American journal of therapeutics最新文献

{"title":"Urinary Alkalinization for Salicylate Poisoning Is Infrequently Measured nor Achieved.","authors":"Bernard Weigel, Chanell Davis, Sean M Bryant","doi":"10.1097/MJT.0000000000001930","DOIUrl":"https://doi.org/10.1097/MJT.0000000000001930","url":null,"abstract":"<p><strong>Background: </strong>Urinary alkalinization is a key intervention for salicylate poisoning, and clinical guidelines recommend serial urinary pH measurements during treatment.</p><p><strong>Study question: </strong>How frequently are urine pH measurements obtained, and how often is alkalinization achieved when managing salicylate poisoning with sodium bicarbonate therapy?</p><p><strong>Study design: </strong>This is a retrospective poison center study. Salicylate cases managed by a regional poison center for a 5-year period (2019-2023) were analyzed. Inclusion criteria included all patients receiving bicarbonate therapy for salicylate concentrations >30 mg/dL that were managed in a health care facility. Patients requiring hemodialysis were excluded to eliminate confounding factors.</p><p><strong>Measures and outcomes: </strong>The primary outcome was the documentation of a urine pH in the poison center chart. Secondary outcomes included the frequency of urine pH measurements and the achievement of a urinary pH ≥7.5. Data were analyzed using descriptive statistics. Multivariable logistic regression was performed to determine variables associated with increased odds of urine pH measurement.</p><p><strong>Results: </strong>Among 352 cases, urine pH was documented in 144 (41%). Median urine pH values ranged from 6.0 to 8.5 across serial measurements. Urinary alkalinization (pH ≥7.5) was achieved in 34% of cases with documented urine pH. Higher peak salicylate concentrations were associated with increased odds of urine pH measurement (OR = 1.04, P < 0.001). Verbal recommendations significantly increased the likelihood of pH measurement (OR = 3.43, P < 0.001). Formal guidelines faxed or emailed to clinicians, ICU admission, and toxicology consultation were not significant predictors of urine pH testing.</p><p><strong>Conclusions: </strong>Urine pH was measured in fewer than half of cases, indicating poor adherence to guidelines recommending urinary pH monitoring during alkalinization therapy. Verbal recommendations were more effective than written guidelines in promoting pH measurement. Further investigation into the clinical utility and adherence barriers of urine pH measurement is warranted.</p>","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Topical Finasteride and Oral Finasteride in the Treatment of Androgenic Alopecia. A Systemic Review and Meta-Analysis.","authors":"Syed Ali Arsal, Aashish Kumar, Umer Iqbal, Muhammad Aniq Amir, Muhammad Maaz, Muhammad Abrar Amir","doi":"10.1097/MJT.0000000000001887","DOIUrl":"https://doi.org/10.1097/MJT.0000000000001887","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient Hyperprolactinemia After a Single Low-Dose PRN Olanzapine ODT in a Low-Functioning Autistic Boy.","authors":"Ahmed Naguy, Nadyah Alayadhi, Dalal Elsori, Bibi Alamiri","doi":"10.1097/MJT.0000000000001942","DOIUrl":"https://doi.org/10.1097/MJT.0000000000001942","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Reporting Quality of Randomized Controlled Trials That Investigate the Efficacy of Curcumin for Treating Depression.","authors":"Alexandra Valera, Theodoros Mprotsis, Chrysoula Doxani","doi":"10.1097/MJT.0000000000001958","DOIUrl":"https://doi.org/10.1097/MJT.0000000000001958","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Decrease of PD-L1 Expression Affects the Efficacy of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients With Lung Squamous Cell Carcinoma.","authors":"Yin Jie, Du Mingzhan, Gong Yinhua, Shen Dan","doi":"10.1097/MJT.0000000000001965","DOIUrl":"https://doi.org/10.1097/MJT.0000000000001965","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myelodysplastic Syndrome Accompanied by Monoclonal Gammopathy of Undetermined Significance and Blastic Plasmacytoid Dendritic Cell Neoplasm Treated by Venetocla + Azacitidine.","authors":"Hua-Yun Geng, Juan Zheng, Guang-Yao Li","doi":"10.1097/MJT.0000000000001905","DOIUrl":"https://doi.org/10.1097/MJT.0000000000001905","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the Use of Ketamine in Treatment-Resistant Depression and Other Psychiatric Disorders: A Scoping Review of Practice Patterns, Efficacy, and Patient Demographic Trends.","authors":"Amna M Aslam, Kenneth Shinozuka, Owen Muir, Burton J Tabaac","doi":"10.1097/MJT.0000000000001951","DOIUrl":"https://doi.org/10.1097/MJT.0000000000001951","url":null,"abstract":"<p><strong>Background: </strong>Ketamine has emerged as a novel treatment for psychiatric disorders, particularly treatment-resistant depression (TRD). Although intravenous (IV) ketamine is not approved by the Food and Drug Administration (FDA) for TRD, esketamine, an FDA-approved therapeutic, has contributed to the widespread clinical use of off-label IV ketamine across the United States. This scoping review highlights significant shifts in ketamine therapy, particularly after FDA approval of esketamine, the impact of COVID-19 on treatment accessibility, and increased regulatory scrutiny from the Drug Enforcement Administration (DEA) and FDA.</p><p><strong>Areas of uncertainty: </strong>What are the current practice patterns, patient demographics, and barriers to accessing ketamine for psychiatric disorders, particularly TRD?</p><p><strong>Data sources: </strong>This scoping review focused on provider utilization patterns (including frequency of ketamine administration, provider roles, and treatment settings), preferred administration methods (IV infusions, intramuscular injections, and other routes), and patient characteristics (age, sex, socioeconomic status, and primary psychiatric diagnoses treated). The Web of Science, PubMed, CBM, MEDLINE, Cochrane Library, University Theses, and Embase databases were searched.</p><p><strong>Results: </strong>Two survey-based studies were included. IV administration was the most common method of administration reported in both studies, with alternative methods such as intramuscular and sublingual routes emerging in limited use. Patients receiving ketamine therapy were predominantly middle aged (36-64 years old), with financial barriers identified as a notable obstacle because of limited insurance coverage. Access to ketamine was limited in rural areas, illustrating the need for expanded provider networks. Private clinics exhibited greater flexibility in treatment approaches than hospital settings, which adhered to standardized protocols. The absence of long-term outcome data and variability in treatment protocols emphasize the need for standardized practices and further research.</p><p><strong>Conclusions: </strong>This scoping review highlights the widespread use of ketamine for TRD, but reveals significant variability in practice patterns and accessibility barriers. Findings emphasize the need for standardized protocols, expanded insurance coverage, and further research to optimize the role of ketamine in psychiatric care.</p>","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Newer Uterotonics With Standard-Dose Oxytocin for Postpartum Hemorrhage Prophylaxis: A Network Meta-analysis.","authors":"Argyro Papadopoulou, Georgios Tournas, Sofoklis Stavros, Ekaterini Domali, Georgios Daskalakis","doi":"10.1097/MJT.0000000000001976","DOIUrl":"https://doi.org/10.1097/MJT.0000000000001976","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Progression-Free Survival With Sunitinib in Advanced Recurrent Adrenocortical Carcinoma.","authors":"Ali Turker, Mahmut Buyuksimsek, İrem Kolsuz Turker, Mehmet Turker, İrfan Alisan","doi":"10.1097/MJT.0000000000001943","DOIUrl":"https://doi.org/10.1097/MJT.0000000000001943","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring External Complementary Therapeutic Methods for Knee Osteoarthritis: Implications for Clinical Practice.","authors":"Qi Yang, Jian-Jun Dong, Jiong Du, Jing Wang, Yun-Da Li, Cheng-Hao Ma, Hai-Ping Hong","doi":"10.1097/MJT.0000000000001953","DOIUrl":"https://doi.org/10.1097/MJT.0000000000001953","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}