新型多磷酸肌苷在细胞生长和活化中的作用。

IF 3.5 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
K R Auger, L C Cantley
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引用次数: 0

摘要

“传统的”多磷酸肌肽途径对于信号在细胞膜上的传递和放大是重要的。配体诱导的磷脂酶C活化导致磷脂酰肌醇4,5-二磷酸水解,产生表征良好的第二信使,肌醇1,4,5-三磷酸和二酰基甘油。最近,三种新的多磷酸肌苷被认为是细胞增殖和激活的重要信号分子。这些脂质在肌醇环的D-3位置被磷酸化,似乎代表了传统多磷酸肌醇途径的分支点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Novel polyphosphoinositides in cell growth and activation.

The "conventional" polyphosphoinositide pathway is important for the transmission and amplification of signals across the cell membrane. Ligand-induced activation of phospholipase C results in the hydrolysis of phosphatidylinositol 4,5-bisphosphate to produce the well-characterized second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Recently, three novel polyphosphoinositides have been implicated as important signaling molecules for cell proliferation and activation. These lipids are phosphorylated in the D-3 position of the inositol ring and appear to represent branch points from the conventional polyphosphoinositide pathway.

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