01-01 DOI: 10.1089/cdd.1987.4.159

J D Liddil, R T Dorr

引用次数: 4

Management of infectious complications of intraventricular reservoirs in cancer patients: low incidence and successful treatment without reservoir removal. 肿瘤患者脑室内储液器感染性并发症的处理:低发病率和成功治疗而不移除储液器。

Cancer drug delivery Pub Date : 1987-01-01 DOI: 10.1089/cdd.1987.4.105

P A Dinndorf, W A Bleyer

{"title":"Management of infectious complications of intraventricular reservoirs in cancer patients: low incidence and successful treatment without reservoir removal.","authors":"P A Dinndorf, W A Bleyer","doi":"10.1089/cdd.1987.4.105","DOIUrl":"https://doi.org/10.1089/cdd.1987.4.105","url":null,"abstract":"At the time of analysis, the first 30 patients with Ommaya reservoirs (OR) at the Children's Orthopedic Hospital and Medical Center in Seattle, Washington had had 32 reservoirs for a mean duration of 28 months. In all, the reservoir chambers had been punctured for either diagnostic or therapeutic purposes a total of 1,287 times with a mean of 40 injections per reservoir and 1.4 injections per month. Six reservoir infections were diagnosed in five patients--a rate of one infection for every 153 reservoir-months. Four infections were attributed to reservoir use--a rate of one infection for every 322 reservoir entries, and less than one infection in 900 entries when a standard aseptic protocol for sampling and injection was applied. There was no correlation between infectious complications and the frequency with which reservoirs were injected, but there was evidence that some of the infections resulted from incomplete compliance with recommended technique for skin preparation and reservoir entry. Four infections were treated successfully with intravenous and intra-reservoir antibiotics without reservoir removal. Only one reservoir had to be removed because of persistent infection. Two other reservoirs were removed because of trauma and malfunction. Twenty-seven patients (90%) retained their original reservoir, up to 9.5 years after implantation. Intraventricular chemotherapy via an indwelling subcutaneous reservoir is a preferred method for delivery of intrathecal chemotherapy, with an acceptable infection risk relative to the benefits of patient comfort and therapeutic efficacy.","PeriodicalId":77686,"journal":{"name":"Cancer drug delivery","volume":"4 2","pages":"105-17"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/cdd.1987.4.105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14605190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Pharmacokinetics of methotrexate and 7-hydroxy-methotrexate after methotrexate infusions. 甲氨蝶呤输注后甲氨蝶呤和7-羟基甲氨蝶呤的药动学。

Cancer drug delivery Pub Date : 1987-01-01 DOI: 10.1089/cdd.1987.4.177

P Bore, A Iliadis, J Catalin, S Just, J P Cano

引用次数: 2

Restoration of drug sensitivity by nitroxazepine hydrochloride in P388 murine leukemia cells resistant to adriamycin. 盐酸硝基沙西平对阿霉素耐药小鼠白血病细胞P388的药物敏感性恢复。

Cancer drug delivery Pub Date : 1987-01-01 DOI: 10.1089/cdd.1987.4.1

M P Chitnis, S G Pradhan, K Satyamoorthy, V S Basrur

{"title":"Restoration of drug sensitivity by nitroxazepine hydrochloride in P388 murine leukemia cells resistant to adriamycin.","authors":"M P Chitnis, S G Pradhan, K Satyamoorthy, V S Basrur","doi":"10.1089/cdd.1987.4.1","DOIUrl":"https://doi.org/10.1089/cdd.1987.4.1","url":null,"abstract":"Attempts were made to reverse the acquired resistance of P388 murine leukemia utilizing non-toxic concentration of nitroxazepine hydrochloride, an antidepressant. The effect of nitroxazepine hydrochloride on the intracellular accumulation of adriamycin and the inhibition of DNA synthesis were studied in these cells. The survival of mice bearing adriamycin-resistant P388 murine leukemia cells treated in vitro with nitroxazepine hydrochloride, adriamycin and a combination of the two drugs was also investigated. The results show that treatment of these cells with nitroxazepine hydrochloride significantly enhanced (1) the intracellular accumulation of adriamycin, (2) inhibition of DNA biosynthesis, and (3) the survival of mice transplanted with adriamycin-resistant P388 murine leukemia cells treated in vitro with a combination of nitroxazepine hydrochloride and adriamycin. The mechanism of restoration of drug sensitivity by nitroxazepine hydrochloride in adriamycin-resistant P388 cells could be due to an enhanced intracellular accumulation of adriamycin. The implications of the present investigations are promising, leaving hope for the utility of nitroxazepine hydrochloride in restoring drug sensitivity in adriamycin-resistant tumors.","PeriodicalId":77686,"journal":{"name":"Cancer drug delivery","volume":"4 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/cdd.1987.4.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14728589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effect of cyclophosphamide on the immunogenicity of monoclonal antimelanoma antibody-ricin A chain immunotoxin in rats. 环磷酰胺对大鼠抗黑素瘤单克隆抗体-蓖麻毒素A链免疫毒素免疫原性的影响。

Cancer drug delivery Pub Date : 1987-01-01 DOI: 10.1089/cdd.1987.4.151

S Harkonen, R Mischak, H Lopez, J Stoudemire

{"title":"Effect of cyclophosphamide on the immunogenicity of monoclonal antimelanoma antibody-ricin A chain immunotoxin in rats.","authors":"S Harkonen, R Mischak, H Lopez, J Stoudemire","doi":"10.1089/cdd.1987.4.151","DOIUrl":"https://doi.org/10.1089/cdd.1987.4.151","url":null,"abstract":"This study was performed to determine the effect of treatment with cyclophosphamide (CY) on the formation of antimurine and anti-ricin A chain antibodies in rats treated with a murine monoclonal antimelanoma antibody-ricin A chain immunotoxin (IT). Animals received treatment with either IT alone or IT plus CY. IT treatment consisted of daily IV injections at a dose of 1 mg/kg/day on days 0, 1, 2, 3, 4. CY treatment consisted of a 25 mg/kg IP dose on day -1 followed by daily IP doses of 5 mg/kg/day on days 0, 1, 2, 3, 4. Antibody binding activities in treated animals were measured by enzyme-linked immunosorbent assay and reported as optical density values. Rats treated with IT plus CY had lower binding activity on day 7 (0.09 vs 0.6; p = .02), day 14 (0.42 vs 1.22; p = .001), and day 21 (0.11 vs 1.3; p = .001) compared to rats treated with IT alone. Lower levels of anti-ricin A chain binding activity were observed in CY treated rats on day 14 (0.35 vs 1.25; p = .001), but not on day 7 or day 21. These results indicate that treatment with CY can abrogate the immune response to murine antibody and partially abrogate the immune response to ricin A chain.","PeriodicalId":77686,"journal":{"name":"Cancer drug delivery","volume":"4 3","pages":"151-7"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/cdd.1987.4.151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14626781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Folate and methotrexate polyglutamate tissue levels in rhesus monkeys following chronic low-dose methotrexate. 慢性低剂量甲氨蝶呤后恒河猴叶酸和多谷氨酸组织水平。

Cancer drug delivery Pub Date : 1987-01-01 DOI: 10.1089/cdd.1987.4.25

N J Winick, B A Kamen, F M Balis, J Holcenberg, C M Lester, D G Poplack

引用次数: 24

5-Fluorouracil incorporation into RNA of a rat liver adenocarcinoma after hepatic artery injection together with degradable starch microspheres. 肝动脉注射后5-氟尿嘧啶与可降解淀粉微球在大鼠肝腺癌RNA中的掺入。

Cancer drug delivery Pub Date : 1987-01-01 DOI: 10.1089/cdd.1987.4.169

H Teder, C Erichsen, P I Christensson, P E Jönsson, U Stenram

引用次数: 3

Resistance of V79 multicell spheroids to mitoxantrone: drug uptake and cytotoxicity. V79多细胞球体对米托蒽醌的耐药性:药物摄取和细胞毒性。

Cancer drug delivery Pub Date : 1987-01-01 DOI: 10.1089/cdd.1987.4.201

T J Bichay, W R Inch

{"title":"Resistance of V79 multicell spheroids to mitoxantrone: drug uptake and cytotoxicity.","authors":"T J Bichay, W R Inch","doi":"10.1089/cdd.1987.4.201","DOIUrl":"https://doi.org/10.1089/cdd.1987.4.201","url":null,"abstract":"We have previously shown that V79 multicell spheroids are resistant to the anthracenedione mitoxantrone (1). In this paper we demonstrate that this resistance is not solely due to restricted drug penetration into the spheroid, but also to an altered intrinsic resistance of the cells when grown as a three-dimensional structure. We have studied the uptake and toxicity of mitoxantrone in V79-OCF4 monolayers, 100 micron spheroids, 650 micron spheroids, and outer and inner cells of 650 micron spheroids. The LD90 for cells exposed as monolayers to mitoxantrone for two hours was 0.016 microgram/ml, 0.055 microgram/ml for 100 micron spheroids, 1.5 micrograms/ml for outer spheroid cells and 6.2 micrograms/ml for inner spheroid cells. Uptake of [14C]mitoxantrone was linear for all populations with no plateau up to the highest doses used. The uptake of drug required to kill 90% of the cells in a population (UP90) of monolayers was 3.7 ng/10(6) cells, 10.7 ng/10(6) cells for 100 micron spheroids, 169 ng/10(6) cells for outer spheroid cells, and 146 ng/10(6) cells for inner spheroid cells. The relative resistance of spheroids compared to monolayers, based on drug concentration in the medium, was 3.4 for small spheroids, 92 for outer cells, and 390 for inner cells. When cell survival was normalized to drug uptake, the relative resistance of spheroids to monolayers was 2.9 for small spheroids, 46 for outer cells and 40 for inner cells of large spheroids. The data demonstrate that the resistance of multicell spheroids to mitoxantrone is not solely due to restricted drug penetration into the cell aggregate but is also due to a spheroid-induced altered intrinsic resistance of the V79 cells.","PeriodicalId":77686,"journal":{"name":"Cancer drug delivery","volume":"4 4","pages":"201-11"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/cdd.1987.4.201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14578495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Humoral immune response to a ricin A chain immunotoxin in patients with metastatic melanoma. 转移性黑色素瘤患者对蓖麻毒素a链免疫毒素的体液免疫反应

Cancer drug delivery Pub Date : 1987-01-01 DOI: 10.1089/cdd.1987.4.245

A A Hertler, L E Spitler, A E Frankel

{"title":"Humoral immune response to a ricin A chain immunotoxin in patients with metastatic melanoma.","authors":"A A Hertler, L E Spitler, A E Frankel","doi":"10.1089/cdd.1987.4.245","DOIUrl":"https://doi.org/10.1089/cdd.1987.4.245","url":null,"abstract":"Immunotoxins, hybrid molecules consisting of a monoclonal antibody linked to a polypeptide toxin have shown anti-tumor activity in both animal models and early clinical trials. However, their potential value in the treatment of human cancer may be limited by the development of host antibodies against the conjugate. Such antibodies could potentially alter immunotoxin pharmacokinetics and pharmacodynamics as well as precipitate serum sickness or anaphylaxis. Using a radioimmunoassay we have measured serial anti-ricin A chain (anti-RTA) and anti-murine immunoglobulin (anti-MIG) titers in 22 patients who received the anti-melanoma immunotoxin XomaZymeR-Mel. Significant titers of anti-RTA and/or anti-MIG were detected in 17 of 21 evaluable patients. Of the four patients not developing antibodies, two were likely immunosuppressed secondary to dexamethasone, and CCNU and dexamethasone respectively. Both patients who received immunotoxin at a time when they had detectable anti-immunotoxin antibodies experienced infusion reactions consistent with immune mediated allergic responses. There was a decrease in peak immunotoxin level in the one patient who had serum immunotoxin levels measured at a time when anti-RTA was present. Strategies to suppress the human immune response to immunotoxins are required before repetitive courses of immunotoxin of this design may be administered.","PeriodicalId":77686,"journal":{"name":"Cancer drug delivery","volume":"4 4","pages":"245-53"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/cdd.1987.4.245","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14625099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39