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Naltrexone treatment of bulimia: clinical and theoretical findings linking eating disorders and substance abuse. 纳曲酮治疗暴食症:将饮食失调和药物滥用联系起来的临床和理论发现。
Advances in alcohol & substance abuse Pub Date : 1988-02-05 DOI: 10.1300/J251V07N01_03
J. Jonas, M. Gold
{"title":"Naltrexone treatment of bulimia: clinical and theoretical findings linking eating disorders and substance abuse.","authors":"J. Jonas, M. Gold","doi":"10.1300/J251V07N01_03","DOIUrl":"https://doi.org/10.1300/J251V07N01_03","url":null,"abstract":"Eating disorders and substance abuse may occur together frequently. Studies have demonstrated that 25%-50% of individuals with anorexia nervosa and bulimia will have a history of substance abuse, and that certain groups of drug abusers may have elevated rates of eating disorders. One mechanism which may explain this relationship is the role of endogenous opiate peptides in triggering the compulsion to binge-eat. The authors report the successful use of the long-acting opiate antagonist naltrexone in treating a group of bulimic individuals, and discuss the implications of these findings.","PeriodicalId":77481,"journal":{"name":"Advances in alcohol & substance abuse","volume":"7 1 1","pages":"29-37"},"PeriodicalIF":0.0,"publicationDate":"1988-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1300/J251V07N01_03","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66186436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 33
Discovery of novel brain lipoxygenase products formed from docosahexaenoic acid (22:6w3). 发现由二十二碳六烯酸形成的新型脑脂氧合酶产物(22:6w3)。
Advances in alcohol & substance abuse Pub Date : 1988-01-01 DOI: 10.1300/J251v07n03_31
T Shingu, J W Karanian, H Y Kim, J A Yergey, N Salem
{"title":"Discovery of novel brain lipoxygenase products formed from docosahexaenoic acid (22:6w3).","authors":"T Shingu,&nbsp;J W Karanian,&nbsp;H Y Kim,&nbsp;J A Yergey,&nbsp;N Salem","doi":"10.1300/J251v07n03_31","DOIUrl":"https://doi.org/10.1300/J251v07n03_31","url":null,"abstract":"<p><p>It is known that alcohol exposure leads to a decline in brain docosahexaenoate (22:6w3). We hypothesized that alcohol could stimulate the metabolism of this polyunsaturated fatty acid to bioactive products. Several oxidized products of 22:6w3 were indeed observed when rat brain homogenate was incubated with 14C22:6w3 in vitro. A similar group of metabolites was formed in vivo from 14C-22:6w3 injected into the lateral ventricle. These metabolites were characterized by thermospray- and GC/MS as well as by the synthesis of standards using purified enzymes. Platelet lipoxygenase also proved useful in identifying one of the brain metabolites and served as a source of enzyme for preparative studies. Their physiological effects on smooth muscle tone and platelet aggregation will be presented.</p>","PeriodicalId":77481,"journal":{"name":"Advances in alcohol & substance abuse","volume":"7 3-4","pages":"235-40"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1300/J251v07n03_31","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14110805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Alcohol research from bench to bedside. Proceedings from a symposium. 1987, Bethesda, Maryland. 从实验室到临床的酒精研究。会议记录。1987年，马里兰州贝塞斯达。
Advances in alcohol & substance abuse Pub Date : 1988-01-01 DOI: 10.1300/J251v07n03_01
{"title":"Alcohol research from bench to bedside. Proceedings from a symposium. 1987, Bethesda, Maryland.","authors":"","doi":"10.1300/J251v07n03_01","DOIUrl":"https://doi.org/10.1300/J251v07n03_01","url":null,"abstract":"","PeriodicalId":77481,"journal":{"name":"Advances in alcohol & substance abuse","volume":"7 3-4","pages":"1-247"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1300/J251v07n03_01","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14351228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alpha-2-adrenoceptor function in alcoholics. -2肾上腺素受体在酗酒者中的作用。
Advances in alcohol & substance abuse Pub Date : 1988-01-01 DOI: 10.1300/J251v07n03_07
D J Nutt, P Glue
{"title":"Alpha-2-adrenoceptor function in alcoholics.","authors":"D J Nutt,&nbsp;P Glue","doi":"10.1300/J251v07n03_07","DOIUrl":"https://doi.org/10.1300/J251v07n03_07","url":null,"abstract":"<p><p>Alpha-2-adrenoceptor function has been assessed using the iv clonidine challenge test. During withdrawal clonidine effects on blood pressure, sedation and body temperature were blunted compared with the abstinent state and healthy controls. In contrast the growth hormone response was blunted in both the withdrawing and abstinent alcoholics. These findings suggest that a deficit of alpha-2-inhibitory control is a feature of withdrawal and, in the case of the endocrine response, may persist for some time.</p>","PeriodicalId":77481,"journal":{"name":"Advances in alcohol & substance abuse","volume":"7 3-4","pages":"43-6"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1300/J251v07n03_07","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13989568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Alcohol research. 酒精的研究。
Advances in alcohol & substance abuse Pub Date : 1988-01-01 DOI: 10.1300/J251v07n03_33
L K Morgan, J E Raper
{"title":"Alcohol research.","authors":"L K Morgan,&nbsp;J E Raper","doi":"10.1300/J251v07n03_33","DOIUrl":"https://doi.org/10.1300/J251v07n03_33","url":null,"abstract":"","PeriodicalId":77481,"journal":{"name":"Advances in alcohol & substance abuse","volume":"7 3-4","pages":"249-57"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1300/J251v07n03_33","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14197665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Epidermal growth factor binding in the presence of ethanol. 乙醇存在时表皮生长因子的结合。
Advances in alcohol & substance abuse Pub Date : 1988-01-01 DOI: 10.1300/J251v07n03_26
M J Gerhart, B Y Reed, R L Veech
{"title":"Epidermal growth factor binding in the presence of ethanol.","authors":"M J Gerhart,&nbsp;B Y Reed,&nbsp;R L Veech","doi":"10.1300/J251v07n03_26","DOIUrl":"https://doi.org/10.1300/J251v07n03_26","url":null,"abstract":"<p><p>Epidermal growth factor (EGF) is a mitogen which has been shown to stimulate maxillo-facial growth and DNA synthesis. Ethanol has been reported to inhibit cell regeneration in vivo and in vitro and to produce diminished maxillo-facial development in fetal alcohol syndrome. Recent findings from this laboratory have elucidated rapid metabolic changes in the hepatic content of some of the glycolytic intermediates resulting from injection of EGF, ethanol or EGF combined with ethanol in vivo. An immediate effect of EGF in vivo is to increase hepatic tissue content of 3-phosphoglycerate and phosphoenolpyruvate 1.2-1.3 fold when compared to saline treatment. Ethanol however causes a marked fall in the hepatic content of 3-phosphoglycerate and phosphoenolpyruvate 3.2-3.7 fold below saline treated levels. Ethanol in combination with EGF decreases hepatic values for 3-phosphoglycerate and phosphoenolpyruvate 2.0-2.3 fold from saline treated, but elevates the content of phosphoenolpyruvate 1.6 fold over ethanol treatment alone. Such metabolite changes occurring with ethanol treatment have been attributed alternately to redox shifts or to membrane perturbations. We wished to determine whether dimunition of 3-phosphoglycerate and or phosphoenolpyruvate below certain levels perhaps critically necessary for normal mitogenic action of EGF was due in this case to ethanol effects of binding of EGF to the cell membrane.</p>","PeriodicalId":77481,"journal":{"name":"Advances in alcohol & substance abuse","volume":"7 3-4","pages":"209-11"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1300/J251v07n03_26","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14392665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
RO 15-4513 and its interaction with ethanol. RO 15-4513及其与乙醇的相互作用。
Advances in alcohol & substance abuse Pub Date : 1988-01-01 DOI: 10.1300/J251v07n03_19
R G Lister, D J Nutt
{"title":"RO 15-4513 and its interaction with ethanol.","authors":"R G Lister,&nbsp;D J Nutt","doi":"10.1300/J251v07n03_19","DOIUrl":"https://doi.org/10.1300/J251v07n03_19","url":null,"abstract":"<p><p>It has recently been claimed that RO 15-4513 selectively opposes some of the behavioral actions of ethanol. Our studies on the intrinsic effects of this compound have shown it to be proconvulsant and to reduce exploratory behavior in mice. In these respects RO 15-4513 resembles a benzodiazepine receptor partial inverse agonist. Such intrinsic actions may well explain its alcohol-antagonizing properties, and argue against its potential in humans. In addition to partially reversing the effects of ethanol, RO 15-4513 also partially reverses the behavioral effect of a barbiturate and completely reverses the effects of a benzodiazepine.</p>","PeriodicalId":77481,"journal":{"name":"Advances in alcohol & substance abuse","volume":"7 3-4","pages":"119-23"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1300/J251v07n03_19","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13989682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Treatment of alcoholic organic brain syndrome with the serotonin reuptake inhibitor fluvoxamine: a preliminary study. 5 -羟色胺再摄取抑制剂氟伏沙明治疗酒精性器质性脑综合征的初步研究
Advances in alcohol & substance abuse Pub Date : 1988-01-01 DOI: 10.1300/J251v07n03_08
J M Stapleton, M J Eckardt, P Martin, B Adinoff, L Roehrich, G Bone, D Rubinow, M Linnoila
{"title":"Treatment of alcoholic organic brain syndrome with the serotonin reuptake inhibitor fluvoxamine: a preliminary study.","authors":"J M Stapleton,&nbsp;M J Eckardt,&nbsp;P Martin,&nbsp;B Adinoff,&nbsp;L Roehrich,&nbsp;G Bone,&nbsp;D Rubinow,&nbsp;M Linnoila","doi":"10.1300/J251v07n03_08","DOIUrl":"https://doi.org/10.1300/J251v07n03_08","url":null,"abstract":"<p><p>The chronic effects of fluvoxamine (200 mg per day for 4 weeks) were studied in ten alcoholic organic brain syndrome patients in a double-blind cross-over design. Complete neuropsychological evaluation was performed as well as measurement of neurochemical changes in CSF. Fluvoxamine produced a small but significant improvement in memory performance. An analysis of fluvoxamine minus placebo difference scores showed a significant correlation between memory functioning and CSF 5HIAA levels. Alcohol amnestic syndrome patients who had the highest blood levels of fluvoxamine demonstrated the largest changes in CSF 5HIAA and improvement in memory performance under fluvoxamine. These findings implicate a role of serotonergic mechanisms in alcoholic organic brain syndrome and suggest that with individual titration of the drug dose, fluvoxamine might be a clinically useful agent in the treatment of this syndrome.</p>","PeriodicalId":77481,"journal":{"name":"Advances in alcohol & substance abuse","volume":"7 3-4","pages":"47-51"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1300/J251v07n03_08","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13612592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Induction of rat hepatic microsomal drug metabolizing enzymes by pyrazole and 4-substituted pyrazoles. 吡唑和4-取代吡唑对大鼠肝微粒体药物代谢酶的诱导作用。
Advances in alcohol & substance abuse Pub Date : 1988-01-01 DOI: 10.1300/J251v07n03_24
A L Hayes, L J Marden, M V McGuire, N W Cornell
{"title":"Induction of rat hepatic microsomal drug metabolizing enzymes by pyrazole and 4-substituted pyrazoles.","authors":"A L Hayes,&nbsp;L J Marden,&nbsp;M V McGuire,&nbsp;N W Cornell","doi":"10.1300/J251v07n03_24","DOIUrl":"https://doi.org/10.1300/J251v07n03_24","url":null,"abstract":"Pyrazole and 4-methylpyrazole are potent inhibitors of liver alcohol dehydrogenase and as such have been proposed as potential antidotes to alcohol poisoning. These drugs are also inducers of hepatic cytochrome P-450. We tested pyrazole and four 4-substituted pyrazoles for their potential as inducers of cytochrome P-450 and drug metabolism in mature male rats. Total cytochrome P-450 was significantly increased (p < 0.05) 1.3 fold by treatment with 4-methylpyrazole. P-nitrophenol hydroxylase (PNPH) activity (nmol/min/mg protein) was increased 1.9 fold following treatment with pyrazole and with 4-methylpyrazole. Treatment with 4-methyl-pyrazole also resulted in a 2.9 fold increase in ethoxyresorufin deethylase (EROD) activity. In addition, pyrazole treatment led to a significant decrease in the activity of benzphetamine demethylase. 4-lodopyrazole increased the turnover (nmol/min/nmol P-450) of EROD and PNPH by 1.5 fold each. 4-Nitropyrazole had no significant effect on any of the activities or turnover rat...","PeriodicalId":77481,"journal":{"name":"Advances in alcohol & substance abuse","volume":"7 3-4","pages":"199-203"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1300/J251v07n03_24","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14351230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Ethanol's effects on neurotransmitter release and intracellular free calcium in PC12 cells. 乙醇对PC12细胞神经递质释放和胞内游离钙的影响。
Advances in alcohol & substance abuse Pub Date : 1988-01-01 DOI: 10.1300/J251v07n03_14
C S Rabe, F F Weight
{"title":"Ethanol's effects on neurotransmitter release and intracellular free calcium in PC12 cells.","authors":"C S Rabe,&nbsp;F F Weight","doi":"10.1300/J251v07n03_14","DOIUrl":"https://doi.org/10.1300/J251v07n03_14","url":null,"abstract":"<p><p>The effect of ethanol on muscarine-stimulated release of [3H]NE was studied using the rat pheochromocytoma cell line, PC12. At concentrations of 25 mM and above, ethanol produced a dose dependent inhibition of muscarine-stimulated release of [3H]NE. The inhibition of muscarine-stimulated transmitter release occurred in the absence of any effect of ethanol on [3H]NE uptake, metabolism or on muscarinic binding to the cells. However, ethanol produced an inhibition of muscarine-stimulated elevation of intracellular free Ca2+ which corresponded with the inhibition of transmitter release. At concentrations greater than 100 mM, ethanol produced both a stimulation of the release of [3H]NE as well as an increase in intracellular free Ca2+. The increase in basal transmitter release and intracellular free Ca2+ occurred independent of the inhibition by ethanol of muscarine-stimulated elevation of intracellular free Ca2+ or transmitter section. These results demonstrate the relationship of the effects of ethanol on cellular free Ca2+ and neurotransmitter release.</p>","PeriodicalId":77481,"journal":{"name":"Advances in alcohol & substance abuse","volume":"7 3-4","pages":"95-7"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1300/J251v07n03_14","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14352742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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