Cancer drug delivery最新文献_第10页

Altered tissue distribution of amphotericin B by liposomal encapsulation: comparison of normal mice to mice infected with Candida albicans. 脂质体包封改变两性霉素B的组织分布:正常小鼠与感染白色念珠菌小鼠的比较。

Cancer drug delivery Pub Date : 1984-01-01 DOI: 10.1089/cdd.1984.1.199

G Lopez-Berestein, M G Rosenblum, R Mehta

引用次数: 108

Intrathecally administered m-AMSA in the rhesus monkey. 恒河猴鞘内注射m-AMSA。

Cancer drug delivery Pub Date : 1984-01-01 DOI: 10.1089/cdd.1984.1.101

P Gormley, R Riccardi, D O'Neill, D Poplack

引用次数: 0

1-beta-D-arabinofuranosylcytosine-phospholipid conjugates as prodrugs of Ara-C. 1- β - d -阿拉伯糖醛基胞嘧啶-磷脂缀合物作为Ara-C的前药。

Cancer drug delivery Pub Date : 1984-01-01 DOI: 10.1089/cdd.1984.1.181

C I Hong, S H An, D J Buchheit, A Nechaev, A J Kirisits, C R West, E K Ryu, M MacCoss

{"title":"1-beta-D-arabinofuranosylcytosine-phospholipid conjugates as prodrugs of Ara-C.","authors":"C I Hong, S H An, D J Buchheit, A Nechaev, A J Kirisits, C R West, E K Ryu, M MacCoss","doi":"10.1089/cdd.1984.1.181","DOIUrl":"https://doi.org/10.1089/cdd.1984.1.181","url":null,"abstract":"The L-, D-, and D,L-isomers of 1-beta-D-arabinofuranosylcytosine 5'-diphosphate-1,2-dipalmitin, new prodrugs of ara-C5, have been evaluated for antitumor activity in L1210 lymphoid leukemic mice. The L-isomer produced significant increase in life span (ILS), and longterm survivors among mice bearing i.p. and i.c. implanted L1210 leukemia and the maximal ILS values found were greater than 543 and greater than 374% with five and four 45-day survivors out of six mice, respectively, at the optimal single doses of 300 mg/kg and 125 mg/kg. The D- and D,L-isomers also displayed significant in vivo antitumor activity against both i.p. and i.c. implanted L1210 leukemia in mice with ILS range of 144-293% at a total dose of 125-250 mg/kg. Significant schedule dependency was not observed when the conjugates were administered i.p. once daily for 5 days, once every 4 days, or as a single dose, but single doses typically produced the best effects. The L-isomer was found to be a more effective prodrug of ara-C than its isomers and other lipophilic prodrugs, 5'-O-palmitoyl-ara-C and N4-acyl-ara-C. Unlike the latter prodrugs, the new conjugates are water soluble by sonication method.","PeriodicalId":77686,"journal":{"name":"Cancer drug delivery","volume":"1 3","pages":"181-90"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/cdd.1984.1.181","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17601453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Cytotoxic activity of echinomycin in a human tumor cloning system. 棘霉素在人肿瘤克隆系统中的细胞毒活性研究。

Cancer drug delivery Pub Date : 1984-01-01 DOI: 10.1089/cdd.1984.1.191

B Lathan, D D Von Hoff

引用次数: 13

Comparative tumor dose from 131I-labeled polyclonal anti-ferritin, anti-AFP, and anti-CEA in primary liver cancers. 131i标记的多克隆抗铁蛋白、抗afp和抗cea在原发性肝癌中的肿瘤剂量比较。

Cancer drug delivery Pub Date : 1984-01-01 DOI: 10.1089/cdd.1984.1.321

P K Leichner, J L Klein, E K Fishman, S S Siegelman, D S Ettinger, S E Order

{"title":"Comparative tumor dose from 131I-labeled polyclonal anti-ferritin, anti-AFP, and anti-CEA in primary liver cancers.","authors":"P K Leichner, J L Klein, E K Fishman, S S Siegelman, D S Ettinger, S E Order","doi":"10.1089/cdd.1984.1.321","DOIUrl":"https://doi.org/10.1089/cdd.1984.1.321","url":null,"abstract":"Results of dosimetric studies are reported for 30 patients with hepatoma and 5 patients with primary hepatic cholangiocarcinoma who received treatment with 131I-labeled polyclonal antibodies. Studies included liver and tumor volume computations from X-ray CT scans, in vivo quantitation of the activity of radiolabeled antibodies in hepatic tumors and normal liver tissue, and effective half-life measurements. Twenty-two patients with hepatoma were administered 131I-labeled polyclonal anti-ferritin. Five hepatoma patients, who were AFP-positive, were administered anti-alpha-fetoprotein (AFP). Three patients with AFP-positive hepatomas received both 131I-labeled anti-ferritin and anti-AFP in a bolus. The five cholangiocarcinoma patients were treated with 131I-labeled anti-carcinoembryonic antigen (CEA). For administered activities of 30 mCi on day 0 and 20 mCi on day 5, mean values of the radiation dose to hepatomas were approximately 1100 rads for anti-ferritin, 350 rads for anti-AFP, and 960 rads for the combination of anti-ferritin and anti-AFP. Polyclonal anti-ferritin has, therefore, become the antibody of choice in the treatment of hepatoma. The radiation dose to cholangiocarcinomas from 131I-labeled anti-CEA and administered activities of 20 mCi on day 0 and 10 mCi on day 5 was approximately 620 rads. Total-body irradiation for these injection schedules ranged from 30 to 50 rads.","PeriodicalId":77686,"journal":{"name":"Cancer drug delivery","volume":"1 4","pages":"321-8"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/cdd.1984.1.321","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17152938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Phase-I study of continuous infusion cyclophosphamide for protracted durations: a preliminary report. 长期持续输注环磷酰胺的i期研究:初步报告。

Cancer drug delivery Pub Date : 1984-01-01 DOI: 10.1089/cdd.1984.1.329

J J Lokich, A Bothe

引用次数: 8

Importance of clinical exposure on verapamil enhancement of adriamycin-vincristine cytotoxicity in human neuroblastoma. 临床暴露对维拉帕米增强阿霉素-长春新碱对人神经母细胞瘤细胞毒性的重要性。

Cancer drug delivery Pub Date : 1984-01-01 DOI: 10.1089/cdd.1984.1.303

L Helson, B Member, C Helson

引用次数: 18

Labeling monoclonal antibodies and F(ab')2 fragments with (111In) indium using cyclic DTPA anhydride and their in vivo behavior in mice bearing human tumor xenografts. 用环DTPA酸酐标记单克隆抗体和F(ab’)2片段(111In)铟及其在人肿瘤移植小鼠体内的行为

Cancer drug delivery Pub Date : 1984-01-01 DOI: 10.1089/cdd.1984.1.125

J Powe, K Y Pak, C H Paik, Z Steplewski, M A Ebbert, D Herlyn, C Ernst, A Alavi, W C Eckelman, R C Reba

{"title":"Labeling monoclonal antibodies and F(ab')2 fragments with (111In) indium using cyclic DTPA anhydride and their in vivo behavior in mice bearing human tumor xenografts.","authors":"J Powe, K Y Pak, C H Paik, Z Steplewski, M A Ebbert, D Herlyn, C Ernst, A Alavi, W C Eckelman, R C Reba","doi":"10.1089/cdd.1984.1.125","DOIUrl":"https://doi.org/10.1089/cdd.1984.1.125","url":null,"abstract":"Monoclonal antibodies (MAb) and their F(ab')2 fragments to human colorectal carcinoma (CRC) and human melanoma-associated antigens were conjugated to diethylenetriaminepentaacetic acid (DTPA) via an acylation reaction using cyclic DTPA dianhydride. Relative immunoreactivity of the F(ab')2 fragments was as high as 70% when an average of only 0.7 DTPA molecules was conjugated per fragment, decreasing rapidly to less than 5% when 9.0 DTPA molecules were conjugated. The 111In-labeled whole MAb in mice bearing human tumor xenografts showed higher concentrations in tumor, liver, kidney, and spleen 7 days after injection of MAb when compared with the same MAb labeled with 131I. F(ab')2 labeled with 111In showed a marked persistence in the tumor-bearing mice with higher concentrations in all organs except blood, when compared with 131I-labeled F(ab')2. Radioactivity was particularly high in the kidneys. Although images of human tumor xenografts were easily visualized using 131I-labeled F(ab')2 3 days after injection, it was difficult to visualize tumor grafts with 111In-labeled F(ab')2 due to persistently high renal, liver, and background activity. Increased catabolism of the 131I-labeled MAb may be the cause of the difference; but antibodies with high immunological activity are a necessity for in vivo imaging studies before firm conclusions can be drawn.","PeriodicalId":77686,"journal":{"name":"Cancer drug delivery","volume":"1 2","pages":"125-35"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/cdd.1984.1.125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17602480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29

Predictive value of trypan blue exclusion viability measurements for colony formation in a human tumor cloning assay. 台盼蓝排斥活力测定在人肿瘤克隆实验中对菌落形成的预测价值。

Cancer drug delivery Pub Date : 1984-01-01 DOI: 10.1089/cdd.1984.1.95

J D Cowan, D D Von Hoff, B Neuenfeldt, G M Mills, G M Clark

引用次数: 9

Chemotherapeutic sensitivity of acute lymphoblastic leukemia cells in culture: correlation with clinical efficacy on donor patients. 急性淋巴细胞白血病培养细胞的化疗敏感性:与供体患者临床疗效的关系。

Cancer drug delivery Pub Date : 1984-01-01 DOI: 10.1089/cdd.1984.1.307

J T Beranek, T Ohnuma, I Takahashi, J Minowada, J F Holland

{"title":"Chemotherapeutic sensitivity of acute lymphoblastic leukemia cells in culture: correlation with clinical efficacy on donor patients.","authors":"J T Beranek, T Ohnuma, I Takahashi, J Minowada, J F Holland","doi":"10.1089/cdd.1984.1.307","DOIUrl":"https://doi.org/10.1089/cdd.1984.1.307","url":null,"abstract":"The establishment of permanent acute lymphocytic leukemia (ALL) lines of different phenotypes permits the study of their sensitivity to chemotherapeutic agents. The sensitivity of four ALL cell lines, two T-cell lines and one each of B- and non-T/non-B cell lines, to eight chemotherapeutic agents was studied by means of clonogenic assay. Response data were analyzed by two criteria--one based on concentrations obtainable from the elimination phase and the other based on peak concentration--both derived from pharmacokinetic studies in man. The overall correlation between the two criteria was good and only in 5 of 32 occasions were there major discrepancies. A retrospective analysis of the clinical course of the four donor patients showed that although the one set of criteria gave a positive correlation of asparaginase response in vivo, the other positively correlated the daunorubicin response, but not vice versa. No new cut-off line could be drawn to satisfy completely in vitro/in vivo correlation for all the drugs. Although the possibility exists that a leukemic cell line may not actually be predictive of chemotherapeutic responsiveness in the donor patients, our data indicate a need to reexamine the in vitro system in predictive testing of antileukemic agents.","PeriodicalId":77686,"journal":{"name":"Cancer drug delivery","volume":"1 4","pages":"307-19"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1089/cdd.1984.1.307","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17306902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1