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Cancer cells (Cold Spring Harbor, N.Y. : 1989)最新文献

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Receptor-mediated mitogenic signals and lung cancer. 受体介导的有丝分裂信号与肺癌。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-12-01
H M Schüller
{"title":"Receptor-mediated mitogenic signals and lung cancer.","authors":"H M Schüller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Most lung cancers are simultaneously stimulated by several autocrine and paracrine growth factors. Diseases resulting in excessive production of these factors and/or changes in the receptors, second messengers, or genes comprising their signal transduction pathways can thus result in the stimulation of continuous cell proliferation characteristic of cancer. Some carcinogenic N-nitrosamines mimic the stimulatory effect of cell-type-specific growth factors by binding to their receptors, and in this way mediate their selective carcinogenic effects. In this review I discuss the significance of receptor-mediated mitogenic signal transduction pathways for the initiation and progression of lung cancer, and describe novel lung cancer therapeutics that target components of these pathways.</p>","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12834187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photodynamic therapy of malignant tumors--recent developments. 恶性肿瘤的光动力治疗——最新进展。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-11-01
C W Lin
{"title":"Photodynamic therapy of malignant tumors--recent developments.","authors":"C W Lin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Photodynamic therapy (PDT) is a promising new cancer treatment modality in which tumor cells are killed as a result of photoactivation of a tumor-localizing photosensitizing agent. Since activating light can be targeted specifically to tumors, and tumor-selective photosensitizing agents are being developed, this treatment has the potential to induce highly selective destruction of malignant cells. To date, PDT has been applied to a large variety of human carcinomas, resulting in successful eradication of single tumor nodules and several types of superficial tumors. Current research is aimed at improving the efficacy and tumor-selectivity and tumor destruction. The most immediate benefits of PDT are likely to be seen in patients treated with a combination of this and other forms of therapy.</p>","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12924113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radioprotection with cytokines: a clarification of terminology. 细胞因子的辐射防护:术语澄清。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-11-01
R Neta, J J Oppenheim
{"title":"Radioprotection with cytokines: a clarification of terminology.","authors":"R Neta,&nbsp;J J Oppenheim","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12924115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Growth-regulated signal transduction by the MAP kinases and RSKs. MAP激酶和rsk的生长调节信号转导。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-11-01
J Blenis
{"title":"Growth-regulated signal transduction by the MAP kinases and RSKs.","authors":"J Blenis","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12827406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaccination against papillomavirus. 预防乳头瘤病毒的疫苗。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-11-01
M S Campo
{"title":"Vaccination against papillomavirus.","authors":"M S Campo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Both in humans and in animals, papillomaviruses are the causative agents of a variety of benign epidermal tumors including common warts, flat warts, condylomas, and papillomas. These lesions most often regress, occasionally persist, and, in the presence of additional critical factors, can progress to cancer. Vaccines that protect against papillomavirus infection or induce tumor regression would be beneficial in the treatment of recalcitrant warts and in preventing malignant progression. Recently, successful prophylaxis and rejection of epidermal and alimentary canal tumors have been achieved in cattle with both conventional and genetically engineered vaccines. Successful vaccination in animals has important implications for the management of papillomavirus-associated tumors in humans, particularly laryngeal papillomas and cervical carcinomas.</p>","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12827405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
All about B cells. 都是关于B细胞的。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-11-01
A L DeFranco
{"title":"All about B cells.","authors":"A L DeFranco","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12924114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene-specific repair of DNA damage induced by UV irradiation and cancer chemotherapeutics. 紫外线照射和癌症化疗诱导的DNA损伤的基因特异性修复。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-11-01
C J Link, R K Burt, V A Bohr
{"title":"Gene-specific repair of DNA damage induced by UV irradiation and cancer chemotherapeutics.","authors":"C J Link,&nbsp;R K Burt,&nbsp;V A Bohr","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>DNA repair processes are critically important in the prevention of carcinogenesis, and currently much research is directed toward elucidation of the biochemical mechanisms by which DNA repair occurs. Techniques have been developed for examining individual genes to quantitate the lesions induced by various chemotherapeutic agents and to measure the rate of gene-specific DNA repair. In mammalian cells, the DNA repair response exhibits intragenomic heterogeneity-active genes are preferentially repaired and the transcribed strand of DNA is repaired more rapidly than the nontranscribed strand. These studies have provided new insight into the molecular biology of DNA repair and a new perspective on the role of repair processes in cellular resistance to DNA damage and malignancy. Elucidation of the mechanisms by which gene-specific lesions are formed and repaired will be important if we are to understand the fundamental processes of malignancy.</p>","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12924112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chromosome 11q13 abnormalities in human cancer. 染色体11q13在人类癌症中的异常。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-11-01
G A Lammie, G Peters
{"title":"Chromosome 11q13 abnormalities in human cancer.","authors":"G A Lammie,&nbsp;G Peters","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Structural abnormalities affecting band q13 of chromosome 11 have been reported in a variety of human tumors, particularly multiple endocrine neoplasia type 1 (MEN1), certain low-grade B-cell neoplasms, and a significant subset of breast and squamous cell carcinomas. The perturbations of the region are also varied, ranging from allele loss and deletions to specific translocations and DNA amplification. Given their clinical relevance in classifying tumors and identifying patients at increased risk, it is important to locate and characterize the genes on which these aberrations impinge. Here we assess the candidate genes identified thus far and the evidence that implicates them in tumorigenesis.</p>","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12924111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transformation of hemopoietic cells by raf and myc oncogenes: a new perspective on lineage commitment. 造血细胞的raf和myc癌基因转化:谱系承诺的新视角。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-10-01
S P Klinken
{"title":"Transformation of hemopoietic cells by raf and myc oncogenes: a new perspective on lineage commitment.","authors":"S P Klinken","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of the raf and myc oncogenes on murine hemopoietic cells are quite distinct. The raf-1 gene, which encodes a serine/threonine kinase that is involved in signal transduction, preferentially transforms erythroid cells, whereas myc, which encodes a DNA-binding protein, induces lymphoid and myeloid neoplasms. Together, raf and myc form a potent leukemogenic combination and they act synergistically to transform cells from all hemopoietic lineages. Strikingly, the expression of exogenous raf and myc in lymphoid and erythroid cells enables these cells to change lineages and become myeloid cells, an observation that raises interesting questions concerning commitment to specific lineages.</p>","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12940087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A role for arachidonic acid and its metabolites in the regulation of p21ras activity. 花生四烯酸及其代谢物在调节p21ras活性中的作用。
Cancer cells (Cold Spring Harbor, N.Y. : 1989) Pub Date : 1991-10-01
E Rozengurt
{"title":"A role for arachidonic acid and its metabolites in the regulation of p21ras activity.","authors":"E Rozengurt","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77504,"journal":{"name":"Cancer cells (Cold Spring Harbor, N.Y. : 1989)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12940090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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