{"title":"[The role of nonspecific nasal reactivity in the evaluation of induced bronchial hyperreactivity].","authors":"D Plavec, J Godnić-Cvar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The excitation of the irritant receptors in the upper respiratory tract may result in reflex bronchoconstriction. Does the raised reactivity of the nasal mucus membrane--the place of the first contact with respiratory irritants--play an important role in the expression of IBH? The level of NNR and the existence of relation between NNR and IBH have been assessed in 32 healthy subjects and 28 workers exposed to irritants with respiratory disorders. Nonspecific nasal provocation was performed by spraying of doubled concentrations of histamine solution in saline (0.03-16 mg/mL) in both nostrils in three minute intervals. The reaction was monitored by measurement of nasal peak inspiratory flow, nasal resistance, nasal forced expiratory volume in first second and nasal forced expiratory mid-flow. The level of NNR was expressed as provocation concentrations of histamine solution that produced significant change of all four measured parameters. Nonspecific bronchial provocation with histamine was performed by the modified method of Chai H. et al. The criterion for hyperreactivity was PC20FEV1 less than or equal to 8 mg/mL of histamine. There was statistically no significant correlation between NNR and IBH.</p>","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"42 1-2","pages":"33-5"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13369168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Etiopathogenic mechanisms of increased airway responsiveness].","authors":"S Tanurdzić, J Balaban, V Durić, Z Dimcić","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Views on mechanisms of increased airway responsiveness in patients with bronchial asthma and other respiratory tract are presented. The data have been divided into three parts: mucosal and submucosal changes, changes in airway regulations and effector cells. In the first part the etiopathological mechanisms of inflammatory processes in airways are explained. The second part views the neurogenic and other airway disorders (vagus reflex arc, local axon reflex, epithelial relaxing factor) while the third focuses on the receptor activity changes and cellular mechanisms known to cause airway hypersensitivity and hyperreactivity.</p>","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"42 1-2","pages":"5-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13370754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Tuberculosis of the peripheral lymph nodes].","authors":"I Pongrac, M Roglić, Z Kotarski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An analysis of 2.414 fine needle aspiration specimens, obtained from peripheral lymph nodes, was done in 2.287 patients during the period from 1979 till the end of 1989. This investigation was performed at the Cytologic Laboratory of the Clinic for Lung Diseases \"Jordanovac\" in Zagreb. Totally, there were 150 (6.2%) aspirates which, cytomorphologically, appeared to have a granulomatous reaction with necrosis. Of 150 aspirates, Mycobacterium tuberculosis was found microscopically and/or by culture in 73 (3.02%) of them. The patients were less than 40 years of age in 63% of the cases. As to the localization, the highest rate of tuberculous lymph nodes (91.8%) was found in the neck and supraclavicular areas.</p>","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"42 1-2","pages":"71-3"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13370761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Pulmonary silicosis complicated by systemic vasculitis].","authors":"T Susković, J Mose, Z Vucicević","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A patient is described who had been--as a cutter of crystal--for 40 yrs exposed to the silica dust. At regular medical examinations at out-patients' department for pulmonary diseases first stage of pulmonary silicosis had been found and confirmed at the Institute for Occupational Health. Nine years after the retirement the clinical symptoms of febrility, cough, joint and muscular pains appeared together with the difficulties in swallowing and dyspnea even at minor physical activities. During the treatment the systemic vasculitis, probably visceral erythematodes, was established with satisfactory response to the corticosteroid therapy.</p>","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"42 1-2","pages":"77-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13371490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Basić-Grbac, M Krstić-Burić, I Grbac, I Z Letoja
{"title":"[Primary mucociliary transport insufficiency].","authors":"M Basić-Grbac, M Krstić-Burić, I Grbac, I Z Letoja","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Case histories of 3 patients with primary mucociliary transport failure are described. Two of them had immotile cilia syndrome and one cystic fibrosis. In all three patients the same clinical picture was found and they had the same treatment, although the etiology of diseases was not the same. The treatment in two patients was not much successful since they had associated respiratory failure.</p>","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"42 1-2","pages":"80-4"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13371491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Modulation of nonspecific bronchial hyperreactivity].","authors":"S Suskovic","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nonspecific bronchial hyperresponsiveness (NBHR) is a typical characteristic of asthmatic patients. The impairment of NBHR is due to the airway inflammations caused by the viruses, irritants from the air and especially by specific allergens from natural and working environment. NBHR is diminished by elimination of inflammatory triggers as well as by antiinflammatory measures, the most important being inhalatory glucocorticoids which should be administered for long-term period in order to achieve the successful decrease of NBHR.</p>","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"42 1-2","pages":"19-21"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13369164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Preventive measures in bronchial provocation tests].","authors":"A Gruden-Gros","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The author's own experiences together with the data from the literature are presented for application the bronchial provocation tests in the hospital and in out-patient's department for pulmonary disease. Contraindications and side effects in testing the nonspecific provocative agents are presented (metacholine, histamine, carbachol), in specific provocative agents as well as in exercise testing. These tests are relatively harmless if the preventive measures are taken into account.</p>","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"42 1-2","pages":"50-1"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13370755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[26th Golnik symposium. Bronchial hyperreactivity. Proceedings].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"42 1-2","pages":"5-65"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13135945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Provocation agents for the evaluation of nonspecific bronchial responsiveness].","authors":"S Grobovsek-Opara","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Different pharmacological and nonpharmacological provocative agents used in the assessment of nonspecific bronchial responsiveness are presented. Their advantages and disadvantages as well as the attempt of the evaluation of their clinical applicability are discussed. The choice of provocative agent has still been the matter of personal judgement.</p>","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"42 1-2","pages":"46-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13369171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Normal reactivity and hyperreactivity in the bronchi induced by respiratory irritants].","authors":"J Godnić-Cvar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The influence of age, sex, atopy, baseline spirometry and smoking habit on the presentation of airway reactivity (AR), and the prevalence of hyperreactive subjects was assessed in 176 normals and 143 subjects occupationally exposed to respiratory irritants. The study protocol comprised: a respiratory disease questionnaire, physical examination, skin prick-test to 13 common inhalant allergens, IgE level, spirometry. The nonspecific bronchoprovocation test (NBPT) was performed by the cumulative method proposed by Chai et al. (J Allergy Clin Immunol 1975; 56: 323-327). The results are expressed as PC20FEV1, PC25FEF50, PC25FEF25 and PC25FEF25/75. Age, sex, atopy, baseline spirometric values and smoking are not significantly correlated with indeces of AR. There are no hyperreactors among healthy subjects--according to the criterion: PC20FEV1 less than or equal to 2.17 micromoles of histamine. When the response was measured by flow-volume parameters, there were between 5.1% and 9% hyperreactors. In both examined groups AR has proved to be a highly variable feature. Among workers exposed to irritants there were 5.6% hyperreactors according to PC20FEV1 and between 11.1% and 13.9% when flow-volume parameters were applied. A significant correlation between AR and smoking habit of subjects occupationally exposed to irritants was not found. The level of AR when monitored by flow-volume parameters of subjects continuously exposed to irritants was found to be significantly lower than in normals. The chosen criterion separates successfully airway normo- from hyperreactives. It is a useful diagnostic method in occupational medicine.</p>","PeriodicalId":77589,"journal":{"name":"Plucne bolesti : casopis Udruzenja pneumoftiziologa Jugoslavije = the journal of Yugoslav Association of Phthisiology and Pneumology","volume":"42 1-2","pages":"30-2"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13369172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}