Annales de l'Institut Pasteur. Virology最新文献

{"title":"Epidemiological and clinical study and electrophoretyping survey of rotavirus acute diarrhoea in a children's infectious disease unit in Casablanca, Morocco","authors":"L. Tazi-Lakhsassi ,&nbsp;A. Garbarg-Chenon ,&nbsp;J.-C. Nicolas ,&nbsp;H. Soubhi ,&nbsp;M. Benbachir ,&nbsp;N. El Mdaghri ,&nbsp;M. Tazi ,&nbsp;F. Bricout ,&nbsp;J.-M. Huraux","doi":"10.1016/S0769-2617(88)80018-2","DOIUrl":"10.1016/S0769-2617(88)80018-2","url":null,"abstract":"<div><p>Rotavirus antigen was detected by ELISA or latex technique in faecal specimens of 64 (20%) out of 327 children hospitalized with acute diarrhoeal disease during a 12-month period in Casablanca, Morocco. The rotaviral diarrhoeas were more frequent in autumn and winter, but more geographically limited during these seasons. Nine different electrophoretypes (A-I) were observed in 38 of the rotavirus-positive samples containing sufficient viral RNA to give a visible electrophoretic pattern. Two ≪long≫ types, A and B, accounted for 74% of all rotaviruses identified. Over the one-year period. a clear shift in the predominant electrophoretype was observed between the autumn-winter (type A) and summer period (type B). Six additional electrophoretypes co-circulated in association with type A, whereas only one case of type E was recognized during the summer in association with type-B outbreak. Vomiting and severe dehydration were more prevalent in the rotavirus antigen-positive children and, although not statistically proven, in the electrophoretype A group.</p></div><div><p>L'antigène rotavirus a été détecté dans les selles, par une technique au latex ou par ELISA, chez 64 (20%) des 327 enfants hospitalisés pour diarrhée aiguë à Casablanca, au cours d'une période de 12 mois. Les diarrhées à rotavirus sont aparues plus fréquentes en automne-hiver, où leur localisation géographique est la plus circonscrite. Neuf électrophorétypes différents (A à I) ont été identifiés dans les 38 selles contenant assez d'ARN viral pour permettre le typage. Deux types, A et B, représentent 78% de tous les virus dont l'élec-trophorétype a pu être déterminé. Sur un an d'étude on a observé un changement de l'électrophorétype dominant entre la période automno-hivernale (type A) et l'été (type B). Six autres électrophorétypes ont circulé dans la population en même temps que le type A, alors que durant l'épidémie à type B un seul autre électrophorétype (type E) a été associé à un cas de diarrhée. Vomissements et déshydratation marquée ont été statistiquement plus fréquents chez les enfants pour lesquels l'antigène rotavirus a été détecté dans les selles, et ces symptômes avaient tendance à être plus fréquents chez les enfants infectés par l'électrophorétype A.</p></div>","PeriodicalId":77667,"journal":{"name":"Annales de l'Institut Pasteur. Virology","volume":"139 ","pages":"Pages 205-215"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0769-2617(88)80018-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13988212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural study of adenovirus type 2 fibre using anti-fibre and anti-peptide sera","authors":"M.L. Caillet-Boudin ,&nbsp;A. Novelli ,&nbsp;J.C. Gesquière ,&nbsp;P. Lemay","doi":"10.1016/S0769-2617(88)80013-3","DOIUrl":"10.1016/S0769-2617(88)80013-3","url":null,"abstract":"<div><p>Peptides corresponding to the N- and C-extremities of the adenovirus 2 fibre polypeptide were synthesized, coupled to tetanus toxoid and injected into rabbits. Two sera were obtained: the anti-N_TT serum and the anti-C_TT serum. These sera and an anti-native-fibre serum were used to study fragments generated by hydrochloric acid cleavage of the fibre. The 44-Kd fragment corresponding to the 2/3 N-terminal part of the molecule retained its antigenic reactivity. This is consistent with a shaft structure for this part of the fibre. The anti-peptide sera were used to orientate the fibre, <em>i.e.</em>, to determine the site of anchorage of this protein in the penton base. First, immunorevelation of blots of enzymatic digests of native or dissociated penton suggested that the N-extremity of the fibre was involved in the assembly of this protein in the penton base. Second, attempts were made to determine the accessibility of the fibre ends in the penton structure by ELISA assays and by immunorevelation of penton in Western blots. The results agreed with the proposed orientation derived from study of the enzymatic digests. Since the 2 anti-peptide sera and the peptides were unable to affect viral adsorption, it was not possible to determine how the fibre is orientated with respect to the cell receptor. However, the anti-peptide sera were found to inhibit viral production slighty.</p></div><div><p>Deux peptides correspondant aux extrémités N- et C-terminales de la fibre de l'adénovirus type 2 ont été synthétisés puis couplés, grâce au glutaraldéhyde, sur l'anatoxine tétanique et injectés à des lapins. Deux sérums ont ainsi été obtenus: les sérums anti-N_TT et anti-C_TT. Ils ont été utilisés pour des études structurales de la fibre. Le peptide N-terminal est révélé par le sérum antifibre, ce qui suggère une antigénicité naturelle de cette extrémité. Ces sérums ont permis d'identifier les fragments engedrés par le clivage chimique de la fibre à l'acide chlorhydrique et de montrer ainsi (1) la spécificité des sérums et (2) l'existence d'une structure antigénique hautement résistante et correspondant à un fragment de 44 Kd contenant les 2/3 N-terminaux de la fibre; cela est en accord avec une structure en bâtonnet pour cette zone de la fibre.</p><p>Les immunsérums ont aussi été utilisés pour déterminer l'orientation de la fibre, c'est-à-dire le site d'ancrage de cette protéine dans la base du penton, et cela grâce à des cinétiques de digestion enzymatique du penton qui montrent que l'extrémité N-terminale de la fibre est plus rapidement digérée lorsque cette protéine est dissociée de la base du penton. L'accessibilité des extrémités de la fibre a pu être définie (1) par des révélations du penton natif ou dissocié en test ELISA et (2) par des immunotransferts. Les résultats de ces expériences sont compatibles avec l'existence d'une liaison à la base du penton grâce à l'extrémité N-terminale de la fibre. Enfin, l","PeriodicalId":77667,"journal":{"name":"Annales de l'Institut Pasteur. Virology","volume":"139 ","pages":"Pages 141-156"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0769-2617(88)80013-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14286390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction of HIV infection with nervous tissue may play a crucial role in the development of AIDS","authors":"G. Parisi","doi":"10.1016/S0769-2617(88)80085-6","DOIUrl":"10.1016/S0769-2617(88)80085-6","url":null,"abstract":"<div><p>In this note, we first review some of the immunopathogenic mechanisms of HIV infection and discuss the possible role of the idiotypic network in producing immunodeficiency; we then propose that the interaction of HIV with the nervous system is such as to generate signals which are misinterpreted by the nervous system: the feedback reaction of the nervous system may play a crucial role in the development of AIDS. We conclude by studying a very simple model for the dynamics of AIDS.</p></div><div><p>Nous passons en revue quelques mécanismes immunopathogéniques de l'infection par le VIH et discutons le rôle possible du réseau idiotypique dans la production de l'immunodéficience; nous pensons que l'interaction du VIH avec le système nerveux est telle qu'elle peut engendrer des signaux qui sont mal interprétés par le système nerveux: le rétro-contrôle du système nerveux pourrait jouer un rôle crucial dans le développement du SIDA. Nous concluons par l'étude d'un modèle très simple de la dynamique de la maladie.</p></div>","PeriodicalId":77667,"journal":{"name":"Annales de l'Institut Pasteur. Virology","volume":"139 ","pages":"Pages 467-476"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0769-2617(88)80085-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14041629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and histopathological aspects of Kaposi's sarcoma in Africa: Relationship with HIV serology","authors":"J.L. Lesbordes ,&nbsp;P.M.V. Martin ,&nbsp;P. Ravisse ,&nbsp;M.C. Georges-Courbot ,&nbsp;A.J. Georges","doi":"10.1016/S0769-2617(88)80017-0","DOIUrl":"10.1016/S0769-2617(88)80017-0","url":null,"abstract":"<div><p>From 1983 to 1987, 45 Kaposi's sarcomas (KS) were diagnosed at the University Hospital in Bangui; 37 cases were easily classified as either endemic or AIDS-related KS on clinical grounds and HIV serology. Moreover, probably due to the stage at which patients consulted and lesions were sampled, noticeable histopathological differences were observed between the two clinical presentations. But for 8/45 which we classified as “borderline KS”, strong discrepancies occurred between clinical aspects, patient evolution, HIV serology and histopathology. In two cases, HIV-positive patients had typical endemic non-evolutive KS and have survived 15 and 36 months.</p></div><div><p>De 1983 à 1987, 45 sarcomes de Kaposi (SK) ont été diagnostiqués au Centre National Hospitalier Universitaire de Bangui; 37 cas ont été aisément classés en SK endémique ou SK relié au SIDA, sur les données cliniques et sérologiques. De plus, des différences histopathologiques notables ont été relevées entre les deux formes cliniques. Cela était probablement du au stade d'évolution de la maladie auquel les prélèvements ont été pratiqués. Mais pour 8/45 SK classés comme “borderline”, de grandes discordances entre l'aspect clinique, l'évolution des malades, la sérologie HIV, et l'histopathologie sont apparues. Dans 2 cas, des malades HIV-positifs avaient un SK endémique non-évolutif typique, et ont survécu pendant 15 et 36 mois respectivement.</p></div>","PeriodicalId":77667,"journal":{"name":"Annales de l'Institut Pasteur. Virology","volume":"139 ","pages":"Pages 197-203"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0769-2617(88)80017-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14042172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal transmission of hepatitis B virus-associated hepatitis D virus","authors":"S. Ramia ,&nbsp;H. Bahakim","doi":"10.1016/S0769-2617(88)80041-8","DOIUrl":"10.1016/S0769-2617(88)80041-8","url":null,"abstract":"<div><p>Sera from 185 HBsAg carrier, pregnant Saudi women were tested for HBeAg, antibody to HBeAg (anti-HBe) and for antibody to hepatitis D virus (anti-HDV); 9.7% of the carrier mothers were anti-HDV-positive and the majority of them (94.4%) were anti-HBe-positive. Follow-up of 17 infants of anti-HDV-positive carrier mothers until about 7 months of age showed no evidence of perinatal transmission of HDV. Age-specific prevalence of anti-HDV in 280 Saudi carriers showed that infection with HDV is infrequent in infants and is mainly acquired during the second and third decades of life, which suggests that transmission of HDV is predominantly horizontal.</p></div><div><p>L'antigène Hbe et les anticorps anti-HBe (contre l'HBeAg) et anti-HDV (contre le virus de l'hépatite D) ont été recherchés dans le sérum de 185 femmes saoudiennes gestantes, porteuses de l'HBsAg; 9,7% de ces «mèreså porteuses sont anti-HDV⁺, et la majorité d'entre elles (94,4%) sont anti-HBe⁺. Le suivi de 17 enfants de mères anti-HDV⁺, jusqu'à l'âge de 7 mois, n'a pas permis de mettre en évidence la transmission périnatale de l'HDV. L'étude de la prévalence des anticorps anti-HDV en fonction de l'âge chez 285 porteurs saoudiens, montre que l'infection par l'HDV est rare chez les enfants et qu'elle se fait principalement au cours de la seconde ou troisième décade de la vie, ce qui suggère que la transmission de l'HDV est essentiellement horizontale.</p></div>","PeriodicalId":77667,"journal":{"name":"Annales de l'Institut Pasteur. Virology","volume":"139 ","pages":"Pages 285-290"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0769-2617(88)80041-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14337067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The epidemiology of the human rabies threat in the grand duchy of Luxembourg","authors":"P. Huberty-Krau ,&nbsp;R. Wigand","doi":"10.1016/S0769-2617(88)80011-X","DOIUrl":"10.1016/S0769-2617(88)80011-X","url":null,"abstract":"<div><p>Epidemiological data were recorded and blood samples were obtained from a group of 297 individuals from Luxembourg who had been in contact with rabies-infected or-suspected animals from 1979 to 1985, and who had been vaccinated with a complete course of HDCS rabies vaccine.</p><p>The majority of the subjects were farmers aged between 30 and 59. The most frequent source of infection was cattle, followed by foxes, sheep and cats. Dogs were in the fifth position only, probably as a direct result of obligatory vaccination of dogs in Luxembourg. Animal rabies was proven in 253 of the 297 cases; in 35 cases, rabies diagnosis was not confirmed, and in 9 cases the animals escaped.</p><p>Concerning the mode of contact, most people (86 %) reported having had contact which caused no skin lesions. Contact with skin lesion, <em>i.e.</em> by biting, scratching or scraping, was only reported in connection with dogs, cats and wild animals, whereas with cattle and other farm animals, contact was mostly without skin lesion. The hand was the part of the body (85 %) most frequently involved. Sera were tested by an enzyme immunoassay for rabies antibodies. The results were unsatisfactory: 21.5 % of the cases had no demonstrable antibodies and 15.2 % had antibodies in low titre. No decline in antibody titre was found according to the time interval after vaccination. Therefore, the enzyme immunoassay does not appear to be optimal to determine long-term immunity.</p></div><div><p>De 1979 à 1985, 295 personnes du Luxembourg ayant été en contact avec un animal enragé ou suspect d'être enragé, ont été traitées par un vaccin antirabique préparé sur cellules diploïdes humaines. Un échantillon de sérum a été prélevé chez ces personnes et des données épidémiologiques ont été recueillies.</p><p>Ces personnes sont pour la plupart des fermiers âgés de 30 à 59 ans. Les espèces animales à l'origine de la contamination, les plus représentées sont (1) le bovin, (2) le renard, (3) l'ovin et (4) le chat. Le chien occupe seulement la 5^e position, ce qui est probablement dû à la vaccination antirabique obligatoire pour les chiens au Luxembourg. La confirmation de rage chez l'animal de contact est apportée dans 253 des cas; dans 35 cas l'examen de laboratoire de l'animal en question est négatif et dans 9 cas l'animal a disparu. Quant au mode de transmission, 86 % des personnes signalent des contacts sans lésion cutanée. Ces lésions s'observent seulement en cas de contact avec un chien, un chat ou un animal sauvage, tandis que de simples contacts sans lésion ont lieu avec des bovins ou d'autres animaux de ferme. La main est la partie du corps la plus exposée.</p><p>Le dosage des anticorps antirabiques a été réalisé par titrage immunoenzymatique. Les résultats n'ont pas donné satisfaction puisque 21,5 % des personnes ne présentent pas d'anticorps et 15,2 % un taux d'anticorps insuffisant. Une baisse du taux des anticorps en relation avec l'intervalle de temps entre vaccin","PeriodicalId":77667,"journal":{"name":"Annales de l'Institut Pasteur. Virology","volume":"139 ","pages":"Pages 113-122"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0769-2617(88)80011-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14337966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunological relationships between rabies virus and rabies-related viruses studied with monoclonal antibodies to Mokola virus","authors":"J. Vincent,&nbsp;F. Bussereau,&nbsp;P. Sureau","doi":"10.1016/S0769-2617(88)80014-5","DOIUrl":"10.1016/S0769-2617(88)80014-5","url":null,"abstract":"<div><p>Specific monoclonal antibodies (mAb) were prepared against a rabies-related lyssavirus, Mokola virus. A strain isolated in the Central African Republic, Mok-3, was used as immunogen. After 3 fusions more than 90 hybridoma cultures secreting mAb were identified. According to their different patterns of reactivity against rabies and rabies-related viruses, 61 ascites fluids were obtained. The antibody class was IgM for 2 of them and IgG for 59. They were specific for one of the 4 major viral proteins, as determined by immunofluorescence, neutralization and immunoblotting tests. Their patterns of reactivity were determined against 6 different strains of rabies-related viruses: Lagos-bat virus from Nigeria (Lag-1) and the Central African Republic (Lag-2), Duvenhage virus from the Republic of South Africa (Duv-1) and Federal Republic of Germany (Duv-3), Mokola virus from Nigeria (Mok-1) and Cameroon (Mok-2) and a fixed strain of rabies virus, the challenge virus strain (CVS). According to their reactivities with these strains and the pattern of fluorescence, the mAb were classified into 11 different groups with intracytoplasmic fluorescence and 7 groups with cell surface fluorescence. A differential diagnosis of these lyssaviruses is possible in tissue culture using some of these mAb.</p></div><div><p>Des anticorps monoclonaux ont été obtenus avec le virus Mokola, un lyssavirus apparenté au virus rabique. Une souche isolée en République Centrafricaine (Mok-3) a été utilisée comme antigène. A la suite de 3 fusions, plus de 90 hybridomes secrétant des anticorps monoclonaux ont été caractérisés. Au regard de la réactivité avec le virus rabique et les virus apparentés, 61 liquides d'ascites ont été produits. Deux appartiennent à la classe des IgM et 59 à celle des IgG. Par immunofluorescence, neutralisation et «Western blotå, il a été montré que chaque anticorps monoclonal est spécifique d'une des 4 protéines majeures du virion. Le profil de réactivité de chaque anticorps a été déterminé vis-à-vis de 6 souches de virus apparentés: le virus Lagosbat du Nigéria (Lag-1) et celui de République Centrafricaine (Lag-2), le virus Duvenhage d'Afrique du Sud (Duv-1) et celui de République Fédérale d'Allemagne (Duv-3), le virus Mokola du Nigéria (Mok-1) et celui du Cameroun (Mok-2) et une souche fixe de virus rabique, CVS. En tenant compte de leur réactivité à l'égard de ces souches ainsi que du type de fluorescence, les anticorps monoclonaux ont été classés en 11 groupes différents ayant une fluorescence intracytoplasmique, et en 7 groupes différents ayant une fluorescence membranaire. Avec ces anticorps monoclonaux un diagnostic différentiel de ces lyssavirus est possible en culture de cellules.</p></div>","PeriodicalId":77667,"journal":{"name":"Annales de l'Institut Pasteur. Virology","volume":"139 ","pages":"Pages 157-173"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0769-2617(88)80014-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14337969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Les vaccinations antirabiques en France en 1987","authors":"S. Savin","doi":"10.1016/S0769-2617(88)80050-9","DOIUrl":"10.1016/S0769-2617(88)80050-9","url":null,"abstract":"","PeriodicalId":77667,"journal":{"name":"Annales de l'Institut Pasteur. Virology","volume":"139 ","pages":"Pages 331-332"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0769-2617(88)80050-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"103330942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Les vaccinations antirabiques en France en 1987","authors":"J. Frémont,&nbsp;C. Gaudiot,&nbsp;J.P. Malo","doi":"10.1016/S0769-2617(88)80051-0","DOIUrl":"10.1016/S0769-2617(88)80051-0","url":null,"abstract":"","PeriodicalId":77667,"journal":{"name":"Annales de l'Institut Pasteur. Virology","volume":"139 ","pages":"Pages 333-335"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0769-2617(88)80051-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"100807894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"F. Tekaïa","doi":"10.1016/S0769-2617(88)80038-8","DOIUrl":"https://doi.org/10.1016/S0769-2617(88)80038-8","url":null,"abstract":"","PeriodicalId":77667,"journal":{"name":"Annales de l'Institut Pasteur. Virology","volume":"139 ","pages":"Page 259"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0769-2617(88)80038-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136615191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}