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Cancer cells (Cold Spring Harbor, N.Y. : 1989)最新文献

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Basic fibroblast growth factor in human melanoma. 人黑色素瘤中的碱性成纤维细胞生长因子。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-08-01
U Rodeck, D Becker, M Herlyn
{"title":"Basic fibroblast growth factor in human melanoma.","authors":"U Rodeck,&nbsp;D Becker,&nbsp;M Herlyn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Basic fibroblast growth factor (bFGF) is a major factor contributing to human melanoma cell growth. bFGF is produced constitutively by cells from each stage of the disease, but not by normal melanocytes, although the latter cells are dependent on the factor for growth in vitro. Two lines of evidence suggest that bFGF functions in an autocrine manner in melanoma: (1) inhibition of bFGF activity by bFGF-specific antibodies or antisense sequences suppresses melanoma cell growth in vitro; and (2) retrovirus-mediated transfer of a bFGF cDNA into normal murine melanocytes renders the recipient cell bFGF-independent. Constitutive production of bFGF is not by itself sufficient for the establishment of the transformed phenotype, however, since bFGF-expressing melanocytes are neither immortalized nor tumorigenic in nude mice.</p>","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13091387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell transformation by the epidermal growth factor receptor and v-erbB. 表皮生长因子受体和v-erbB的细胞转化。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-08-01
M J Hayman, P J Enrietto
{"title":"Cell transformation by the epidermal growth factor receptor and v-erbB.","authors":"M J Hayman,&nbsp;P J Enrietto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It has become increasingly apparent that growth factor receptors can function as oncogenic proteins and play causal roles in cell transformation. A prime example is the epidermal growth factor receptor (EGFR), which belongs to the ligand-activated tyrosine kinase receptor family and is overexpressed in certain human tumors. The transforming gene of avian erythroblastosis virus, v-erbB, encodes a truncated form of the EGFR whose kinase domain is constitutively activated by deletion of the ligand binding domain. Recent comparative studies of the v-erbB gene in different viral isolates have revealed that subtle sequence changes (point mutations, small deletions) can alter both the pathogenic spectrum of the virus and the range of cell types susceptible to transformation in vitro. Therefore, the possibility exists that similar, as-yet-unidentified, mutations may exist in the EGFR gene; if so, the EGFR may be an oncogenic factor in tumors other than those with which it has been associated to date.</p>","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12846713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hormonal carcinogenesis. 激素致癌作用。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-08-01
J J Li
{"title":"Hormonal carcinogenesis.","authors":"J J Li","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13091388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mls, Mtv, and T cells: possible roles in retroviral diseases. Mls、Mtv和T细胞:在逆转录病毒疾病中的可能作用
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-08-01
S Macphail
{"title":"Mls, Mtv, and T cells: possible roles in retroviral diseases.","authors":"S Macphail","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12822995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heat shock: the role of transient inducible responses in cell damage, transformation, and differentiation. 热休克:瞬时诱导反应在细胞损伤、转化和分化中的作用。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-08-01
R I Morimoto
{"title":"Heat shock: the role of transient inducible responses in cell damage, transformation, and differentiation.","authors":"R I Morimoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The stress response is ubiquitous among all organisms of the bacterial, plant, and animal kingdoms. A prominent feature of this response is the synthesis of a discrete set of proteins, known as heat shock proteins, that have been shown to be essential in a plethora of protein biosynthetic and processing reactions, including protein folding and oligomerization, translocation, and secretion. During heat shock and other forms of physiological stress, heat shock proteins act as intracellular sentinels to recognize malfolded proteins. The heat shock response is tightly regulated and encompasses selective transcriptional and translational mechanisms that control the preferential synthesis of stress proteins during physiological stress. Deregulation of stress gene expression is associated with various human diseases. It is likely that the balance of interactions between damaged protein molecules and stress proteins has profound effects that impinge on normal cell growth and differentiation.</p>","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13091386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel polyphosphoinositides in cell growth and activation. 新型多磷酸肌苷在细胞生长和活化中的作用。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-07-01
K R Auger, L C Cantley
{"title":"Novel polyphosphoinositides in cell growth and activation.","authors":"K R Auger,&nbsp;L C Cantley","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The \"conventional\" polyphosphoinositide pathway is important for the transmission and amplification of signals across the cell membrane. Ligand-induced activation of phospholipase C results in the hydrolysis of phosphatidylinositol 4,5-bisphosphate to produce the well-characterized second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Recently, three novel polyphosphoinositides have been implicated as important signaling molecules for cell proliferation and activation. These lipids are phosphorylated in the D-3 position of the inositol ring and appear to represent branch points from the conventional polyphosphoinositide pathway.</p>","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12820853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are acinar cells involved in the pathogenesis of ductal adenocarcinoma of the pancreas? 腺泡细胞是否参与胰腺导管腺癌的发病机制?
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-07-01
D G Scarpelli, M S Rao, J K Reddy
{"title":"Are acinar cells involved in the pathogenesis of ductal adenocarcinoma of the pancreas?","authors":"D G Scarpelli,&nbsp;M S Rao,&nbsp;J K Reddy","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12820854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epithelial cancers of the aerodigestive tract: biology, prevention, and therapy. 气消化道上皮癌:生物学、预防和治疗。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-07-01
S A Maxwell
{"title":"Epithelial cancers of the aerodigestive tract: biology, prevention, and therapy.","authors":"S A Maxwell","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13070447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor metastasis and nm23: current concepts. 肿瘤转移和nm23:目前的概念。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-07-01
P S Steeg, K H Cohn, A Leone
{"title":"Tumor metastasis and nm23: current concepts.","authors":"P S Steeg,&nbsp;K H Cohn,&nbsp;A Leone","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Reduced expression and/or somatic allelic deletion of nm23 is associated with high metastatic potential in several types of rodent tumors and human breast and colorectal carcinomas. Transfection of murine nm23-1 cDNA into highly metastatic murine K-1735 TK melanoma cells results in a reduced incidence of primary tumor formation, significant reduction in tumor metastatic potential, and altered responsiveness to the cytokine, transforming growth factor beta. Here we discuss emerging concepts concerning nm23, such as its varied pattern of alteration/expression in tumor metastasis, its effect on tumorigenesis, and its possible biochemical functions.</p>","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13070444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular and cellular biology of antigen processing and presentation. 抗原加工和递呈的分子和细胞生物学。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-07-01
J Yewdell
{"title":"Molecular and cellular biology of antigen processing and presentation.","authors":"J Yewdell","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13070446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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