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Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc最新文献

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Immunotoxicology: environmental contamination by polybrominated biphenyls and immune dysfunction among residents of the State of Michigan. 免疫毒理学:密歇根州居民中多溴联苯的环境污染和免疫功能障碍。
Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01
J G Bekesi, J P Roboz, A Fischbein, P Mason
{"title":"Immunotoxicology: environmental contamination by polybrominated biphenyls and immune dysfunction among residents of the State of Michigan.","authors":"J G Bekesi,&nbsp;J P Roboz,&nbsp;A Fischbein,&nbsp;P Mason","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In 1973, inadvertent contamination occurred in a special farm feed supplement for lactating cows. Polybrominated biphenyls (PBBs) were used in place of magnesium oxide resulting in serious harm to farm animals, including cattle, chickens, geese, ducks. Farm families, accustomed to eating their own products, were most heavily exposed. To study the impact of PBBs, 336 adult Michigan farm residents, 117 general consumers for comparison, 75 dairy farm residents in Wisconsin, who had not eaten PBB-contaminated food, were examined, as were 79 healthy subjects in New York City. Abnormalities in the Michigan groups included hypergammaglobulinemia, exaggerated hypersensitive response to streptococci, significant decrease in absolute numbers and percentage of T and B-lymphocytes, and increased number of lymphocytes with no detectable surface markers (\"null cells\"). Significant reduction of in vitro immune function was noted in 20-25% of the Michigan farm residents who had eaten food containing PBB. The decreased immune function detected among the PBB-exposed farm residents tended to affect families as a unit and was independent of exposed individuals' age or sex, pointing against the possibility of genetic predisposition.</p>","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"29-37"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13963928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imbalance of the Epstein-Barr virus-host relationship in AIDS-related complex patients. 艾滋病相关复杂患者Epstein-Barr病毒-宿主关系失衡
Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01
G Ragona, M C Sirianni
{"title":"Imbalance of the Epstein-Barr virus-host relationship in AIDS-related complex patients.","authors":"G Ragona,&nbsp;M C Sirianni","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Patients affected by AIDS related-complex (ARC) showed several immunological abnormalities that could lead to a disregulation of immunosurveillance against viral latent infections. We report Epstein-Barr virus (EBV) reactivation was found in seven of eight ARC patients and in two of seven affected by persistent generalized lymphoadenopathy. These patients showed either elevated levels of circulating EBV-positive transformed cells and/or depressed EBV-specific T cell cytotoxicity as assessed by the regression assay. Natural killer cell activity was found to be decreased and correlated with evidence of circulating EBV-infected cells and with impaired EBV-specific immune control. Our data demonstrate that loss of control of EBV latency in the infected host by specific immune mechanisms increases the risk for EBV reactivation and emergence of clones with unlimited growth potential. A role of EBV as a cofactor in the development of ARC is suggested.</p>","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"549-52"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13963930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serological evaluation of melanoma patients in a phase I/II trial of vaccinia melanoma oncolysate (VMO) immunotherapy. 免疫治疗痘苗黑色素瘤(VMO)的I/II期试验中黑色素瘤患者的血清学评估
Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01
M K Wallack, J A Bash, K R McNally, E Leftheriotis
{"title":"Serological evaluation of melanoma patients in a phase I/II trial of vaccinia melanoma oncolysate (VMO) immunotherapy.","authors":"M K Wallack,&nbsp;J A Bash,&nbsp;K R McNally,&nbsp;E Leftheriotis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Vaccinia melanoma oncolysates (VMO) were tested in a Southeastern Cancer Study Group (SECSG)-sponsored phase I/II multiinstitutional trial. Forty-eight patients with stage I or II disease were placed on study at six different dose levels of VMO and two different dose schedules, immediate or delayed. Patients' sera, obtained before treatment and every 3 months following initiation of treatment, were tested for antimelanoma antibodies using a Staphylococcus protein A (SpA) assay. Pretreatment sera were negative in 46 of 47 patients, and only two of 19 patients on delayed treatment developed reactivity by 6 months. However, 13 of 23 on immediate treatment developed reactivity, including eight of eight at the higher doses (1.5 and 2.0 mg). Neither anti-HLA antibody tested by a standard microcytotoxicity assay nor circulating immune complexes measured by both Clq and conglutinin binding assays were produced as a result of the immunization. The demonstration of immunogenicity of VMO at the 2 mg dose and immediate schedule supported the rationale for the use of this dose and schedule for the ongoing second phase Ia/Ib trial and for the future phase III randomized prospective study.</p>","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"351-9"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14286673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AIDS and lymphadenopathy syndrome (LAS) patients display similar abnormal in vitro proliferation and differentiation of T-colony forming cells (T-CFC). 艾滋病和淋巴结病综合征(LAS)患者在体外t集落形成细胞(T-CFC)的增殖和分化方面表现出类似的异常。
Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01
Y Lunardi Iskandar, V Georgoulias, W Rozenbaum, D Vittecoq, P Meyer, M Gentilini, C Jasmin
{"title":"AIDS and lymphadenopathy syndrome (LAS) patients display similar abnormal in vitro proliferation and differentiation of T-colony forming cells (T-CFC).","authors":"Y Lunardi Iskandar,&nbsp;V Georgoulias,&nbsp;W Rozenbaum,&nbsp;D Vittecoq,&nbsp;P Meyer,&nbsp;M Gentilini,&nbsp;C Jasmin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>T-cell colonies were generated from the peripheral blood and bone marrow of 61 patients with acquired immunodeficiency syndrome (AIDS), 54 patients with persistent lymphadenopathy syndrome (LAS), 14 clinically normal male homosexuals, and 17 healthy heterosexuals. Mononuclear cells were cultured in methylcellulose in the presence of IL2-containing conditioned medium. The number of T-cell forming cells (T-CFC) from healthy male homosexuals and AIDS and LAS patients was significantly (P less than 0.01) reduced compared to T-CFC from healthy heterosexuals. In AIDS patients, the low colony growth capacity of T-CFC was independent of the presence of either opportunistic infections or Kaposi sarcoma. Twelve LAS patients who subsequently developed AIDS showed the lowest capacity of peripheral blood and bone marrow T-CFC to proliferate. Pooled induced colonies from AIDS and LAS patients and normal homosexuals were composed of immature cells bearing the T3+, T4+, T6+, and T8+ surface phenotype, unlike colonies from normal heterosexuals, which displayed mature cells bearing the T3+, T4+, T6-, and T3+, T8+, T6- surface phenotype. Moreover, most T-CFC from primary colonies had lost their self-renewal capacity. In some AIDS and LAS patients but not healthy homosexuals peripheral blood and bone marrow T-CFC were capable of generating colonies with recombinant IL2 (rIL2) without any other mitogenic stimulation. The rIL2-induced colony growth was abrogated by a monoclonal antibody against the IL2 receptor. These results suggest that early impairment of T-CFC plays a predominant role in the pathogenesis of AIDS.</p>","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"525-33"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14624304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exposure to hair dyes and polychlorinated dibenzo-p-dioxins in AIDS patients with Kaposi sarcoma: an epidemiological investigation. 艾滋病卡波西肉瘤患者染发剂和多氯二苯并对二恶英暴露:流行病学调查。
Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01
L Hardell, A Moss, D Osmond, P Volberding
{"title":"Exposure to hair dyes and polychlorinated dibenzo-p-dioxins in AIDS patients with Kaposi sarcoma: an epidemiological investigation.","authors":"L Hardell,&nbsp;A Moss,&nbsp;D Osmond,&nbsp;P Volberding","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fifty male AIDS patients with Kaposi sarcoma and 50 matched controls were interviewed about occupation, exposure to pesticides, Vietnam service, smoking habits, etc. No difference in use of pesticides was seen. One case but no control had served in Vietnam and was thereby exposed to agent orange. Dioxins are known to be immunosuppressive in animals. No significant difference in exposure to dioxin-containing products was found between cases and controls, however. Of interest was the fact that four cases but no control were occupationally exposed to hair dyes, some of which have been reported to be carcinogenic.</p>","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"567-70"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14602523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AIDS in subsaharan Africa. 撒哈拉以南非洲的艾滋病。
Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01
R J Biggar
{"title":"AIDS in subsaharan Africa.","authors":"R J Biggar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>AIDS has existed in subsaharan Africa at least since 1980. However, the genesis of this condition and its emergence as a health problem remain obscured by lack of data and by antibody data that are now questionable. In Africa, as elsewhere, AIDS is associated with an immunodeficiency associated with the LAV/HTLV-III retrovirus. The clinical manifestations vary somewhat because of the different range of opportunistic pathogens in that environment. Although the \"classical,\" more indolent, endemic form of African Kaposi sarcoma is not associated with this virus or with immunodeficiency, a new, aggressive variety of Kaposi sarcoma in Africa appears to be. The origin of LAV/HTLV-III remains unclear, but the clinical syndrome of AIDS has emerged in Africa only in the past decade. A pattern of geographic spread can be recognized, in which AIDS was seen earliest in Kinshasa, Zaïre, and then emerged in Zambia, Rwanda, and Uganda. Recently, reports indicate spread into Tanzania and Kenya. Transmission appears to be primarily heterosexual, but the factors enhancing heterosexual spread in Africa to a greater extent than in the U.S. and Europe need to be further studied.</p>","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"487-91"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14604683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distribution of p24 HTLV3 major core protein in lymph nodes of LAS patients. p24 HTLV3主要核心蛋白在LAS患者淋巴结中的分布。
Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01
C D Baroni, F Pezzella
{"title":"Distribution of p24 HTLV3 major core protein in lymph nodes of LAS patients.","authors":"C D Baroni,&nbsp;F Pezzella","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lymph nodes of patients with lymphadenopathy syndrome (LAS) are characterized by two main histological patterns: hyperplastic reactive (H) and regressive (R). In both conditions, the paracortex (PC) is markedly activated with presence of selectively Ia-1+ high endothelial venules. Using a monoclonal antibody for p24, the major core protein of HTLV3, we have immunohistochemically determined the distribution of p24+ cells in lymph nodes from 23 LAS patients' HTLV3-ab serologically positive. p24+ cells were demonstrated in 11 cases. Control nodes were negative. p24+ cells included high endothelial cells of PC postcapillary venules, large perivenular cells, large mono- or binucleated cells in PC and in GC, and few lymphocytelike cells. Our preliminary observations indicate that the majority of p24+ cells are high endothelial and accessory cells that may act either as virus reservoir or as antigen-presenting cells to T4 lymphocytes and to GC B cells. In addition, the positivity of high endothelial cells for p24 might help to explain their selective Ia-1+.</p>","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"553-6"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14251414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extrathecal and intrathecal IgG response to the AIDS virus LAV/HTLV-III in experimental infection of chimpanzees. 黑猩猩实验感染艾滋病病毒LAV/HTLV-III时鞘外和鞘内IgG的反应。
Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01
J Goudsmit, C J Gibbs, D M Asher, D C Gajdusek
{"title":"Extrathecal and intrathecal IgG response to the AIDS virus LAV/HTLV-III in experimental infection of chimpanzees.","authors":"J Goudsmit,&nbsp;C J Gibbs,&nbsp;D M Asher,&nbsp;D C Gajdusek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Seven of seven chimpanzees inoculated with LAV/HTLV-III and three of three chimpanzee-to-chimpanzee passages seroconverted for LAV/HTLV-III as tested by ELISA and immunoblotting. Serum IgG reactivity to gag-gene products emerged between 3 and 6 weeks after inoculation, p24gag reactivity always reaching maximum titers first. Serum IgG antibodies to env-related proteins occurred 11-21 weeks after inoculation. Throughout the observation period (greater than 36 weeks), IgG reactivity to gag, pol, and env gene products persisted. Matched serum and cerebrospinal fluid (CSF) from three LAV/HTLV-III-infected chimpanzees were available in the chronic phase of infection and titers of viral antibody and albumin and IgG content were determined. By calculation of antibody/albumin indices, evidence was obtained for intrathecal synthesis of IgG antibodies to LAV/HTLV-III in one animal.</p>","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"509-14"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14604685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoclonal antibodies detecting plasminogen activators on the membrane of leukemic lymphoid cells of T-cell origin. 检测t细胞源性白血病淋巴样细胞膜上纤溶酶原激活物的单克隆抗体。
Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01
K G Stünkel, E Thiel, H G Opitz, H D Schlumberger, U Opitz, D Catovsky, V Klimetzek
{"title":"Monoclonal antibodies detecting plasminogen activators on the membrane of leukemic lymphoid cells of T-cell origin.","authors":"K G Stünkel,&nbsp;E Thiel,&nbsp;H G Opitz,&nbsp;H D Schlumberger,&nbsp;U Opitz,&nbsp;D Catovsky,&nbsp;V Klimetzek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The specificities of six monoclonal antibodies produced against plasminogen activator of the human Bowes melanoma cell line are described. They have been used to detect membrane-bound plasminogen activator on cultured human lymphoid cell lines and in neoplastic human lymphocytic and myeloid cells of leukemic patients. These studies indicate that only certain phenotypic subsets of the T-cell lineage derived from patients with chronic lymphocytic leukemia or with Szezary syndrome express plasminogen activator on their surface membrane.</p>","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"269-77"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14623006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Production of interleukin-2 and expression of tac antigen in Hodgkin disease. 霍奇金病中白细胞介素-2的产生和tac抗原的表达。
Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01
N N Joshi, R Mukhopadhyay, S H Advani, S G Gangal
{"title":"Production of interleukin-2 and expression of tac antigen in Hodgkin disease.","authors":"N N Joshi,&nbsp;R Mukhopadhyay,&nbsp;S H Advani,&nbsp;S G Gangal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Phytohemagglutinin (PHA)- induced Interleukin-2 (IL-2) production by peripheral blood mononuclear cells was studied in 28 untreated patients with Hodgkin Disease (HD). A group of 28 patients were also investigated for the expression of Tac antigen in the resting stage of lymphocytes and after activation with PHA and mixed leukocyte culture (using anti-Tac monoclonal antibody). The blastogenic response to PHA and IL-2 production by lymphocytes of HD patients was significantly lower than that of normal lymphocytes. Production of IL-2 appeared to be severely affected in 14 of 28 HD patients who also showed PHA response less than the normal range. The Tac antigen expression was found to be lower in PHA-stimulated but not alloantigen-stimulated lymphocytes from the HD patients. No correlation was observed between the levels of IL-2 production, Tac antigen expression, and blastogenic response to PHA or allogeneic cells and the stage of disease when tested in the same patients.</p>","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"137-43"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13963924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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