Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc最新文献_第5页

Immunobiology of cancer and AIDS. Etiology, diagnosis, and management. Selected papers presented at the First International Symposium on Immunobiology of Cancer and Allied Immune Dysfunctions. Copenhagen, Denmark. 癌症和艾滋病的免疫生物学。病因、诊断和处理。第一届国际癌症和相关免疫功能障碍免疫生物学研讨会上发表的论文选集。丹麦哥本哈根。

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

引用次数: 0

Protein deficiency reduces natural antitumor immunity. 蛋白质缺乏会降低天然的抗肿瘤免疫力。

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

R Ruffmann, E Schlick, T Tartaris, W Budzynski, M A Chirigos

引用次数: 0

Monoclonal antibody to HSV2 protein as an immunodiagnostic marker in cervical cancer. HSV2蛋白单克隆抗体作为宫颈癌的免疫诊断标志物。

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

S Costa, A D'Errico, W F Grigioni, C Orlandi, C C Smith, A M Mancini, L Aurelian

{"title":"Monoclonal antibody to HSV2 protein as an immunodiagnostic marker in cervical cancer.","authors":"S Costa, A D'Errico, W F Grigioni, C Orlandi, C C Smith, A M Mancini, L Aurelian","doi":"","DOIUrl":"","url":null,"abstract":"The present study was designed to evaluate the possible use of monoclonal antibodies (mAbs) as diagnostic adjuncts to exfoliative cytology and tissue sections in intraepithelial (CIN) and invasive cervical cancer. Specimens were collected from 42 patients with various degrees of CIN, 15 patients with invasive cancer and two patients with condylomatous changes only. mAb H17, that recognizes a herpes simplex virus protein (ICP) representing a component of the viral ribonucleotide reductase, stained atypical exfoliated cells from 55% of patients with mild dysplasia and 100% of those with more severe lesions. The mean percentage of positive atypical cells increased as a function of the grading of CIN (32.6 +/- 6.3%, 63.5 +/- 2.7%, 67.9 +/- 8.1%, 81.4 +/- 10.1%, and 85.6 +/- 2.0% for mild, moderate, and marked dysplasia, CIS, and invasive cancer, respectively). Only a very small proportion of atypical cells from only two patients stained with a mAb to another herpes simplex virus protein (gA/B). Normal squamous, metaplastic, inflammatory, or koilocytotic cells did not stain with the mAbs. Of the 15 cases examined by cryostatic fresh sections with immunohistochemical techniques, only one case of invasive cancer did not stain with mAb anti-ICP, and all controls were negative. The high specificity and sensitivity of MAbH17 suggests that it may be a useful diagnostic/prognostic marker in CIN.","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"189-205"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13963926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunotoxicology: environmental contamination by polybrominated biphenyls and immune dysfunction among residents of the State of Michigan. 免疫毒理学:密歇根州居民中多溴联苯的环境污染和免疫功能障碍。

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

J G Bekesi, J P Roboz, A Fischbein, P Mason

{"title":"Immunotoxicology: environmental contamination by polybrominated biphenyls and immune dysfunction among residents of the State of Michigan.","authors":"J G Bekesi, J P Roboz, A Fischbein, P Mason","doi":"","DOIUrl":"","url":null,"abstract":"In 1973, inadvertent contamination occurred in a special farm feed supplement for lactating cows. Polybrominated biphenyls (PBBs) were used in place of magnesium oxide resulting in serious harm to farm animals, including cattle, chickens, geese, ducks. Farm families, accustomed to eating their own products, were most heavily exposed. To study the impact of PBBs, 336 adult Michigan farm residents, 117 general consumers for comparison, 75 dairy farm residents in Wisconsin, who had not eaten PBB-contaminated food, were examined, as were 79 healthy subjects in New York City. Abnormalities in the Michigan groups included hypergammaglobulinemia, exaggerated hypersensitive response to streptococci, significant decrease in absolute numbers and percentage of T and B-lymphocytes, and increased number of lymphocytes with no detectable surface markers (\"null cells\"). Significant reduction of in vitro immune function was noted in 20-25% of the Michigan farm residents who had eaten food containing PBB. The decreased immune function detected among the PBB-exposed farm residents tended to affect families as a unit and was independent of exposed individuals' age or sex, pointing against the possibility of genetic predisposition.","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"29-37"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13963928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of CEA polyclonal antibodies, CEA monoclonal antibodies, tissue polypeptide antigen in the sera of supposedly healthy individuals. 推定健康人血清中CEA多克隆抗体、CEA单克隆抗体、组织多肽抗原的比较

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

E P Pluygers, M P Beauduin, P E Baldewyns

{"title":"Comparison of CEA polyclonal antibodies, CEA monoclonal antibodies, tissue polypeptide antigen in the sera of supposedly healthy individuals.","authors":"E P Pluygers, M P Beauduin, P E Baldewyns","doi":"","DOIUrl":"","url":null,"abstract":"Serum determinations of carcinoembryonic antigen (CEA) using both polyclonal antibodies (PAbs) and monoclonal antibodies (MAbs) were carried out in 348 supposedly healthy screenees. A correlation of the two CEA-detection methods was observed for MAb values higher than 0.5 ng/ml, but not for the lower MAb values that failed to detect CEA. Of 162 such cases (46.5% of the total population that were screened by MAbs), only 39 (11.2%) remained undetected by PAbs, with values as high as 3-4 ng/ml. CEA PAbs thus enabled a more subtle analysis of values in the lower range, a potentially useful factor in screening. In 18 screenees (5.1%) the values were above 2 SD of the mean by MAbs against 13 by PAbs; values above 3 SD were present in three by MAbs and in none by PAbs. In 14 of 18 cases high CEA values were related to smoking and to chronic gastrointestinal disease. The suggested specificity of CEA MAbs for cancer cells thus could not be confirmed because no cancer was detected in this series. Elevated tissue polypeptide antigen values were observed in 14 individuals and were not correlated with either CEA or smoking. Estrogens and estrogen-progestogens were administered to five females whereas four males had gynecomasty, and in three cases leukemia was reported among close relatives.","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"231-4"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14602803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening of hybridoma supernatants raised against membrane fractions from breast cancer using an immunodot assay. 利用免疫点法筛选乳腺癌膜组分培养的杂交瘤上清。

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

R Heinsohn, C R Seitz, A C Hollinshead, W Hyun, A Poschmann

引用次数: 0

Imaging of primary and metastatic colorectal carcinoma with monoclonal antibody 791T/36 and the therapeutic potential of antibody-drug conjugates. 单克隆抗体791T/36对原发性和转移性结直肠癌的成像及抗体-药物偶联物的治疗潜力

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

M V Pimm, N C Armitage, K Ballantyne, R W Baldwin, A C Perkins, L G Durrant, M C Garnett, J D Hardcastle

{"title":"Imaging of primary and metastatic colorectal carcinoma with monoclonal antibody 791T/36 and the therapeutic potential of antibody-drug conjugates.","authors":"M V Pimm, N C Armitage, K Ballantyne, R W Baldwin, A C Perkins, L G Durrant, M C Garnett, J D Hardcastle","doi":"","DOIUrl":"","url":null,"abstract":"Monoclonal antibody 791T/36, prepared against a tumour-associated 72,000 dalton glycoprotein, reacted with cells from primary and metastatic colorectal carcinomas. I-131 or In-111-labelled antibody localized in xenografts of colorectal carcinomas established from in vitro clonogenic populations. Clinically, with I-131-labelled antibody, 8/11 colonic tumours imaged positively. Imaging was negative in four patients with benign colon disease. 5/11 rectal tumours were positively imaged, but excreted I-131 in the bladder obscured tumours in several studies. In-111-labelled antibody gave superior images and positively imaged primary and metastatic sites in 13/14 patients. Prospectively in the detection of recurrent disease, I-131 or In-111-antibody detected 29/33 separate sites in 24 patients. Seven negative patients remain disease free. There were 3 false positives; overall sensitivity was 88%, with 70% specificity. Specific localization of radiolabel was confirmed immunochemically and by counting radioactivity in resected specimens. Antibody conjugates with methotrexate, vindesine and daunomycin retained drug activity and antibody function, including xenograft localization and conjugates were therapeutically effective against xenografts. 791T/36 antibody has potential for immunodetection of primary and recurrent colorectal carcinoma and for targeting of therapeutic agents.","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"249-62"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14602806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastasis models for human tumors in athymic mice: useful models for drug development. 人类肿瘤在胸腺小鼠体内的转移模型:药物开发的有用模型。

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

D L Fine, R Shoemaker, A Gazdar, J G Mayo, O Fodstad, M R Boyd, B J Abbott, P A Donovan

引用次数: 0

Cell regulatory and immunorestorative activity of picibanil (OK432). 吡替尼(OK432)的细胞调节和免疫恢复活性。

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

M A Chirigos, T Saito, J E Talmadge, W Budzynski, E Gruys

引用次数: 0

Impaired natural killer cytotoxicity during recrudescence of recurrent herpes simplex virus type 1 infection. 1型单纯疱疹病毒复发时自然杀伤细胞毒性受损。

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

Y C Kuo, C Y Lin, S F Cheng, C C Lin, W T Liu

引用次数: 0