{"title":"Lutte contre la fièvre jaune en Afrique","authors":"","doi":"10.1016/S0769-2617(88)80033-9","DOIUrl":"https://doi.org/10.1016/S0769-2617(88)80033-9","url":null,"abstract":"","PeriodicalId":77667,"journal":{"name":"Annales de l'Institut Pasteur. Virology","volume":"139 ","pages":"Page 256"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0769-2617(88)80033-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136815512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Jaegle, J.-P. Briand, J. Burckard, M.H.V. Van Regenmortel
{"title":"Accessibility of three continuous epitopes in tomato bushy stunt virus","authors":"M. Jaegle, J.-P. Briand, J. Burckard, M.H.V. Van Regenmortel","doi":"10.1016/S0769-2617(88)80004-2","DOIUrl":"10.1016/S0769-2617(88)80004-2","url":null,"abstract":"<div><p>Three peptides corresponding to residues 28–40, 138–154 and 380–387 of the coat protein of tomato bushy stunt virus (TBSV) were synthesized by the solid phase method and used to raise specific antibodies. These antibodies were used to follow the conformational changes that occur when TBSV particles swell under slightly alkaline conditions. Peptides 28–40 and 380–387 were found to correspond to continuous epitopes in the dissociated viral protein as well as in both compact and swollen virions. The region 138–154, which is also a continuous epitope of the monomeric protein, became accessible to antibody binding in the virion only when the particles were in the swollen state.</p></div><div><p>Trois peptides correspondant aux résidus 28–40, 138–154 et 380–387 de la protéine capsulaire du virus du rabougrissement de la tomate (TBSV), ont été synthétisés par une méthode en phase solide et utilisés pour mettre en évidence les anticorps spécifiques. Ces anticorps ont été utilisés pour suivre les changements de conformation qui surviennent quand les particules de TBSV gonflent dans des conditions de faible alcalinité. Les peptides 28–40 et 380–387 correspondent à des épitopes continus dans la protéine virale dissociée de même que chez les virions, compacts ou gonflés. La région 138–154, qui est aussi un épitope continu de la protéine monomérique, devient accessible à l'anticorps chez le virion uniquement quand les particules sont gonflées.</p></div>","PeriodicalId":77667,"journal":{"name":"Annales de l'Institut Pasteur. Virology","volume":"139 ","pages":"Pages 39-50"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0769-2617(88)80004-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14337967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Potential usefulness of the chimaeric type 1/type 2 poliovirus, V510 in universal reduction of poliomyelitis morbidity","authors":"S.C. Arya","doi":"10.1016/S0769-2617(88)80083-2","DOIUrl":"10.1016/S0769-2617(88)80083-2","url":null,"abstract":"","PeriodicalId":77667,"journal":{"name":"Annales de l'Institut Pasteur. Virology","volume":"139 ","pages":"Pages 461-462"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0769-2617(88)80083-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14344179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J.P. Gonzalez , C.C. Mathiot , J.C. Bouquety , J.M. Diemer , L. Guerre , J.L. Lesbordes , M.C. Madelon , A.J. Georges
{"title":"Status of hantavirus in the Central African Republic","authors":"J.P. Gonzalez , C.C. Mathiot , J.C. Bouquety , J.M. Diemer , L. Guerre , J.L. Lesbordes , M.C. Madelon , A.J. Georges","doi":"10.1016/S0769-2617(88)80044-3","DOIUrl":"10.1016/S0769-2617(88)80044-3","url":null,"abstract":"<div><p>Le point sur les hantavirus en République centrafricaine</p><p>Après la mise en évidence, en 1982, d'anticorps spécifiques dirigés contre les virus Hantaan dans les populations humaines de RCA, des études ont été entreprises pour en déterminer la prévalence et un éventuel niveau d'endémie. D'une part, une surveillance des patients a permis de démontrer l'existence d'un syndrome associant fièvre, insuffisance rénale passagère et hépatite d'étiopathogénie imprécise, évoluant rapidement vers la guérison; d'autre part, des captures de rongeurs semblent désigner <em>Rattus rattus</em> comme réservoir de virus. Des enquêtes de séroprévalence dans les populations humaines et animales restent toutefois en faveur d'un niveau d'endémicité faible.</p></div>","PeriodicalId":77667,"journal":{"name":"Annales de l'Institut Pasteur. Virology","volume":"139 ","pages":"Pages 301-304"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0769-2617(88)80044-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14042177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inhibition of late influenza virus genome expression by diamidinophenylindole","authors":"G. Conti , P. Portincasa , C. Chezzi , A. Sanna","doi":"10.1016/S0769-2617(88)80007-8","DOIUrl":"10.1016/S0769-2617(88)80007-8","url":null,"abstract":"<div><p>The growth cycle of influenza virus strain FPV, Ulster 73, was altered by treatment of LLC-MK2 cells with diamidinophenylindole. Viral protein synthesis was restricted to the early pattern of virus multiplication, and postreatment experiments showed the ability of the drug to block virus replication until the 4th hour p.i. Drug addition (followed by removal) revealed the inhibition of synthesis of late viral products, and especially of membrane protein. Kinetic studies on the production of viral RNA indicated a decrease in the synthesis of late virus-induced RNA species, suggesting that the target of DAPI is probably the late transcription of the virus genome. The non-permissive condition mediated by the drug could represent a suitable model to study cellular intervention during viral growth.</p></div><div><p>Le cycle de croissance du virus grippal souche FPV, Ulster 73, est altéré quand on traite les cellules LLC-MK2 par le diamidinophényl-indole (DAPI). La synthèse des protéines virales est restreinte à la phase précoce de la multiplication virale, et les expériences après traitement par le DAPI montrent qu'il est capable de bloquer la réplication virale jusqu'à la 4<sup>e</sup> heure post-infection. L'addition de DAPI (suivie de son élimination) révèle qu'il inhibe la synthèse de produits viraux tardifs et en particulier la production de la protéine membranaire. Des études de la cinétique de la production d'ARN viral montrent une diminution de la synthèse de types de ARN induits tardivement, ce qui suggère que la cible du DAPI est probablement la transcription tardive du génome viral. Les conditions non permissives provoquées par le DAPI forment un modèle acceptable pour l'étude de l'intervention cellulaire au cours de la croissance virale.</p></div>","PeriodicalId":77667,"journal":{"name":"Annales de l'Institut Pasteur. Virology","volume":"139 ","pages":"Pages 69-78"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0769-2617(88)80007-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14109951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Les vaccinations antirabiques en France en 1987","authors":"M. Bientz, F. Lautier, B. Cordier","doi":"10.1016/S0769-2617(88)80053-4","DOIUrl":"10.1016/S0769-2617(88)80053-4","url":null,"abstract":"","PeriodicalId":77667,"journal":{"name":"Annales de l'Institut Pasteur. Virology","volume":"139 ","pages":"Pages 341-345"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0769-2617(88)80053-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"103049119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}