{"title":"非霍奇金淋巴瘤肿瘤浸润性Leu 7 +自然杀伤样细胞的表型和功能分析。","authors":"D Banerjee","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Biopsy specimens of lymphoid tissues were analysed by two-colour flow cytometry to determine the proportions and phenotypes of natural killer-like cells present in the lesions. No significant difference was found between the proportions of Leu 7+ cells in reactive and malignant nodes. Low numbers of Leu 11+ cells were found in both benign and malignant nodes. The most common phenotype among the tumour-infiltrating Leu 7+ cells in the malignant nodes was Leu 7+OKT3+OKM1-. Only low numbers of Leu 7+ cells in malignant nodes coexpressed OKM1. Isolated Leu 7+ cells from four out of five malignant nodes were unable to lyse autologous B lymphoma cells in vitro. However, in one of five malignant nodes tested, autologous B lymphoma cells were lysed by isolated tumour-infiltrating Leu 7+ cells but not by Leu 7- cells. These observations indicate that tumour-infiltrating Leu 7+ cells are infrequently capable of lysing autologous lymphoma cells.</p>","PeriodicalId":77685,"journal":{"name":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","volume":"1 ","pages":"103-9"},"PeriodicalIF":0.0000,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Phenotypic and functional analyses of tumour-infiltrating Leu 7 + natural killer-like cells in non-Hodgkin lymphomas.\",\"authors\":\"D Banerjee\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Biopsy specimens of lymphoid tissues were analysed by two-colour flow cytometry to determine the proportions and phenotypes of natural killer-like cells present in the lesions. No significant difference was found between the proportions of Leu 7+ cells in reactive and malignant nodes. Low numbers of Leu 11+ cells were found in both benign and malignant nodes. The most common phenotype among the tumour-infiltrating Leu 7+ cells in the malignant nodes was Leu 7+OKT3+OKM1-. Only low numbers of Leu 7+ cells in malignant nodes coexpressed OKM1. Isolated Leu 7+ cells from four out of five malignant nodes were unable to lyse autologous B lymphoma cells in vitro. However, in one of five malignant nodes tested, autologous B lymphoma cells were lysed by isolated tumour-infiltrating Leu 7+ cells but not by Leu 7- cells. These observations indicate that tumour-infiltrating Leu 7+ cells are infrequently capable of lysing autologous lymphoma cells.</p>\",\"PeriodicalId\":77685,\"journal\":{\"name\":\"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc\",\"volume\":\"1 \",\"pages\":\"103-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1987-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer detection and prevention. Supplement : official publication of the International Society for Preventive Oncology, Inc","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Phenotypic and functional analyses of tumour-infiltrating Leu 7 + natural killer-like cells in non-Hodgkin lymphomas.
Biopsy specimens of lymphoid tissues were analysed by two-colour flow cytometry to determine the proportions and phenotypes of natural killer-like cells present in the lesions. No significant difference was found between the proportions of Leu 7+ cells in reactive and malignant nodes. Low numbers of Leu 11+ cells were found in both benign and malignant nodes. The most common phenotype among the tumour-infiltrating Leu 7+ cells in the malignant nodes was Leu 7+OKT3+OKM1-. Only low numbers of Leu 7+ cells in malignant nodes coexpressed OKM1. Isolated Leu 7+ cells from four out of five malignant nodes were unable to lyse autologous B lymphoma cells in vitro. However, in one of five malignant nodes tested, autologous B lymphoma cells were lysed by isolated tumour-infiltrating Leu 7+ cells but not by Leu 7- cells. These observations indicate that tumour-infiltrating Leu 7+ cells are infrequently capable of lysing autologous lymphoma cells.
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