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American journal of therapeutics最新文献

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Do Not Treat a Sequencing Report: Therapeutic Stewardship in Endometrial Microbiome Testing. 不要治疗测序报告：子宫内膜微生物组检测的治疗管理。
IF 3.5 4区 医学
American journal of therapeutics Pub Date : 2026-07-01 Epub Date: 2026-06-22 DOI: 10.1097/MJT.0000000000002175
Argyro Papadopoulou, Georgios Tournas, Panagiotis Antsaklis, Georgios Daskalakis, Ekaterini Domali
{"title":"Do Not Treat a Sequencing Report: Therapeutic Stewardship in Endometrial Microbiome Testing.","authors":"Argyro Papadopoulou, Georgios Tournas, Panagiotis Antsaklis, Georgios Daskalakis, Ekaterini Domali","doi":"10.1097/MJT.0000000000002175","DOIUrl":"10.1097/MJT.0000000000002175","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":"e349-e350"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148275708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scropifav Antivenom Versus Supportive Care Alone in the Treatment of Pediatric Scorpion Envenomation. 斯克罗非芬抗蛇毒血清与单纯支持治疗治疗小儿蝎子中毒的比较。
IF 3.5 4区 医学
American journal of therapeutics Pub Date : 2026-07-01 Epub Date: 2025-12-17 DOI: 10.1097/MJT.0000000000002046
Inbal Kestenbom, Shaked Bar-Moshe, Gidon Test, Or Kaplan, Tal Grupel, Michael Shilo, Natalya Bilenko, Michael Friger, Michal S Maimon, Dennis Scolnik, Miguel Glatstein
{"title":"Scropifav Antivenom Versus Supportive Care Alone in the Treatment of Pediatric Scorpion Envenomation.","authors":"Inbal Kestenbom, Shaked Bar-Moshe, Gidon Test, Or Kaplan, Tal Grupel, Michael Shilo, Natalya Bilenko, Michael Friger, Michal S Maimon, Dennis Scolnik, Miguel Glatstein","doi":"10.1097/MJT.0000000000002046","DOIUrl":"10.1097/MJT.0000000000002046","url":null,"abstract":"<p><strong>Background: </strong>Scorpion envenomation is a significant public health concern in specific regions and can have severe consequences in pediatric patients. The efficacy of antivenom treatment remains controversial.</p><p><strong>Objective: </strong>To compare the clinical course and outcomes of pediatric scorpion envenomation in patients receiving SCORPIFAV antivenom versus supportive care alone.</p><p><strong>Methods: </strong>We conducted a retrospective study of children aged 0-18 years presenting with grade ≥2 scorpion envenomation to the pediatric emergency department at Soroka University Medical Center, Israel, between 2014 and 2020. Clinical outcomes were compared between patients who received SCORPIFAV and those treated with supportive care alone.</p><p><strong>Results: </strong>A total of 194 children were included (median age: 3 years, interquartile range: 2-8 years); 125 received SCORPIFAV and 69 received supportive care only. Patients treated with SCORPIFAV required less sedation (10.3% vs. 23.4%, P = 0.02), less analgesia (53.3% vs. 81.3%, P < 0.001), and fewer antihypertensive medications (0% vs. 17.2%, P < 0.001). SCORPIFAV administration was associated with higher odds of requiring minimal additional treatment (OR = 2.568, 95% CI, 1.168-5.646, P = 0.019). No significant differences were found in pediatric intensive care unit admission rates or length of stay.</p><p><strong>Conclusions: </strong>In pediatric patients with grade ≥2 scorpion envenomation, SCORPIFAV use was associated with reduced need for sedatives, analgesics, and antihypertensive medications. These findings suggest that early administration of SCORPIFAV in the emergency setting may help attenuate the sympathetic response and reduce overall treatment intensity.</p>","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":"e285-e291"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abrocitinib for Erythema Multiforme-like Drug Eruptions. 阿布替尼治疗多形性红斑样药疹。
IF 3.5 4区 医学
American journal of therapeutics Pub Date : 2026-07-01 Epub Date: 2026-06-15 DOI: 10.1097/MJT.0000000000002153
Xiang-Yu Chen, Xin-Yu Wei, Bing-Jun Shi
{"title":"Abrocitinib for Erythema Multiforme-like Drug Eruptions.","authors":"Xiang-Yu Chen, Xin-Yu Wei, Bing-Jun Shi","doi":"10.1097/MJT.0000000000002153","DOIUrl":"10.1097/MJT.0000000000002153","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":"e354-e358"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tofacitinib for Pigmented Purpuric Dermatoses: Subtype-Specific Therapeutic Responses and Clinical Implications. 托法替尼治疗色素性紫癜性皮肤病：亚型特异性治疗反应和临床意义。
IF 3.5 4区 医学
American journal of therapeutics Pub Date : 2026-07-01 Epub Date: 2026-06-15 DOI: 10.1097/MJT.0000000000002058
Yu-Ting Gan, Shi Yan, Yi Liu, Feng-Lin Chen
{"title":"Tofacitinib for Pigmented Purpuric Dermatoses: Subtype-Specific Therapeutic Responses and Clinical Implications.","authors":"Yu-Ting Gan, Shi Yan, Yi Liu, Feng-Lin Chen","doi":"10.1097/MJT.0000000000002058","DOIUrl":"10.1097/MJT.0000000000002058","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":"e358-e359"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychedelic Therapy: A Primer for Primary Care Clinicians-Mescaline. 致幻剂治疗：初级保健临床医生的入门-美斯卡灵。
IF 3.5 4区 医学
American journal of therapeutics Pub Date : 2026-07-01 Epub Date: 2026-06-17 DOI: 10.1097/MJT.0000000000002160
Burton J Tabaac, Kenneth Shinozuka, Mahdi Fadel, Greg Jones, Jared Worchel, Owen S Muir
{"title":"Psychedelic Therapy: A Primer for Primary Care Clinicians-Mescaline.","authors":"Burton J Tabaac, Kenneth Shinozuka, Mahdi Fadel, Greg Jones, Jared Worchel, Owen S Muir","doi":"10.1097/MJT.0000000000002160","DOIUrl":"10.1097/MJT.0000000000002160","url":null,"abstract":"<p><strong>Background: </strong>Mescaline (3,4,5-trimethoxyphenethylamine) is a classic serotonergic psychedelic with a history of indigenous ceremonial use. There is renewed scientific interest in mescaline because of the potential psychiatric benefits of psychedelic-assisted therapy. Mescaline primarily exerts its psychoactive effects through serotonin-2A (5-HT 2A ) receptor agonism.</p><p><strong>Areas of uncertainty: </strong>There is a lack of controlled clinical trials evaluating mescaline in patient populations, and most modern safety data are derived from healthy volunteers. Consequently, its safety in individuals with cardiovascular, metabolic, or psychiatric comorbidities remains unclear. Additional uncertainty exists regarding its psychological risks, long duration of action, and long-term safety in therapeutic settings.</p><p><strong>Therapeutic advances: </strong>Randomized, placebo-controlled studies in healthy participants demonstrate that mescaline produces dose-dependent subjective effects with moderate, transient autonomic stimulation and no serious medical complications under controlled conditions. Adverse effects are generally self-limited, and pooled safety analyses and observational data support an overall favorable safety profile in screened human populations.</p><p><strong>Conclusion: </strong>Mescaline shows preliminary safety in healthy humans but remains understudied in clinical populations. Controlled clinical trials are needed to establish its safety and therapeutic potential.</p>","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":"e318-e323"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood Pressure Targets in Thoracic Aortic Disease: A Practical Comparison of ACC/AHA Guidance and Post-2024 European Guidelines. 胸主动脉疾病的血压目标：ACC/AHA指南和2024年后欧洲指南的实际比较
IF 3.5 4区 医学
American journal of therapeutics Pub Date : 2026-07-01 Epub Date: 2026-06-15 DOI: 10.1097/MJT.0000000000002158
Georgios Tournas Androulakis, Argyro Papadopoulou
{"title":"Blood Pressure Targets in Thoracic Aortic Disease: A Practical Comparison of ACC/AHA Guidance and Post-2024 European Guidelines.","authors":"Georgios Tournas Androulakis, Argyro Papadopoulou","doi":"10.1097/MJT.0000000000002158","DOIUrl":"10.1097/MJT.0000000000002158","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":"e333-e335"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Comment on: Safety and Tolerability of Multimodal Therapy (Ivermectin, Doxycycline, Vitamin C, Vitamin D, and Zinc) With or Without Famotidine in Australian Patients With COVID-19 Infection: A Pilot Cohort Trial," for Potential Publication in the American Journal of Therapeutics. 《评论：法莫替丁加或不加法莫替丁治疗澳大利亚COVID-19感染患者的多模式治疗（伊维菌素、多西环素、维生素C、维生素D和锌）的安全性和耐受性：一项试点队列试验》，即将在《美国治疗学杂志》上发表。
IF 3.5 4区 医学
American journal of therapeutics Pub Date : 2026-07-01 Epub Date: 2026-06-05 DOI: 10.1097/MJT.0000000000002135
Nawazish Ali, Muneeba Attique, Musawar Khan, Aqib Ali, Atif Hussain
{"title":"\"Comment on: Safety and Tolerability of Multimodal Therapy (Ivermectin, Doxycycline, Vitamin C, Vitamin D, and Zinc) With or Without Famotidine in Australian Patients With COVID-19 Infection: A Pilot Cohort Trial,\" for Potential Publication in the American Journal of Therapeutics.","authors":"Nawazish Ali, Muneeba Attique, Musawar Khan, Aqib Ali, Atif Hussain","doi":"10.1097/MJT.0000000000002135","DOIUrl":"10.1097/MJT.0000000000002135","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":"e361-e362"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterizing Clinical Effects of 7-Hydroxymitragynine at a US Poison Control Center. 在美国中毒控制中心描述7-羟米特拉吉宁的临床效果。
IF 3.5 4区 医学
American journal of therapeutics Pub Date : 2026-07-01 Epub Date: 2026-04-29 DOI: 10.1097/MJT.0000000000002134
Taylor N Wahrenbrock, Madison Bompard, John W Downs
{"title":"Characterizing Clinical Effects of 7-Hydroxymitragynine at a US Poison Control Center.","authors":"Taylor N Wahrenbrock, Madison Bompard, John W Downs","doi":"10.1097/MJT.0000000000002134","DOIUrl":"10.1097/MJT.0000000000002134","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":"e339-e341"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Levodopa Withdrawal Presenting as Fever in a Patient Receiving Concomitant Enteral Nutrition: A Case Report and Literature Review. 左旋多巴戒断患者同时接受肠内营养时表现为发热：1例报告及文献回顾。
IF 3.5 4区 医学
American journal of therapeutics Pub Date : 2026-07-01 Epub Date: 2026-06-15 DOI: 10.1097/MJT.0000000000002162
Yu-Shuang Qiu, Di Zhao, Pei-Pei Meng, Dong-Jie Li, Yi-Bo Fei, Bo Yang, Fu-Ming Shen
{"title":"Levodopa Withdrawal Presenting as Fever in a Patient Receiving Concomitant Enteral Nutrition: A Case Report and Literature Review.","authors":"Yu-Shuang Qiu, Di Zhao, Pei-Pei Meng, Dong-Jie Li, Yi-Bo Fei, Bo Yang, Fu-Ming Shen","doi":"10.1097/MJT.0000000000002162","DOIUrl":"10.1097/MJT.0000000000002162","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":"e335-e339"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148256980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upadacitinib as a Successful Sequential Therapy After Abrocitinib Failure in a Patient With Refractory Darier Disease. 在阿布替尼治疗失败后，Upadacitinib作为一种成功的序贯疗法治疗难治性肾癌患者。
IF 3.5 4区 医学
American journal of therapeutics Pub Date : 2026-07-01 Epub Date: 2026-06-15 DOI: 10.1097/MJT.0000000000002091
Yu-Ting Gan, Shi Yan, Wei-Na Xie, Yi Liu, Feng-Lin Chen
{"title":"Upadacitinib as a Successful Sequential Therapy After Abrocitinib Failure in a Patient With Refractory Darier Disease.","authors":"Yu-Ting Gan, Shi Yan, Wei-Na Xie, Yi Liu, Feng-Lin Chen","doi":"10.1097/MJT.0000000000002091","DOIUrl":"10.1097/MJT.0000000000002091","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":"e352-e354"},"PeriodicalIF":3.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148256978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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