American journal of therapeutics最新文献

{"title":"Vildagliptin-Induced Leukocytoclastic Vasculitis: A Case Report and Review of Published Cases.","authors":"Nour Elhouda Zouaoui, Imen Hamza, Ons Charfi, Sana Debbeche, Imen Aouinti, Ahmed Zaiem, Ghozlane Lakhoua, Sarrah Kastalli, Sihem El Aidli","doi":"10.1097/MJT.0000000000002216","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002216","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148885996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phosphodiesterase-5 Inhibitor Use and Clinical Outcomes in Left Ventricular Assist Device Recipients: A Real-World Analysis of 31,465 Patients.","authors":"Dimitrios E Magouliotis, Andrew Xanthopoulos, Serge Sicouri, Stephanie Kjelstrom, Massimo Baudo, Vasiliki Androutsopoulou, Alexandros Briasoulis, Ulrich Jorde, Omar Saeed, Randall C Starling, Basel Ramlawi","doi":"10.1097/MJT.0000000000002177","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002177","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sotatercept in Patients With Pulmonary Arterial Hypertension: An Updated Meta-Analysis of Randomized Controlled Trials.","authors":"Mushood Ahmed, Ayça Zal, Zahra Zahiri, Hirad Meshkati, Hadiah Ashraf, Eman Ibrahim Elzain Hassan, Hritvik Jain, Faizan Ahmed, Himaja Dutt Chigurupati, Sivaram Neppala","doi":"10.1097/MJT.0000000000002194","DOIUrl":"10.1097/MJT.0000000000002194","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":"e453-e460"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Concurrent use of Antibiotics With Inhibitory Effect Against Clostridioides difficile Alter Stool Enzyme Immunoassay Toxin Results in Hospitalized Patients?","authors":"Joshua Piticaru, Lisa Avery, Alex Aubertine, Vardaan Sandhu, Muhammad Hasan","doi":"10.1097/MJT.0000000000002164","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002164","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":"33 5","pages":"e423-e425"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upadacitinib as an Effective Rescue Therapy in a Case of Adalimumab-Refractory Perifolliculitis Capitis Abscedens et Suffodiens.","authors":"Yu-Ting Gan, Shi Yan, Wei-Na Xie, Yi Liu, Feng-Lin Chen","doi":"10.1097/MJT.0000000000002084","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002084","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":"33 5","pages":"e408-e409"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissociation and Hallucinations Induced by Fluoxetine and Atomoxetine Combination in a Child.","authors":"Hazal S Soyugür, Oya Güleşen Kapan, Mustafa Kapan","doi":"10.1097/MJT.0000000000002196","DOIUrl":"10.1097/MJT.0000000000002196","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":"e451-e452"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148787273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-Year Biomarker Trends and Kidney/Mortality Outcomes After Semaglutide Versus Phentermine-Topiramate and Naltrexone-Bupropion in People With Obesity and Without Diabetes.","authors":"Shao-Chia Chen, Kai-Wen Liu, Yu-Nan Huang, Gideon Meyerowitz-Katz, Pen-Hua Su","doi":"10.1097/MJT.0000000000002132","DOIUrl":"10.1097/MJT.0000000000002132","url":null,"abstract":"<p><strong>Background: </strong>Laboratory changes after antiobesity drugs in routine care are not well-described.</p><p><strong>Study question: </strong>In adults with obesity and no diabetes, how do 2-year laboratory trends and major clinical outcomes compare after starting semaglutide versus naltrexone-bupropion or phentermine-topiramate?</p><p><strong>Study design: </strong>Retrospective cohort study in the TriNetX US Collaborative Network (2021-2025). New users were propensity-score matched 1:1 and followed for up to 24 months in an intention-to-treat framework. A prespecified 3-month landmark analysis and a global network replication were performed.</p><p><strong>Measures and outcomes: </strong>Lipids, HbA1c, ALT, AST, lipase, creatinine, and estimated glomerular filtration rate were assessed at baseline and at 6, 12, and 24 months. Outcomes were all-cause mortality, major adverse kidney events (MAKEs), major adverse liver outcomes, and acute pancreatitis. Cox models estimated hazard ratios (HRs); 24-month absolute risk differences (ARDs) were derived from Kaplan-Meier estimates.</p><p><strong>Results: </strong>Matching yielded 11,484 semaglutide-naltrexone-bupropion pairs and 16,316 semaglutide-phentermine-topiramate pairs. Compared with each comparator, semaglutide users had lower total cholesterol and LDL-C across follow-up; triglycerides were lower versus naltrexone-bupropion. HDL-C was higher with phentermine-topiramate at 12-24 months. HbA1c was lower with semaglutide versus naltrexone-bupropion at 12 and 24 months and slightly higher versus phentermine-topiramate. Between-group differences in creatinine and estimated glomerular filtration rate were limited. Semaglutide use was associated with lower hazards of mortality (vs. naltrexone-bupropion: HR 0.51; ARD -0.4%; vs. phentermine-topiramate: HR 0.62; ARD -0.2%) and MAKE (vs. naltrexone-bupropion: HR 0.47; ARD -0.5%; vs. phentermine-topiramate: HR 0.48; ARD -0.4%). Major adverse liver outcome and pancreatitis estimates were near the null, and landmark results were similar.</p><p><strong>Conclusions: </strong>Over 2 years in routine care, semaglutide use was associated with lower atherogenic lipid levels and lower hazards of death and MAKEs than naltrexone-bupropion or phentermine-topiramate, while kidney laboratory differences were limited.</p>","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":"e373-e383"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Janus Kinase Inhibitors in Pigmented Purpuric Dermatoses: A Retrospective Study.","authors":"Xiaoxuan Cai, Jianjun Qiao","doi":"10.1097/MJT.0000000000002163","DOIUrl":"https://doi.org/10.1097/MJT.0000000000002163","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":"33 5","pages":"e426-e428"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary Artery Calcium as a Key Indicator of Chemotherapy Cardiotoxicity in Patients With Colorectal Cancer.","authors":"Ahmad Jabri, Sant Kumar, Anand Reddy Maligireddy, Firas Anaya, Macie Matta, Hassan Dehaini, Fares Sukhon, Ahmad Al-Abdouh, Nour Hammad, Richard Bloomingdale, Simon Dixon, Justin Trivax, Ashish Aneja, Kathir Balakumaran","doi":"10.1097/MJT.0000000000002045","DOIUrl":"10.1097/MJT.0000000000002045","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":"e471-e474"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Critique to Cautionary Tale: A Methodological Response to Qasim's Flawed Appraisal of Proton Pump Inhibitors for Upper Gastrointestinal Bleeding Prevention in Dual Antiplatelet Therapy.","authors":"Javier Arredondo Montero","doi":"10.1097/MJT.0000000000002059","DOIUrl":"10.1097/MJT.0000000000002059","url":null,"abstract":"","PeriodicalId":7760,"journal":{"name":"American journal of therapeutics","volume":" ","pages":"e475-e478"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}