Chromosome 11q13 abnormalities in human cancer.

IF 3.5 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
G A Lammie, G Peters
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Abstract

Structural abnormalities affecting band q13 of chromosome 11 have been reported in a variety of human tumors, particularly multiple endocrine neoplasia type 1 (MEN1), certain low-grade B-cell neoplasms, and a significant subset of breast and squamous cell carcinomas. The perturbations of the region are also varied, ranging from allele loss and deletions to specific translocations and DNA amplification. Given their clinical relevance in classifying tumors and identifying patients at increased risk, it is important to locate and characterize the genes on which these aberrations impinge. Here we assess the candidate genes identified thus far and the evidence that implicates them in tumorigenesis.

染色体11q13在人类癌症中的异常。
影响11号染色体q13带的结构异常已在多种人类肿瘤中报道,特别是多发性内分泌瘤1型(MEN1),某些低级别b细胞肿瘤,以及乳腺癌和鳞状细胞癌的重要亚群。该区域的扰动也是多种多样的,从等位基因丢失和缺失到特定的易位和DNA扩增。鉴于它们在肿瘤分类和识别风险增加的患者方面的临床相关性,定位和表征这些畸变所影响的基因是很重要的。在这里,我们评估到目前为止确定的候选基因和证据,暗示他们在肿瘤发生。
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