{"title":"Trustworthy AI in intensive care: From model performance to clinical decisions.","authors":"Xianglilan Zhang, Kwok M Ho","doi":"10.1177/0310057X261494602","DOIUrl":"https://doi.org/10.1177/0310057X261494602","url":null,"abstract":"","PeriodicalId":7746,"journal":{"name":"Anaesthesia and Intensive Care","volume":" ","pages":"310057X261494602"},"PeriodicalIF":1.5,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anne T O'Brien, Alice M McGushin, Arthur Wyns, Madeleine Skellern, Lisa K Pulver, Anita M Shutt, Sonia Chanchlani, Scott Cy Ma, Eugenie A Kayak
{"title":"Desflurane's efficacy, cost and environmental impacts: Considerations for Australian formularies.","authors":"Anne T O'Brien, Alice M McGushin, Arthur Wyns, Madeleine Skellern, Lisa K Pulver, Anita M Shutt, Sonia Chanchlani, Scott Cy Ma, Eugenie A Kayak","doi":"10.1177/0310057X261476076","DOIUrl":"https://doi.org/10.1177/0310057X261476076","url":null,"abstract":"<p><p>Desflurane use is declining in Australia, owing to awareness of its environmental impacts, high costs, effective comparator agents and decisions by hospitals and Medicines and Therapeutics Committees (MTCs) to restrict its use. At a roundtable in June 2024, the Council of Australian Therapeutic Advisory Groups (CATAG) agreed to establish an expert advisory group (EAG) to review evidence on desflurane and provide recommendations for its use in Australian hospitals. The <i>Position Statement on the formulary listing of desflurane</i> was released in March 2025. This article provides the evidence review, alongside recommendations, with updates demonstrating continued progress on the reduction of desflurane use. The review found that desflurane is similar to sevoflurane in its clinical efficacy and safety profile, with desflurane demonstrating modest improvements in extubation times that do not translate to reduced stay in the post-anaesthesia care unit or a reduction in complications. In addition, desflurane is a greenhouse gas, with an impact 40-50 times that of sevoflurane. The review also found that cost savings accompany policies to curtail the use of desflurane in health services. The EAG agreed to the following recommendations, which were endorsed by CATAG: 1. Health Service Organisations and MTCs should consider not listing desflurane on hospital or state-based formularies; 2. Health Service Organisations and MTCs should undertake consultation and planning prior to removal of desflurane from theatres; 3. MTCs may consider establishing limited provisions for exceptional use of desflurane based on clinical need.</p>","PeriodicalId":7746,"journal":{"name":"Anaesthesia and Intensive Care","volume":" ","pages":"310057X261476076"},"PeriodicalIF":1.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Editorial: The end of the paper trail.","authors":"Philip J Peyton, Vida Vilunas","doi":"10.1177/0310057X261489608","DOIUrl":"https://doi.org/10.1177/0310057X261489608","url":null,"abstract":"","PeriodicalId":7746,"journal":{"name":"Anaesthesia and Intensive Care","volume":" ","pages":"310057X261489608"},"PeriodicalIF":1.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"James Moore and a quiet beginning of modern regional anaesthesia.","authors":"Jun D Parker, Peter M Reid","doi":"10.1177/0310057X261486481","DOIUrl":"https://doi.org/10.1177/0310057X261486481","url":null,"abstract":"<p><p>In contrast to the public spectacle of the Ether Demonstration in 1846, modern regional anaesthesia had a quiet beginning in 1784. That year, James Moore (1762-1860), a Scottish junior surgeon, published the first English book devoted solely to anaesthesia: 'A Method of Preventing or Diminishing Pain in Several Operations of Surgery'. Using a purpose-made iron nerve compressor, Moore successfully anaesthetised the lower limb and completed a near-painless below-knee amputation with John Hunter (1728-1793). Similarly, he also performed the first brachial plexus anaesthesia, introducing the concept of 'plexus anaesthesia'. Beyond this achievement, Moore's 50-page book covers essential perioperative practices that are still relevant today. With the recent rediscovery of a Moore's compressor in Scotland by the authors, this paper critically analyses Moore's contribution. It reframes his narrative through frameworks such as the sociological tipping point, self-experimentation, anatomical analysis and collaboration, challenging the prevailing historical paradigm.</p>","PeriodicalId":7746,"journal":{"name":"Anaesthesia and Intensive Care","volume":" ","pages":"310057X261486481"},"PeriodicalIF":1.5,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149057086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Integrating behavioural and physiological data: A multimodal AI framework for perioperative pain assessment.","authors":"Josh Andrews, Alasdair Leslie, Venkatesan Thiruvenkatarajan, Brandon Stretton","doi":"10.1177/0310057X261474523","DOIUrl":"https://doi.org/10.1177/0310057X261474523","url":null,"abstract":"","PeriodicalId":7746,"journal":{"name":"Anaesthesia and Intensive Care","volume":" ","pages":"310057X261474523"},"PeriodicalIF":1.5,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hannah M Lewis, Josephine Alexa Potter, Fiona J Taverner
{"title":"Dexmedetomidine, high-flow nasal oxygen and regional anaesthesia for neonatal hand surgery.","authors":"Hannah M Lewis, Josephine Alexa Potter, Fiona J Taverner","doi":"10.1177/0310057X261491550","DOIUrl":"https://doi.org/10.1177/0310057X261491550","url":null,"abstract":"<p><p>We report the use of dexmedetomidine sedation, high-flow nasal oxygen and regional anaesthesia for a term neonate (16 days old, 2.6 kg) with amniotic band syndrome undergoing hand surgery. We discuss the pharmacokinetics of dexmedetomidine and use of high-flow nasal oxygen insufflation in this age group. Age-dependent pharmacokinetics and pharmacodynamic effects of dexmedetomidine make dosing challenging in neonates, but when used appropriately it can minimise the need for exposure to general anaesthesia, airway instrumentation and mechanical ventilation, all of which are associated with adverse perioperative events in neonates, such as apnoea, bradycardia and prolonged postoperative ventilation.</p>","PeriodicalId":7746,"journal":{"name":"Anaesthesia and Intensive Care","volume":" ","pages":"310057X261491550"},"PeriodicalIF":1.5,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Minimising the cost of care: Anaesthesia and perioperative care during acute fuel resource shortages.","authors":"Zheng J Lim, Forbes McGain","doi":"10.1177/0310057X261446970","DOIUrl":"https://doi.org/10.1177/0310057X261446970","url":null,"abstract":"","PeriodicalId":7746,"journal":{"name":"Anaesthesia and Intensive Care","volume":" ","pages":"310057X261446970"},"PeriodicalIF":1.5,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"History repeats itself: Sister anaesthetists in the Second World War - Lessons from the past.","authors":"Basel O Obeidat, Peter J Featherstone","doi":"10.1177/0310057X261481918","DOIUrl":"https://doi.org/10.1177/0310057X261481918","url":null,"abstract":"<p><p>During the Second World War, acute shortages of medically qualified personnel prompted Addenbrooke's Hospital, Cambridge to train experienced nursing sisters to administer anaesthetics. Drawing on material from the Addenbrooke's archives, personal memoirs of participants, records from hospitals in Norwich and Ipswich, and contemporaneous correspondence published in the <i>British Medical Journal</i> and the <i>Lancet</i>, this article examines the development, professional reception, and eventual cessation of the Sister Anaesthetist scheme at Addenbrooke's Hospital. This scheme was formally proposed in May 1940, and modelled on an existing programme which had been established at the Norfolk and Norwich Hospital almost two decades previously. Despite the requirement for a structured 6-month apprenticeship and ongoing evidence of clinical competency by those enrolled, the scheme generated fierce opposition from local Honorary Anaesthetists, culminating in a collective threat of resignation in June 1941. Sister Anaesthetists were consistently framed as a temporary emergency measure and their employment formally ended in May 1946 when a medically qualified Resident Anaesthetist was appointed. We briefly consider how these historical patterns - pragmatic necessity versus professional identity, training variability, medicolegal uncertainty, and the contested temporariness of non-physician roles - resonate with present-day discussions surrounding Anaesthesia Associates in the United Kingdom.</p>","PeriodicalId":7746,"journal":{"name":"Anaesthesia and Intensive Care","volume":" ","pages":"310057X261481918"},"PeriodicalIF":1.5,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The development of the Taipan Antivenom - An Australian story from Far North Queensland.","authors":"Robert F Grace","doi":"10.1177/0310057X261486046","DOIUrl":"https://doi.org/10.1177/0310057X261486046","url":null,"abstract":"<p><p>The development of the taipan antivenom in Australia is a unique story, centred in Far North Queensland. It is infused with idealism and heroism. The taipan is one of the world's deadliest snakes. A live specimen of the coastal taipan was not captured until 1950, and the antivenom only became available in 1955. Until then a bite from the coastal taipan was universally fatal. Kevin Budden a snake enthusiast was bitten in the process of capturing the specimen. Budden extracted a promise from those around him that the snake would not be killed but be sent to the Commonwealth Serum Laboratories in Melbourne for milking. From this courageous act, the antivenom was developed and many lives subsequently saved. The first use of the taipan antivenom was on a boy in Cairns. He survived and grew up to become an anaesthetist.</p>","PeriodicalId":7746,"journal":{"name":"Anaesthesia and Intensive Care","volume":" ","pages":"310057X261486046"},"PeriodicalIF":1.5,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Survey of anaesthetists' attitudes to random alcohol and drug testing in the workplace.","authors":"Richard H Riley","doi":"10.1177/0310057X261478648","DOIUrl":"https://doi.org/10.1177/0310057X261478648","url":null,"abstract":"<p><p>Attitudes among trainee and practising anaesthetists to random drug and alcohol testing (RDT) were surveyed in the anaesthesia workplace. There were 270 (22% trainees, 68% male) respondents to an online survey instrument. Sixty-three percent supported RDT for anaesthetists, and there were similar levels of support for RDT of surgeons (62%), anaesthesia assistants (66%), post-anaesthesia care unit staff (65%), operating theatre nurses (64%), and hospital pharmacists (66%). If RDT was introduced, respondents differed in their preferred frequency of testing (26% twice a year, 27% unsure, 9% monthly). RDT of road users by police was supported by 96% of respondents, and there were widely differing views on current systems for drug security, distribution or disposal being a deterrent or reducing drug diversion.</p>","PeriodicalId":7746,"journal":{"name":"Anaesthesia and Intensive Care","volume":" ","pages":"310057X261478648"},"PeriodicalIF":1.5,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}