Thyroidology最新文献_第8页

Increased cellular growth of FRTL-5 thyroid cells mediated by discontinuous stimulation with bTSH. bTSH间断刺激介导FRTL-5甲状腺细胞的细胞生长增加。

Thyroidology Pub Date : 1991-12-01

T Klugmann, I Mons, B E Wenzel

引用次数: 0

Modulation of nuclear T3 binding by T3 in a human hepatocyte cell-line (Chang-liver) - T3 stimulation of cell growth but not of malic enzyme, glucose-6-phosphatdehydrogenase or 6-phosphogluconate-dehydrogenase. T3在人肝细胞细胞系(Chang-liver)中调节核T3结合- T3刺激细胞生长，但不刺激苹果酸酶、葡萄糖-6-磷酸脱氢酶或6-磷酸葡萄糖-脱氢酶。

Thyroidology Pub Date : 1991-05-01

L E Matzen, S R Kristensen, J Kvetny

{"title":"Modulation of nuclear T3 binding by T3 in a human hepatocyte cell-line (Chang-liver) - T3 stimulation of cell growth but not of malic enzyme, glucose-6-phosphatdehydrogenase or 6-phosphogluconate-dehydrogenase.","authors":"L E Matzen, S R Kristensen, J Kvetny","doi":"","DOIUrl":"","url":null,"abstract":"Unlabelled: The T3 modulation of nuclear T3 binding (NBT3), the T3 effect on cell growth, and the T3 and insulin effects on malic enzyme (ME), glucose-6-phosphat-dehydrogenase (G6PD) and 6-phosphogluconat-dehydrogenase (G6PD) were studied in a human hepatocyte cell-line (Chang-liver). T3 was bound to a high affinity site with (mean +/- SD, n = 7) Ka1 3.0 +/- 0.3 * 10(9) M-1 and maximal binding capacity (MBC1 112.1 +/- 20.7 fmol/mg DNA, and to a low affinity site with (median, (range), n = 7) Ka2 1.4 (0.6 - 2.6) * 10(7) M-1 and MBC2 766 (461-2687) fmol/mg DNA. Incubation of cells with T3 6 nmol/l for 20 hours reduced the area under the T3 binding curves (AUC) to 80.9% +/- 10.0% of AUC in cells incubated without T3 (p < 0.01, n = 7). The downregulation, being reversible and associated with receptor saturation, was caused by a reduction in MBC1 of the high affinity site to 66.6 fmol/mg DNA, whereas Ka1 was unchanged. T3 stimulated cell growth (p < 0.05, n = 8), but had no effect on the activities of ME, G6PD, and 6PGD. Insulin (1 mumol/l) enhanced the activities of ME (p < 0.01, n = 6) and 6PGD (p < 0.05, n = 6).In conclusion: The cellular effects of T3 in the human hepatocyte cell-line was: 1) a reversible modulation of NBT3 associated to receptor saturation; 2) stimulation of cell growth; 3) contrary to the findings in rat hepatocytes no stimulation of ME, G6PD or 6PGD. Insulin enhanced ME and 6PGD.","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"3 2","pages":"37-45"},"PeriodicalIF":0.0,"publicationDate":"1991-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12890476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid stimulating antibodies in patients with Graves' ophthalmopathy. Graves眼病患者甲状腺刺激抗体的研究。

Thyroidology Pub Date : 1991-05-01

J M Gomez, J Soler, M A Navarro

引用次数: 0

Treatment of supraventricular tachyarrhythmias associated with hyperthyroidism by radioiodine, amiodarone and propylthiouracil. 放射性碘、胺碘酮和丙硫脲嘧啶治疗伴甲亢的室上性心动过速。

Thyroidology Pub Date : 1991-05-01

J Unger, N Mavroudakis, A Lipski, A van Coevorden

{"title":"Treatment of supraventricular tachyarrhythmias associated with hyperthyroidism by radioiodine, amiodarone and propylthiouracil.","authors":"J Unger, N Mavroudakis, A Lipski, A van Coevorden","doi":"","DOIUrl":"","url":null,"abstract":"Beta-blockers and calcium antagonists have been advocated for thyrotoxicosis induced tachyarrhythmias. Amiodarone is generally considered as contraindicated because of its high iodine content. Since amiodarone combined with propylthiouracil induced a greater fall in serum thyroid hormone concentrations than propylthiouracil alone, we treated 2 hyperthyroid patients with supraventricular arrhythmias by radioiodine (day 0) followed after 24 h by amiodarone and propylthiouracil. Serum T3 was normalized on day 2 (patient 1) and 3 (patient 2). Effective t1/2 of intrathyroidal 131I were 6.6 and 4.3 days (versus 5.9 days for 131I given alone). In patient 1, atrial fibrillation, reverted to sinus rhythm after verapamil and digoxin, and did not recur. In patient 2, conversion of atrial fibrillation to sinus rhythm occurred on day 11; from day 0 to day 11, ventricular rate decreased and was significantly correlated to T3 (r = 0.82; p < 0.05). In conclusion, amiodarone may be beneficial in thyrotoxicosis associated tachyarrhythmias, given with propylthiouracil 24 h after radioiodine, it did not decrease thyroid irradiation and rapidly decreased serum T3.","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"3 2","pages":"85-8"},"PeriodicalIF":0.0,"publicationDate":"1991-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12890424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graves' orbitopathy and restrictive myopathy. Graves眼窝病和限制性肌病。

Thyroidology Pub Date : 1991-05-01

B Biedner, M Marcus, Y Yassur

{"title":"Graves' orbitopathy and restrictive myopathy.","authors":"B Biedner, M Marcus, Y Yassur","doi":"","DOIUrl":"","url":null,"abstract":"Restrictive myopathy in Graves' orbitopathy is a disabling disorder, difficult to treat, involving clinically the inferior and medial recti. Most patients do not return to the normal, premorbid state of muscular alignment and the goal of treatment is to reach binocular vision in the important directions of gaze--straight ahead (primary position) and downgaze (reading position). The treatment in the acute, congestive stage is optical, prisms or patching, or medical. The medical treatment principally consists of a course of oral or intravenous corticosteroid treatment, and in selected patients orbital irradiation can be of benefit. Surgery is performed on the euthyroid patient after the muscular imbalance has stabilized, usually six months from the onset of the disorder. The mainstay of therapy is a large recession of the involved muscles, if possible on an adjustable suture. Sometimes marginal myotomies are added to the muscle recession. A fadenoperation on the contralateral, minimally involved inferior rectus has been suggested as a means of increasing muscular alignment in both primary position and downgaze. Thorough evaluation of the course of the disease, and the benefit of different treatment modalities is possible only with long term follow-up.","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"3 2","pages":"79-83"},"PeriodicalIF":0.0,"publicationDate":"1991-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12890423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Basal and stimulated TSH serum concentrations in euthyroid thyroid nodule patients. 正常甲状腺结节患者的基础和刺激TSH血清浓度。

Thyroidology Pub Date : 1991-05-01

A Carpri, M G Toni, C De Gaudio, A Mita, A Sagripanti

{"title":"Basal and stimulated TSH serum concentrations in euthyroid thyroid nodule patients.","authors":"A Carpri, M G Toni, C De Gaudio, A Mita, A Sagripanti","doi":"","DOIUrl":"","url":null,"abstract":"Serum TSH concentrations were determined by a sensitive second generation immunoradiometric (IRMA) assay, basally and 20 min after i.v. injection of 200 micrograms of TRH, in 630 consecutive ambulatory clinically and biochemically euthyroid patients with palpable thyroid nodules. The TSH response was defined as normal when the stimulated TSH values was higher than the basal one by at least 2 microU/ml, as suppressed when the difference between the two TSH values was less than 1 microU/ml and as blunted when this difference was between 1 and 2 microU/ml. The TSH response was normal in 511 patients (81.1%), suppressed in 78 (12.4%) and blunted in 41 cases (6.5%). Nodule patients with suppressed responses showed significantly higher mean age (52.7 vs 45.8 years; p < 0.05) and mean serum concentrations of TT4 (9.32 vs 8.71 micrograms/dl; p < 0.05), TT3 (161 vs 137 ng/dl; p < 0.01) and fT3 (4.94 vs 3.86 pg/ml; p < 0.01) than those with normal TSH secretion. Analysis of the distribution of the different TSH responses in the patients grouped according to basal TSH concentration values showed that 50% of the patient group with basal TSH concentration between > 0.2 and 0.3 microU/ml had normal TSH response to TRH. A normal response occurred in 86.5% of patients with basal TSH between > 0.4 and 0.5 microU/ml and in 95.3% of those with basal TSH between > 0.7 and 0.8 microU/ml. The proportion of normal responses in the patients with basal TSH up to 0.1 microU/ml was 15.7% and that of abnormal responses in those with basal TSH > 1.5 microU/ml was 2.7%.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"3 2","pages":"69-73"},"PeriodicalIF":0.0,"publicationDate":"1991-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12890421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The outcome of benign thyroid nodules correlates with the findings of fine needle biopsy. 良性甲状腺结节的预后与细针活检的结果相关。

Thyroidology Pub Date : 1991-05-01

S Tseleni-Balafouta, K Katsouyanni, J Kitsopanides, D A Koutras

引用次数: 0

Vitiligo in autoimmune thyroid disease. 自身免疫性甲状腺疾病中的白癜风。

Thyroidology Pub Date : 1991-05-01

Y K Shong, J A Kim

引用次数: 0

Thyrotropin-releasing hormone degradation in patients with insulin dependent diabetes mellitus. Effects of metabolic control. 胰岛素依赖型糖尿病患者促甲状腺激素释放激素的降解。代谢控制的效果。

Thyroidology Pub Date : 1991-05-01

L Duntas, F S Keck, C Wolf, H Hauner, E F Pfeiffer

{"title":"Thyrotropin-releasing hormone degradation in patients with insulin dependent diabetes mellitus. Effects of metabolic control.","authors":"L Duntas, F S Keck, C Wolf, H Hauner, E F Pfeiffer","doi":"","DOIUrl":"","url":null,"abstract":"We investigated thyrotropin releasing hormone (TRH) degradation in terms of half-life (t1/2) and metabolic clearance rate (MCR) in eight subjects with insulin dependent diabetes mellitus (IDDM) before and after strict metabolic control. The results were compared with those of six healthy control subjects. The basal plasma TRH-IR levels (31 +/- 9 fmoles/ml) were on the lowest normal limit in the IDDM patients and were not considerably changed (24 +/- 10) after strict metabolic control. The basal and delta max rise of TSH to TRH (200 micrograms i.v.) were not significantly different before or after improved metabolic control in IDDM and as compared to controls. The TRH-degradation curves showed similar exponential decay before and after improvement of metabolic control (t1/2: 7.6 +/- 0.4 min and 7.3 +/- 0.3 respectively; 6.5 +/- 0.4 min for the controls). The MCR of exogenously administered TRH in IDDM before (65.5 +/- 8.6 l/m2/day) and after (65.0 +/- 8.9) control was not different compared to the normals (76.5 +/- 9.6). The area under the plasma concentration-time curve (AUC) in IDDM before (52.193 +/- 6.773 fmoles.ml-1.min) and after improvement of metabolic control (53.186 +/- 7.856) was slightly higher than in the healthy subjects (40.151 +/- 3.741, n.s.). These findings demonstrate that a) the degradation of exogenous TRH is not dependent on the glucose metabolic state, b) insulin deficient diabetes mellitus does not affect the enzymatic system responsible for TRH degradation and, c) the hypothalamic-pituitary axis appears to be intact in IDDM.","PeriodicalId":77445,"journal":{"name":"Thyroidology","volume":"3 2","pages":"51-7"},"PeriodicalIF":0.0,"publicationDate":"1991-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12890418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autonomously functioning thyroid adenoma in a seven year old boy. 七岁男童的自主功能甲状腺腺瘤。

Thyroidology Pub Date : 1991-05-01

G De Rosa, V Sammito, A Testa, V Rufini, M A Satta, A Butti, M Cagossi, L Troncone

引用次数: 0