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Cancer cells (Cold Spring Harbor, N.Y. : 1989)最新文献

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Hematopoietic stem cells, 1961-1991 (meeting report) 造血干细胞，1961-1991(会议报告)
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-10-01
L H Trümper, H L Atkins
{"title":"Hematopoietic stem cells, 1961-1991 (meeting report)","authors":"L H Trümper, H L Atkins","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12940091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radioprotection with cytokines--learning from nature to cope with radiation damage. 利用细胞因子进行辐射防护——向大自然学习以应对辐射损伤。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-10-01
R Neta, J J Oppenheim
{"title":"Radioprotection with cytokines--learning from nature to cope with radiation damage.","authors":"R Neta,&nbsp;J J Oppenheim","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The quest for methods to protect cells from the damaging effects of ionizing radiation led to the observation that cytokines, endogenously produced hormone-like polypeptides, are radioprotective. Interleukin-1 and tumor necrosis factor-alpha, given before irradiation, can protect mice from doses of radiation that would be fatal to untreated animals. At lower doses of radiation, the hemopoietic growth factors, interleukin-1, interleukin-4, interleukin-6, tumor necrosis factor-alpha, interferon, and leukemia inhibitory factor can promote recovery when administered after irradiation. Exposure to ionizing radiation selectively induces expression of some cytokines. Recent work suggests that certain cytokines may initiate autocrine/paracrine regulated recovery and repair pathways. Thus, the radioprotective and therapeutic effects of supplementary pharmacological doses of cytokines may act by amplifying innate defenses to ionizing radiation.</p>","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12940089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abnormal patterns of DNA methylation in human neoplasia: potential consequences for tumor progression. 人类肿瘤中DNA甲基化的异常模式:肿瘤进展的潜在后果。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-10-01
S B Baylin, M Makos, J J Wu, R W Yen, A de Bustros, P Vertino, B D Nelkin
{"title":"Abnormal patterns of DNA methylation in human neoplasia: potential consequences for tumor progression.","authors":"S B Baylin,&nbsp;M Makos,&nbsp;J J Wu,&nbsp;R W Yen,&nbsp;A de Bustros,&nbsp;P Vertino,&nbsp;B D Nelkin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An imbalance of DNA methylation, involving widespread hypomethylation, regional hypermethylation and increased cellular capacity for methylation, is characteristic of human neoplasia. This imbalance begins in preneoplastic cells and becomes more extensive throughout subsequent stages of tumor progression. In normal cells, a primary function of DNA methylation may be to modulate compartmentalization of DNA to ensure that regional areas of transcriptionally active chromatin replicate earlier than the bulk transcriptionally inactive chromatin. We argue here that the altered methylation patterns observed during tumor progression, especially regional hypermethylation, may mark--or even help to establish--abnormalities of chromatin organization. In turn, these changes in chromatin structure may, through direct transcriptional inactivation of genes, predisposition to mutations, and allelic deletions, mediate the progressive losses of gene expression associated with tumor development.</p>","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12940088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maud Slye. 莫德Slye。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-09-01
J Cuddihy
{"title":"Maud Slye.","authors":"J Cuddihy","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isoprenoid modification and plasma membrane association: critical factors for ras oncogenicity. 类异戊二烯修饰和质膜关联:ras致癌性的关键因素。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-09-01
C J Der, A D Cox
{"title":"Isoprenoid modification and plasma membrane association: critical factors for ras oncogenicity.","authors":"C J Der,&nbsp;A D Cox","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Association of ras protein with the plasma membrane is critical for its transforming activity. This association is promoted by a series of post-translational modifications that are signaled by the consensus C-terminal CAAX motif present in all ras proteins. The recent discovery that a 15-carbon isoprenoid (farnesyl) group, derived from an essential intermediate in cholesterol biosynthesis, is attached covalently to ras proteins has stimulated considerable interest and has suggested several important new directions for ras studies. In particular, one promising pharmacologic approach for antagonizing oncogenic ras activity in human malignancies would be to design specific inhibitors of the enzymes that catalyze ras processing and thereby interfere with ras protein association with the plasma membrane.</p>","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA tumor virus update. RNA肿瘤病毒更新。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-09-01
M L Linial, M Emerman
{"title":"RNA tumor virus update.","authors":"M L Linial,&nbsp;M Emerman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12848986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Growth control and neoplastic transformation in the brain. 脑内生长控制与肿瘤转化。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-09-01
O D Wiestler, P Herrlich
{"title":"Growth control and neoplastic transformation in the brain.","authors":"O D Wiestler,&nbsp;P Herrlich","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>For many scientists it is often difficult to predict which meetings, among the plethora convening each year, will be the most rewarding. A particular strength of the Zülch symposium was the lively exchange of novel findings and ideas among researchers tackling problems as diverse as photoreceptor cell development in Drosophila and the molecular basis of tumor metastasis. It is these small focused meetings which draw together molecular biologists, clinicians, and pathologists that bear the key to success. Both of us felt strongly that all participants took ideas back home. What else could we ask for? If Zülch had been granted the opportunity to come to Goslar, he would have enjoyed this symposium very much.</p>","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12848987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The DNA-activated protein kinase, DNA-PK: a potential coordinator of nuclear events. dna活化蛋白激酶，DNA-PK:核事件的潜在协调者。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-09-01
S P Lees-Miller, C W Anderson
{"title":"The DNA-activated protein kinase, DNA-PK: a potential coordinator of nuclear events.","authors":"S P Lees-Miller,&nbsp;C W Anderson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>DNA-PK is a moderately abundant serine/threonine protein kinase found in the nucleus of a wide range of eukaryotic cells. It is one of the few known cellular enzymes whose activity is regulated directly by DNA. Many DNA binding proteins, including a number of transcription factors, are substrates for DNA-PK in vitro. We suggest that this kinase may coordinate signal transduction pathways and nuclear events, including transcription, in response to changes in DNA or chromatin state.</p>","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The transmembrane hyaluronate receptor (CD44): multiple functions, multiple forms. 跨膜透明质酸受体(CD44):多种功能，多种形式。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-09-01
B F Haynes, H X Liao, K L Patton
{"title":"The transmembrane hyaluronate receptor (CD44): multiple functions, multiple forms.","authors":"B F Haynes,&nbsp;H X Liao,&nbsp;K L Patton","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12885542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antitumor ether lipids: endocytosis as a determinant of cellular sensitivity. 抗肿瘤醚类脂质:内吞作用是细胞敏感性的决定因素。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-08-01
P Workman
{"title":"Antitumor ether lipids: endocytosis as a determinant of cellular sensitivity.","authors":"P Workman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12822996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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