American journal of therapeutics最新文献

{"title":"Methodological Considerations in the PACT Trial of Multimodal Repurposed Therapy for COVID-19.","authors":"Metin Öner, İbrahim Altundağ","doi":"10.1097/MJT.0000000000002211","DOIUrl":"10.1097/MJT.0000000000002211","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":"e470"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and Safety of Risankizumab in Crohn Disease After Failure of a First Line of Advanced Therapy: A Long-Term, Real-Life Study.","authors":"Antonio Tursi, Giammarco Mocci, Franco Scaldaferri, Daniele Napolitano, Federica Gaiani, Gianluigi De' Angelis, Davide Giuseppe Ribaldone, Eleonora Schillaci, Edoardo V Savarino, Caterina D E Barba, Emanuele Bendia, Laura Bolognini, Daniele Balducci, Claudia Quatraccioni, Francesco Martini, Michele Montori, Giovanni Maconi, Giovanni Cataletti, Alessandro Massari, Elena Del Zanna, Francesco Costa, Linda Ceccarelli, Antonietta G Gravina, Raffaele Pellegrino, Giorgia Bodini, Andrea Pasta, Manuela Marzo, Agnese Miranda, Antonio Cuomo, Laura Donnarumma, Giovanni Lombardi, Marta Patturelli, Mariaelena Serio, Antonella Scarcelli, Giuseppe Pranzo, Chiara Maria Palmisano, Rocco Spagnuolo, Francesco Luzza, Domenico Morano, Giuliana Vespere, Silvia Sedda, Leonardo D E Luca, Walter Elisei, Rita Monterubbianesi, Michela Di Fonzo, Libera Fanigliulo, Roberta Pica, Claudio Cassieri, Andrea Cocco, Elisa Stasi, Laurino Grossi, Lorenzo Bertani, Fabio Cortellini, Simona Piergallini, Patrizio Scarozza, Girolamo Bevevino, Giulia Zerboni, Federico Iacopini, Stefano Rodino', Ladislava Sebkova, Davide Checchin, Francesca Lamboglia, Francesco Ferrara, Nicola Della Valle, Raffaele Colucci, Francesco Bachetti, Domenico Catarella, Dario D'agostino, Elisabetta D I Bartolo, Ileana Luppino, Mario Erboso, Giulia Rocco, Carlotta Sacchi, Costantino Zampaletta, Giacomo Forti, Serafina Fiorella, Gabrio Bassotti, Elisabetta Antonelli, Caterina Mucherino, Elvira D'Antonio, Laura Montesano, Maurizio Giovannone, Giuseppina Vincoli, Alessandro Gigliozzi, Berardino D'Ascoli, Marina Rizzi, Pietro Capone, Giovanni Aragona, Patrizia Perazzo, Leonardo Allegretta, Paolo Tonti, Viviana Neve, Cristiano Pagnini, Antonio Grandolfo, Francesco Gatti, Antongiulio Bucci, Massimiliano Rizzi, Marcello Picchio, Francesca Maria Onidi, Paolo Usai Satta, Alfredo Papa","doi":"10.1097/MJT.0000000000002171","DOIUrl":"10.1097/MJT.0000000000002171","url":null,"abstract":"<p><strong>Background: </strong>Risankizumab (RZB) is an anti-interleukin 23 (anti-IL-23) approved for the treatment of Crohn disease (CD).</p><p><strong>Study question: </strong>We aimed to evaluate the effectiveness and safety of RZB in the treatment of CD in real-world settings.</p><p><strong>Study design: </strong>We performed a retrospective review of a multicentre consortium of patients with CD treated with RZB.</p><p><strong>Measures and outcomes: </strong>Coprimary outcomes were clinical remission at week 12, 24, and 52 (Harvey-Bradshaw Index score of ≤4), and safety. Secondary outcomes included steroid-free clinical remission, clinical response, and endoscopic remission at 52 weeks.</p><p><strong>Results: </strong>A total of 487 patients were included. The median follow-up was 24 (interquartile range: 16-38) weeks. A total of 372 (76.4%) patients achieved clinical remission at maximal follow-up. According to the treatment line in which RZB was administered, clinical remission occurred in 115/134 (85.8%) patients on second-line therapy, 112/153 (73.2%) on third-line therapy, and 145/200 (72.5%) on fourth-line therapy, with a significant difference ( P = 0.010). Adverse events occurred in 60 patients (12.6%) during follow-up; most of them were mild (50/60, 83.3%). Regarding the secondary outcomes: steroid-free clinical remission was achieved in 342 (71.8%) patients, and clinical response was observed in 443 (91.0%) patients. Six (1.2%) patients underwent surgery during follow-up. Mucosal healing was achieved in 34/67 (50.7%) patients.</p><p><strong>Conclusions: </strong>In this extensive, real-world study, RZB was effective and well tolerated in an advanced-therapy-exposed population of patients with CD and associated with favorable clinical and endoscopic outcomes.</p>","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":"e363-e372"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148576926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of POLE-Mutated, dMMR/MSI Colorectal Cancer With an Exceptional Response to Immunotherapy.","authors":"Srijan Valasapalli, Joshua Zweigle, Mustafa Erdem Arslan, Emmanuel E Zervos, Mahvish Muzaffar","doi":"10.1097/MJT.0000000000002186","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002186","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Considerations in the DAPA-STEMI Trial: Interpreting a Promising but Preliminary Signal.","authors":"Fiza Amir, Farheen Gul, Bilal Arshad","doi":"10.1097/MJT.0000000000002201","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002201","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fecal Soiling Following Low-Dose Aripiprazole Treatment in a Child.","authors":"Hilal Tüter Mavi, Şahin Bodur, Furkan Mavi, Cansel Azizağaoğlu, Nazlıcan Tekin, Mustafa Kapan","doi":"10.1097/MJT.0000000000002203","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002203","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Heart Rate: Interpreting the Hemodynamic Response to Ivabradine in Pediatric Cardiac Critical Care.","authors":"Fabio Savorgnan","doi":"10.1097/MJT.0000000000002202","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002202","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148676906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbamazepine-Associated Granulomatous Hepatitis in a Pediatric Patient: A Case Report.","authors":"Selcuk Teke, Yasin M Ergen, Birce I Akcay, Tugba Cavis, Edibe G Basaran, Bulent Unay, Necati Balamtekin","doi":"10.1097/MJT.0000000000002198","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002198","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risperidone-Associated Diffuse Myalgia in a 5-Year-Old Child With Attention-Deficit/Hyperactivity Disorder: A Rare Tolerability-Limiting Adverse Effect.","authors":"Mehri Durak, Halenur Teke","doi":"10.1097/MJT.0000000000002197","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002197","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upadacitinib for Chronic Spontaneous Urticaria: A Retrospective Study.","authors":"Yu-Ting Gan, Shi Yan, Yi Liu, Feng-Lin Chen","doi":"10.1097/MJT.0000000000002174","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002174","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148560733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Stroke Outcomes With Carotid Endarterectomy Versus Medical Therapy in Asymptomatic Carotid Stenosis.","authors":"Tallal M Hashmi, Mushood Ahmed, Hadiah Ashraf, Zain Tariq, Faizan Ahmed, Majid T Aized, Adeel Saleemi, Ameer E Hassan","doi":"10.1097/MJT.0000000000002168","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002168","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148560799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}