人黑色素瘤中的碱性成纤维细胞生长因子。

IF 3.5 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
U Rodeck, D Becker, M Herlyn
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引用次数: 0

摘要

碱性成纤维细胞生长因子(bFGF)是促进人类黑色素瘤细胞生长的主要因子。bFGF是由来自疾病各个阶段的细胞组成的,而不是由正常的黑色素细胞产生,尽管后者的细胞在体外生长依赖于该因子。两种证据表明bFGF在黑色素瘤中以自分泌方式起作用:(1)bFGF特异性抗体或反义序列抑制bFGF活性可抑制体外黑色素瘤细胞生长;(2)逆转录病毒介导的bFGF cDNA转移到正常小鼠黑色素细胞中,使受体细胞不依赖bFGF。然而,bFGF的组成性产生本身并不足以建立转化表型,因为表达bFGF的黑素细胞在裸鼠中既不会永生化也不会致瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Basic fibroblast growth factor in human melanoma.

Basic fibroblast growth factor (bFGF) is a major factor contributing to human melanoma cell growth. bFGF is produced constitutively by cells from each stage of the disease, but not by normal melanocytes, although the latter cells are dependent on the factor for growth in vitro. Two lines of evidence suggest that bFGF functions in an autocrine manner in melanoma: (1) inhibition of bFGF activity by bFGF-specific antibodies or antisense sequences suppresses melanoma cell growth in vitro; and (2) retrovirus-mediated transfer of a bFGF cDNA into normal murine melanocytes renders the recipient cell bFGF-independent. Constitutive production of bFGF is not by itself sufficient for the establishment of the transformed phenotype, however, since bFGF-expressing melanocytes are neither immortalized nor tumorigenic in nude mice.

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