Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc最新文献

Immunological effects of isoprinosine as a pulse immunotherapy in melanoma and ARC patients. 异丙甘氨酸作为脉冲免疫疗法在黑色素瘤和ARC患者中的免疫效果。

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

A Pompidou, C Soubrane, V Cour, L Telvi, C Meunier, C Jacquillat

{"title":"Immunological effects of isoprinosine as a pulse immunotherapy in melanoma and ARC patients.","authors":"A Pompidou, C Soubrane, V Cour, L Telvi, C Meunier, C Jacquillat","doi":"","DOIUrl":"","url":null,"abstract":"Immunomodulatory effect of Isoprinosine are presented in melanoma and HTLV-III/LAV infected patients. Isoprinosine (50 mg/kg) was used as a pulse immunotherapy according to two different schedules: A) 5 days every 15 days and B) 5 days every 15 days for 2 months, then 5 days every 2 months. The patients' immunological profiles were tested before and during the treatment in terms of T-cell subsets, cell number requirement for PHA-induced proliferation, and delayed hypersensitivity reaction to recall antigens. Primary malignant melanoma patients are randomized between surgery alone or associated to isotherapy (schedule A or B). Schedule A, after an initial improvement of surgery-induced immune deficiency, is responsible for an immunodepression, whereas schedule B determines a prolonged restoration in immune responses in melanoma and AIDS related complex or Kaposi sarcoma patients as well. In vitro effects of Isoprinosine on HTLV-III/LAV infection are presented. These data exhibit 1) the need of an immunological follow-up during isotherapy and 2) the immunological benefit of a pulse immunotherapy during acquired immunodeficiencies related to cancer surgery or to HTLV-III/LAV infection in man.","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"457-62"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13591976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Normalization of immunoregulatory T-helper T-suppressor sublineages and cell-mediated immunity by isoprinosine in vitro in the early stages of AIDS. 艾滋病早期体外免疫调节t辅助t抑制亚谱系和细胞介导免疫的异丙苷正常化

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

P Tsang, J G Bekesi

{"title":"Normalization of immunoregulatory T-helper T-suppressor sublineages and cell-mediated immunity by isoprinosine in vitro in the early stages of AIDS.","authors":"P Tsang, J G Bekesi","doi":"","DOIUrl":"","url":null,"abstract":"Applying flow cytometric analysis and a panel of monoclonal antibodies that define functional subsets and stages of lymphocyte differentiation, we found both inducer and suppressor regulating subsets of helper T cells to be depressed with concurrent increase in the functionally active effector suppressor T cells in prodromal homosexuals and patients with AIDS. Concomitantly a broad spectrum of aberrations in all stages of B cell developments were observed. Failure of isolated peripheral blood lymphocytes from these subjects to respond to formalin-fixed Staphylococcus aureus cowan 1 (SAC) indicated intrinsic defects in their resting B cells, while impairment in pokeweed mitogen (PWM)-induced blastogenesis coupled with increased levels of Ig secretion signified regulatory defects in their mature B cells, which may be related to helper-suppressor dysfunctions. Based on these findings, a multifactorial immunodysfunction in AIDS was proposed. The antiviral biological modulator drug isoprinosine was shown to enhance PWM-induced, T-cell dependent, B-cell blastogenesis and normalize the spontaneous secretion of Ig while showing no modulative effects on SAC-induced (resting B-cell) transformations. It also modified, in a selective fashion, the phenotypic coexpression of both HLA-DR and Leu8 antigen on helper and suppressor T cells. Among prodromal subjects at risk to develop AIDS, isoprinosine augmented the expression of both helper T-cell subsets while reducing the number of suppressor effector cells and activated suppressor cells. These interferences with the helper-suppressor regulatory loop may explain the therapeutic efficacy of this drug in the early stages of AIDS.","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"611-8"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13591978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Do tuftsin and bestatin constitute a biopharmacological immunoregulatory system? 是否tuftsin和bestatin构成了一个生物药理学免疫调节系统?

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

G Mathé

{"title":"Do tuftsin and bestatin constitute a biopharmacological immunoregulatory system?","authors":"G Mathé","doi":"","DOIUrl":"","url":null,"abstract":"Tuftsin is the tetrapeptide Thr-Lys-Pro-Arg. It is spontaneously released from the Fc fragment of IgG by two specific enzymes. One 25-micrograms dose administered to mice in good immunologic status stimulated phagocytosis, macrophage killing of tumor cells, delayed hypersensitivity, cytolytic T-cell activity, antibody production, antibody-dependent cell-mediated cytotoxicity (ADCC), and natural killer (NK) cell activity. Administered for 6 months at the dose of 10 micrograms once a week to old, immunodepressed mice, tuftsin restored macrophage and T-cell cytotoxic activities. At this dosage, tuftsin prevented spontaneous tumor development. Tuftsin was also well tolerated in phase I studies in humans in increased polymorphonuclear leukocytes and OKT4-positive lymphocytes. Bestatin is extracted from Streptomyces olivoreticuli. One 100-micrograms dose of bestatin injected in young mice with normal immunologic status increased macrophage cytotoxicity, antibody production, ADCC, and NK cell activities. Long-term administration of bestatin (100 micrograms once a week) corrected macrophage and T-cell cytotoxicity and prevented age-related spontaneous tumors. Bestatin inhibited lymphocyte membrane aminopeptidase, which degrades tuftsin into a tripeptide that is an antagonist competing with it for receptors. Tuftsin and bestatin constitute a biopharmacologic system that can be developed as other aminopeptidase inhibitors are available for study.","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"445-55"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14445865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenotypic and functional analyses of tumour-infiltrating Leu 7 + natural killer-like cells in non-Hodgkin lymphomas. 非霍奇金淋巴瘤肿瘤浸润性Leu 7 +自然杀伤样细胞的表型和功能分析。

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

D Banerjee

引用次数: 0

Clinical efficacy of lentinan on patients with stomach cancer: end point results of a four-year follow-up survey. 香菇多糖对胃癌患者的临床疗效:一项为期四年的随访调查的终点结果。

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

T Taguchi

引用次数: 0

A subset of normal human B lymphocytes expresses an antigen cross-reactive with gp52 of murine mammary tumor virus. 正常人B淋巴细胞亚群表达一种与小鼠乳腺肿瘤病毒gp52交叉反应的抗原。

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

A Tax, L A Manson

引用次数: 0

Transfer factor for adjuvant immunotherapy in cervical cancer. 宫颈癌辅助免疫治疗的转移因子。

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

G Wagner, W Knapp, E Gitsch, S Selander

引用次数: 0

Escape of hybridomas from cellular defense mechanisms: an in vitro study using autologous and allogeneic lymphocytes. 从细胞防御机制中逃脱杂交瘤:使用自体和异体淋巴细胞的体外研究。

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

K S Zänker, G Blümel, J Lange, J R Siewert

引用次数: 0

Flow cytofluorometric analysis of choriogonadotropin-like material on the surface of human and mouse malignant cells. 人和小鼠恶性细胞表面绒毛膜促性腺激素样物质的流式细胞荧光分析。

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

R B Raikow, H F Acevedo, A Krichevsky, M J Buffo, P Fogarty

{"title":"Flow cytofluorometric analysis of choriogonadotropin-like material on the surface of human and mouse malignant cells.","authors":"R B Raikow, H F Acevedo, A Krichevsky, M J Buffo, P Fogarty","doi":"","DOIUrl":"","url":null,"abstract":"Quantitation by flow cytofluorometry of the distribution of human choriogonadotropin (hCG)-like material on the surface of various human and mouse tumor cells grown in tissue culture and as solid tumors has been done using fluorescein-tagged rabbit antisera (IgG fraction) to intact hCG and, in one experiment, by use of two monoclonal antibodies specific for hCG. Fibroblasts were used as a negative (nontumorigenic) cell control, and a rabbit antiserum to human hemoglobin was used as reagent control. All malignant cells tested stained more intensely with the anti-hCG serum than with the antihuman hemoglobin serum. Positive reaction with the monoclonal antibodies specific for hCG provided strong evidence that the material stained was identical to hCG. Heterogeneity of the expression of the hCG-like material was notable both within each cell line and between different cell lines. This heterogeneity was not associated with cell-cycle phase. 3T3 fibroblast-like cells in vitro were originally negative for hCG but acquired reactivity with anti-hCG serum after ten passages.","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"173-81"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14603920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of immunization against human choriogonadotropin on the growth of transplanted Lewis lung carcinoma and spontaneous mammary adenocarcinoma in mice. 人绒毛膜促性腺激素免疫对小鼠移植性Lewis肺癌和自发性乳腺腺癌生长的影响。

Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc Pub Date : 1987-01-01

H F Acevedo, R B Raikow, J E Powell, V C Stevens

{"title":"Effects of immunization against human choriogonadotropin on the growth of transplanted Lewis lung carcinoma and spontaneous mammary adenocarcinoma in mice.","authors":"H F Acevedo, R B Raikow, J E Powell, V C Stevens","doi":"","DOIUrl":"","url":null,"abstract":"We studied the effects of preimmunization with a synthetic carboxy-terminal peptide of the beta-subunit of human choriogonadotropin (hCG) conjugated to diphtheria toxoid on the growth of two tumor models, the transplantable Lewis lung carcinoma in C57BL/6J mice and the spontaneous mammary carcinoma in C3H/OuJ mice. Immunization with the conjugate prior to Lewis lung tumor implantation significantly (P less than 0.05) retarded the growth of tumors as measured by tumor weight 18 days following transplantation. The weights of Lewis lung tumors in animals preimmunized with the hCG immunogen were inversely correlated (r = 0.61) with the levels of circulating antibodies against human chorionic gonadotropin, whereas no statistical correlation was found between tumor weights and the levels of antibodies reactive to diphtheria toxoid. The number of conjugate-treated C3H/OuJ mice that developed mammary tumors was significantly (P less than 0.05) reduced compared to their vehicle-treated cohorts. Pretreatment with the synthetic muramyl dipeptide analog utilized as an adjuvant with both immunogens did not show any effect on the tumor growth in either tumor system.","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"477-86"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14604682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0