Transformation of hemopoietic cells by raf and myc oncogenes: a new perspective on lineage commitment.

IF 3.5 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
S P Klinken
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引用次数: 0

Abstract

The effects of the raf and myc oncogenes on murine hemopoietic cells are quite distinct. The raf-1 gene, which encodes a serine/threonine kinase that is involved in signal transduction, preferentially transforms erythroid cells, whereas myc, which encodes a DNA-binding protein, induces lymphoid and myeloid neoplasms. Together, raf and myc form a potent leukemogenic combination and they act synergistically to transform cells from all hemopoietic lineages. Strikingly, the expression of exogenous raf and myc in lymphoid and erythroid cells enables these cells to change lineages and become myeloid cells, an observation that raises interesting questions concerning commitment to specific lineages.

造血细胞的raf和myc癌基因转化:谱系承诺的新视角。
raf和myc癌基因对小鼠造血细胞的影响是完全不同的。编码丝氨酸/苏氨酸激酶参与信号转导的raf-1基因优先转化红系细胞,而编码dna结合蛋白的myc基因诱导淋巴和髓系肿瘤。raf和myc一起形成了一种强效的致白血病组合,它们协同作用转化来自所有造血谱系的细胞。引人注目的是,外源性raf和myc在淋巴细胞和红细胞中的表达使这些细胞能够改变谱系并成为髓细胞,这一观察结果引发了有关特定谱系的有趣问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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